JP2013507991A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013507991A5 JP2013507991A5 JP2012536968A JP2012536968A JP2013507991A5 JP 2013507991 A5 JP2013507991 A5 JP 2013507991A5 JP 2012536968 A JP2012536968 A JP 2012536968A JP 2012536968 A JP2012536968 A JP 2012536968A JP 2013507991 A5 JP2013507991 A5 JP 2013507991A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- amino acid
- residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000025171 antigen binding proteins Human genes 0.000 claims 38
- 108091000831 antigen binding proteins Proteins 0.000 claims 38
- 125000000539 amino acid group Chemical group 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 238000006467 substitution reaction Methods 0.000 claims 20
- 238000012217 deletion Methods 0.000 claims 19
- 230000037430 deletion Effects 0.000 claims 19
- 238000003780 insertion Methods 0.000 claims 18
- 230000037431 insertion Effects 0.000 claims 18
- 108010065637 Interleukin-23 Proteins 0.000 claims 15
- 102000013264 Interleukin-23 Human genes 0.000 claims 15
- 239000002904 solvent Substances 0.000 claims 6
- 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 238000002424 x-ray crystallography Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25498209P | 2009-10-26 | 2009-10-26 | |
| US61/254,982 | 2009-10-26 | ||
| US38128710P | 2010-09-09 | 2010-09-09 | |
| US61/381,287 | 2010-09-09 | ||
| PCT/US2010/054148 WO2011056600A1 (en) | 2009-10-26 | 2010-10-26 | Human il-23 antigen binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015236268A Division JP2016102122A (ja) | 2009-10-26 | 2015-12-03 | ヒトｉｌ−２３抗原結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507991A JP2013507991A (ja) | 2013-03-07 |
| JP2013507991A5 true JP2013507991A5 (enExample) | 2013-12-05 |
| JP5930968B2 JP5930968B2 (ja) | 2016-06-08 |
Family
ID=43413789
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012536968A Active JP5930968B2 (ja) | 2009-10-26 | 2010-10-26 | ヒトｉｌ−２３抗原結合タンパク質 |
| JP2015236268A Pending JP2016102122A (ja) | 2009-10-26 | 2015-12-03 | ヒトｉｌ−２３抗原結合タンパク質 |
| JP2018045121A Pending JP2018117626A (ja) | 2009-10-26 | 2018-03-13 | ヒトｉｌ−２３抗原結合タンパク質 |
| JP2019166277A Active JP7023908B2 (ja) | 2009-10-26 | 2019-09-12 | ヒトｉｌ－２３抗原結合タンパク質 |
| JP2021177428A Active JP7278355B2 (ja) | 2009-10-26 | 2021-10-29 | ヒトｉｌ－２３抗原結合タンパク質 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015236268A Pending JP2016102122A (ja) | 2009-10-26 | 2015-12-03 | ヒトｉｌ−２３抗原結合タンパク質 |
| JP2018045121A Pending JP2018117626A (ja) | 2009-10-26 | 2018-03-13 | ヒトｉｌ−２３抗原結合タンパク質 |
| JP2019166277A Active JP7023908B2 (ja) | 2009-10-26 | 2019-09-12 | ヒトｉｌ－２３抗原結合タンパク質 |
| JP2021177428A Active JP7278355B2 (ja) | 2009-10-26 | 2021-10-29 | ヒトｉｌ－２３抗原結合タンパク質 |
Country Status (39)
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3244B1 (ar) * | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| EP2635601B1 (en) | 2010-11-04 | 2016-07-20 | Boehringer Ingelheim International GmbH | Anti-il-23 antibodies |
| EP2667885B1 (en) * | 2011-01-25 | 2018-08-08 | Monell Chemical Senses Center | Compositions and methods for providing or modulating sweet taste and methods of screening therefor |
| EP2583979B1 (en) * | 2011-10-19 | 2015-12-16 | Effimune | Methods to prepare antibodies directed against p19 subunit of human IL-23 |
