JP2019530441A5 - - Google Patents
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- JP2019530441A5 JP2019530441A5 JP2019512782A JP2019512782A JP2019530441A5 JP 2019530441 A5 JP2019530441 A5 JP 2019530441A5 JP 2019512782 A JP2019512782 A JP 2019512782A JP 2019512782 A JP2019512782 A JP 2019512782A JP 2019530441 A5 JP2019530441 A5 JP 2019530441A5
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- JP
- Japan
- Prior art keywords
- domain
- car
- cancer
- car according
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 230000035772 mutation Effects 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- -1 ICOS-1 Proteins 0.000 claims 2
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 101710145634 Antigen 1 Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 238000011467 adoptive cell therapy Methods 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383139P | 2016-09-02 | 2016-09-02 | |
| US62/383,139 | 2016-09-02 | ||
| US201662419817P | 2016-11-09 | 2016-11-09 | |
| US62/419,817 | 2016-11-09 | ||
| PCT/US2017/046630 WO2018052594A1 (en) | 2016-09-02 | 2017-08-11 | I domain chimeric antigen receptor specific to icam-1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530441A JP2019530441A (ja) | 2019-10-24 |
| JP2019530441A5 true JP2019530441A5 (https=) | 2020-09-17 |
| JP6996772B2 JP6996772B2 (ja) | 2022-02-21 |
Family
ID=61281980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512782A Active JP6996772B2 (ja) | 2016-09-02 | 2017-08-11 | Ｉｃａｍ－１に特異的なｉドメインキメラ抗原受容体 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US10577408B2 (https=) |
| EP (1) | EP3522718B1 (https=) |
| JP (1) | JP6996772B2 (https=) |
| KR (1) | KR102613109B1 (https=) |
| CN (1) | CN108697096B (https=) |
| AU (1) | AU2017325678B2 (https=) |
| CA (1) | CA3033846C (https=) |
| ES (1) | ES2971550T3 (https=) |
| SG (1) | SG11201901505SA (https=) |
| WO (2) | WO2018044534A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2971550T3 (es) * | 2016-09-02 | 2024-06-05 | Univ Cornell | Receptor de antígeno quimérico de dominio I específico para ICAM-1 |
| MX2019008538A (es) | 2017-01-20 | 2019-11-05 | Juno Therapeutics Gmbh | Conjugados de superficie celular y composiciones y métodos celulares relacionados. |
| EP3607319A1 (en) * | 2017-04-07 | 2020-02-12 | Juno Therapeutics, Inc. | Engineered cells expressing prostate-specific membrane antigen (psma) or a modified form thereof and related methods |
| US11866494B2 (en) * | 2018-08-31 | 2024-01-09 | Innovative Cellular Therapeutics Holdings, Ltd. | CAR T therapy through uses of co-stimulation |
| WO2022126084A1 (en) * | 2020-12-09 | 2022-06-16 | Affyimmune Therapeutics, Inc. | Dual chimeric antigen receptor targeting epcam and icam-1 |
| CN114907485B (zh) * | 2021-02-08 | 2024-04-26 | 浙江大学 | 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体 |
| CA3267581A1 (en) * | 2022-09-14 | 2024-03-21 | Biosceptre (Aust) Pty Ltd | IN VIVO DETECTION OF IMMUNE CELLS |
| US12385818B2 (en) | 2023-02-14 | 2025-08-12 | Saudi Arabian Oil Company | Modeling gas desorption in a subsurface reservoir |
| WO2024206155A1 (en) | 2023-03-24 | 2024-10-03 | Cornell University | Utilizing t cells derived from tumor draining lymph nodes for chimeric antigen receptor (car) t cell therapy for the treatment of cancer |
| US20250288611A1 (en) * | 2024-03-04 | 2025-09-18 | AffyImmune Therapeutics Inc. | Icam-1 targeted car constructs and methods of treatment |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2204183A1 (en) | 1994-11-01 | 1996-05-09 | Andrew Lawrence Feldhaus | Chimeric receptors for the generation of selectively-activatable th-independent cytotoxic t cells |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7052906B1 (en) | 1999-04-16 | 2006-05-30 | Celltech R & D Limited | Synthetic transmembrane components |
| WO2001095928A2 (en) | 2000-06-09 | 2001-12-20 | Bristol-Myers Squibb Company | Methods for regulating a cell-mediated immune response by blocking lymphocytic signals and by blocking lfa-1 mediated adhesion |
| US7176187B2 (en) | 2001-02-15 | 2007-02-13 | Board Of Regents, The University Of Texas System | Fusion proteins based upon somatostatin receptors |
| US8021668B2 (en) * | 2005-12-12 | 2011-09-20 | Immune Disease Institute, Inc. | Integrin alpha L I domain mutants with increased binding affinity |
| US9731023B2 (en) * | 2010-09-08 | 2017-08-15 | Board Of Regents, The University Of Texas System | Somatostatin receptor-based cancer therapy |
| WO2013051718A1 (ja) | 2011-10-07 | 2013-04-11 | 国立大学法人三重大学 | キメラ抗原受容体 |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| US11083744B2 (en) * | 2015-03-20 | 2021-08-10 | Mie University | Therapeutic agent associated with suppression of proliferation and metastasis of tumor, which comprises exosomes released from cytotoxic T cells and targets cancer stromal/mesenchymal cells |
| ES2971550T3 (es) * | 2016-09-02 | 2024-06-05 | Univ Cornell | Receptor de antígeno quimérico de dominio I específico para ICAM-1 |
-
2017
- 2017-08-11 ES ES17851258T patent/ES2971550T3/es active Active
- 2017-08-11 JP JP2019512782A patent/JP6996772B2/ja active Active
- 2017-08-11 CN CN201780004619.1A patent/CN108697096B/zh active Active
- 2017-08-11 US US15/675,419 patent/US10577408B2/en active Active
- 2017-08-11 WO PCT/US2017/046618 patent/WO2018044534A1/en not_active Ceased
- 2017-08-11 US US15/675,508 patent/US10428136B2/en active Active
- 2017-08-11 EP EP17851258.8A patent/EP3522718B1/en active Active
- 2017-08-11 KR KR1020197009375A patent/KR102613109B1/ko active Active
- 2017-08-11 CA CA3033846A patent/CA3033846C/en active Active
- 2017-08-11 AU AU2017325678A patent/AU2017325678B2/en active Active
- 2017-08-11 SG SG11201901505SA patent/SG11201901505SA/en unknown
- 2017-08-11 WO PCT/US2017/046630 patent/WO2018052594A1/en not_active Ceased
-
2019
- 2019-09-25 US US16/582,206 patent/US11046748B2/en active Active
-
2020
- 2020-02-11 US US16/787,539 patent/US11634471B2/en active Active
-
2021
- 2021-06-21 US US17/304,412 patent/US12410235B2/en active Active
-
2023
- 2023-03-21 US US18/187,268 patent/US12325736B2/en active Active
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