JP2024522766A - 縮合四環系化合物、その調製方法及びその医薬的応用 - Google Patents

縮合四環系化合物、その調製方法及びその医薬的応用 Download PDF

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JP2024522766A
JP2024522766A JP2023577689A JP2023577689A JP2024522766A JP 2024522766 A JP2024522766 A JP 2024522766A JP 2023577689 A JP2023577689 A JP 2023577689A JP 2023577689 A JP2023577689 A JP 2023577689A JP 2024522766 A JP2024522766 A JP 2024522766A
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cancer
compound
salt
membered
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JP2024522766A5 (https=
Inventor
心 李
峰 沈
懐徳 董
陽 陳
峰 賀
維康 陶
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Shanghai Hengrui Pharmaceutical Co Ltd
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Shanghai Hengrui Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2023577689A 2021-06-21 2022-06-21 縮合四環系化合物、その調製方法及びその医薬的応用 Pending JP2024522766A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN202110687643 2021-06-21
CN202110687643.8 2021-06-21
CN202110880105 2021-08-02
CN202110880105.0 2021-08-02
CN202111073775 2021-09-14
CN202111073775.8 2021-09-14
CN202111225928.6 2021-10-21
CN202111225928 2021-10-21
PCT/CN2022/100016 WO2022268051A1 (zh) 2021-06-21 2022-06-21 稠合四环类化合物、其制备方法及其在医药上的应用

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JP2024522766A true JP2024522766A (ja) 2024-06-21
JP2024522766A5 JP2024522766A5 (https=) 2025-07-01

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JP2023577689A Pending JP2024522766A (ja) 2021-06-21 2022-06-21 縮合四環系化合物、その調製方法及びその医薬的応用

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US (1) US20240327434A1 (https=)
EP (1) EP4361157A4 (https=)
JP (1) JP2024522766A (https=)
KR (1) KR20240024903A (https=)
CN (1) CN117255793A (https=)
AU (1) AU2022297474A1 (https=)
BR (1) BR112023024646A2 (https=)
CA (1) CA3220929A1 (https=)
MX (1) MX2023015533A (https=)
TW (1) TW202317587A (https=)
WO (1) WO2022268051A1 (https=)

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JP2024525993A (ja) * 2021-07-23 2024-07-12 スゾウ、ザンロン、ファーマ、リミテッド Ｋｒａｓ ｇ１２ｄ阻害剤およびその使用

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WO2024208305A1 (zh) * 2023-04-07 2024-10-10 江苏恒瑞医药股份有限公司 稠合四环类化合物、其制备方法及其在医药上的应用
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TW202517649A (zh) * 2023-07-18 2025-05-01 大陸商泰勵生物科技（上海）有限公司 具有抗ｋｒａｓ突變腫瘤活性的化合物
WO2025045141A1 (en) * 2023-08-31 2025-03-06 Suzhou Zanrong Pharma Limited Kras inhibitors and uses thereof
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US20250114346A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
US20250114339A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor
AU2024374420A1 (en) * 2023-11-02 2026-04-16 Kumquat Biosciences Inc. Degraders and uses thereof
WO2025108443A2 (en) * 2023-11-23 2025-05-30 Beigene Switzerland Gmbh Heterocyclic compounds, compositions thereof, and methods of treatment therewith
WO2025146194A1 (en) * 2024-01-05 2025-07-10 Jacobio Pharmaceuticals Co., Ltd. Fused tetracyclic compounds and use thereof
WO2025153038A1 (en) * 2024-01-17 2025-07-24 Suzhou Zanrong Pharma Limited Kras inhibitors and uses thereof
CN119684315A (zh) * 2024-01-26 2025-03-25 苏州盛迪亚生物医药有限公司 一种苯并噻吩取代稠环化合物的结晶形式及其制备方法
WO2025157261A1 (zh) * 2024-01-26 2025-07-31 江苏恒瑞医药股份有限公司 G12d抑制剂化合物晶型及其制备方法
CN119661556B (zh) * 2024-01-26 2025-12-09 苏州盛迪亚生物医药有限公司 一种稠环类化合物的可药用盐、其结晶形式及用途
CN119490512A (zh) * 2024-01-26 2025-02-21 苏州盛迪亚生物医药有限公司 一种苯并噻吩取代稠环化合物的可药用盐、其结晶形式及用途

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JP2024510022A (ja) * 2021-03-17 2024-03-05 ▲勁▼方医▲薬▼科技（上海）有限公司 ピリミジン縮合環系化合物、その製造方法、及び使用
JP2024525993A (ja) * 2021-07-23 2024-07-12 スゾウ、ザンロン、ファーマ、リミテッド Ｋｒａｓ ｇ１２ｄ阻害剤およびその使用

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EP4361157A4 (en) 2024-10-16
CN117255793A (zh) 2023-12-19
AU2022297474A1 (en) 2024-01-18
BR112023024646A2 (pt) 2024-03-05
KR20240024903A (ko) 2024-02-26
US20240327434A1 (en) 2024-10-03
WO2022268051A1 (zh) 2022-12-29
MX2023015533A (es) 2024-01-23
CA3220929A1 (en) 2022-12-29
TW202317587A (zh) 2023-05-01
EP4361157A1 (en) 2024-05-01

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