| WO2013165791A1 (en) * | 2012-05-03 | 2013-11-07 | Boehringer Ingelheim International Gmbh | Anti-il-23p19 antibodies |
| WO2014004436A2 (en) | 2012-06-27 | 2014-01-03 | Merck Sharp & Dohme Corp. | Crystalline anti-human il-23 antibodies |
| US20160060337A1 (en) * | 2013-03-15 | 2016-03-03 | Amgen Inc. | Methods for treating psoriasis using an anti-il-23 antibody |
| AU2014228553B2 (en) | 2013-03-15 | 2019-01-24 | Amgen Inc. | Methods for treating Crohn's disease using an anti-IL23 antibody |
| KR20250066486A (ko) | 2013-10-21 | 2025-05-13 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| KR102665705B1 (ko) | 2013-10-21 | 2024-05-14 | 다케다 파머수티컬 컴패니 리미티드 | 자가면역 질환의 진단 및 치료 |
| KR20160138580A (ko) * | 2014-04-15 | 2016-12-05 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Wisp1에 결합하는 항원 결합 단백질 |
| US10695406B2 (en) | 2014-05-27 | 2020-06-30 | The University Of Queensland | Modulation of cellular stress using a B-cell oxidative and/or endoplasmic reticulum stress inhibitor and a targeting agent |
| WO2016010927A1 (en) | 2014-07-14 | 2016-01-21 | Amgen Inc. | Crystalline antibody formulations |
| EP3172339A1 (en) | 2014-07-24 | 2017-05-31 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| US10059763B2 (en) | 2014-09-03 | 2018-08-28 | Boehringer Ingelheim International Gmbh | Compound targeting IL-23A and TNF-alpha and uses thereof |
| IL307578A (en) | 2015-02-04 | 2023-12-01 | Boehringer Ingelheim Int | Methods of treating inflammatory diseases |
| CN116672446A (zh) | 2015-09-17 | 2023-09-01 | 美国安进公司 | 使用il23途径生物标志物预测il23拮抗剂的临床应答 |
| TWI811716B (zh) * | 2015-09-18 | 2023-08-11 | 德商百靈佳殷格翰國際股份有限公司 | 治療發炎性疾病之方法 |
| EP3365685B1 (en) * | 2015-10-19 | 2020-11-25 | Dyax Corp. | Immunoassay to detect cleaved high molecular weight kininogen |
| BR112018012626A2 (pt) | 2015-12-22 | 2018-12-04 | Amgen Inc | ccl20 como um preditor de resposta clínica a antagonistas de il23 |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| WO2019023812A1 (en) * | 2017-08-04 | 2019-02-07 | The Hospital For Sick Children | VACCINE COMPOSITION AGAINST MALARIA AND METHOD THEREOF |
| DK3661968T3 (da) * | 2017-08-04 | 2022-06-20 | Hospital For Sick Children | Nanopartikelplatform til antistof- og vaccineindgivelse |
| TWI744617B (zh) | 2018-03-30 | 2021-11-01 | 美商美國禮來大藥廠 | 治療潰瘍性結腸炎之方法 |
| SG11202100185VA (en) | 2018-07-13 | 2021-02-25 | Astrazeneca Collaboration Ventures Llc | Treating ulcerative colitis with brazikumab |
| GB201820687D0 (en) * | 2018-12-19 | 2019-01-30 | Kymab Ltd | Antagonists |
| CN114025796A (zh) * | 2019-06-04 | 2022-02-08 | 詹森生物科技公司 | 用抗il23特异性抗体治疗银屑病关节炎的安全且有效的方法 |
| AU2020308463A1 (en) | 2019-06-26 | 2022-02-17 | Ap Biosciences, Inc. | Antibodies for T-cell activation |
| CA3164996A1 (en) | 2019-12-20 | 2021-06-14 | Novarock Biotherapeutics, Ltd. | Anti-interleukin-23 p19 antibodies and methods of use thereof |
| CN112807428B (zh) * | 2020-06-12 | 2024-08-27 | 江苏荃信生物医药股份有限公司 | 包含抗人白介素23单克隆抗体的药物组合物 |
| WO2022041390A1 (zh) * | 2020-08-28 | 2022-03-03 | 江苏荃信生物医药股份有限公司 | 包含高浓度抗人白介素23单克隆抗体的低粘度液体制剂及其制备方法 |
| TW202428304A (zh) | 2020-09-10 | 2024-07-16 | 美商美國禮來大藥廠 | 治療性抗體調配物 |
| CN113156134B (zh) * | 2020-11-26 | 2024-01-23 | 江苏荃信生物医药股份有限公司 | 用于检测人白介素23的elisa试剂盒及检测方法 |
| US20220373539A1 (en) * | 2021-05-24 | 2022-11-24 | Amgen Inc. | Prediction of clinical response to il23-antagonists using il23 pathway biomarkers |
