JP2013506411A5 - - Google Patents
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- JP2013506411A5 JP2013506411A5 JP2012531451A JP2012531451A JP2013506411A5 JP 2013506411 A5 JP2013506411 A5 JP 2013506411A5 JP 2012531451 A JP2012531451 A JP 2012531451A JP 2012531451 A JP2012531451 A JP 2012531451A JP 2013506411 A5 JP2013506411 A5 JP 2013506411A5
- Authority
- JP
- Japan
- Prior art keywords
- vhh
- binding
- seq
- dll4
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700041286 delta Proteins 0.000 claims 8
- 101150109170 dll4 gene Proteins 0.000 claims 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 7
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 102000058223 human VEGFA Human genes 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172137 | 2009-10-02 | ||
| EP09172137.3 | 2009-10-02 | ||
| EP10175316 | 2010-09-03 | ||
| EP10175316.8 | 2010-09-03 | ||
| PCT/EP2010/064695 WO2011039370A1 (en) | 2009-10-02 | 2010-10-01 | Bispecific binding molecules for anti-angiogenesis therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015211551A Division JP2016026207A (ja) | 2009-10-02 | 2015-10-28 | 抗脈管形成療法のための二重特異性結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506411A JP2013506411A (ja) | 2013-02-28 |
| JP2013506411A5 true JP2013506411A5 (https=) | 2013-11-14 |
| JP5833009B2 JP5833009B2 (ja) | 2015-12-16 |
Family
ID=43431796
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531451A Expired - Fee Related JP5833009B2 (ja) | 2009-10-02 | 2010-10-01 | 抗脈管形成療法のための二重特異性結合分子 |
| JP2015211551A Pending JP2016026207A (ja) | 2009-10-02 | 2015-10-28 | 抗脈管形成療法のための二重特異性結合分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015211551A Pending JP2016026207A (ja) | 2009-10-02 | 2015-10-28 | 抗脈管形成療法のための二重特異性結合分子 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20110172398A1 (https=) |
| EP (1) | EP2483314A1 (https=) |
| JP (2) | JP5833009B2 (https=) |
| KR (1) | KR20120101375A (https=) |
| CN (2) | CN102639566B (https=) |
| AP (1) | AP2012006188A0 (https=) |
| AR (1) | AR078515A1 (https=) |
| AU (1) | AU2010302589A1 (https=) |
| BR (1) | BR112012007239A2 (https=) |
| CA (1) | CA2775422A1 (https=) |
| CL (1) | CL2012000826A1 (https=) |
| EA (1) | EA201200548A1 (https=) |
| EC (1) | ECSP12011835A (https=) |
| IL (1) | IL218542A0 (https=) |
| IN (1) | IN2012DN02752A (https=) |
| MA (1) | MA33607B1 (https=) |
| MX (1) | MX2012003897A (https=) |
| NZ (2) | NZ626302A (https=) |
| PE (1) | PE20121024A1 (https=) |
| PH (1) | PH12012500525A1 (https=) |
| TN (1) | TN2012000145A1 (https=) |
| TW (1) | TW201124533A (https=) |
| UY (1) | UY32920A (https=) |
| WO (1) | WO2011039370A1 (https=) |
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| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| KR101722961B1 (ko) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | 알부민 변이체 및 접합체 |
| JP2012525149A (ja) | 2009-04-27 | 2012-10-22 | オンコメッド ファーマシューティカルズ インコーポレイテッド | ヘテロ多量体分子を作製するための方法 |
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| BR112012021941A2 (pt) | 2010-03-02 | 2022-02-01 | Abbvie Inc | Proteínas terapêuticas de ligação a dll4 |
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| EP2848939A1 (en) | 2010-07-19 | 2015-03-18 | F. Hoffmann-La Roche AG | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
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-
2010
- 2010-09-30 US US12/894,989 patent/US20110172398A1/en not_active Abandoned
- 2010-09-30 UY UY0001032920A patent/UY32920A/es not_active Application Discontinuation
- 2010-10-01 BR BR112012007239A patent/BR112012007239A2/pt not_active IP Right Cessation
- 2010-10-01 KR KR1020127011329A patent/KR20120101375A/ko not_active Ceased
- 2010-10-01 CN CN201080054891.9A patent/CN102639566B/zh not_active Expired - Fee Related
- 2010-10-01 PH PH1/2012/500525A patent/PH12012500525A1/en unknown
- 2010-10-01 AR ARP100103596A patent/AR078515A1/es unknown
- 2010-10-01 CN CN201510363066.1A patent/CN105037542A/zh active Pending
- 2010-10-01 NZ NZ626302A patent/NZ626302A/en not_active IP Right Cessation
- 2010-10-01 EA EA201200548A patent/EA201200548A1/ru unknown
- 2010-10-01 NZ NZ598956A patent/NZ598956A/en not_active IP Right Cessation
- 2010-10-01 IN IN2752DEN2012 patent/IN2012DN02752A/en unknown
- 2010-10-01 JP JP2012531451A patent/JP5833009B2/ja not_active Expired - Fee Related
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- 2010-10-01 EP EP10768428A patent/EP2483314A1/en not_active Withdrawn
- 2010-10-01 MX MX2012003897A patent/MX2012003897A/es not_active Application Discontinuation
- 2010-10-01 CA CA2775422A patent/CA2775422A1/en not_active Abandoned
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- 2010-10-01 WO PCT/EP2010/064695 patent/WO2011039370A1/en not_active Ceased
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2012
- 2012-03-08 IL IL218542A patent/IL218542A0/en unknown
- 2012-03-26 MA MA34720A patent/MA33607B1/fr unknown
- 2012-03-29 TN TNP2012000145A patent/TN2012000145A1/en unknown
- 2012-04-02 CL CL2012000826A patent/CL2012000826A1/es unknown
- 2012-04-26 EC ECSP12011835 patent/ECSP12011835A/es unknown
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2013
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2015
- 2015-10-28 JP JP2015211551A patent/JP2016026207A/ja active Pending
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