JP2013502209A5

JP2013502209A5 -

Download PDF

Info

Publication number: JP2013502209A5
Authority: JP; Japan
Prior art keywords: seq; immunoconjugate; variable region; chain variable; region sequence
Prior art date: 2010-08-13
Legal status : Granted

Application number

JP2012525147A

Other languages

English (en)

Japanese (ja)

Other versions

JP2013502209A (ja

JP5764127B2 (ja

Filing date

2010-08-13

Publication date

2013-05-16

2010-08-13 Application filed filed Critical

2010-08-13 Priority claimed from PCT/EP2010/061810 external-priority patent/WO2011020783A2/en

2013-01-24 Publication of JP2013502209A publication Critical patent/JP2013502209A/ja

2013-05-16 Publication of JP2013502209A5 publication Critical patent/JP2013502209A5/ja

2015-08-12 Application granted granted Critical

2015-08-12 Publication of JP5764127B2 publication Critical patent/JP5764127B2/ja

Status Active legal-status Critical Current

2030-08-13 Anticipated expiration legal-status Critical

Links

229940127121 immunoconjugate Drugs 0.000 claims description 590
239000000427 antigen Substances 0.000 claims description 269
238000009739 binding Methods 0.000 claims description 268
102000036639 antigens Human genes 0.000 claims description 267
230000027455 binding Effects 0.000 claims description 267
108091007433 antigens Proteins 0.000 claims description 266
239000012636 effector Substances 0.000 claims description 253
108090000765 processed proteins & peptides Proteins 0.000 claims description 239
102000004196 processed proteins & peptides Human genes 0.000 claims description 234
229920001184 polypeptide Polymers 0.000 claims description 231
102000040430 polynucleotide Human genes 0.000 claims description 156
108091033319 polynucleotide Proteins 0.000 claims description 156
239000002157 polynucleotide Substances 0.000 claims description 156
210000004027 cell Anatomy 0.000 claims description 143
108010002350 Interleukin-2 Proteins 0.000 claims description 101
102000000588 Interleukin-2 Human genes 0.000 claims description 101
239000012634 fragment Substances 0.000 claims description 91
125000003275 alpha amino acid group Chemical group 0.000 claims description 85
108090000623 proteins and genes Proteins 0.000 claims description 69
206010028980 Neoplasm Diseases 0.000 claims description 54
102000004127 Cytokines Human genes 0.000 claims description 50
108090000695 Cytokines Proteins 0.000 claims description 50
239000000203 mixture Substances 0.000 claims description 50
102000004169 proteins and genes Human genes 0.000 claims description 41
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 39
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 38
230000014509 gene expression Effects 0.000 claims description 32
108010065805 Interleukin-12 Proteins 0.000 claims description 29
102000013462 Interleukin-12 Human genes 0.000 claims description 29
229940117681 interleukin-12 Drugs 0.000 claims description 29
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 25
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 21
102000007000 Tenascin Human genes 0.000 claims description 20
108010008125 Tenascin Proteins 0.000 claims description 20
201000011510 cancer Diseases 0.000 claims description 20
102000016359 Fibronectins Human genes 0.000 claims description 19
201000010099 disease Diseases 0.000 claims description 19
108010067306 Fibronectins Proteins 0.000 claims description 18
102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 claims description 16
101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 claims description 16
239000013604 expression vector Substances 0.000 claims description 16
238000011282 treatment Methods 0.000 claims description 16
239000003814 drug Substances 0.000 claims description 13
230000004913 activation Effects 0.000 claims description 12
102000006992 Interferon-alpha Human genes 0.000 claims description 11
108010047761 Interferon-alpha Proteins 0.000 claims description 11
210000004899 c-terminal region Anatomy 0.000 claims description 10
238000004519 manufacturing process Methods 0.000 claims description 9
210000002950 fibroblast Anatomy 0.000 claims description 8
102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 5
108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 5
239000003937 drug carrier Substances 0.000 claims description 5
210000002744 extracellular matrix Anatomy 0.000 claims description 5
230000006337 proteolytic cleavage Effects 0.000 claims description 4
241000700605 Viruses Species 0.000 claims description 3
238000012258 culturing Methods 0.000 claims description 3
102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 2
235000001014 amino acid Nutrition 0.000 description 96
241000282414 Homo sapiens Species 0.000 description 94
229940024606 amino acid Drugs 0.000 description 90
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 67
238000000034 method Methods 0.000 description 51
101000666340 Homo sapiens Tenascin Proteins 0.000 description 42
150000007523 nucleic acids Chemical class 0.000 description 40
235000018102 proteins Nutrition 0.000 description 39
102100020773 Immunoglobulin kappa variable 1-12 Human genes 0.000 description 38
238000000746 purification Methods 0.000 description 38
102000039446 nucleic acids Human genes 0.000 description 36
108020004707 nucleic acids Proteins 0.000 description 36
102100038126 Tenascin Human genes 0.000 description 35
239000011780 sodium chloride Substances 0.000 description 34
101100274557 Heterodera glycines CLE1 gene Proteins 0.000 description 33
150000001413 amino acids Chemical group 0.000 description 33
108010038453 Interleukin-2 Receptors Proteins 0.000 description 32
102000010789 Interleukin-2 Receptors Human genes 0.000 description 32
239000000243 solution Substances 0.000 description 31
241000699670 Mus sp. Species 0.000 description 27
230000000694 effects Effects 0.000 description 27
239000002585 base Substances 0.000 description 25
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 24
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 24
108700025316 aldesleukin Proteins 0.000 description 24
229940087463 proleukin Drugs 0.000 description 24
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 23
108060003951 Immunoglobulin Proteins 0.000 description 23
102000018358 immunoglobulin Human genes 0.000 description 23
230000000890 antigenic effect Effects 0.000 description 22
230000037396 body weight Effects 0.000 description 22
102000005962 receptors Human genes 0.000 description 22
108020003175 receptors Proteins 0.000 description 22
238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 22
241001529936 Murinae Species 0.000 description 21
230000002829 reductive effect Effects 0.000 description 20
230000004083 survival effect Effects 0.000 description 20
108010074328 Interferon-gamma Proteins 0.000 description 19
238000009472 formulation Methods 0.000 description 19
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 18
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 18
102100037850 Interferon gamma Human genes 0.000 description 18
239000000047 product Substances 0.000 description 18
241000124008 Mammalia Species 0.000 description 17
238000001727 in vivo Methods 0.000 description 17
239000002245 particle Substances 0.000 description 17
230000035755 proliferation Effects 0.000 description 17
239000006228 supernatant Substances 0.000 description 17
210000004881 tumor cell Anatomy 0.000 description 17
239000003795 chemical substances by application Substances 0.000 description 16
238000012217 deletion Methods 0.000 description 16
230000037430 deletion Effects 0.000 description 16
239000002773 nucleotide Substances 0.000 description 16
125000003729 nucleotide group Chemical group 0.000 description 16
239000013598 vector Substances 0.000 description 16
238000002474 experimental method Methods 0.000 description 15
108020004414 DNA Proteins 0.000 description 14
-1 IL- 10 Proteins 0.000 description 14
239000001509 sodium citrate Substances 0.000 description 14
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 14
210000001519 tissue Anatomy 0.000 description 14
241001465754 Metazoa Species 0.000 description 13
239000007924 injection Substances 0.000 description 13
238000002347 injection Methods 0.000 description 13
230000008685 targeting Effects 0.000 description 13
238000002965 ELISA Methods 0.000 description 12
239000004471 Glycine Substances 0.000 description 12
238000003556 assay Methods 0.000 description 12
239000000872 buffer Substances 0.000 description 12
108020001507 fusion proteins Proteins 0.000 description 12
102000037865 fusion proteins Human genes 0.000 description 12
230000001939 inductive effect Effects 0.000 description 12
230000003993 interaction Effects 0.000 description 12
108091028043 Nucleic acid sequence Proteins 0.000 description 11
230000009824 affinity maturation Effects 0.000 description 11
238000004458 analytical method Methods 0.000 description 11
230000004069 differentiation Effects 0.000 description 11