| EP4359444A4 (en) * | 2021-06-25 | 2025-07-16 | Sangamo Therapeutics Inc | IL-23R-SPECIFIC ANTIGEN BINDERS AND THEIR USES |
| EP4409298A1 (en) | 2021-09-30 | 2024-08-07 | Eli Lilly and Company | Anti-il-23p19 antibody regulation of genes involved in bowel urgency in ulcerative colitis |
| CN114994331B (zh) * | 2022-05-17 | 2023-02-24 | 无锡科金生物科技有限公司 | 一种检测蛋白表达水平的试剂盒及其制备方法和应用 |
| WO2024077113A1 (en) | 2022-10-06 | 2024-04-11 | Eli Lilly And Company | Methods of treating fatigue in ulcerative colitis |
| WO2025083549A1 (en) | 2023-10-16 | 2025-04-24 | Sun Pharma Advanced Research Company Limited | Methods and combinations of inhibitors of il-23 pathway and modulators of s1p signaling pathway for the treatment of autoimmune disorders |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5457038A (en) | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6683046B1 (en) | 1989-12-22 | 2004-01-27 | Hoffmann-La Roche Inc. | Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto |
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| CA2111348A1 (en) | 1991-06-14 | 1992-12-23 | John S. Logan | Production of human hemoglobin in transgenic pigs |
| EP0593592B1 (en) | 1991-07-08 | 1998-03-25 | The University Of Massachusetts At Amherst | Thermotropic liquid crystal segmented block copolymer |
| ES2237747T3 (es) | 1991-11-14 | 2005-08-01 | Prionics Ag | Animales transgenicos no humanos que carecen de proteinas prionicas. |
| US5262522A (en) | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
| NZ255101A (en) | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
| JP3589665B2 (ja) | 1992-10-23 | 2004-11-17 | イミュネックス・コーポレーション | 可溶性オリゴマー蛋白質の調製法 |
| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US6060284A (en) | 1997-07-25 | 2000-05-09 | Schering Corporation | DNA encoding interleukin-B30 |
| CO4810232A1 (es) | 1997-07-25 | 1999-06-30 | Schering Corp | Citoquinas de mamiferos y sus secuencias codificadoras |
| US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| JP4124573B2 (ja) * | 1998-03-17 | 2008-07-23 | 中外製薬株式会社 | Ｉｌ−６アンタゴニストを有効成分として含有する炎症性腸疾患の予防又は治療剤 |
| DE69942607D1 (de) | 1998-04-14 | 2010-09-02 | Chugai Pharmaceutical Co Ltd | Neues cytokinartiges protein |
| US20020142374A1 (en) | 1998-08-17 | 2002-10-03 | Michael Gallo | Generation of modified molecules with increased serum half-lives |
| US7883704B2 (en) | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| US7090847B1 (en) | 1999-09-09 | 2006-08-15 | Schering Corporation | Mammalian cytokines; related reagents and methods |
| IL148300A0 (en) | 1999-09-09 | 2002-09-12 | Schering Corp | Mammalian cytokines; related reagents and methods |
| WO2006069036A2 (en) | 2004-12-21 | 2006-06-29 | Centocor, Inc. | Anti-il-12 antibodies, epitopes, compositions, methods and uses |
| MXPA05004512A (es) | 2002-10-30 | 2005-07-26 | Genentech Inc | Inhibicion de la produccion de il-17. |
| WO2004058178A2 (en) | 2002-12-23 | 2004-07-15 | Schering Corporation | Uses of mammalian cytokine; related reagents |
| WO2004071517A2 (en) | 2003-02-06 | 2004-08-26 | Schering Corporation | Uses of il-23 related reagents |
| JP4605798B2 (ja) | 2003-03-10 | 2011-01-05 | シェーリング コーポレイション | Ｉｌ−２３アゴニストおよびｉｌ−２３アンタゴニスト；関連試薬の使用 |
