MX357865B - Procedimientos eficientes para preparación a gran escala de agentes antitumorales de fosfaplatinos. - Google Patents

Procedimientos eficientes para preparación a gran escala de agentes antitumorales de fosfaplatinos.

Info

Publication number
MX357865B
MX357865B MX2014004181A MX2014004181A MX357865B MX 357865 B MX357865 B MX 357865B MX 2014004181 A MX2014004181 A MX 2014004181A MX 2014004181 A MX2014004181 A MX 2014004181A MX 357865 B MX357865 B MX 357865B
Authority
MX
Mexico
Prior art keywords
phosphaplatins
large scale
antitumor agents
scale preparation
efficient processes
Prior art date
Application number
MX2014004181A
Other languages
English (en)
Other versions
MX2014004181A (es
Inventor
Moghaddas Shadi
N Bose Rathindra
Dezvareh Homa
Original Assignee
N Bose Rathindra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N Bose Rathindra filed Critical N Bose Rathindra
Priority claimed from PCT/US2012/059016 external-priority patent/WO2013052839A1/en
Publication of MX2014004181A publication Critical patent/MX2014004181A/es
Publication of MX357865B publication Critical patent/MX357865B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)

Abstract

Se describe un procedimiento eficiente para sintetizar fosfaplatinas en grandes cantidades al agregar complejo de platino a una solución concentrada de pirofosfato a pH de entre aproximadamente 6.0 a 8.5; después de agitar, se reduce la temperatura y el pH para precipitar las fosfaplatinas deseadas; particularmente, los procedimientos descritos reducen la necesidad de usar grandes volúmenes de materiales de partida, y acortar el tiempo de reacción; además, se describe un procedimiento para reciclar materiales sin reaccionar a partir de una primera síntesis de fosfaplatinas.
MX2014004181A 2011-10-05 2012-10-05 Procedimientos eficientes para preparación a gran escala de agentes antitumorales de fosfaplatinos. MX357865B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161543540P 2011-10-05 2011-10-05
PCT/US2012/059016 WO2013052839A1 (en) 2011-10-05 2012-10-05 Efficient processes for large scale preparation of phosphaplatins antitumor agents

Publications (2)

Publication Number Publication Date
MX2014004181A MX2014004181A (es) 2015-02-05
MX357865B true MX357865B (es) 2018-07-25

Family

ID=48655214

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004181A MX357865B (es) 2011-10-05 2012-10-05 Procedimientos eficientes para preparación a gran escala de agentes antitumorales de fosfaplatinos.

Country Status (4)

Country Link
US (1) US9012669B2 (es)
EP (1) EP2763537B1 (es)
JP (1) JP6027619B2 (es)
MX (1) MX357865B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101052513B1 (ko) * 2009-03-27 2011-07-29 삼성중공업 주식회사 다단 압축기용 냉각사이클 장치
PL2575802T3 (pl) 2010-06-04 2017-04-28 Ohio University Fosfaplatyny oraz ich zastosowanie w leczeniu nowotworów
ES2751668T3 (es) * 2012-05-24 2020-04-01 Phosplatin Therapeutics Llc Método de purificación para compuestos de fosfaplatino
EA039525B1 (ru) * 2016-04-06 2022-02-07 Фосплатин Терапьютикс Инк. Фосфаплатиновые жидкие составы
JP7023968B2 (ja) * 2017-01-06 2022-02-22 フォスプラティン・セラピューティクス・インコーポレーテッド 骨がんまたは血液がんの治療のための治療薬としてのホスファプラチン化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234500A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
SI2173337T1 (sl) 2007-08-06 2014-10-30 Ohio University Fosfaplatini in njihova uporaba pri zdravljenju vrst raka, odpornih proti cisplatinu in karboplatinu
US20110092465A1 (en) * 2009-10-21 2011-04-21 Syracuse University Monomeric pyrophosphate complexes and methods of treatment using the complexes
PL2575802T3 (pl) * 2010-06-04 2017-04-28 Ohio University Fosfaplatyny oraz ich zastosowanie w leczeniu nowotworów

Also Published As

Publication number Publication date
EP2763537B1 (en) 2018-01-10
JP6027619B2 (ja) 2016-11-16
HK1199795A1 (en) 2015-07-24
EP2763537A1 (en) 2014-08-13
MX2014004181A (es) 2015-02-05
US20130165680A1 (en) 2013-06-27
US9012669B2 (en) 2015-04-21
EP2763537A4 (en) 2015-03-25
JP2014534189A (ja) 2014-12-18

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