JP2013504548A - パーキンソン病治療用医薬品としての用途への、ｎｕｒｒ−１活性化剤としてのインドール誘導体の使用 - Google Patents

パーキンソン病治療用医薬品としての用途への、ｎｕｒｒ−１活性化剤としてのインドール誘導体の使用 Download PDF

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JP2013504548A
JP2013504548A JP2012528430A JP2012528430A JP2013504548A JP 2013504548 A JP2013504548 A JP 2013504548A JP 2012528430 A JP2012528430 A JP 2012528430A JP 2012528430 A JP2012528430 A JP 2012528430A JP 2013504548 A JP2013504548 A JP 2013504548A
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methyl
indol
sulfonyl
phenyl
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ジェローム アモドリュ，
ベナイサ ブービア，
ドンヘン， マリア ヨハンナ ペトロネラ ファン
ファブリス ギイエ，
オリヴィア プーパダン−オリヴィエ，
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ラボラトワール フルニエ エス・アー
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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JP2012528430A 2009-09-11 2010-09-10 パーキンソン病治療用医薬品としての用途への、ｎｕｒｒ−１活性化剤としてのインドール誘導体の使用 Pending JP2013504548A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0956259A FR2950053B1 (fr) 2009-09-11 2009-09-11 Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
FR0956259 2009-09-11
FR1050107A FR2950058B1 (fr) 2009-09-11 2010-01-08 Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
FR1050107 2010-01-08
PCT/FR2010/051884 WO2011030068A1 (fr) 2009-09-11 2010-09-10 Utilisation de derives d'indole comme activateurs de nurr-1, pour leur application en tant que medicament pour le traitement de la maladie de parkinson

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US (1) US20120232070A1 (enExample)
EP (1) EP2475642A1 (enExample)
JP (1) JP2013504548A (enExample)
KR (1) KR20120065345A (enExample)
CN (2) CN102596906A (enExample)
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AU (1) AU2010294018A1 (enExample)
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WO2018136575A1 (en) * 2017-01-18 2018-07-26 Albert Einstein College Of Medicine, Inc. Pxr agonists and uses thereof for gut barrier dysfunction treatment and prevention

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JP2004501092A (ja) * 2000-04-28 2004-01-15 バクスター　ヘルスケア　ソシエテ　アノニム ２−アシル−インドール誘導体および抗腫瘍剤としてのその使用
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Title
JPN6014034146; Ｇｒｉｂｂｌｅ，　Ｇｏｒｄｏｎ　Ｗ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ５４（１４）, 1989, ｐ．　３２６４-３２６９ *
JPN6014034147; Ｇｒｉｂｂｌｅ，　Ｇｏｒｄｏｎ　Ｗ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ５７（２２）, 1992, ｐ．　５８９１-５８９９ *
JPN6014034148; Ｒｕｃｋｄｅｓｃｈｅｌ，　Ｊｏｈｎ　Ｃ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ ３５（２６）, 1992, ｐ．　４８５４-４８５７ *
JPN6014034149; Ｐｒａｌｙ-Ｄｅｐｒｅｚ，　Ｉｓａｂｅｌｌｅ　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ，　Ｐｅｒｋｉｎ　Ｔｒａｎｓａｃｔｉｏｎｓ　１ （１２）, 1991, ｐ．　３１６５-３１７１ *
JPN6014034150; Ｋｅｔｃｈａ，　Ｄａｎｉｅｌ　Ｍ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ５０（２６）, 1985, ｐ．　５４５１-５４５７ *
JPN6014034151; Ｄａｖｉｓ，　Ｄｅｂｏｒａｈ　Ａ．　ｅｔ　ａｌ．: Ｈｅｔｅｒｏｃｙｃｌｅｓ ３４（８）, 1992, ｐ．　１６１３-１６２１ *
JPN6014034152; Ｃｅｌｉｎｅ　Ｄｕｂｉｏｓ　ｅｔ　ａｌ: ＣｈｅｍＭｅｄＣｈｅｍ １, 2006, ｐ．　９５５-９５８ *

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MX2012003027A (es) 2012-04-19
US20120232070A1 (en) 2012-09-13
IN2012DN02005A (enExample) 2015-07-24
FR2950053B1 (fr) 2014-08-01
NZ598576A (en) 2014-05-30
TW201119650A (en) 2011-06-16
CL2012000632A1 (es) 2012-10-19
AR078358A1 (es) 2011-11-02
SG178451A1 (en) 2012-03-29
DOP2012000061A (es) 2012-09-30
EP2475642A1 (fr) 2012-07-18
AU2010294018A1 (en) 2012-03-29
SA110310698B1 (ar) 2014-11-16
CN103554006A (zh) 2014-02-05
CA2772697A1 (fr) 2011-03-17
CO6511224A2 (es) 2012-08-31
ECSP12011718A (es) 2012-04-30
FR2950058B1 (fr) 2016-04-01
CN102596906A (zh) 2012-07-18
FR2950053A1 (fr) 2011-03-18
WO2011030068A1 (fr) 2011-03-17
PE20121346A1 (es) 2012-10-15
PH12012500390A1 (en) 2012-10-22
ZA201201400B (en) 2013-05-29
RU2012110883A (ru) 2013-10-20
KR20120065345A (ko) 2012-06-20
BR112012005480A2 (pt) 2019-09-24
CR20120131A (es) 2012-07-27
FR2950058A1 (fr) 2011-03-18

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