| JP2007515939A (ja) | 2003-05-09 | 2007-06-21 | セントカー・インコーポレーテツド | ＩＬ−２３ｐ４０特異的免疫グロブリン由来タンパク質、組成物、方法および用途 |
| US20050287593A1 (en) | 2004-05-03 | 2005-12-29 | Schering Corporation | Use of cytokine expression to predict skin inflammation; methods of treatment |
| AU2005241020B2 (en) | 2004-05-03 | 2008-07-10 | Merck Sharp & Dohme Corp. | Use of IL-17 expression to predict skin inflammation; methods of treatment |
| AR051444A1 (es) | 2004-09-24 | 2007-01-17 | Centocor Inc | Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos |
| TWI363091B (en) | 2004-12-20 | 2012-05-01 | Schering Corp | Uses of mammalian cytokine; related reagents |
| ES2410406T3 (es) | 2005-06-30 | 2013-07-01 | Janssen Biotech, Inc. | Anticuerpos anti-IL-23, composiciones, procedimientos y usos |
| CN103145840A (zh) | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
| EP1937721B1 (en) | 2005-08-25 | 2010-07-28 | Eli Lilly And Company | Anti-il-23 antibodies |
| HUE032131T2 (en) | 2005-08-31 | 2017-09-28 | Merck Sharp & Dohme | Constructed anti-IL-23 antibodies |
| CN1955248B (zh) * | 2005-10-28 | 2011-10-12 | 安集微电子（上海）有限公司 | 钽阻挡层用化学机械抛光浆料 |
| AU2006330410A1 (en) | 2005-12-28 | 2007-07-05 | Centocor, Inc. | Markers and methods for assessing and treating psoriasis and related disorders |
| EP3219328B1 (en) * | 2005-12-29 | 2020-06-17 | Janssen Biotech, Inc. | Human anti-il-23 antibodies, compositions, method and uses |
| US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
| AU2007260787A1 (en) | 2006-06-13 | 2007-12-21 | Zymogenetics, Inc | IL-17 and IL-23 antagonists and methods of using the same |
| KR20150038227A (ko) * | 2007-01-16 | 2015-04-08 | 애브비 인코포레이티드 | 건선의 치료방법 |
| TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Ｉｌ-２３拮抗劑於治療感染之用途 |
| ATE554791T1 (de) * | 2007-02-23 | 2012-05-15 | Schering Corp | Gentechnisch hergestellte anti-il-23p19- antikörper |
| EP2064242A1 (en) | 2007-02-23 | 2009-06-03 | Schering Corporation | Engineered anti-il-23p19 antibodies |
| AR068723A1 (es) | 2007-10-05 | 2009-12-02 | Glaxo Group Ltd | Proteina que se une a antigenos que se une a il-23 humana y sus usos |
| AU2008328779B2 (en) | 2007-11-27 | 2014-06-05 | Ablynx N.V. | Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| US8557239B2 (en) * | 2009-09-14 | 2013-10-15 | Abbvie Inc. | Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23 |
| TWI461210B (zh) | 2008-03-18 | 2014-11-21 | Abbvie Inc | 治療牛皮癬的方法 |
| CN102177178B (zh) | 2008-08-14 | 2015-07-01 | 梯瓦制药澳大利亚私人有限公司 | 抗il-12/il-23抗体 |
| WO2010027766A1 (en) | 2008-08-27 | 2010-03-11 | Schering Corporation | Lyophilized formulatons of engineered anti-il-23p19 antibodies |
| WO2010115786A1 (en) | 2009-04-01 | 2010-10-14 | Glaxo Group Limited | Anti-il-23 immunoglobulins |
| WO2010115092A2 (en) | 2009-04-02 | 2010-10-07 | The Johns Hopkins University | Compositions and methods for treating or preventing inflammatory bowel disease and colon cancer |
| WO2010142534A1 (en) | 2009-05-27 | 2010-12-16 | Ablynx Nv | Biparatopic protein constructs directed against il-23 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| WO2011088120A1 (en) | 2010-01-15 | 2011-07-21 | Amgen Inc. | Antibody formulation and therapeutic regimens |
| WO2011103105A1 (en) | 2010-02-18 | 2011-08-25 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind il-23 |
