JP2020526498A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020526498A5 JP2020526498A5 JP2019572355A JP2019572355A JP2020526498A5 JP 2020526498 A5 JP2020526498 A5 JP 2020526498A5 JP 2019572355 A JP2019572355 A JP 2019572355A JP 2019572355 A JP2019572355 A JP 2019572355A JP 2020526498 A5 JP2020526498 A5 JP 2020526498A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- phenyl
- carboxamide
- piperidine
- thiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 I*1CCNCC1 Chemical compound I*1CCNCC1 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022171152A JP7379639B2 (ja) | 2017-06-29 | 2022-10-26 | キナーゼ阻害剤ならびに作製および使用のための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762526838P | 2017-06-29 | 2017-06-29 | |
| US62/526,838 | 2017-06-29 | ||
| PCT/US2018/040021 WO2019006126A1 (en) | 2017-06-29 | 2018-06-28 | KINASE INHIBITORS AND METHODS OF MAKING AND USING THEM |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022171152A Division JP7379639B2 (ja) | 2017-06-29 | 2022-10-26 | キナーゼ阻害剤ならびに作製および使用のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020526498A JP2020526498A (ja) | 2020-08-31 |
| JP2020526498A5 true JP2020526498A5 (https=) | 2021-08-05 |
| JP7167069B2 JP7167069B2 (ja) | 2022-11-08 |
Family
ID=62976284
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572355A Active JP7167069B2 (ja) | 2017-06-29 | 2018-06-28 | キナーゼ阻害剤ならびに作製および使用のための方法 |
| JP2022171152A Active JP7379639B2 (ja) | 2017-06-29 | 2022-10-26 | キナーゼ阻害剤ならびに作製および使用のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022171152A Active JP7379639B2 (ja) | 2017-06-29 | 2022-10-26 | キナーゼ阻害剤ならびに作製および使用のための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10590121B2 (https=) |
| EP (1) | EP3645525A1 (https=) |
| JP (2) | JP7167069B2 (https=) |
| CN (1) | CN111032642B (https=) |
| CA (1) | CA3068305A1 (https=) |
| WO (1) | WO2019006126A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3068305A1 (en) * | 2017-06-29 | 2019-01-03 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and methods for making and using |
| WO2020132651A1 (en) | 2018-12-20 | 2020-06-25 | Amgen Inc. | Kif18a inhibitors |
| EP3898616B1 (en) | 2018-12-20 | 2024-10-02 | Amgen Inc. | Heteroaryl amides useful as kif18a inhibitors |
| JP7676308B2 (ja) * | 2018-12-20 | 2025-05-14 | アムジエン・インコーポレーテツド | Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド |
| US11390604B2 (en) * | 2019-03-08 | 2022-07-19 | Hoffmann-La Roche Inc. | Imidazole-pyrazole derivatives |
| WO2021018118A1 (en) * | 2019-07-29 | 2021-02-04 | Janssen Pharmaceutica Nv | Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 1 proteins |
| US12540129B2 (en) | 2019-08-02 | 2026-02-03 | Amgen Inc. | KIF18A inhibitors |
| WO2021026099A1 (en) | 2019-08-02 | 2021-02-11 | Amgen Inc. | Kif18a inhibitors |
| WO2021035257A1 (en) * | 2019-08-21 | 2021-02-25 | The Scripps Research Institute | Monocyclic agonists of stimulator of interferon genes sting |
| CN110592056A (zh) * | 2019-09-19 | 2019-12-20 | 昆明理工大学 | 噬菌体裂解酶复合粉剂及其制备方法和应用 |
| CN114981259B (zh) * | 2020-01-22 | 2024-06-18 | 豪夫迈·罗氏有限公司 | 新型杂环化合物 |
| AR121717A1 (es) * | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
| US20230295146A1 (en) * | 2020-07-24 | 2023-09-21 | The University Of Rochester | Inhibitors of interleukin-1 receptor-associated kinases 1 and 4 |
| JP2024506021A (ja) * | 2021-02-07 | 2024-02-08 | エフ． ホフマン－ラ ロシュ アーゲー | 新規ヘテロアリール置換イミダゾール誘導体 |
| WO2022197575A1 (en) * | 2021-03-17 | 2022-09-22 | Merck Sharp & Dohme Llc | Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| WO2023088435A1 (zh) * | 2021-11-19 | 2023-05-25 | 成都奥睿药业有限公司 | 三取代吡啶衍生物的制备及作为芳香烃受体调节物的应用 |
