JP2013500720A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013500720A5 JP2013500720A5 JP2012523037A JP2012523037A JP2013500720A5 JP 2013500720 A5 JP2013500720 A5 JP 2013500720A5 JP 2012523037 A JP2012523037 A JP 2012523037A JP 2012523037 A JP2012523037 A JP 2012523037A JP 2013500720 A5 JP2013500720 A5 JP 2013500720A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza virus
- gene segment
- type
- virus gene
- coding region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000712461 unidentified influenza virus Species 0.000 claims 100
- 108090000623 proteins and genes Proteins 0.000 claims 80
- 108091026890 Coding region Proteins 0.000 claims 37
- 239000002773 nucleotide Substances 0.000 claims 25
- 125000003729 nucleotide group Chemical group 0.000 claims 25
- 108700026244 Open Reading Frames Proteins 0.000 claims 24
- 230000000295 complement effect Effects 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 19
- 108091092724 Noncoding DNA Proteins 0.000 claims 16
- 108091081024 Start codon Proteins 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 108020005067 RNA Splice Sites Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 101150106774 9 gene Proteins 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000037432 silent mutation Effects 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22985809P | 2009-07-30 | 2009-07-30 | |
| US61/229,858 | 2009-07-30 | ||
| PCT/US2010/043697 WO2011014645A1 (en) | 2009-07-30 | 2010-07-29 | Influenza viruses and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500720A JP2013500720A (ja) | 2013-01-10 |
| JP2013500720A5 true JP2013500720A5 (enExample) | 2013-09-12 |
| JP5845180B2 JP5845180B2 (ja) | 2016-01-20 |
Family
ID=42937563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523037A Active JP5845180B2 (ja) | 2009-07-30 | 2010-07-29 | インフルエンザウイルス及びそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8828406B2 (enExample) |
| EP (1) | EP2459585B1 (enExample) |
| JP (1) | JP5845180B2 (enExample) |
| CA (1) | CA2805505C (enExample) |
| WO (1) | WO2011014645A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012521786A (ja) | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
| WO2010138564A1 (en) | 2009-05-26 | 2010-12-02 | Mount Sinai School Of Medicine Of New York University | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| MX2012011300A (es) | 2010-03-30 | 2012-11-29 | Sinai School Medicine | Vacunas del virus de influenza y usos de las mismas. |
| US20130189303A1 (en) * | 2011-08-02 | 2013-07-25 | Yan Zhou | Recombinant swine influenza virus and uses thereof |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| US20140302077A1 (en) * | 2011-09-02 | 2014-10-09 | Westfaelische Wilhelms-Universitaet Munester | Live attenuated influenza virus |
| HK1200102A1 (en) | 2011-09-20 | 2015-07-31 | 西奈山医学院 | Influenza virus vaccines and uses thereof |
| NZ627796A (en) | 2012-12-18 | 2017-07-28 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US20160258005A1 (en) * | 2013-07-02 | 2016-09-08 | The Trustees Of The University Of Pennsylvania | Methods for rapid ribonucleic acid fluorescence in situ hybridization |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3247389A4 (en) | 2015-01-23 | 2019-10-30 | Icahn School of Medicine at Mount Sinai | INFLUENZAVIRUSSCHUTZIMPFPLÄNE |
| RU2628690C2 (ru) * | 2015-11-06 | 2017-08-21 | Общество С Ограниченной Ответственностью 'Фарминтерпрайсез' | Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний |
| CN109477074B (zh) | 2016-02-19 | 2023-01-24 | 威斯康星旧生研究基金会 | 用于疫苗开发的改进的乙型流感病毒复制 |
| WO2017147486A1 (en) * | 2016-02-26 | 2017-08-31 | Alere San Diego Inc. | Redox labeled oligonucleotide probes and their use |
| MX2018015755A (es) | 2016-06-15 | 2019-08-29 | Icahn School Med Mount Sinai | Proteinas de hemaglutinina de virus de influenza y usos de las mismas. |