150000003839 salts Chemical class 0.000 description 11
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 11
239000001488 sodium phosphate Substances 0.000 description 11
229910000162 sodium phosphate Inorganic materials 0.000 description 11
238000006467 substitution reaction Methods 0.000 description 11
230000001225 therapeutic effect Effects 0.000 description 11
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 11
108091026890 Coding region Proteins 0.000 description 10
241000283984 Rodentia Species 0.000 description 10
210000001744 T-lymphocyte Anatomy 0.000 description 10
230000003321 amplification Effects 0.000 description 10
238000010494 dissociation reaction Methods 0.000 description 10
230000005593 dissociations Effects 0.000 description 10
239000007788 liquid Substances 0.000 description 10
238000003199 nucleic acid amplification method Methods 0.000 description 10
210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 10
238000002360 preparation method Methods 0.000 description 10
241000588724 Escherichia coli Species 0.000 description 9
108010076504 Protein Sorting Signals Proteins 0.000 description 9
238000012933 kinetic analysis Methods 0.000 description 9
239000002609 medium Substances 0.000 description 9
230000019491 signal transduction Effects 0.000 description 9
238000001542 size-exclusion chromatography Methods 0.000 description 9
238000013518 transcription Methods 0.000 description 9
230000035897 transcription Effects 0.000 description 9
101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 description 8
241000699666 Mus <mouse, genus> Species 0.000 description 8
238000011579 SCID mouse model Methods 0.000 description 8
238000001042 affinity chromatography Methods 0.000 description 8
210000003719 b-lymphocyte Anatomy 0.000 description 8
230000004071 biological effect Effects 0.000 description 8
239000002775 capsule Substances 0.000 description 8
229940079593 drug Drugs 0.000 description 8
238000010828 elution Methods 0.000 description 8
230000001976 improved effect Effects 0.000 description 8
230000006698 induction Effects 0.000 description 8
238000005259 measurement Methods 0.000 description 8
OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 8
239000008194 pharmaceutical composition Substances 0.000 description 8
238000012216 screening Methods 0.000 description 8
210000000952 spleen Anatomy 0.000 description 8
230000001988 toxicity Effects 0.000 description 8
231100000419 toxicity Toxicity 0.000 description 8
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 8
108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
102000000013 Chemokine CCL3 Human genes 0.000 description 7
102000001326 Chemokine CCL4 Human genes 0.000 description 7
108010055165 Chemokine CCL4 Proteins 0.000 description 7
102000004890 Interleukin-8 Human genes 0.000 description 7
108090001007 Interleukin-8 Proteins 0.000 description 7
102100020870 La-related protein 6 Human genes 0.000 description 7
108050008265 La-related protein 6 Proteins 0.000 description 7
101710120037 Toxin CcdB Proteins 0.000 description 7
108090001012 Transforming Growth Factor beta Proteins 0.000 description 7
102000004887 Transforming Growth Factor beta Human genes 0.000 description 7
OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 7
108010072257 fibroblast activation protein alpha Proteins 0.000 description 7
230000004927 fusion Effects 0.000 description 7
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 7
229940096397 interleukin-8 Drugs 0.000 description 7
239000000463 material Substances 0.000 description 7
239000011159 matrix material Substances 0.000 description 7
210000000822 natural killer cell Anatomy 0.000 description 7
229920001223 polyethylene glycol Polymers 0.000 description 7
239000003755 preservative agent Substances 0.000 description 7
230000002062 proliferating effect Effects 0.000 description 7
230000011664 signaling Effects 0.000 description 7
239000000725 suspension Substances 0.000 description 7
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 7
NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 6
241000894006 Bacteria Species 0.000 description 6
108700012434 CCL3 Proteins 0.000 description 6
101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
102000008394 Immunoglobulin Fragments Human genes 0.000 description 6
108010021625 Immunoglobulin Fragments Proteins 0.000 description 6
102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 6
102000001712 STAT5 Transcription Factor Human genes 0.000 description 6
108010029477 STAT5 Transcription Factor Proteins 0.000 description 6
108060008682 Tumor Necrosis Factor Proteins 0.000 description 6
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 6
239000004480 active ingredient Substances 0.000 description 6
239000012491 analyte Substances 0.000 description 6
239000011324 bead Substances 0.000 description 6
210000004369 blood Anatomy 0.000 description 6
239000008280 blood Substances 0.000 description 6
230000004663 cell proliferation Effects 0.000 description 6
210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 6
208000015181 infectious disease Diseases 0.000 description 6
230000000670 limiting effect Effects 0.000 description 6
125000005647 linker group Chemical group 0.000 description 6
230000001404 mediated effect Effects 0.000 description 6
108020004999 messenger RNA Proteins 0.000 description 6
230000036961 partial effect Effects 0.000 description 6
238000002823 phage display Methods 0.000 description 6
239000000546 pharmaceutical excipient Substances 0.000 description 6
230000026731 phosphorylation Effects 0.000 description 6
238000006366 phosphorylation reaction Methods 0.000 description 6
239000000843 powder Substances 0.000 description 6
230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 6
230000028327 secretion Effects 0.000 description 6
239000000829 suppository Substances 0.000 description 6
238000012360 testing method Methods 0.000 description 6
239000003981 vehicle Substances 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 5
239000007993 MOPS buffer Substances 0.000 description 5
241000288906 Primates Species 0.000 description 5
108010090804 Streptavidin Proteins 0.000 description 5
239000012505 Superdex™ Substances 0.000 description 5
102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 5
230000009471 action Effects 0.000 description 5
238000007792 addition Methods 0.000 description 5
125000000539 amino acid group Chemical group 0.000 description 5
238000012436 analytical size exclusion chromatography Methods 0.000 description 5
230000001580 bacterial effect Effects 0.000 description 5
230000008901 benefit Effects 0.000 description 5
239000000969 carrier Substances 0.000 description 5
238000004113 cell culture Methods 0.000 description 5
238000012054 celltiter-glo Methods 0.000 description 5
230000036755 cellular response Effects 0.000 description 5
238000012512 characterization method Methods 0.000 description 5
238000004590 computer program Methods 0.000 description 5
230000006378 damage Effects 0.000 description 5
230000001419 dependent effect Effects 0.000 description 5
239000000839 emulsion Substances 0.000 description 5
230000006870 function Effects 0.000 description 5
230000012010 growth Effects 0.000 description 5
230000036541 health Effects 0.000 description 5
238000000338 in vitro Methods 0.000 description 5
239000003112 inhibitor Substances 0.000 description 5
238000003780 insertion Methods 0.000 description 5
230000037431 insertion Effects 0.000 description 5
210000003734 kidney Anatomy 0.000 description 5
210000004698 lymphocyte Anatomy 0.000 description 5
210000001616 monocyte Anatomy 0.000 description 5
239000013612 plasmid Substances 0.000 description 5
230000001737 promoting effect Effects 0.000 description 5
230000008929 regeneration Effects 0.000 description 5
238000011069 regeneration method Methods 0.000 description 5
239000012146 running buffer Substances 0.000 description 5
239000003826 tablet Substances 0.000 description 5
230000003827 upregulation Effects 0.000 description 5
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
241000282412 Homo Species 0.000 description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
239000004472 Lysine Chemical group 0.000 description 4
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
229920002873 Polyethylenimine Polymers 0.000 description 4
229920001213 Polysorbate 20 Polymers 0.000 description 4
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
239000007983 Tris buffer Substances 0.000 description 4
KYIKRXIYLAGAKQ-UHFFFAOYSA-N abcn Chemical compound C1CCCCC1(C#N)N=NC1(C#N)CCCCC1 KYIKRXIYLAGAKQ-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
239000000443 aerosol Substances 0.000 description 4
238000010171 animal model Methods 0.000 description 4
230000000259 anti-tumor effect Effects 0.000 description 4
230000006907 apoptotic process Effects 0.000 description 4
239000011230 binding agent Substances 0.000 description 4
230000001413 cellular effect Effects 0.000 description 4
