JP2013227218A5 - - Google Patents
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- Publication number
- JP2013227218A5 JP2013227218A5 JP2013120309A JP2013120309A JP2013227218A5 JP 2013227218 A5 JP2013227218 A5 JP 2013227218A5 JP 2013120309 A JP2013120309 A JP 2013120309A JP 2013120309 A JP2013120309 A JP 2013120309A JP 2013227218 A5 JP2013227218 A5 JP 2013227218A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- platinum
- trans
- cyclohexanediamine
- dihydroxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 29
- 239000000203 mixture Substances 0.000 claims 16
- 229910052697 platinum Inorganic materials 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 239000000178 monomer Substances 0.000 claims 5
- SSJXIUAHEKJCMH-PHDIDXHHSA-N (1r,2r)-cyclohexane-1,2-diamine Chemical compound N[C@@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-PHDIDXHHSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- YMHQVDAATAEZLO-UHFFFAOYSA-N cyclohexane-1,1-diamine Chemical compound NC1(N)CCCCC1 YMHQVDAATAEZLO-UHFFFAOYSA-N 0.000 claims 3
- NDBYXKQCPYUOMI-UHFFFAOYSA-N platinum(4+) Chemical compound [Pt+4] NDBYXKQCPYUOMI-UHFFFAOYSA-N 0.000 claims 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 2
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 claims 2
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 claims 2
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000004984 aromatic diamines Chemical class 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95412607P | 2007-08-06 | 2007-08-06 | |
| US60/954,126 | 2007-08-06 | ||
| US97392607P | 2007-09-20 | 2007-09-20 | |
| US60/973,926 | 2007-09-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520294A Division JP5385274B2 (ja) | 2007-08-06 | 2008-08-06 | ホスファプラチン、ならびにシスプラチンおよびカルボプラチンに対し耐性を有する癌の治療におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013227218A JP2013227218A (ja) | 2013-11-07 |
| JP2013227218A5 true JP2013227218A5 (enExample) | 2013-12-19 |
| JP5647300B2 JP5647300B2 (ja) | 2014-12-24 |
Family
ID=40342030
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520294A Active JP5385274B2 (ja) | 2007-08-06 | 2008-08-06 | ホスファプラチン、ならびにシスプラチンおよびカルボプラチンに対し耐性を有する癌の治療におけるその使用 |
| JP2013120309A Active JP5647300B2 (ja) | 2007-08-06 | 2013-06-07 | ホスファプラチン、ならびにシスプラチンおよびカルボプラチンに対し耐性を有する癌の治療におけるその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520294A Active JP5385274B2 (ja) | 2007-08-06 | 2008-08-06 | ホスファプラチン、ならびにシスプラチンおよびカルボプラチンに対し耐性を有する癌の治療におけるその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7700649B2 (enExample) |
| EP (2) | EP2668949A1 (enExample) |
| JP (2) | JP5385274B2 (enExample) |
| CN (1) | CN101801369B (enExample) |
| CY (1) | CY1115504T1 (enExample) |
| DK (1) | DK2173337T3 (enExample) |
| ES (1) | ES2495743T3 (enExample) |
| HR (1) | HRP20140808T1 (enExample) |
| PL (1) | PL2173337T3 (enExample) |
| PT (1) | PT2173337E (enExample) |
| SI (1) | SI2173337T1 (enExample) |
| WO (2) | WO2009021081A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2173337T3 (pl) | 2007-08-06 | 2014-11-28 | Univ Ohio | Fosfaplatyny i ich zastosowanie w leczeniu raków opornych na cisplatynę i karboplatynę |
| JP5860872B2 (ja) * | 2010-06-04 | 2016-02-16 | オハイオ ユニバーシティー | ホスファプラチン、及び癌治療のためのそれらの使用 |
| EP2663301A1 (en) | 2011-01-12 | 2013-11-20 | Ohio University | Phosphaplatins having anti-angiogenic, anti-metastatic, and pro-apoptotic properties and uses thereof |
| MX354678B (es) | 2011-07-08 | 2018-03-15 | Dow Global Technologies Llc | Composicion de mezcla de polietileno adecuada para pelicula soplada, metodo para producir la misma y peliculas hechas a partir de la misma. |