| US11596683B2 (en) | 2016-07-12 | 2023-03-07 | Duke University | Engineered influenza polynucleotides, viruses, vaccines and methods of making and using the same |
| CA3058652A1 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| US12364746B2 (en) | 2018-06-21 | 2025-07-22 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| EP3840780A1 (en) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein |
| WO2020163768A1 (en) | 2019-02-07 | 2020-08-13 | Duke University | Stabilized 9 and 10 segmented influenza viruses as a vaccine platform and methods of making and using same |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CA3137160A1 (en) | 2019-04-24 | 2020-10-29 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US20220249652A1 (en) * | 2019-06-26 | 2022-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus neuraminidase and uses thereof |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| EP4093415A1 (en) | 2020-01-24 | 2022-11-30 | Wisconsin Alumni Research Foundation (WARF) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| US20230390383A1 (en) * | 2020-10-20 | 2023-12-07 | Duke University | Replication incompetent influenza vaccine platform for foreign protein delivery |
| CN113073115B (zh) * | 2021-06-08 | 2021-10-01 | 北京溯本源和生物科技有限公司 | 一种包装重组流感病毒的重组载体和重组流感病毒及其构建方法和应用 |
| CN115724920A (zh) * | 2021-12-31 | 2023-03-03 | 中国人民解放军军事科学院军事医学研究院 | 冠状病毒和流感病毒的二联核酸疫苗 |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US5106619A (en) | 1983-12-20 | 1992-04-21 | Diamond Scientific Co. | Preparation of inactivated viral vaccines |
| US4693981A (en) | 1983-12-20 | 1987-09-15 | Advanced Genetics Research Institute | Preparation of inactivated viral vaccines |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US20060019350A1 (en) * | 1989-08-28 | 2006-01-26 | Peter Palese | Recombinant negative strand RNA virus expression system and vacccines |
| ES2284161T3 (es) | 1990-01-12 | 2007-11-01 | Amgen Fremont Inc. | Generacion de anticuerpos xenogenicos. |
| US6887699B1 (en) | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| PT1696031E (pt) | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US6022726A (en) | 1992-02-03 | 2000-02-08 | Palese; Peter | Genetically engineered attenuated viruses |
| JPH06105020B2 (ja) | 1992-06-09 | 1994-12-21 | ホッペ・アーゲー | ラッチ及びロックアップシステム |
| DK0702085T4 (da) | 1994-07-18 | 2010-04-06 | Conzelmann Karl Klaus Prof Dr | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| ATE181112T1 (de) | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| CA2230033C (en) | 1995-09-27 | 2010-01-26 | Peter L. Collins | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| EP0912724B1 (en) | 1996-07-15 | 2009-12-09 | The Government of The United States of America, as represented by The Department of Health and Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
| BR9712138A (pt) | 1996-09-27 | 2000-01-18 | American Cyanamid Co | Vìrus de rna isolado, vacina, processo para imunizr um indivìduo para induzir proteção contra um vìrus de rna não segmentado, sentido negativo, de filamento único, da ordem mononegavirales e para produzir vìrus de rna, molécula de ácido nucleico isolada e composição. |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| ATE549918T1 (de) | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
| US5891705A (en) | 1997-04-08 | 1999-04-06 | Pentose Pharmaceuticals, Inc. | Method for inactivating a virus |
| TR199902553T2 (xx) | 1997-04-14 | 2000-03-21 | Micromet Gesellschaft F�R Biomedizinische Forschung Mbh | �nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�. |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| DE69842165D1 (de) | 1997-05-23 | 2011-04-21 | Us Of America As Represented By The Secretary Of The Dept Of Health And Human Services | Herstellung attenuierter parainfluenza-virus impfstoffe aus klonierten nukleotidsequenzen |
| ES2287977T3 (es) | 1997-07-11 | 2007-12-16 | Yale University | Rabdovirus con cubiertas rediseñadas. |
