JP2022546410A5 - - Google Patents
Info
- Publication number
- JP2022546410A5 JP2022546410A5 JP2022513159A JP2022513159A JP2022546410A5 JP 2022546410 A5 JP2022546410 A5 JP 2022546410A5 JP 2022513159 A JP2022513159 A JP 2022513159A JP 2022513159 A JP2022513159 A JP 2022513159A JP 2022546410 A5 JP2022546410 A5 JP 2022546410A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- hydroxyacetamide
- difluorophenyl
- methylphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962893512P | 2019-08-29 | 2019-08-29 | |
| US62/893,512 | 2019-08-29 | ||
| PCT/US2020/048619 WO2021041973A1 (en) | 2019-08-29 | 2020-08-28 | Perk inhibiting compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022546410A JP2022546410A (ja) | 2022-11-04 |
| JP2022546410A5 true JP2022546410A5 (https=) | 2023-08-28 |
Family
ID=72521702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513159A Pending JP2022546410A (ja) | 2019-08-29 | 2020-08-28 | Ｐｅｒｋ阻害化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12473296B2 (https=) |
| EP (1) | EP4021893A1 (https=) |
| JP (1) | JP2022546410A (https=) |
| KR (1) | KR20220068224A (https=) |
| CN (1) | CN114585606A (https=) |
| AU (1) | AU2020340427A1 (https=) |
| BR (1) | BR112022003768A2 (https=) |
| CA (1) | CA3152512A1 (https=) |
| IL (1) | IL290881A (https=) |
| MX (1) | MX2022002443A (https=) |
| PH (1) | PH12022550497A1 (https=) |
| WO (1) | WO2021041973A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114585606A (zh) | 2019-08-29 | 2022-06-03 | 希伯塞尔股份有限公司 | 抑制perk的化合物 |
| JP2023517666A (ja) | 2020-03-11 | 2023-04-26 | アドバンシックス・レジンズ・アンド・ケミカルズ・リミテッド・ライアビリティ・カンパニー | 農業用製品のための界面活性剤 |
| US20250000859A1 (en) | 2021-08-25 | 2025-01-02 | Alesta Therapeutics BV | Use of gcn2 inhibitors in treating cancer |
| CN121399099A (zh) * | 2023-03-30 | 2026-01-23 | 希伯塞尔股份有限公司 | (r)-2-氨基-5-(4-(2-(3,5-二氟苯基)-2-羟基乙酰胺基)-2-甲基苯基)-n-异丙基烟酰胺的晶形及其使用方法 |
| GB202407386D0 (en) | 2024-05-24 | 2024-07-10 | Apollo Ap45 Ltd | 1H-pyrazolo(4,3-D)pyrimidine derivatives |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903297A (en) | 1973-11-01 | 1975-09-02 | Upjohn Co | Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs |
| US7863444B2 (en) | 1997-03-19 | 2011-01-04 | Abbott Laboratories | 4-aminopyrrolopyrimidines as kinase inhibitors |
| TR199902301T2 (xx) | 1997-03-19 | 1999-12-21 | Basf Aktiengesellschaft | Pirilo $2,3D]pirimidinler ve onlar�n kullan�m�. |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| EP1501514B1 (en) | 2002-05-03 | 2012-12-19 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| WO2004080982A1 (en) * | 2003-03-11 | 2004-09-23 | Pfizer Products Inc. | Pyrazine compounds as transforming growth factor (tgf) inhibitors |
| EP1663978B1 (en) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| EP1663204B1 (en) * | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit modulators and methods of use |
| TWI387592B (zh) | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
| US8211919B2 (en) | 2005-09-02 | 2012-07-03 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| AU2009219437B2 (en) | 2008-02-25 | 2014-10-16 | Nestec S.A. | Drug selection for breast cancer therapy using antibody-based arrays |
| WO2010080992A1 (en) | 2009-01-09 | 2010-07-15 | The Trustees Of The University Of Pennsylvania | Regulators of the interferon-alpha receptor 1 (ifnar1) chain of the interferon receptor |
| CA2794153C (en) | 2010-03-25 | 2018-01-02 | Glaxosmithkline Llc | Substituted indoline derivatives as perk inhibitors |