230000008859 change Effects 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
238000010276 construction Methods 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
239000013020 final formulation Substances 0.000 description 4
239000000499 gel Substances 0.000 description 4
210000004602 germ cell Anatomy 0.000 description 4
238000002873 global sequence alignment Methods 0.000 description 4
210000003714 granulocyte Anatomy 0.000 description 4
239000005556 hormone Substances 0.000 description 4
229940088597 hormone Drugs 0.000 description 4
102000057345 human TNC Human genes 0.000 description 4
230000003463 hyperproliferative effect Effects 0.000 description 4
230000028993 immune response Effects 0.000 description 4
230000002163 immunogen Effects 0.000 description 4
238000001802 infusion Methods 0.000 description 4
230000005764 inhibitory process Effects 0.000 description 4
239000008101 lactose Substances 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
230000035772 mutation Effects 0.000 description 4
238000006386 neutralization reaction Methods 0.000 description 4
108010087904 neutravidin Proteins 0.000 description 4
239000003921 oil Substances 0.000 description 4
235000019198 oils Nutrition 0.000 description 4
239000012071 phase Substances 0.000 description 4
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
229910000160 potassium phosphate Inorganic materials 0.000 description 4
235000011009 potassium phosphates Nutrition 0.000 description 4
238000001556 precipitation Methods 0.000 description 4
230000009467 reduction Effects 0.000 description 4
230000001105 regulatory effect Effects 0.000 description 4
239000000523 sample Substances 0.000 description 4
238000002864 sequence alignment Methods 0.000 description 4
239000001632 sodium acetate Substances 0.000 description 4
235000017281 sodium acetate Nutrition 0.000 description 4
239000002904 solvent Substances 0.000 description 4
230000009870 specific binding Effects 0.000 description 4
239000007921 spray Substances 0.000 description 4
238000010561 standard procedure Methods 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000000758 substrate Substances 0.000 description 4
238000013268 sustained release Methods 0.000 description 4
239000012730 sustained-release form Substances 0.000 description 4
239000006188 syrup Substances 0.000 description 4
235000020357 syrup Nutrition 0.000 description 4
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
238000011144 upstream manufacturing Methods 0.000 description 4
238000005406 washing Methods 0.000 description 4
QZNNVYOVQUKYSC-JEDNCBNOSA-N (2s)-2-amino-3-(1h-imidazol-5-yl)propanoic acid;hydron;chloride Chemical compound Cl.OC(=O)[C@@H](N)CC1=CN=CN1 QZNNVYOVQUKYSC-JEDNCBNOSA-N 0.000 description 3
MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
101150007969 ADORA1 gene Proteins 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
125000001433 C-terminal amino-acid group Chemical group 0.000 description 3
102000000844 Cell Surface Receptors Human genes 0.000 description 3
108010001857 Cell Surface Receptors Proteins 0.000 description 3
206010009944 Colon cancer Diseases 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 3
102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 3
241000196324 Embryophyta Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
102100027581 Forkhead box protein P3 Human genes 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 3
101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 description 3
101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 3
101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 3
102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 3
108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 3
108010067060 Immunoglobulin Variable Region Proteins 0.000 description 3
102000017727 Immunoglobulin Variable Region Human genes 0.000 description 3
108090000467 Interferon-beta Proteins 0.000 description 3
102000004083 Lymphotoxin-alpha Human genes 0.000 description 3
108090000542 Lymphotoxin-alpha Proteins 0.000 description 3
125000000729 N-terminal amino-acid group Chemical group 0.000 description 3
102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 3
108700026244 Open Reading Frames Proteins 0.000 description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
206010035226 Plasma cell myeloma Diseases 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
208000035415 Reinfection Diseases 0.000 description 3
229920002684 Sepharose Polymers 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 3
241000251539 Vertebrata <Metazoa> Species 0.000 description 3
210000001015 abdomen Anatomy 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
230000000903 blocking effect Effects 0.000 description 3
230000021164 cell adhesion Effects 0.000 description 3
230000024245 cell differentiation Effects 0.000 description 3
238000001516 cell proliferation assay Methods 0.000 description 3
210000004978 chinese hamster ovary cell Anatomy 0.000 description 3
238000000576 coating method Methods 0.000 description 3
239000008120 corn starch Substances 0.000 description 3
210000004748 cultured cell Anatomy 0.000 description 3
210000004443 dendritic cell Anatomy 0.000 description 3
238000001514 detection method Methods 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
239000002612 dispersion medium Substances 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
239000003623 enhancer Substances 0.000 description 3
239000012467 final product Substances 0.000 description 3
239000000796 flavoring agent Substances 0.000 description 3
230000037406 food intake Effects 0.000 description 3
235000003599 food sweetener Nutrition 0.000 description 3
239000012458 free base Substances 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
229940014259 gelatin Drugs 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
239000000833 heterodimer Substances 0.000 description 3
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Chemical group OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
230000016784 immunoglobulin production Effects 0.000 description 3
230000001965 increasing effect Effects 0.000 description 3
238000011534 incubation Methods 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
150000002632 lipids Chemical class 0.000 description 3
239000002502 liposome Substances 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
238000007726 management method Methods 0.000 description 3
201000000050 myeloid neoplasm Diseases 0.000 description 3
208000002154 non-small cell lung carcinoma Diseases 0.000 description 3
238000011275 oncology therapy Methods 0.000 description 3
244000052769 pathogen Species 0.000 description 3
239000006187 pill Substances 0.000 description 3
229920005862 polyol Polymers 0.000 description 3
150000003077 polyols Chemical class 0.000 description 3
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
239000001267 polyvinylpyrrolidone Substances 0.000 description 3
229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
238000007639 printing Methods 0.000 description 3
230000008569 process Effects 0.000 description 3
210000003289 regulatory T cell Anatomy 0.000 description 3
229920006395 saturated elastomer Polymers 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000003381 stabilizer Substances 0.000 description 3
239000011550 stock solution Substances 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
239000004094 surface-active agent Substances 0.000 description 3
239000003765 sweetening agent Substances 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
238000007910 systemic administration Methods 0.000 description 3
230000009885 systemic effect Effects 0.000 description 3
208000001608 teratocarcinoma Diseases 0.000 description 3
230000009261 transgenic effect Effects 0.000 description 3
238000013519 translation Methods 0.000 description 3
238000000870 ultraviolet spectroscopy Methods 0.000 description 3
230000035899 viability Effects 0.000 description 3
230000003442 weekly effect Effects 0.000 description 3
241000416162 Astragalus gummifer Species 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
206010006187 Breast cancer Diseases 0.000 description 2
208000026310 Breast neoplasm Diseases 0.000 description 2
102000000905 Cadherin Human genes 0.000 description 2
108050007957 Cadherin Proteins 0.000 description 2
101100028791 Caenorhabditis elegans pbs-5 gene Proteins 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 2
206010008342 Cervix carcinoma Diseases 0.000 description 2
102000019034 Chemokines Human genes 0.000 description 2
108010012236 Chemokines Proteins 0.000 description 2
108020004705 Codon Proteins 0.000 description 2
108010047041 Complementarity Determining Regions Proteins 0.000 description 2
102000003903 Cyclin-dependent kinases Human genes 0.000 description 2
108090000266 Cyclin-dependent kinases Proteins 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
102000053602 DNA Human genes 0.000 description 2