| US9127057B2 (en) | 2010-07-20 | 2015-09-08 | Teva Pharmaceuticals Ausralia Pty Ltd | Anti-IL-23 heterodimer specific antibodies |
| CN103813804A (zh) | 2010-10-06 | 2014-05-21 | Abbvie公司 | 用于治疗银屑病的方法 |
| CN103154031A (zh) | 2010-10-08 | 2013-06-12 | 诺华有限公司 | 利用il-17拮抗剂治疗牛皮癣的方法 |
| EP2635601B1 (en) | 2010-11-04 | 2016-07-20 | Boehringer Ingelheim International GmbH | Anti-il-23 antibodies |
| JP2014506132A (ja) | 2011-01-07 | 2014-03-13 | アッヴィ・インコーポレイテッド | 抗ｉｌ−１２／ｉｌ−２３抗体およびその使用 |
| AU2014228553B2 (en) | 2013-03-15 | 2019-01-24 | Amgen Inc. | Methods for treating Crohn's disease using an anti-IL23 antibody |
| CN116672446A (zh) | 2015-09-17 | 2023-09-01 | 美国安进公司 | 使用il23途径生物标志物预测il23拮抗剂的临床应答 |
| BR112018012626A2 (pt) | 2015-12-22 | 2018-12-04 | Amgen Inc | ccl20 como um preditor de resposta clínica a antagonistas de il23 |
| SG11202100185VA (en) | 2018-07-13 | 2021-02-25 | Astrazeneca Collaboration Ventures Llc | Treating ulcerative colitis with brazikumab |
| AU2020332371A1 (en) | 2019-08-21 | 2022-03-03 | Astrazeneca Collaboration Ventures, Llc | Use of brazikumab to treat crohn's disease |
-
2010
- 2010-10-18 JO JOP/2010/0356A patent/JO3244B1/ar active
- 2010-10-26 NZ NZ625630A patent/NZ625630A/en not_active IP Right Cessation
- 2010-10-26 SM SM20170069T patent/SMT201700069T1/it unknown
- 2010-10-26 CA CA3030092A patent/CA3030092C/en active Active
- 2010-10-26 NZ NZ599875A patent/NZ599875A/en not_active IP Right Cessation
- 2010-10-26 AU AU2010315557A patent/AU2010315557B2/en not_active Ceased
- 2010-10-26 AR ARP100103927A patent/AR078778A1/es active IP Right Grant
- 2010-10-26 EP EP16199576.6A patent/EP3181586A1/en not_active Withdrawn
- 2010-10-26 TW TW103103013A patent/TW201417830A/zh unknown
- 2010-10-26 EP EP19202723.3A patent/EP3656790A1/en not_active Withdrawn
- 2010-10-26 MY MYPI2012001807A patent/MY156286A/en unknown
- 2010-10-26 SG SG10202103260TA patent/SG10202103260TA/en unknown
- 2010-10-26 WO PCT/US2010/054148 patent/WO2011056600A1/en not_active Ceased
- 2010-10-26 US US13/504,449 patent/US8722033B2/en active Active
- 2010-10-26 CN CN201080059062.XA patent/CN102741285B/zh active Active
- 2010-10-26 BR BR112012009854A patent/BR112012009854B8/pt not_active IP Right Cessation
- 2010-10-26 ES ES10774095.3T patent/ES2613236T3/es active Active
- 2010-10-26 HR HRP20170037TT patent/HRP20170037T1/hr unknown
- 2010-10-26 UA UAA201206355A patent/UA113609C2/uk unknown
- 2010-10-26 EP EP10774095.3A patent/EP2493925B1/en active Active
- 2010-10-26 JP JP2012536968A patent/JP5930968B2/ja active Active
- 2010-10-26 SI SI201031391A patent/SI2493925T1/sl unknown
- 2010-10-26 SG SG10201800682SA patent/SG10201800682SA/en unknown
- 2010-10-26 EA EA201270571A patent/EA025366B1/ru unknown
- 2010-10-26 PH PH1/2012/500771A patent/PH12012500771A1/en unknown
- 2010-10-26 TW TW099136594A patent/TWI432210B/zh not_active IP Right Cessation
- 2010-10-26 PL PL10774095T patent/PL2493925T3/pl unknown
- 2010-10-26 RS RS20170119A patent/RS55666B1/sr unknown
- 2010-10-26 MX MX2012004868A patent/MX358249B/es active IP Right Grant
- 2010-10-26 PT PT107740953T patent/PT2493925T/pt unknown
- 2010-10-26 BR BR122020002402A patent/BR122020002402B8/pt active IP Right Grant
- 2010-10-26 UY UY0001032971A patent/UY32971A/es not_active Application Discontinuation
- 2010-10-26 KR KR1020167022998A patent/KR20160118278A/ko not_active Ceased
