JP2013516456A5 - - Google Patents

Info

Publication number

JP2013516456A5

JP2013516456A5 JP2012547587A JP2012547587A JP2013516456A5 JP 2013516456 A5 JP2013516456 A5 JP 2013516456A5 JP 2012547587 A JP2012547587 A JP 2012547587A JP 2012547587 A JP2012547587 A JP 2012547587A JP 2013516456 A5 JP2013516456 A5 JP 2013516456A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

seq

viral

viral vector

therapy

Prior art date

2011-01-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000013603 viral vector Substances 0.000 claims description 18
• 239000002245 particle Substances 0.000 claims description 10
• 230000003612 virological effect Effects 0.000 claims description 10
• 108091033319 polynucleotide Proteins 0.000 claims description 9
• 102000040430 polynucleotide Human genes 0.000 claims description 9
• 239000002157 polynucleotide Substances 0.000 claims description 9
• 206010018338 Glioma Diseases 0.000 claims description 7
• 208000029824 high grade glioma Diseases 0.000 claims description 7
• 201000011614 malignant glioma Diseases 0.000 claims description 7
• 239000013598 vector Substances 0.000 claims description 6
• 210000002889 endothelial cell Anatomy 0.000 claims description 5
• 238000011282 treatment Methods 0.000 claims description 5
• 206010003571 Astrocytoma Diseases 0.000 claims description 4
• 206010014967 Ependymoma Diseases 0.000 claims description 2
• 206010021143 Hypoxia Diseases 0.000 claims description 2
• 108091027981 Response element Proteins 0.000 claims description 2
• 208000005017 glioblastoma Diseases 0.000 claims description 2
• 230000007954 hypoxia Effects 0.000 claims description 2
• 230000003362 replicative effect Effects 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 24
• 230000000295 complement effect Effects 0.000 claims 4
• 238000002560 therapeutic procedure Methods 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 229940041181 antineoplastic drug Drugs 0.000 claims 2
• 238000001356 surgical procedure Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
• 201000010133 Oligodendroglioma Diseases 0.000 claims 1
• BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
• 238000010317 ablation therapy Methods 0.000 claims 1
• 229960000397 bevacizumab Drugs 0.000 claims 1
• 238000002725 brachytherapy Methods 0.000 claims 1
• 238000002659 cell therapy Methods 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 238000009169 immunotherapy Methods 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 230000035764 nutrition Effects 0.000 claims 1
• 235000016709 nutrition Nutrition 0.000 claims 1
• 238000002428 photodynamic therapy Methods 0.000 claims 1
• 238000001126 phototherapy Methods 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 229960004964 temozolomide Drugs 0.000 claims 1
• 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
• 210000003462 vein Anatomy 0.000 claims 1
• 238000000034 method Methods 0.000 description 24
• 108020004707 nucleic acids Proteins 0.000 description 7
• 102000039446 nucleic acids Human genes 0.000 description 7
• 150000007523 nucleic acids Chemical class 0.000 description 7
• 210000004027 cell Anatomy 0.000 description 4
• 239000000463 material Substances 0.000 description 3
• 230000001886 ciliary effect Effects 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 230000000366 juvenile effect Effects 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1