238000001712 DNA sequencing Methods 0.000 description 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 2
238000008157 ELISA kit Methods 0.000 description 2
108010087819 Fc receptors Proteins 0.000 description 2
102000009109 Fc receptors Human genes 0.000 description 2
206010061968 Gastric neoplasm Diseases 0.000 description 2
102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 2
101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 2
102100026720 Interferon beta Human genes 0.000 description 2
108010002386 Interleukin-3 Proteins 0.000 description 2
102000000646 Interleukin-3 Human genes 0.000 description 2
108090000978 Interleukin-4 Proteins 0.000 description 2
102000004388 Interleukin-4 Human genes 0.000 description 2
108010002616 Interleukin-5 Proteins 0.000 description 2
102000000743 Interleukin-5 Human genes 0.000 description 2
108090001005 Interleukin-6 Proteins 0.000 description 2
102000004889 Interleukin-6 Human genes 0.000 description 2
102000010781 Interleukin-6 Receptors Human genes 0.000 description 2
108010038501 Interleukin-6 Receptors Proteins 0.000 description 2
102000015696 Interleukins Human genes 0.000 description 2
108010063738 Interleukins Proteins 0.000 description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
239000012515 MabSelect SuRe Substances 0.000 description 2
108700018351 Major Histocompatibility Complex Proteins 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
102100022430 Melanocyte protein PMEL Human genes 0.000 description 2
102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 2
102000000440 Melanoma-associated antigen Human genes 0.000 description 2
108050008953 Melanoma-associated antigen Proteins 0.000 description 2
206010027476 Metastases Diseases 0.000 description 2
101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
101710160107 Outer membrane protein A Proteins 0.000 description 2
206010033128 Ovarian cancer Diseases 0.000 description 2
206010061535 Ovarian neoplasm Diseases 0.000 description 2
108091093037 Peptide nucleic acid Proteins 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 2
101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 description 2
108010039918 Polylysine Proteins 0.000 description 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
206010060862 Prostate cancer Diseases 0.000 description 2
108010072866 Prostate-Specific Antigen Proteins 0.000 description 2
102100038358 Prostate-specific antigen Human genes 0.000 description 2
208000000236 Prostatic Neoplasms Diseases 0.000 description 2
102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
108020004511 Recombinant DNA Proteins 0.000 description 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Chemical group OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
239000004280 Sodium formate Substances 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
101800001271 Surface protein Proteins 0.000 description 2
230000006052 T cell proliferation Effects 0.000 description 2
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
108020005038 Terminator Codon Proteins 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
229920001615 Tragacanth Polymers 0.000 description 2
206010052779 Transplant rejections Diseases 0.000 description 2
208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
239000013543 active substance Substances 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
235000010443 alginic acid Nutrition 0.000 description 2
239000000783 alginic acid Substances 0.000 description 2
229920000615 alginic acid Polymers 0.000 description 2
229960001126 alginic acid Drugs 0.000 description 2
150000004781 alginic acids Chemical class 0.000 description 2
230000000844 anti-bacterial effect Effects 0.000 description 2
230000000340 anti-metabolite Effects 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
229940121375 antifungal agent Drugs 0.000 description 2
229940100197 antimetabolite Drugs 0.000 description 2
239000002256 antimetabolite Substances 0.000 description 2
239000003963 antioxidant agent Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
238000000429 assembly Methods 0.000 description 2
230000000712 assembly Effects 0.000 description 2
238000007845 assembly PCR Methods 0.000 description 2
230000001363 autoimmune Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
229940098773 bovine serum albumin Drugs 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
230000010261 cell growth Effects 0.000 description 2
210000000170 cell membrane Anatomy 0.000 description 2
239000006285 cell suspension Substances 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
201000010881 cervical cancer Diseases 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
208000029742 colonic neoplasm Diseases 0.000 description 2
230000000295 complement effect Effects 0.000 description 2
239000012050 conventional carrier Substances 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
238000012937 correction Methods 0.000 description 2
239000006071 cream Substances 0.000 description 2
102000003675 cytokine receptors Human genes 0.000 description 2
108010057085 cytokine receptors Proteins 0.000 description 2
239000000824 cytostatic agent Substances 0.000 description 2
230000001085 cytostatic effect Effects 0.000 description 2
230000034994 death Effects 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
230000001934 delay Effects 0.000 description 2
238000004925 denaturation Methods 0.000 description 2
230000036425 denaturation Effects 0.000 description 2
239000007884 disintegrant Substances 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
125000002228 disulfide group Chemical group 0.000 description 2
239000008298 dragée Substances 0.000 description 2
239000000975 dye Substances 0.000 description 2
210000003527 eukaryotic cell Anatomy 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
238000000684 flow cytometry Methods 0.000 description 2
125000000524 functional group Chemical group 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
210000002443 helper t lymphocyte Anatomy 0.000 description 2
238000005734 heterodimerization reaction Methods 0.000 description 2
238000001794 hormone therapy Methods 0.000 description 2
210000004408 hybridoma Anatomy 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
238000003018 immunoassay Methods 0.000 description 2
230000005847 immunogenicity Effects 0.000 description 2
229940072221 immunoglobulins Drugs 0.000 description 2
239000002955 immunomodulating agent Substances 0.000 description 2
229940121354 immunomodulator Drugs 0.000 description 2
229940047122 interleukins Drugs 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
238000002955 isolation Methods 0.000 description 2
239000007951 isotonicity adjuster Substances 0.000 description 2
210000003292 kidney cell Anatomy 0.000 description 2
239000003446 ligand Substances 0.000 description 2
230000022288 lymphocyte chemotaxis Effects 0.000 description 2
229910001629 magnesium chloride Inorganic materials 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
210000004962 mammalian cell Anatomy 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
230000009401 metastasis Effects 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
244000005700 microbiome Species 0.000 description 2
150000007522 mineralic acids Chemical class 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
238000010369 molecular cloning Methods 0.000 description 2
239000000178 monomer Substances 0.000 description 2
229940100656 nasal solution Drugs 0.000 description 2
239000013642 negative control Substances 0.000 description 2
210000004882 non-tumor cell Anatomy 0.000 description 2
230000003647 oxidation Effects 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
230000001717 pathogenic effect Effects 0.000 description 2
239000008188 pellet Substances 0.000 description 2
210000004303 peritoneum Anatomy 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
229920000656 polylysine Polymers 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
239000013641 positive control Substances 0.000 description 2
229920001592 potato starch Polymers 0.000 description 2
230000002335 preservative effect Effects 0.000 description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
238000003259 recombinant expression Methods 0.000 description 2
210000000664 rectum Anatomy 0.000 description 2
230000004044 response Effects 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
238000012552 review Methods 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
230000003248 secreting effect Effects 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
235000004400 serine Nutrition 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 2
235000019254 sodium formate Nutrition 0.000 description 2
239000007909 solid dosage form Substances 0.000 description 2
238000013112 stability test Methods 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
231100001274 therapeutic index Toxicity 0.000 description 2
WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