| JP2025513716A (ja) | 2022-03-23 | 2025-04-30 | ライジェル・ファーマシューティカルズ・インコーポレイテッド | Ｉｒａｋ阻害剤としてのピリミド－２－イル－ピラゾール化合物 |
| AU2024214768A1 (en) * | 2023-01-30 | 2025-08-07 | The Johns Hopkins University | 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor |
| CN118027009B (zh) * | 2024-04-15 | 2024-07-12 | 北京师范大学 | 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| EP0431519B1 (en) | 1989-12-04 | 1994-06-15 | G.D. Searle & Co. | System for transdermal albuterol administration |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| DE69228827T2 (de) | 1991-12-18 | 1999-10-21 | Minnesota Mining And Mfg. Co., Saint Paul | Mehrschichtige sperrstrukturen |
| EP0553769B1 (de) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Ballspielschläger, insbesondere Tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| JP2016505012A (ja) * | 2013-01-10 | 2016-02-18 | ニンバス アイリス， インコーポレイテッド | Ｉｒａｋ阻害剤およびその使用 |
| EP3079682A4 (en) * | 2013-12-13 | 2017-08-30 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| EA039043B1 (ru) * | 2015-04-22 | 2021-11-25 | Райджел Фармасьютикалз, Инк. | Пиразольные соединения и способ получения и применения данных соединений |
| BR112018000624A2 (pt) * | 2015-07-15 | 2018-09-18 | Aurigene Discovery Technologies Limited | compostos de indazol e azaindazol como inibidores de irak-4 |
| JP6994454B2 (ja) * | 2015-08-04 | 2022-01-14 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ベンズアゾール化合物ならびに該化合物の作製方法および使用方法 |
| CA3068305A1 (en) * | 2017-06-29 | 2019-01-03 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and methods for making and using |
-
2018
- 2018-06-28 CA CA3068305A patent/CA3068305A1/en active Pending
- 2018-06-28 EP EP18743281.0A patent/EP3645525A1/en not_active Withdrawn
- 2018-06-28 US US16/022,323 patent/US10590121B2/en active Active
- 2018-06-28 WO PCT/US2018/040021 patent/WO2019006126A1/en not_active Ceased
- 2018-06-28 CN CN201880052620.6A patent/CN111032642B/zh not_active Expired - Fee Related
- 2018-06-28 JP JP2019572355A patent/JP7167069B2/ja active Active
-
2020
- 2020-02-12 US US16/789,131 patent/US11059814B2/en active Active
-
2021
- 2021-06-08 US US17/341,817 patent/US20210309655A1/en not_active Abandoned
-
2022
- 2022-10-26 JP JP2022171152A patent/JP7379639B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020526498A5 (https=) | ||
| JP2018528181A5 (https=) | ||
| US10717730B1 (en) | Dihydroisoquinoline compound | |
| JP7379639B2 (ja) | キナーゼ阻害剤ならびに作製および使用のための方法 | |
| ES2789331T3 (es) | Inhibidores de TGF-beta | |
| JP6994454B2 (ja) | ベンズアゾール化合物ならびに該化合物の作製方法および使用方法 | |
| JP5612678B2 (ja) | 抗ウイルス性複素環化合物 | |
| CN106573914B (zh) | 作为激酶抑制剂的吡唑基-脲 | |
| JP6608918B2 (ja) | Ｐ３８キナーゼ阻害剤としてのジアリール尿素誘導体 | |
| JP2019094350A (ja) | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 | |
| ES2664219T3 (es) | Inhibición de IL17 e IFN-gamma para el tratamiento de una inflamación autoinmunitaria | |
| JP7328323B2 (ja) | ＳＭＡＲＣＡ２／ＢＲＭ ＡＴＰａｓｅ阻害剤としての尿素化合物及び組成物 | |
| JP7713934B2 (ja) | Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶溶媒和形 | |
| CN115103709A (zh) | Masp-2抑制剂和使用方法 | |
| SI2797918T1 (en) | Bromodomain inhibitors | |
| CN105899493A (zh) | 用于抑制shp2活性的1-(三嗪-3-基/哒嗪-3-基)-哌(-嗪)啶衍生物及其组合物 | |
| JP2013504604A (ja) | ウイルスポリメラーゼ阻害剤としてのキナゾリノン誘導体 | |
| CN106459063A (zh) | Mertk‑特异性嘧啶化合物 | |
| RU2010137635A (ru) | Гетероциклические антивирусные соединения | |
| CN105246884A (zh) | 用作激酶抑制剂的脲衍生物 | |
| WO2018181883A1 (ja) | ４－ピリドン化合物またはその塩、それを含む医薬組成物および剤 | |
| CN102648198A (zh) | 作为s1p1/edg1受体调节剂的吡啶衍生物 | |
| JP7379640B2 (ja) | Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法 | |
| TWI870449B (zh) | 吡唑化合物，其配製物以及使用該化合物和/或配製物之方法 | |
| JP2019537577A5 (https=) |