| CA2851254A1 (en) * | 2011-10-05 | 2013-04-11 | The University Of Houston System | Efficient processes for large scale preparation of phophaplatins antitumor agents |
| MX357865B (es) | 2011-10-05 | 2018-07-25 | N Bose Rathindra | Procedimientos eficientes para preparación a gran escala de agentes antitumorales de fosfaplatinos. |
| EP2768498B1 (en) | 2011-10-20 | 2020-03-04 | Nerium Biotechnology, Inc. | Therapeutic combination for the treatment of cancer |
| PT3202769T (pt) | 2012-05-24 | 2019-10-31 | Phosplatin Therapeutics Llc | Processos de síntese e de purificação para compostos de fosfaplatina e aplicações dos mesmos |
| US9333211B2 (en) * | 2013-02-22 | 2016-05-10 | University Of Houston System | Phosphaplatin mediated modulation of pigment epithelial derived factor and uses thereof |
| US20150231151A1 (en) * | 2014-02-19 | 2015-08-20 | University Of Houston System | Compositions and methods for the treatment of neurodegenerative diseases |
| SG11201610306RA (en) | 2014-06-11 | 2017-01-27 | Univ Texas | Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance |
| EP3397642A1 (en) | 2015-12-30 | 2018-11-07 | Atilim Universitesi | Dna targeted mono and heterodinuclear complexes |
| KR102419247B1 (ko) | 2016-04-06 | 2022-07-11 | 포스플라틴 테라퓨틱스 인코포레이티드 | 포스파플라틴 액제 제형 |
| CN110381952B (zh) | 2017-01-06 | 2023-10-20 | 弗斯普拉廷治疗有限公司 | 作为治疗剂用于治疗骨癌或血癌的磷铂化合物 |
| JP7381083B2 (ja) * | 2017-09-08 | 2023-11-15 | フォスプラティン テラピューティクス インコーポレイテッド | 免疫調節剤としてのホスファプラチン化合物およびその治療的使用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234500A (en) | 1979-03-07 | 1980-11-18 | Engelhard Minerals & Chemicals Corporation | Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes |
| US4291027A (en) | 1979-03-07 | 1981-09-22 | Engelhard Minerals & Chemicals Corp. | Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes |
| CA2017739A1 (en) * | 1989-07-18 | 1991-01-18 | Engelhard Corporation | Cis-diamineplatinum complexes with methanediphosphonate and substituted methanediphosphonate ligands as antitumor agents |
| WO2005000858A2 (en) * | 2003-06-27 | 2005-01-06 | Akira Odani | Bisphosphonate complexes |
| WO2009008345A1 (ja) * | 2007-07-06 | 2009-01-15 | Tmrc Co., Ltd. | 金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体 |
| PL2173337T3 (pl) | 2007-08-06 | 2014-11-28 | Univ Ohio | Fosfaplatyny i ich zastosowanie w leczeniu raków opornych na cisplatynę i karboplatynę |
-
2008
- 2008-08-06 PL PL08797320T patent/PL2173337T3/pl unknown
- 2008-08-06 WO PCT/US2008/072397 patent/WO2009021081A2/en not_active Ceased
- 2008-08-06 HR HRP20140808AT patent/HRP20140808T1/hr unknown
- 2008-08-06 US US12/187,376 patent/US7700649B2/en active Active
- 2008-08-06 ES ES08797320.2T patent/ES2495743T3/es active Active
- 2008-08-06 CN CN2008801015774A patent/CN101801369B/zh active Active
- 2008-08-06 EP EP13182512.7A patent/EP2668949A1/en not_active Withdrawn
- 2008-08-06 WO PCT/US2008/072398 patent/WO2009021082A2/en not_active Ceased
- 2008-08-06 EP EP08797320.2A patent/EP2173337B1/en active Active
- 2008-08-06 PT PT87973202T patent/PT2173337E/pt unknown
- 2008-08-06 JP JP2010520294A patent/JP5385274B2/ja active Active
- 2008-08-06 SI SI200831280T patent/SI2173337T1/sl unknown
- 2008-08-06 DK DK08797320.2T patent/DK2173337T3/da active
-
2010
- 2010-03-11 US US12/722,189 patent/US8034964B2/en active Active
-
2011
- 2011-08-30 US US13/221,458 patent/US8445710B2/en active Active
-
2013
- 2013-03-15 US US13/842,885 patent/US8653132B2/en active Active
- 2013-06-07 JP JP2013120309A patent/JP5647300B2/ja active Active
-
2014
- 2014-08-27 CY CY20141100686T patent/CY1115504T1/el unknown
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