229960000187 tissue plasminogen activator Drugs 0.000 description 2
230000009466 transformation Effects 0.000 description 2
230000001052 transient effect Effects 0.000 description 2
150000003626 triacylglycerols Chemical class 0.000 description 2
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
210000001215 vagina Anatomy 0.000 description 2
230000029812 viral genome replication Effects 0.000 description 2
230000003612 virological effect Effects 0.000 description 2
239000011534 wash buffer Substances 0.000 description 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
FFILOTSTFMXQJC-QCFYAKGBSA-N (2r,4r,5s,6s)-2-[3-[(2s,3s,4r,6s)-6-[(2s,3r,4r,5s,6r)-5-[(2s,3r,4r,5r,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2r,3s,4r,5r,6r)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(e)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hy Chemical compound O[C@@H]1[C@@H](O)[C@H](OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 FFILOTSTFMXQJC-QCFYAKGBSA-N 0.000 description 1
ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 description 1
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 1
DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
WEYNBWVKOYCCQT-UHFFFAOYSA-N 1-(3-chloro-4-methylphenyl)-3-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}urea Chemical compound O1C(CN(C)C)=CC=C1CSCCNC(=O)NC1=CC=C(C)C(Cl)=C1 WEYNBWVKOYCCQT-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
101800001622 120 kDa surface-exposed protein Proteins 0.000 description 1
UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 1
HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 description 1
BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 description 1
101800000504 3C-like protease Proteins 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
229940117976 5-hydroxylysine Drugs 0.000 description 1
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
102000007469 Actins Human genes 0.000 description 1
108010085238 Actins Proteins 0.000 description 1
101710137115 Adenylyl cyclase-associated protein 1 Proteins 0.000 description 1
102100021879 Adenylyl cyclase-associated protein 2 Human genes 0.000 description 1
101710137132 Adenylyl cyclase-associated protein 2 Proteins 0.000 description 1
206010067484 Adverse reaction Diseases 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 1
102000003730 Alpha-catenin Human genes 0.000 description 1
108090000020 Alpha-catenin Proteins 0.000 description 1
102100023635 Alpha-fetoprotein Human genes 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
244000144725 Amygdalus communis Species 0.000 description 1
108010083359 Antigen Receptors Proteins 0.000 description 1
101100504181 Arabidopsis thaliana GCS1 gene Proteins 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
102000015790 Asparaginase Human genes 0.000 description 1
108010024976 Asparaginase Proteins 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
108091008875 B cell receptors Proteins 0.000 description 1
102100035526 B melanoma antigen 1 Human genes 0.000 description 1
102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
102100038080 B-cell receptor CD22 Human genes 0.000 description 1
102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
102000015735 Beta-catenin Human genes 0.000 description 1
108060000903 Beta-catenin Proteins 0.000 description 1
206010005003 Bladder cancer Diseases 0.000 description 1
108010006654 Bleomycin Proteins 0.000 description 1
206010005949 Bone cancer Diseases 0.000 description 1
208000018084 Bone neoplasm Diseases 0.000 description 1
208000003174 Brain Neoplasms Diseases 0.000 description 1
COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
101710155857 C-C motif chemokine 2 Proteins 0.000 description 1
101710155856 C-C motif chemokine 3 Proteins 0.000 description 1
102100032367 C-C motif chemokine 5 Human genes 0.000 description 1
101150013553 CD40 gene Proteins 0.000 description 1
101100455063 Caenorhabditis elegans lmp-1 gene Proteins 0.000 description 1
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 1
102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
102100039510 Cancer/testis antigen 2 Human genes 0.000 description 1
GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 1
GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 description 1
101710132601 Capsid protein Proteins 0.000 description 1
101800001318 Capsid protein VP4 Proteins 0.000 description 1
238000013449 Capto Q chromatography Methods 0.000 description 1
208000005623 Carcinogenesis Diseases 0.000 description 1
DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
102100025064 Cellular tumor antigen p53 Human genes 0.000 description 1
108010055166 Chemokine CCL5 Proteins 0.000 description 1
101710094648 Coat protein Proteins 0.000 description 1
208000001333 Colorectal Neoplasms Diseases 0.000 description 1
108091035707 Consensus sequence Proteins 0.000 description 1
241000186216 Corynebacterium Species 0.000 description 1
108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 1
102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 description 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
241000701022 Cytomegalovirus Species 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
239000012625 DNA intercalator Substances 0.000 description 1
108010092160 Dactinomycin Proteins 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
239000004338 Dichlorodifluoromethane Substances 0.000 description 1
101100216227 Dictyostelium discoideum anapc3 gene Proteins 0.000 description 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
108010016626 Dipeptides Proteins 0.000 description 1
238000012286 ELISA Assay Methods 0.000 description 1
101150029707 ERBB2 gene Proteins 0.000 description 1
206010014733 Endometrial cancer Diseases 0.000 description 1
206010014759 Endometrial neoplasm Diseases 0.000 description 1
241000792859 Enema Species 0.000 description 1
102000009024 Epidermal Growth Factor Human genes 0.000 description 1
108010069621 Epstein-Barr virus EBV-associated membrane antigen Proteins 0.000 description 1
208000000461 Esophageal Neoplasms Diseases 0.000 description 1
108091006020 Fc-tagged proteins Proteins 0.000 description 1
241000724791 Filamentous phage Species 0.000 description 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
241000233866 Fungi Species 0.000 description 1
102100039717 G antigen 1 Human genes 0.000 description 1
102100039699 G antigen 4 Human genes 0.000 description 1
102100039698 G antigen 5 Human genes 0.000 description 1
101710092267 G antigen 5 Proteins 0.000 description 1
102100039713 G antigen 6 Human genes 0.000 description 1
101710092269 G antigen 6 Proteins 0.000 description 1
102100040578 G antigen 7 Human genes 0.000 description 1
108091072337 GAGE family Proteins 0.000 description 1
102000040452 GAGE family Human genes 0.000 description 1
102100029974 GTPase HRas Human genes 0.000 description 1
101710091881 GTPase HRas Proteins 0.000 description 1
102100030525 Gap junction alpha-4 protein Human genes 0.000 description 1
208000015872 Gaucher disease Diseases 0.000 description 1
108700039691 Genetic Promoter Regions Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
102000007390 Glycogen Phosphorylase Human genes 0.000 description 1
108010046163 Glycogen Phosphorylase Proteins 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
208000009329 Graft vs Host Disease Diseases 0.000 description 1
102000002812 Heat-Shock Proteins Human genes 0.000 description 1
108010004889 Heat-Shock Proteins Proteins 0.000 description 1
101710154606 Hemagglutinin Proteins 0.000 description 1
102100021519 Hemoglobin subunit beta Human genes 0.000 description 1
108091005904 Hemoglobin subunit beta Proteins 0.000 description 1
102100024025 Heparanase Human genes 0.000 description 1
108010073141 Hepatitis C virus glycoprotein E2 Proteins 0.000 description 1
241000238631 Hexapoda Species 0.000 description 1
101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 description 1
101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 1
101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 description 1
101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 1
101001027128 Homo sapiens Fibronectin Proteins 0.000 description 1
101000886137 Homo sapiens G antigen 1 Proteins 0.000 description 1
101000886136 Homo sapiens G antigen 4 Proteins 0.000 description 1
101000893968 Homo sapiens G antigen 7 Proteins 0.000 description 1
101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 1
101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
101001036406 Homo sapiens Melanoma-associated antigen C1 Proteins 0.000 description 1
101001057156 Homo sapiens Melanoma-associated antigen C2 Proteins 0.000 description 1
101001057159 Homo sapiens Melanoma-associated antigen C3 Proteins 0.000 description 1
101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
101001114057 Homo sapiens P antigen family member 1 Proteins 0.000 description 1
