|
NL269416A
(https=)
|
1960-09-21 |
|
|
|
|
GB8819826D0
(en)
|
1988-08-20 |
1988-09-21 |
Kabivitrum Ab |
Glycosylated igf-1
|
|
US5679771A
(en)
|
1990-02-13 |
1997-10-21 |
Gropep Pty. Ltd. |
Method for treating intestinal diseases
|
|
DE69133036T2
(de)
|
1990-11-09 |
2003-02-06 |
Stephen D. Gillies |
Cytokine immunokonjugate
|
|
US5632986A
(en)
|
1991-05-09 |
1997-05-27 |
The University Of Washington |
Phospholipid-targeted thrombolytic agents
|
|
US5444045A
(en)
*
|
1992-09-17 |
1995-08-22 |
Gropep, Pty. Ltd. |
Method of administering IGF-1, IGF-2, and analogs thereof to birds
|
|
JP3664727B2
(ja)
*
|
1994-01-24 |
2005-06-29 |
ネオルクス コーポレイション |
放射標識したアネキシン
|
|
WO1995032003A1
(en)
|
1994-05-24 |
1995-11-30 |
Amgen Boulder Inc. |
Modified insulin-like growth factors
|
|
US5780052A
(en)
|
1995-04-24 |
1998-07-14 |
Northeastern University |
Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell
|
|
CA2224859A1
(en)
|
1996-04-17 |
1997-10-23 |
Amitabh Gaur |
Ligand inhibitors of insulin-like growth factor binding proteins and methods of use therefor
|
|
US6121416A
(en)
|
1997-04-04 |
2000-09-19 |
Genentech, Inc. |
Insulin-like growth factor agonist molecules
|
|
US7067109B1
(en)
|
1998-07-13 |
2006-06-27 |
Board Of Regents, The University Of Texas System |
Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
|
|
US6387663B1
(en)
|
1998-07-31 |
2002-05-14 |
University Of Southern California |
Targeting pharmaceutical agents to injured tissues
|
|
AUPP785098A0
(en)
|
1998-12-21 |
1999-01-21 |
Victor Chang Cardiac Research Institute, The |
Treatment of heart disease
|
|
JP2002535967A
(ja)
|
1999-01-06 |
2002-10-29 |
ジェネンテック・インコーポレーテッド |
インシュリン様成長因子（ｉｇｆ）ｉ変異体
|
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
|
ATE316980T1
(de)
|
1999-07-21 |
2006-02-15 |
Univ Southern California |
Fusions-polypeptide zur gewebegeneration und wundheilung zur gezielten matrixanwendung
|
|
JP2001251104A
(ja)
|
2000-03-03 |
2001-09-14 |
Murata Mfg Co Ltd |
非可逆回路素子及び通信機装置
|
|
ATE463252T1
(de)
|
2000-08-29 |
2010-04-15 |
Aurogen Inc |
Methode zur behandlung des zentralnervensystems durch applikation von strukturanaloga von igf
|
|
ME00502B
(me)
|
2001-01-05 |
2011-10-10 |
Amgen Fremont Inc |
Antitjela za insulinu sličan receptor faktora i rasta
|
|
US7635680B2
(en)
|
2001-02-21 |
2009-12-22 |
Alavita Pharmaceuticals, Inc. |
Attenuation of reperfusion injury
|
|
WO2002087510A2
(en)
|
2001-04-30 |
2002-11-07 |
Symbiontics, Inc. |
Subcellular targeting of therapeutic proteins
|
|
US7049286B2
(en)
|
2001-08-30 |
2006-05-23 |
Diatos, S.A. |
Insulin conjugates and methods of use thereof
|
|
US20030072761A1
(en)
|
2001-10-16 |
2003-04-17 |
Lebowitz Jonathan |
Methods and compositions for targeting proteins across the blood brain barrier
|
|
AU2008200706B2
(en)
|
2001-10-16 |
2010-05-27 |
Biomarin Pharmaceutical Inc. |
Methods and compositions for targeting underglycosylated proteins across the blood brain barrier
|
|
KR101271635B1
(ko)
*
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
|
EP1622645B1
(en)
|
2002-04-23 |
2013-10-23 |
Roger Williams Hospital |