| EP2986286A1 (en) * | 2013-04-15 | 2016-02-24 | Universita' Degli Studi di Bari | Galloyl benzamide-based compounds as jnk modulators |
| WO2015056180A1 (en) | 2013-10-15 | 2015-04-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Indoline derivatives as inhibitors of perk |
| JP6493218B2 (ja) | 2013-11-08 | 2019-04-03 | 小野薬品工業株式会社 | ピロロピリミジン誘導体 |
| WO2015136463A1 (en) | 2014-03-11 | 2015-09-17 | Glaxosmithkline Intellectual Property (No.2) Limited | Chemical compounds acting as perk inhibitors |
| WO2016004254A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Combined modulation of ire1 |
| KR102562866B1 (ko) | 2014-11-14 | 2023-08-04 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 단백질 키나아제 억제제로서의 6-아미노-7-바이사이클로-7-데아자-퓨린 유도체 |
| GB201508747D0 (en) | 2015-05-21 | 2015-07-01 | Univ Edinburgh | Compounds |
| CN108026102A (zh) | 2015-07-24 | 2018-05-11 | 蓝印药品公司 | 可用于治疗与kit和pdgfr相关的病症的化合物 |
| ES2965081T3 (es) | 2016-07-07 | 2024-04-11 | Daewoong Pharmaceutical Co Ltd | Derivados 4-aminopirazolo[3,4-d]pirimidinil-azabiciclo y composición farmacéutica que comprende dichos derivados |
| US20190241573A1 (en) | 2016-07-20 | 2019-08-08 | Glaxosmithkline Intellectual Property Development Limited | Isoquinoline derivatives as perk inhibitors |
| CN106748989B (zh) * | 2016-11-14 | 2020-03-17 | 西安交通大学 | 一种具有抗肿瘤活性的二芳基脲类化合物及其制备方法和应用 |
| EP3656382A1 (en) | 2017-01-30 | 2020-05-27 | Université de Liège | Perk and ire-1a inhibitors against neurodevelopmental disorders |
| RS65914B1 (sr) * | 2017-04-18 | 2024-10-31 | Lilly Co Eli | Fenil-2-hidroksi-acetilamino-2-metil-fenil jedinjenja |
| KR102740831B1 (ko) | 2017-11-14 | 2024-12-11 | 칠드런'즈 메디컬 센터 코포레이션 | 신규 이미다조피리미딘 화합물 및 그의 용도 |
| WO2019106156A1 (en) * | 2017-11-30 | 2019-06-06 | Step Pharma S.A.S. | Compounds |
| EP3492454A1 (en) * | 2017-11-30 | 2019-06-05 | Step Pharma S.A.S. | Compounds |
| CA3095156A1 (en) * | 2018-03-26 | 2019-10-03 | Icahn School Of Medicine At Mount Sinai | Methods of treating minimal residual cancer |
| US11186579B2 (en) | 2018-07-06 | 2021-11-30 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| EP3860578A1 (en) | 2018-10-01 | 2021-08-11 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of inhibitors of stress granule formation for targeting the regulation of immune responses |
| WO2021041976A1 (en) | 2019-08-29 | 2021-03-04 | Hibercell, Inc. | Perk inhibiting indolinyl compounds |
| CA3152508A1 (en) | 2019-08-29 | 2021-03-04 | Hibercell, Inc. | Perk inhibiting pyrrolopyrimidine compounds |
| US12331054B2 (en) | 2019-08-29 | 2025-06-17 | Hibercell, Inc. | Perk inhibiting imidazolopyrazine compounds |
| CN114585606A (zh) | 2019-08-29 | 2022-06-03 | 希伯塞尔股份有限公司 | 抑制perk的化合物 |
-
2020
- 2020-08-28 CN CN202080074307.XA patent/CN114585606A/zh active Pending
- 2020-08-28 CA CA3152512A patent/CA3152512A1/en active Pending
- 2020-08-28 KR KR1020227010196A patent/KR20220068224A/ko not_active Ceased
- 2020-08-28 BR BR112022003768A patent/BR112022003768A2/pt not_active IP Right Cessation
- 2020-08-28 US US17/639,169 patent/US12473296B2/en active Active
- 2020-08-28 MX MX2022002443A patent/MX2022002443A/es unknown
- 2020-08-28 WO PCT/US2020/048619 patent/WO2021041973A1/en not_active Ceased
- 2020-08-28 AU AU2020340427A patent/AU2020340427A1/en not_active Abandoned
- 2020-08-28 PH PH1/2022/550497A patent/PH12022550497A1/en unknown
- 2020-08-28 EP EP20772466.7A patent/EP4021893A1/en not_active Withdrawn
- 2020-08-28 JP JP2022513159A patent/JP2022546410A/ja active Pending
-
2022
- 2022-02-24 IL IL290881A patent/IL290881A/en unknown
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