101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 description 1
101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 description 1
101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 description 1
101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 1
241000701806 Human papillomavirus Species 0.000 description 1
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical group O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 1
208000019758 Hypergammaglobulinemia Diseases 0.000 description 1
108010073816 IgE Receptors Proteins 0.000 description 1
102000009438 IgE Receptors Human genes 0.000 description 1
108010073807 IgG Receptors Proteins 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
108700005091 Immunoglobulin Genes Proteins 0.000 description 1
108010043496 Immunoglobulin Idiotypes Proteins 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
108010078049 Interferon alpha-2 Proteins 0.000 description 1
102000003996 Interferon-beta Human genes 0.000 description 1
102000008070 Interferon-gamma Human genes 0.000 description 1
102000014150 Interferons Human genes 0.000 description 1
108010050904 Interferons Proteins 0.000 description 1
102000000589 Interleukin-1 Human genes 0.000 description 1
108010002352 Interleukin-1 Proteins 0.000 description 1
102000004560 Interleukin-12 Receptors Human genes 0.000 description 1
108010017515 Interleukin-12 Receptors Proteins 0.000 description 1
108010002586 Interleukin-7 Proteins 0.000 description 1
102000000704 Interleukin-7 Human genes 0.000 description 1
102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 description 1
108020004684 Internal Ribosome Entry Sites Proteins 0.000 description 1
108091092195 Intron Proteins 0.000 description 1
208000008839 Kidney Neoplasms Diseases 0.000 description 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical group OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
239000005517 L01XE01 - Imatinib Substances 0.000 description 1
239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
239000005551 L01XE03 - Erlotinib Substances 0.000 description 1
108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
108010000817 Leuprolide Proteins 0.000 description 1
102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 1
102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 1
206010058467 Lung neoplasm malignant Diseases 0.000 description 1
102000008072 Lymphokines Human genes 0.000 description 1
108010074338 Lymphokines Proteins 0.000 description 1
206010025323 Lymphomas Diseases 0.000 description 1
208000030289 Lymphoproliferative disease Diseases 0.000 description 1
108010010995 MART-1 Antigen Proteins 0.000 description 1
241000282567 Macaca fascicularis Species 0.000 description 1
241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
101710125418 Major capsid protein Proteins 0.000 description 1
102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
102100039447 Melanoma-associated antigen C1 Human genes 0.000 description 1
102100027252 Melanoma-associated antigen C2 Human genes 0.000 description 1
102100027248 Melanoma-associated antigen C3 Human genes 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
102000029749 Microtubule Human genes 0.000 description 1
108091022875 Microtubule Proteins 0.000 description 1
108020005196 Mitochondrial DNA Proteins 0.000 description 1
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 description 1
102000013967 Monokines Human genes 0.000 description 1
108010050619 Monokines Proteins 0.000 description 1
241000699660 Mus musculus Species 0.000 description 1
101000933447 Mus musculus Beta-glucuronidase Proteins 0.000 description 1
241000238367 Mya arenaria Species 0.000 description 1
102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 1
JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical group CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 description 1
BKAYIFDRRZZKNF-VIFPVBQESA-N N-acetylcarnosine Chemical compound CC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 BKAYIFDRRZZKNF-VIFPVBQESA-N 0.000 description 1
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 1
102000014736 Notch Human genes 0.000 description 1
108010070047 Notch Receptors Proteins 0.000 description 1
108010051791 Nuclear Antigens Proteins 0.000 description 1
102000019040 Nuclear Antigens Human genes 0.000 description 1
101710141454 Nucleoprotein Proteins 0.000 description 1
206010030155 Oesophageal carcinoma Diseases 0.000 description 1
108010038807 Oligopeptides Proteins 0.000 description 1
102000015636 Oligopeptides Human genes 0.000 description 1
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
102000004264 Osteopontin Human genes 0.000 description 1
108010081689 Osteopontin Proteins 0.000 description 1
101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
102100023219 P antigen family member 1 Human genes 0.000 description 1
108060006580 PRAME Proteins 0.000 description 1
102000036673 PRAME Human genes 0.000 description 1
102100034640 PWWP domain-containing DNA repair factor 3A Human genes 0.000 description 1
108050007154 PWWP domain-containing DNA repair factor 3A Proteins 0.000 description 1
229930012538 Paclitaxel Natural products 0.000 description 1
206010061902 Pancreatic neoplasm Diseases 0.000 description 1
208000002774 Paraproteinemias Diseases 0.000 description 1
102100040283 Peptidyl-prolyl cis-trans isomerase B Human genes 0.000 description 1
241000710778 Pestivirus Species 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
108010076039 Polyproteins Proteins 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
208000006994 Precancerous Conditions Diseases 0.000 description 1
101710098940 Pro-epidermal growth factor Proteins 0.000 description 1
102100022407 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Human genes 0.000 description 1
101710083689 Probable capsid protein Proteins 0.000 description 1
101710176177 Protein A56 Proteins 0.000 description 1
206010037549 Purpura Diseases 0.000 description 1
241001672981 Purpura Species 0.000 description 1
241000700159 Rattus Species 0.000 description 1
230000010799 Receptor Interactions Effects 0.000 description 1
101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 description 1
208000015634 Rectal Neoplasms Diseases 0.000 description 1
206010038389 Renal cancer Diseases 0.000 description 1
241000714474 Rous sarcoma virus Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
208000009359 Sezary Syndrome Diseases 0.000 description 1
208000021388 Sezary disease Diseases 0.000 description 1
229920001800 Shellac Polymers 0.000 description 1
108020004682 Single-Stranded DNA Proteins 0.000 description 1
208000000453 Skin Neoplasms Diseases 0.000 description 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
208000005718 Stomach Neoplasms Diseases 0.000 description 1
208000006011 Stroke Diseases 0.000 description 1
101710143177 Synaptonemal complex protein 1 Proteins 0.000 description 1
102100036234 Synaptonemal complex protein 1 Human genes 0.000 description 1
102000019361 Syndecan Human genes 0.000 description 1
108050006774 Syndecan Proteins 0.000 description 1
230000006044 T cell activation Effects 0.000 description 1
108091008874 T cell receptors Proteins 0.000 description 1
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
102100033082 TNF receptor-associated factor 3 Human genes 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
229940123237 Taxane Drugs 0.000 description 1
108091036066 Three prime untranslated region Proteins 0.000 description 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
239000004473 Threonine Substances 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 1
108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
102100039094 Tyrosinase Human genes 0.000 description 1
108060008724 Tyrosinase Proteins 0.000 description 1
208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
208000002495 Uterine Neoplasms Diseases 0.000 description 1
101150117115 V gene Proteins 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
229940122803 Vinca alkaloid Drugs 0.000 description 1
108020000999 Viral RNA Proteins 0.000 description 1
208000033559 Waldenström macroglobulinemia Diseases 0.000 description 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
210000003815 abdominal wall Anatomy 0.000 description 1
230000035508 accumulation Effects 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000021736 acetylation Effects 0.000 description 1
238000006640 acetylation reaction Methods 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
229930183665 actinomycin Natural products 0.000 description 1
239000012190 activator Substances 0.000 description 1
208000009956 adenocarcinoma Diseases 0.000 description 1
230000001919 adrenal effect Effects 0.000 description 1
230000006838 adverse reaction Effects 0.000 description 1
239000008272 agar Substances 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
229940040563 agaric acid Drugs 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000002152 alkylating effect Effects 0.000 description 1