- 2010-10-26 KR KR1020127013696A patent/KR101568461B1/ko not_active Expired - Fee Related
- 2010-10-26 PE PE2012000564A patent/PE20121579A1/es active IP Right Grant
- 2010-10-26 LT LTEP10774095.3T patent/LT2493925T/lt unknown
- 2010-10-26 PE PE2016002001A patent/PE20161327A1/es not_active Application Discontinuation
- 2010-10-26 CA CA2778112A patent/CA2778112C/en active Active
- 2010-10-26 KR KR1020147012130A patent/KR101652609B1/ko not_active Expired - Fee Related
- 2010-10-26 CN CN201910176289.5A patent/CN110407936A/zh active Pending
- 2010-10-26 CN CN201510065612.3A patent/CN104761642A/zh active Pending
- 2010-10-26 HU HUE10774095A patent/HUE030871T2/en unknown
-
2012
- 2012-04-10 TN TNP2012000167A patent/TN2012000167A1/en unknown
- 2012-04-17 IL IL219241A patent/IL219241A/en active IP Right Grant
- 2012-04-25 ZA ZA2012/03058A patent/ZA201203058B/en unknown
- 2012-04-26 CR CR20120210A patent/CR20120210A/es unknown
- 2012-04-26 CO CO12068924A patent/CO6531481A2/es unknown
- 2012-04-26 CL CL2012001096A patent/CL2012001096A1/es unknown
- 2012-05-18 MA MA34877A patent/MA33757B1/fr unknown
-
2014
- 2014-03-28 US US14/228,556 patent/US9487580B2/en active Active
-
2015
- 2015-12-03 JP JP2015236268A patent/JP2016102122A/ja active Pending
-
2016
- 2016-01-06 HK HK16100056.3A patent/HK1212357A1/xx unknown
- 2016-03-28 IL IL244801A patent/IL244801B/en active IP Right Grant
- 2016-09-21 US US15/271,315 patent/US9951129B2/en active Active
-
2017
- 2017-01-24 CY CY20171100096T patent/CY1118576T1/el unknown
-
2018
- 2018-03-13 JP JP2018045121A patent/JP2018117626A/ja active Pending
- 2018-11-19 US US16/194,896 patent/US20190071498A1/en not_active Abandoned
-
2019
- 2019-06-26 US US16/453,482 patent/US20190322737A1/en not_active Abandoned
- 2019-09-12 JP JP2019166277A patent/JP7023908B2/ja active Active
-
2020
- 2020-02-18 US US16/793,610 patent/US20200181255A1/en not_active Abandoned
- 2020-05-24 IL IL274871A patent/IL274871A/en unknown
- 2020-10-01 US US17/060,905 patent/US20210024626A1/en not_active Abandoned
-
2021
- 2021-04-13 US US17/229,607 patent/US20210230267A1/en not_active Abandoned
- 2021-10-29 JP JP2021177428A patent/JP7278355B2/ja active Active
- 2021-11-12 US US17/525,421 patent/US12012449B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013507991A5 (enExample) | ||
| JP2012504955A5 (enExample) | ||
| JP2015508762A5 (enExample) | ||
| JP2014524748A5 (enExample) | ||
| JP2020508303A5 (enExample) | ||
| JP2018505177A5 (enExample) | ||
| JP2019522961A5 (enExample) | ||
| JP2018521638A5 (enExample) | ||
| JP2017528476A5 (enExample) | ||
| JP2011514150A5 (enExample) | ||
| JP2020536888A5 (enExample) | ||
| JP2018064580A5 (enExample) | ||
| JP2009511480A5 (enExample) | ||
| JP2012513214A5 (enExample) | ||
| JP2018527952A5 (enExample) | ||
| JP2011518125A5 (enExample) | ||
| JP2012510461A5 (enExample) | ||
| RU2013110874A (ru) | Антитела против il-18r1 и их применения | |
| JP2011528902A5 (enExample) | ||
| JP2019536806A5 (enExample) | ||
| TW200831533A (en) | Interleukin-13 binding proteins | |
| JP2020506900A5 (enExample) | ||
| JP2015501149A5 (enExample) | ||
| JP2013544492A5 (enExample) | ||
| RU2007138341A (ru) | Антитела-нейтрализаторы гранулоцитарно-макрофагального колониестимулирующего фактора человека |