Compositions and methods for stem cell delivery
|
|
EP1509541B1
(en)
|
2002-06-06 |
2011-11-23 |
Tze Chein Wun |
Novel recombinant anticoagulant proteins
|
|
US9321832B2
(en)
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
US20040213738A1
(en)
|
2003-03-31 |
2004-10-28 |
Susan Croll-Kalish |
CIRL3-Like proteins, nucleic acids, and methods of modulating CIRL3-L-mediated activity
|
|
US7355018B2
(en)
|
2003-09-30 |
2008-04-08 |
Regeneron Pharmaceuticals, Inc. |
Modified IGF1 polypeptides with increased stability and potency
|
|
ES2383300T3
(es)
*
|
2003-11-13 |
2012-06-20 |
Hanmi Holdings Co., Ltd |
Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación
|
|
BRPI0510716A
(pt)
|
2004-05-05 |
2007-11-20 |
Merrimack Pharmaceuticals Inc |
uso de um agente de ligação bi-especìfico, agente de ligação bi-especìfico, composição de um agente de ligação bi-especìfico, e, kit
|
|
WO2006004910A2
(en)
|
2004-06-28 |
2006-01-12 |
Transtarget Inc. |
Improved bispecific antibodies
|
|
US7511016B2
(en)
|
2004-07-07 |
2009-03-31 |
Mosamedix B.V. |
Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof
|
|
US7531318B2
(en)
|
2004-08-20 |
2009-05-12 |
Board Of Regents, The University Of Texas System |
Screening of agents for activity against ischemic myocardial insults
|
|
JP2008510732A
(ja)
|
2004-08-20 |
2008-04-10 |
ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム |
心臓組織の損傷を処置、予防、阻害、または緩和する方法
|
|
WO2006047214A2
(en)
*
|
2004-10-21 |
2006-05-04 |
Igf Oncology, Llc |
Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer
|
|
MY146381A
(en)
*
|
2004-12-22 |
2012-08-15 |
Amgen Inc |
Compositions and methods relating relating to anti-igf-1 receptor antibodies
|
|
JP4988599B2
(ja)
*
|
2005-01-07 |
2012-08-01 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｉｇｆ−１融合ポリペプチドおよびその治療的使用
|
|
EP1841467A4
(en)
|
2005-01-14 |
2009-01-28 |
Cytogen Corp |
COMBINATION CANCER THERAPY WITH ANTI-PSMA ANTIBODIES
|
|
CN101146826A
(zh)
|
2005-01-24 |
2008-03-19 |
得克萨斯大学体系董事会 |
与磷脂酰丝氨酸结合的fc融合构建体及其治疗用途
|
|
CA2599606A1
(en)
|
2005-02-23 |
2006-08-31 |
Merrimack Pharmaceuticals, Inc. |
Bispecific binding agents for modulating biological activity
|
|
US7521211B2
(en)
|
2005-04-05 |
2009-04-21 |
Regeneron Pharmaceuticals, Inc |
IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof
|
|
US20070054851A1
(en)
|
2005-05-27 |
2007-03-08 |
Junyu Lin |
Methods of and compositions for stimulation of glucose uptake into muscle cells and treatment of diseases
|
|
WO2007021494A2
(en)
|
2005-08-12 |
2007-02-22 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
WO2007044887A2
(en)
|
2005-10-11 |
2007-04-19 |
Transtarget, Inc. |
Method for producing a population of homogenous tetravalent bispecific antibodies
|
|
NZ569078A
(en)
|
2005-12-12 |
2012-01-12 |
Mosamedix Bv |
Annexin derivatives suitable for pretargeting in therapy and diagnosis
|
|
US7776816B2
(en)
|
2006-01-20 |
2010-08-17 |
Board Of Regents, The University Of Texas System |
Preserving hypoxic tissue
|
|
CA2638811A1
(en)
|
2006-02-03 |
2007-08-16 |
Medimmune, Llc |
Protein formulations
|
|