230000000172 allergic effect Effects 0.000 description 1
108010026331 alpha-Fetoproteins Proteins 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000009435 amidation Effects 0.000 description 1
238000007112 amidation reaction Methods 0.000 description 1
150000003862 amino acid derivatives Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
229960003896 aminopterin Drugs 0.000 description 1
101150073130 ampR gene Proteins 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
239000004037 angiogenesis inhibitor Substances 0.000 description 1
238000005349 anion exchange Methods 0.000 description 1
230000002280 anti-androgenic effect Effects 0.000 description 1
230000003432 anti-folate effect Effects 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000000051 antiandrogen Substances 0.000 description 1
229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
229940127074 antifolate Drugs 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
229940045719 antineoplastic alkylating agent nitrosoureas Drugs 0.000 description 1
229940041181 antineoplastic drug Drugs 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
239000003886 aromatase inhibitor Substances 0.000 description 1
229940046844 aromatase inhibitors Drugs 0.000 description 1
229960003272 asparaginase Drugs 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
230000003305 autocrine Effects 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
230000008827 biological function Effects 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
229960001561 bleomycin Drugs 0.000 description 1
OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
108010006025 bovine growth hormone Proteins 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
229960002092 busulfan Drugs 0.000 description 1
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
229940087373 calcium oxide Drugs 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
229940127093 camptothecin Drugs 0.000 description 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 1
230000036952 cancer formation Effects 0.000 description 1
208000035269 cancer or benign tumor Diseases 0.000 description 1
229960004117 capecitabine Drugs 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
229960004424 carbon dioxide Drugs 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
231100000504 carcinogenesis Toxicity 0.000 description 1
229960005243 carmustine Drugs 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
230000030833 cell death Effects 0.000 description 1
230000003915 cell function Effects 0.000 description 1
230000004640 cellular pathway Effects 0.000 description 1
230000005754 cellular signaling Effects 0.000 description 1
230000035605 chemotaxis Effects 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
239000007958 cherry flavor Substances 0.000 description 1
210000000038 chest Anatomy 0.000 description 1
229960004630 chlorambucil Drugs 0.000 description 1
JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000011097 chromatography purification Methods 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
230000001886 ciliary effect Effects 0.000 description 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
229960004316 cisplatin Drugs 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
238000010367 cloning Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
108010015408 connexin 37 Proteins 0.000 description 1
238000011109 contamination Methods 0.000 description 1
229940099112 cornstarch Drugs 0.000 description 1
230000009260 cross reactivity Effects 0.000 description 1
108010048032 cyclophilin B Proteins 0.000 description 1
229960004397 cyclophosphamide Drugs 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
230000007402 cytotoxic response Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
229960000975 daunorubicin Drugs 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
229940124447 delivery agent Drugs 0.000 description 1
YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
238000001212 derivatisation Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
235000019821 dicalcium diphosphate Nutrition 0.000 description 1
229910000393 dicalcium diphosphate Inorganic materials 0.000 description 1
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
229940042935 dichlorodifluoromethane Drugs 0.000 description 1
229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
210000002249 digestive system Anatomy 0.000 description 1
UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
238000006471 dimerization reaction Methods 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 1
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
239000003534 dna topoisomerase inhibitor Substances 0.000 description 1
229960003668 docetaxel Drugs 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000003828 downregulation Effects 0.000 description 1
230000007783 downstream signaling Effects 0.000 description 1
229960004679 doxorubicin Drugs 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
210000003372 endocrine gland Anatomy 0.000 description 1
239000002158 endotoxin Substances 0.000 description 1
239000007920 enema Substances 0.000 description 1
229940079360 enema for constipation Drugs 0.000 description 1
239000002532 enzyme inhibitor Substances 0.000 description 1
102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
229930013356 epothilone Natural products 0.000 description 1
HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 description 1
229960001433 erlotinib Drugs 0.000 description 1
AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 1
YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical group NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
201000004101 esophageal cancer Diseases 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
229960005420 etoposide Drugs 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
210000001508 eye Anatomy 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
229960004887 ferric hydroxide Drugs 0.000 description 1
239000000945 filler Substances 0.000 description 1
229960000390 fludarabine Drugs 0.000 description 1
GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
229960002949 fluorouracil Drugs 0.000 description 1
229960002074 flutamide Drugs 0.000 description 1
MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
239000004052 folic acid antagonist Substances 0.000 description 1
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
235000008191 folinic acid Nutrition 0.000 description 1
239000011672 folinic acid Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000012631 food intake Nutrition 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
230000005714 functional activity Effects 0.000 description 1
102000054078 gamma Catenin Human genes 0.000 description 1
108010084448 gamma Catenin Proteins 0.000 description 1
GIVLTTJNORAZON-HDBOBKCLSA-N ganglioside GM2 (18:0) Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 GIVLTTJNORAZON-HDBOBKCLSA-N 0.000 description 1
206010017758 gastric cancer Diseases 0.000 description 1
229960002584 gefitinib Drugs 0.000 description 1
XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
229960005277 gemcitabine Drugs 0.000 description 1
238000003500 gene array Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
230000013595 glycosylation Effects 0.000 description 1
238000006206 glycosylation reaction Methods 0.000 description 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 description 1
208000024908 graft versus host disease Diseases 0.000 description 1
239000003979 granulating agent Substances 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
210000003128 head Anatomy 0.000 description 1
201000010536 head and neck cancer Diseases 0.000 description 1
208000014829 head and neck neoplasm Diseases 0.000 description 1
239000000185 hemagglutinin Substances 0.000 description 1
201000005787 hematologic cancer Diseases 0.000 description 1
208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
230000011132 hemopoiesis Effects 0.000 description 1
108010037536 heparanase Proteins 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
201000008298 histiocytosis Diseases 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
102000054751 human RUNX1T1 Human genes 0.000 description 1
238000009396 hybridization Methods 0.000 description 1
235000011167 hydrochloric acid Nutrition 0.000 description 1
229960001330 hydroxycarbamide Drugs 0.000 description 1
229960002591 hydroxyproline Drugs 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 1
229960002411 imatinib Drugs 0.000 description 1
230000002519 immonomodulatory effect Effects 0.000 description 1
210000002865 immune cell Anatomy 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000003053 immunization Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000002055 immunohistochemical effect Effects 0.000 description 1
238000011532 immunohistochemical staining Methods 0.000 description 1
