AR078358A1 - Uso de derivados de indol como activadores de nurr-1 para la aplicacion como un producto medicinal destinado al tratamiento de la enfermedad de parkinson - Google Patents

Uso de derivados de indol como activadores de nurr-1 para la aplicacion como un producto medicinal destinado al tratamiento de la enfermedad de parkinson

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Publication number
AR078358A1
AR078358A1 ARP100103313A ARP100103313A AR078358A1 AR 078358 A1 AR078358 A1 AR 078358A1 AR P100103313 A ARP100103313 A AR P100103313A AR P100103313 A ARP100103313 A AR P100103313A AR 078358 A1 AR078358 A1 AR 078358A1
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group
carbon atoms
groups
hydrogen atom
treatment
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ARP100103313A
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English (en)
Inventor
Fabrice Guillier
Jerome Amaudrut
Olivia Poupardin-Olivier
Benaissa Boubia
Dongen Maria Johanna Petronella Van
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Fournier Lab Sa
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Application filed by Fournier Lab Sa filed Critical Fournier Lab Sa
Publication of AR078358A1 publication Critical patent/AR078358A1/es

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    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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  • Bioinformatics & Cheminformatics (AREA)
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  • Neurosurgery (AREA)
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  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

El uso de derivados de indol como activadores de NURR-1, para la aplicacion como un producto medicinal destinado al tratamiento de la enfermedad de Parkinson. Se aplica en el campo farmacéutico, para el tratamiento de enfermedades neurodegenerativas y, en particular, para el tratamiento de la enfermedad de Parkinson. Reivindicacion 1: Un compuesto caracterizado porque se selecciona entre: i) los compuestos de la formula: (1) en la cual: Cy representa un grupo fenilo o un grupo heteroaromático, que tiene 5 o 6 miembros en el anillo; R1 y R2, cada uno de ellos, independientemente uno del otro, representa, un átomo de hidrogeno, un átomo de halogeno, un grupo nitro, un grupo alquilo que tiene de 1 a 4 átomos de carbono, opcionalmente, halogenados en forma total o parcial, un grupo alcoxi que tiene de 1 a 4 átomos de carbono, un grupo heterocíclico que tiene de 4 a 6 átomos, un grupo -SCH3, OCF3, -NH2, -NHR o -NR2; R3 y R4, cada uno de ellos, independientemente uno del otro, representa, un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo que tiene de 1 a 4 átomos de carbono, un grupo hidroxilo o un grupo alcoxi que tiene de 1 a 4 átomos de carbono; R5 y R6, cada uno de ellos, independientemente uno del otro, representa, un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo que tiene de 1 a 4 átomos de carbono, un grupo hidroxilo; o R5 y R6 forman, junto con el átomo de carbono al cual están unidos, un grupo cicloalquilo que tiene de 3 a 6 átomos de carbono, un grupo etileno (C=CH2) o un grupo carbonilo (C=O); R7 representa un grupo -COOR, un grupo bioisostérico de ácido carboxílico o un grupo -CN; R8 representa: un grupo alquilo que tiene de 1 a 6 átomos de carbono, un grupo arilo, heteroarilo, cíclico o heterocíclico, grupo que está insustituido o sustituido con uno, dos o tres sustituyentes que pueden ser idénticos o diferentes, seleccionados entre átomos de halogeno, grupos alquilo que tienen de 1 a 6 átomos de carbono, opcionalmente, halogenados en forma total o parcial u opcionalmente, grupos alcoxi hidroxilados, que tienen de 1 a 6 átomos de carbono, opcionalmente, halogenados en forma total o parcial, donde el grupo fenoxi, los grupos cíclicos que tienen de 3 a 6 átomos de carbono, los grupos arilo y heteroarilo, en particular fenilo y pirazolilo, insustituidos o sustituidos con uno o dos sustituyentes, que pueden ser idénticos o diferentes, seleccionados entre átomos de halogeno y grupos alquilo que tienen de 1 a 4 átomos de carbono, los grupos SCHF2 y acil-morfolino; R9 representa un átomo de hidrogeno, un átomo de halogeno o un grupo alquilo que tiene de 1 a 4 átomos de carbono; R representa un átomo de hidrogeno o un grupo alquilo lineal o ramificado, que tiene de 1 a 4 átomos de carbono; ii) las sales farmacéuticamente aceptables de dichos compuestos de la formula (1); para usar como una sustancia terapéuticamente activa.
ARP100103313A 2009-09-11 2010-09-10 Uso de derivados de indol como activadores de nurr-1 para la aplicacion como un producto medicinal destinado al tratamiento de la enfermedad de parkinson AR078358A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0956259A FR2950053B1 (fr) 2009-09-11 2009-09-11 Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
FR1050107A FR2950058B1 (fr) 2009-09-11 2010-01-08 Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson

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AR078358A1 true AR078358A1 (es) 2011-11-02

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US (1) US20120232070A1 (es)
EP (1) EP2475642A1 (es)
JP (1) JP2013504548A (es)
KR (1) KR20120065345A (es)
CN (2) CN103554006A (es)
AR (1) AR078358A1 (es)
AU (1) AU2010294018A1 (es)
BR (1) BR112012005480A2 (es)
CA (1) CA2772697A1 (es)
CL (1) CL2012000632A1 (es)
CO (1) CO6511224A2 (es)
CR (1) CR20120131A (es)
DO (1) DOP2012000061A (es)
EC (1) ECSP12011718A (es)
FR (2) FR2950053B1 (es)
IL (1) IL218526A0 (es)
IN (1) IN2012DN02005A (es)
MX (1) MX2012003027A (es)
NZ (1) NZ598576A (es)
PE (1) PE20121346A1 (es)
RU (1) RU2012110883A (es)
SA (1) SA110310698B1 (es)
SG (1) SG178451A1 (es)
TW (1) TW201119650A (es)
WO (1) WO2011030068A1 (es)
ZA (1) ZA201201400B (es)

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IN2012DN02005A (es) 2015-07-24
ZA201201400B (en) 2013-05-29
FR2950058A1 (fr) 2011-03-18
SA110310698B1 (ar) 2014-11-16
KR20120065345A (ko) 2012-06-20
US20120232070A1 (en) 2012-09-13
FR2950053B1 (fr) 2014-08-01
FR2950053A1 (fr) 2011-03-18
DOP2012000061A (es) 2012-09-30
CN103554006A (zh) 2014-02-05
TW201119650A (en) 2011-06-16
NZ598576A (en) 2014-05-30
AU2010294018A1 (en) 2012-03-29
JP2013504548A (ja) 2013-02-07
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