CA2646508A1
(en)
|
2006-03-17 |
2007-09-27 |
Biogen Idec Ma Inc. |
Stabilized polypeptide compositions
|
|
KR101459789B1
(ko)
|
2006-06-09 |
2014-11-07 |
노파르티스 아게 |
안정화된 인슐린-유사 성장 인자 폴리펩티드
|
|
US9187517B2
(en)
|
2006-11-13 |
2015-11-17 |
The Brigham And Women's Hospital, Inc. |
Methods of promoting cardiac repair using growth factors fused to heparin binding sequences
|
|
SE530073C2
(sv)
|
2007-01-23 |
2008-02-26 |
Teknikbolaget K Samuelsson Ab |
Sprutmunstycksanordning för brandsläckningssystem
|
|
US8003761B2
(en)
|
2007-01-23 |
2011-08-23 |
Hoffmann-La Roche Inc. |
Cancerous disease modifying antibodies
|
|
WO2008124086A2
(en)
|
2007-04-05 |
2008-10-16 |
President And Fellows Of Harvard College |
Chimeric activators: quantitatively designed protein therapeutics and uses thereof
|
|
EP2152751A1
(en)
|
2007-05-31 |
2010-02-17 |
Genmab A/S |
Fusion or linked proteins with extended half life
|
|
US8889140B2
(en)
|
2007-05-31 |
2014-11-18 |
Transtarget, Inc. |
Compositions and methods for tissue repair
|
|
SI2173890T1
(sl)
|
2007-06-21 |
2011-06-30 |
Univ Muenchen Tech |
Biološko aktivni proteini, ki imajo povečano in vivo in/ali in vitro stabilnost
|
|
WO2009030720A2
(en)
|
2007-09-06 |
2009-03-12 |
Novozymes Biopharma Dk A/S |
Process for producing a recombinant protein
|
|
MX2010011145A
(es)
|
2008-04-11 |
2011-04-11 |
Merrimack Pharmaceuticals Inc |
Enlazadores de la albumina de suero humana y conjugados de la misma.
|
|
WO2010059315A1
(en)
|
2008-11-18 |
2010-05-27 |
Merrimack Pharmaceuticals, Inc. |
Human serum albumin linkers and conjugates thereof
|
|
WO2010087976A2
(en)
*
|
2009-01-31 |
2010-08-05 |
Igf Oncology, Llc |
Anti-cancer protein-platinum conjugates
|
|
WO2011011072A2
(en)
|
2009-07-22 |
2011-01-27 |
Ipsen Pharma S.A.S. |
Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59
|
|
WO2011011071A2
(en)
|
2009-07-22 |
2011-01-27 |
Ipsen Pharma S.A.S. |
Analogues of insulin-like growth factor-1 (igf-1)
|
|
AU2010306774A1
(en)
|
2009-10-14 |
2012-05-03 |
Merrimack Pharmaceuticals, Inc. |
Bispecific binding agents targeting IGF-1R and ErbB3 signalling and uses thereof
|
|
EP2493921B1
(en)
|
2009-10-30 |
2018-09-26 |
Albumedix Ltd |
Albumin variants
|
|
EP2571992B1
(en)
|
2010-05-21 |
2018-04-25 |
Merrimack Pharmaceuticals, Inc. |
Bi-specific fusion proteins
|
|
ES2690663T3
(es)
|
2010-12-08 |
2018-11-21 |
Viacyte, Inc. |
Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas
|
|
EP2780364A2
(en)
|
2011-11-18 |
2014-09-24 |
Eleven Biotherapeutics, Inc. |
Proteins with improved half-life and other properties
|
|
CN104011070A
(zh)
|
2011-12-15 |
2014-08-27 |
爱德迪安（北京）生物技术有限公司 |
具有降血糖作用的化合物、组合物及其用途
|
|
EP3395358B1
(en)
|
2012-09-26 |
2019-11-06 |
Indiana University Research and Technology Corporation |
Insulin analog dimers
|
|
HK1220903A1
(zh)
|
2013-03-29 |
2017-05-19 |
Merrimack Pharmaceuticals, Inc. |
软骨结合型融合蛋白
|
|
CA2936675C
(en)
|
2014-01-12 |
2023-06-27 |
Igf Oncology, Llc |
Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof
|
|
CN108367048B
(zh)
|
2015-10-02 |
2022-08-12 |
银溪制药股份有限公司 |
用于组织修复的双特异性治疗性蛋白质
|