230000003308 immunostimulating effect Effects 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000008676 import Effects 0.000 description 1
238000000099 in vitro assay Methods 0.000 description 1
239000000411 inducer Substances 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
102000006495 integrins Human genes 0.000 description 1
108010044426 integrins Proteins 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
230000004068 intracellular signaling Effects 0.000 description 1
238000010212 intracellular staining Methods 0.000 description 1
238000007917 intracranial administration Methods 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000007913 intrathecal administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
229940065638 intron a Drugs 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
229960004768 irinotecan Drugs 0.000 description 1
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 description 1
230000002262 irrigation Effects 0.000 description 1
238000003973 irrigation Methods 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
FABUFPQFXZVHFB-CFWQTKTJSA-N ixabepilone Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)N1)O)C)=C\C1=CSC(C)=N1 FABUFPQFXZVHFB-CFWQTKTJSA-N 0.000 description 1
229960002014 ixabepilone Drugs 0.000 description 1
238000005304 joining Methods 0.000 description 1
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
201000010982 kidney cancer Diseases 0.000 description 1
229940043355 kinase inhibitor Drugs 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
239000002523 lectin Substances 0.000 description 1
230000003902 lesion Effects 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
229960001691 leucovorin Drugs 0.000 description 1
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 1
229960004338 leuprorelin Drugs 0.000 description 1
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
229960004844 lovastatin Drugs 0.000 description 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
201000005202 lung cancer Diseases 0.000 description 1
208000020816 lung neoplasm Diseases 0.000 description 1
210000004324 lymphatic system Anatomy 0.000 description 1
239000012516 mab select resin Substances 0.000 description 1
201000000564 macroglobulinemia Diseases 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
230000022275 macrophage chemotaxis Effects 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
239000000155 melt Substances 0.000 description 1
229960001428 mercaptopurine Drugs 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
238000012737 microarray-based gene expression Methods 0.000 description 1
210000004688 microtubule Anatomy 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000028550 monocyte chemotaxis Effects 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
238000012243 multiplex automated genomic engineering Methods 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
238000002703 mutagenesis Methods 0.000 description 1
231100000350 mutagenesis Toxicity 0.000 description 1
201000005962 mycosis fungoides Diseases 0.000 description 1
210000000066 myeloid cell Anatomy 0.000 description 1
PUPNJSIFIXXJCH-UHFFFAOYSA-N n-(4-hydroxyphenyl)-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide Chemical compound C1=CC(O)=CC=C1NC(=O)CN1S(=O)(=O)C2=CC=CC=C2C1=O PUPNJSIFIXXJCH-UHFFFAOYSA-N 0.000 description 1
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
DIOQZVSQGTUSAI-UHFFFAOYSA-N n-butylhexane Natural products CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 1
210000003928 nasal cavity Anatomy 0.000 description 1
229940037525 nasal preparations Drugs 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
210000003739 neck Anatomy 0.000 description 1
210000000653 nervous system Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
230000011242 neutrophil chemotaxis Effects 0.000 description 1
VFEDRRNHLBGPNN-UHFFFAOYSA-N nimustine Chemical compound CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 VFEDRRNHLBGPNN-UHFFFAOYSA-N 0.000 description 1
229960001420 nimustine Drugs 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229940023490 ophthalmic product Drugs 0.000 description 1
239000007968 orange flavor Substances 0.000 description 1
210000004789 organ system Anatomy 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000008520 organization Effects 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
229960001756 oxaliplatin Drugs 0.000 description 1
101800000607 p15 Proteins 0.000 description 1
229960001592 paclitaxel Drugs 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
208000008443 pancreatic carcinoma Diseases 0.000 description 1
230000003076 paracrine Effects 0.000 description 1
230000000849 parathyroid Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000037361 pathway Effects 0.000 description 1
210000004197 pelvis Anatomy 0.000 description 1
108010044156 peptidyl-prolyl cis-trans isomerase b Proteins 0.000 description 1
239000002304 perfume Substances 0.000 description 1
230000010412 perfusion Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
239000003757 phosphotransferase inhibitor Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
238000013492 plasmid preparation Methods 0.000 description 1
210000002706 plastid Anatomy 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
229920000447 polyanionic polymer Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229940116317 potato starch Drugs 0.000 description 1
238000011045 prefiltration Methods 0.000 description 1
238000004321 preservation Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000009696 proliferative response Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
239000003586 protic polar solvent Substances 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
239000013014 purified material Substances 0.000 description 1
230000001698 pyrogenic effect Effects 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
206010038038 rectal cancer Diseases 0.000 description 1
201000001275 rectum cancer Diseases 0.000 description 1
108091008146 restriction endonucleases Proteins 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
229940100486 rice starch Drugs 0.000 description 1
229920002477 rna polymer Polymers 0.000 description 1
210000003935 rough endoplasmic reticulum Anatomy 0.000 description 1
102220156712 rs751722805 Human genes 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
201000000306 sarcoidosis Diseases 0.000 description 1
230000002000 scavenging effect Effects 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
231100000004 severe toxicity Toxicity 0.000 description 1
239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
201000000849 skin cancer Diseases 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
230000000392 somatic effect Effects 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
241000894007 species Species 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000010186 staining Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
201000011549 stomach cancer Diseases 0.000 description 1
238000003860 storage Methods 0.000 description 1
229960001052 streptozocin Drugs 0.000 description 1
ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
231100000057 systemic toxicity Toxicity 0.000 description 1
229960001603 tamoxifen Drugs 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
210000000115 thoracic cavity Anatomy 0.000 description 1
235000008521 threonine Nutrition 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
229960003087 tioguanine Drugs 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
229940044693 topoisomerase inhibitor Drugs 0.000 description 1
229960000303 topotecan Drugs 0.000 description 1
UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000005030 transcription termination Effects 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
238000001890 transfection Methods 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
238000011830 transgenic mouse model Methods 0.000 description 1
230000014621 translational initiation Effects 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
IUCJMVBFZDHPDX-UHFFFAOYSA-N tretamine Chemical compound C1CN1C1=NC(N2CC2)=NC(N2CC2)=N1 IUCJMVBFZDHPDX-UHFFFAOYSA-N 0.000 description 1
229950001353 tretamine Drugs 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
230000004565 tumor cell growth Effects 0.000 description 1
230000005740 tumor formation Effects 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
230000007306 turnover Effects 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
235000002374 tyrosine Nutrition 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
210000003708 urethra Anatomy 0.000 description 1
201000005112 urinary bladder cancer Diseases 0.000 description 1
210000002229 urogenital system Anatomy 0.000 description 1
206010046766 uterine cancer Diseases 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1
239000004474 valine Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1

JP2012525147A 2009-08-17 2010-08-13 標的化イムノコンジュゲート Active JP5764127B2 (ja)