| JP2001517448A (ja) | 1997-09-19 | 2001-10-09 | アメリカン・サイアナミド・カンパニー | 弱毒化呼吸合胞体ウイルス |
| JP4837827B2 (ja) | 1998-06-12 | 2011-12-14 | マウント シナイ スクール オブ メディシン | 新規なウイルス増殖方法およびそのためのインターフェロン欠損培養基 |
| ES2301241T3 (es) | 1998-06-12 | 2008-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Virus de influenza a atenuados, y composiciones inmunogenicas y formulaciones de vacunas que los contienen. |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| AT407958B (de) | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
| US8715940B2 (en) * | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| DE122007000070I1 (de) | 1999-07-14 | 2008-01-31 | Sinai School Medicine | In Vitro-rekonstitution von segmentierten Negativstrang-Rna-Viren |
| US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| PL205955B1 (pl) | 2000-04-28 | 2010-06-30 | St Jude Childrens Res Hospital | Układ oparty na minimalnej liczbie plazmidów do wytwarzania infekcyjnych wirusów RNA o ujemnej nici, komórka gospodarza zawierająca taki układ, sposób wytwarzania wiriona wirusa RNA o ujemnej nici, sposób wytwarzania atenuowanego wirusa RNA o ujemnej nici, sposób wytwarzania zakaźnego wirusa o ujemnej nici do stosowania w szczepionkach i zastosowanie układu opartego na minimalnej liczbie plazmidów |
| AU2003219745B8 (en) | 2002-02-13 | 2008-10-09 | Wisconsin Alumni Research Foundation | Signal for packaging of influenza virus vectors |
| EP1814990A2 (en) * | 2004-11-19 | 2007-08-08 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with tandem transcription units |
| EP1855713B1 (en) * | 2005-02-15 | 2016-04-27 | Mount Sinai School of Medicine | Genetically engineered equine influenza virus and uses thereof |
| MX2008007056A (es) * | 2005-12-02 | 2008-11-12 | Sinai School Medicine | Virus quimericos que presentan proteinas de superficie no nativas y usos de los mismos. |
| EP2007765B1 (en) | 2006-03-23 | 2012-06-27 | Novartis AG | Immunopotentiating compounds |
| WO2007109813A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| EP3456348B1 (en) | 2006-09-11 | 2025-03-26 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
-
2010
- 2010-07-29 CA CA2805505A patent/CA2805505C/en active Active
- 2010-07-29 JP JP2012523037A patent/JP5845180B2/ja active Active
- 2010-07-29 EP EP10748161.6A patent/EP2459585B1/en active Active
- 2010-07-29 WO PCT/US2010/043697 patent/WO2011014645A1/en not_active Ceased
- 2010-07-29 US US13/387,485 patent/US8828406B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lundstrom | Viral vectors in gene therapy: where do we stand in 2023? | |
| RU2016123086A (ru) | Способы и композиции для лечения болезни хантингтона | |
| ES2640586T3 (es) | Secuencias del factor VIII | |
| JP2016513115A5 (enExample) | ||
| JP2019519218A5 (enExample) | ||
| JP2017514501A5 (enExample) | ||
| KR20100019423A (ko) | 백신에 유용한 약독화 바이러스 | |
| NZ597601A (en) | Treatment and prevention of influenza | |
| Le Nouën et al. | Attenuation of human respiratory viruses by synonymous genome recoding | |
| FI3224376T4 (fi) | Dna-epäpuhtaudet koostumuksessa, joka käsittää parvovirusvirionin | |
| JP2012136542A5 (enExample) | ||
| JP2008056679A5 (enExample) | ||
| JP2014532691A5 (enExample) | ||
| JP2010526542A5 (enExample) | ||
| JP2012515557A5 (enExample) | ||
| US20250223592A1 (en) | Compositions and methods for circular rna affinity purification | |
| Sun et al. | Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19 | |
| JP2011517938A5 (enExample) | ||
| JP2016501528A5 (enExample) | ||
| JP2024531966A (ja) | 操作されたａｄａｒ動員ｒｎａ及びその使用方法 | |
| Zhang et al. | Advances in engineering circular RNA vaccines | |
| CN105582526B (zh) | 三叶因子2在制备治疗及预防肺/支气管急性炎症疾病药物方面的应用 | |
| Almansour et al. | Nucleic acid vaccine candidates encapsulated with mesoporous silica nanoparticles against MERS-CoV | |
| US9795643B2 (en) | Oncolytic measles virus | |
| US20230227849A1 (en) | Methods of identifying and characterizing anelloviruses and uses thereof |