CN102596906A - 吲哚衍生物作为nurr-1激活剂用作治疗帕金森病的药剂的用途 - Google Patents
吲哚衍生物作为nurr-1激活剂用作治疗帕金森病的药剂的用途 Download PDFInfo
- Publication number
- CN102596906A CN102596906A CN2010800509223A CN201080050922A CN102596906A CN 102596906 A CN102596906 A CN 102596906A CN 2010800509223 A CN2010800509223 A CN 2010800509223A CN 201080050922 A CN201080050922 A CN 201080050922A CN 102596906 A CN102596906 A CN 102596906A
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- Prior art keywords
- methyl
- group
- indol
- sulfonyl
- phenyl
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- 0 CC1(C)/C=C(/C(*)=CN2S(*)(=O)=O)\C2=C/C(C)(C)/C=C1 Chemical compound CC1(C)/C=C(/C(*)=CN2S(*)(=O)=O)\C2=C/C(C)(C)/C=C1 0.000 description 8
- VAYHMAFEXNTYNC-UHFFFAOYSA-N C(C1)C2OCS1C2 Chemical compound C(C1)C2OCS1C2 VAYHMAFEXNTYNC-UHFFFAOYSA-N 0.000 description 1
- BAOZQZPGQWXJOW-RITPCOANSA-N C1[C@H]2C=CC[C@@H]12 Chemical compound C1[C@H]2C=CC[C@@H]12 BAOZQZPGQWXJOW-RITPCOANSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
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- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
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- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0956259A FR2950053B1 (fr) | 2009-09-11 | 2009-09-11 | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| FR0956259 | 2009-09-11 | ||
| FR1050107A FR2950058B1 (fr) | 2009-09-11 | 2010-01-08 | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| FR1050107 | 2010-01-08 | ||
| PCT/FR2010/051884 WO2011030068A1 (fr) | 2009-09-11 | 2010-09-10 | Utilisation de derives d'indole comme activateurs de nurr-1, pour leur application en tant que medicament pour le traitement de la maladie de parkinson |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310415421.6A Division CN103554006A (zh) | 2009-09-11 | 2010-09-10 | 吲哚衍生物作为nurr-1激活剂用作治疗帕金森病的药剂的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102596906A true CN102596906A (zh) | 2012-07-18 |
Family
ID=42061922
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800509223A Pending CN102596906A (zh) | 2009-09-11 | 2010-09-10 | 吲哚衍生物作为nurr-1激活剂用作治疗帕金森病的药剂的用途 |
| CN201310415421.6A Pending CN103554006A (zh) | 2009-09-11 | 2010-09-10 | 吲哚衍生物作为nurr-1激活剂用作治疗帕金森病的药剂的用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310415421.6A Pending CN103554006A (zh) | 2009-09-11 | 2010-09-10 | 吲哚衍生物作为nurr-1激活剂用作治疗帕金森病的药剂的用途 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20120232070A1 (enExample) |
| EP (1) | EP2475642A1 (enExample) |
| JP (1) | JP2013504548A (enExample) |
| KR (1) | KR20120065345A (enExample) |
| CN (2) | CN102596906A (enExample) |
| AR (1) | AR078358A1 (enExample) |
| AU (1) | AU2010294018A1 (enExample) |
| BR (1) | BR112012005480A2 (enExample) |
| CA (1) | CA2772697A1 (enExample) |
| CL (1) | CL2012000632A1 (enExample) |
| CO (1) | CO6511224A2 (enExample) |
| CR (1) | CR20120131A (enExample) |
| DO (1) | DOP2012000061A (enExample) |
| EC (1) | ECSP12011718A (enExample) |
| FR (2) | FR2950053B1 (enExample) |
| IL (1) | IL218526A0 (enExample) |
| IN (1) | IN2012DN02005A (enExample) |
| MX (1) | MX2012003027A (enExample) |
| NZ (1) | NZ598576A (enExample) |
| PE (1) | PE20121346A1 (enExample) |
| PH (1) | PH12012500390A1 (enExample) |
| RU (1) | RU2012110883A (enExample) |
| SA (1) | SA110310698B1 (enExample) |
| SG (1) | SG178451A1 (enExample) |
| TW (1) | TW201119650A (enExample) |
| WO (1) | WO2011030068A1 (enExample) |
| ZA (1) | ZA201201400B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105272975B (zh) * | 2014-06-10 | 2019-03-26 | 中国科学院上海药物研究所 | 一类具有1,2,4-恶二唑片段结构的吲哚生物碱及其制备方法和用途 |
| WO2018136575A1 (en) * | 2017-01-18 | 2018-07-26 | Albert Einstein College Of Medicine, Inc. | Pxr agonists and uses thereof for gut barrier dysfunction treatment and prevention |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1086950A1 (en) * | 1998-05-26 | 2001-03-28 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic indole derivatives and mono- or diazaindole derivatives |
| WO2001082909A2 (de) * | 2000-04-28 | 2001-11-08 | Baxter Healthcare Sa | 2-acyl-indolderivate und deren verwendung als antitumormittel |
| CN101304992A (zh) * | 2005-09-07 | 2008-11-12 | 普莱希科公司 | 用作ppar调节剂的1,3-二取代吲哚衍生物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9615441D0 (en) * | 1996-07-23 | 1996-09-04 | Pharmacia Spa | Benzoylpropionic acid ester derivatives |
| GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0119911D0 (en) | 2001-08-15 | 2001-10-10 | Novartis Ag | Organic Compounds |
| GB0303503D0 (en) | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| AR043633A1 (es) * | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
| WO2004108094A2 (en) * | 2003-06-06 | 2004-12-16 | Atherogenics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
| WO2005047268A2 (en) | 2003-11-10 | 2005-05-26 | X-Ceptor Therapeutics, Inc. | Substituted pyrimidine compositions and methods of use |
| WO2005056522A2 (en) | 2003-12-04 | 2005-06-23 | National Health Research Institutes | Indole compounds |
| DK1761519T3 (da) * | 2004-06-21 | 2008-07-21 | Hoffmann La Roche | Indolderivater som histaminreceptorantagonister |
| FR2890071B1 (fr) * | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
| FR2903107B1 (fr) | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2903106B1 (fr) | 2006-07-03 | 2010-07-30 | Sanofi Aventis | Utilisations de 2-benzoyl-imidazopyridines en therapeutique |
| FR2903105A1 (fr) | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
-
2009
- 2009-09-11 FR FR0956259A patent/FR2950053B1/fr active Active
-
2010
- 2010-01-08 FR FR1050107A patent/FR2950058B1/fr active Active
- 2010-09-10 SG SG2012010815A patent/SG178451A1/en unknown
- 2010-09-10 TW TW099130733A patent/TW201119650A/zh unknown
- 2010-09-10 RU RU2012110883/04A patent/RU2012110883A/ru not_active Application Discontinuation
- 2010-09-10 NZ NZ598576A patent/NZ598576A/en not_active IP Right Cessation
- 2010-09-10 EP EP10770545A patent/EP2475642A1/fr not_active Withdrawn
- 2010-09-10 PE PE2012000304A patent/PE20121346A1/es not_active Application Discontinuation
- 2010-09-10 PH PH1/2012/500390A patent/PH12012500390A1/en unknown
- 2010-09-10 CN CN2010800509223A patent/CN102596906A/zh active Pending
- 2010-09-10 CN CN201310415421.6A patent/CN103554006A/zh active Pending
- 2010-09-10 KR KR1020127006186A patent/KR20120065345A/ko not_active Withdrawn
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- 2010-09-10 MX MX2012003027A patent/MX2012003027A/es not_active Application Discontinuation
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Patent Citations (3)
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| EP1086950A1 (en) * | 1998-05-26 | 2001-03-28 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic indole derivatives and mono- or diazaindole derivatives |
| WO2001082909A2 (de) * | 2000-04-28 | 2001-11-08 | Baxter Healthcare Sa | 2-acyl-indolderivate und deren verwendung als antitumormittel |
| CN101304992A (zh) * | 2005-09-07 | 2008-11-12 | 普莱希科公司 | 用作ppar调节剂的1,3-二取代吲哚衍生物 |
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| GORDON W. GRIBBLE,等: "A Versatile and Efficient Construction of the 6H-Pyrido[4,3-b ]carbazole Ring System. Syntheses of the Antitumor Alkaloids Ellipticine9-Met hoxyellipticine, and Olivacine and Their Analogues", 《J. ORG. CHEM》, vol. 57, no. 22, 23 October 1992 (1992-10-23), pages 5891 - 5899 * |
| GORDON W. GRIBBLE,等: "Metalated Heterocycles in the Synthesis of Ellipticine Analogues. A NewRoute to the lOH-Pyrido[2,3-b]carbazole Ring System", 《J. ORG. CHEM》, vol. 54, no. 14, 1 January 1989 (1989-01-01), pages 3264 - 3269 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| IL218526A0 (en) | 2012-07-31 |
| MX2012003027A (es) | 2012-04-19 |
| US20120232070A1 (en) | 2012-09-13 |
| IN2012DN02005A (enExample) | 2015-07-24 |
| FR2950053B1 (fr) | 2014-08-01 |
| NZ598576A (en) | 2014-05-30 |
| TW201119650A (en) | 2011-06-16 |
| CL2012000632A1 (es) | 2012-10-19 |
| AR078358A1 (es) | 2011-11-02 |
| SG178451A1 (en) | 2012-03-29 |
| DOP2012000061A (es) | 2012-09-30 |
| EP2475642A1 (fr) | 2012-07-18 |
| AU2010294018A1 (en) | 2012-03-29 |
| SA110310698B1 (ar) | 2014-11-16 |
| CN103554006A (zh) | 2014-02-05 |
| CA2772697A1 (fr) | 2011-03-17 |
| CO6511224A2 (es) | 2012-08-31 |
| ECSP12011718A (es) | 2012-04-30 |
| FR2950058B1 (fr) | 2016-04-01 |
| FR2950053A1 (fr) | 2011-03-18 |
| WO2011030068A1 (fr) | 2011-03-17 |
| JP2013504548A (ja) | 2013-02-07 |
| PE20121346A1 (es) | 2012-10-15 |
| PH12012500390A1 (en) | 2012-10-22 |
| ZA201201400B (en) | 2013-05-29 |
| RU2012110883A (ru) | 2013-10-20 |
| KR20120065345A (ko) | 2012-06-20 |
| BR112012005480A2 (pt) | 2019-09-24 |
| CR20120131A (es) | 2012-07-27 |
| FR2950058A1 (fr) | 2011-03-18 |
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