MX2014004181A - Procedimientos eficientes para preparacion a gran escala de agentes antitumorales de fosfaplatinos. - Google Patents
Procedimientos eficientes para preparacion a gran escala de agentes antitumorales de fosfaplatinos.Info
- Publication number
- MX2014004181A MX2014004181A MX2014004181A MX2014004181A MX2014004181A MX 2014004181 A MX2014004181 A MX 2014004181A MX 2014004181 A MX2014004181 A MX 2014004181A MX 2014004181 A MX2014004181 A MX 2014004181A MX 2014004181 A MX2014004181 A MX 2014004181A
- Authority
- MX
- Mexico
- Prior art keywords
- phosphaplatins
- large scale
- antitumor agents
- scale preparation
- efficient processes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
- C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
Abstract
Se describe un procedimiento eficiente para sintetizar fosfaplatinas en grandes cantidades al agregar complejo de platino a una solución concentrada de pirofosfato a pH de entre aproximadamente 6.0 a 8.5; después de agitar, se reduce la temperatura y el pH para precipitar las fosfaplatinas deseadas; particularmente, los procedimientos descritos reducen la necesidad de usar grandes volúmenes de materiales de partida, y acortar el tiempo de reacción; además, se describe un procedimiento para reciclar materiales sin reaccionar a partir de una primera síntesis de fosfaplatinas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161543540P | 2011-10-05 | 2011-10-05 | |
PCT/US2012/059016 WO2013052839A1 (en) | 2011-10-05 | 2012-10-05 | Efficient processes for large scale preparation of phosphaplatins antitumor agents |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014004181A true MX2014004181A (es) | 2015-02-05 |
MX357865B MX357865B (es) | 2018-07-25 |
Family
ID=48655214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014004181A MX357865B (es) | 2011-10-05 | 2012-10-05 | Procedimientos eficientes para preparación a gran escala de agentes antitumorales de fosfaplatinos. |
Country Status (5)
Country | Link |
---|---|
US (1) | US9012669B2 (es) |
EP (1) | EP2763537B1 (es) |
JP (1) | JP6027619B2 (es) |
HK (1) | HK1199795A1 (es) |
MX (1) | MX357865B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101052513B1 (ko) * | 2009-03-27 | 2011-07-29 | 삼성중공업 주식회사 | 다단 압축기용 냉각사이클 장치 |
SG185722A1 (en) | 2010-06-04 | 2013-01-30 | Univ Ohio | Phosphaplatins and their use for treatment of cancers |
IN2014KN02722A (es) * | 2012-05-24 | 2015-05-08 | Phosplatin Therapeutics Llc | |
KR102419247B1 (ko) * | 2016-04-06 | 2022-07-11 | 포스플라틴 테라퓨틱스 인코포레이티드 | 포스파플라틴 액제 제형 |
US10668080B2 (en) | 2017-01-06 | 2020-06-02 | Phosplatin Therapeutics Llc | Phosphaplatin compounds as therapeutic agents for treatment of bone or blood cancers |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4234500A (en) * | 1979-03-07 | 1980-11-18 | Engelhard Minerals & Chemicals Corporation | Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes |
PT2173337E (pt) | 2007-08-06 | 2014-09-03 | Univ Ohio | Fosfoplatinas e a sua utilização no tratamento de cancros resistentes à cisplantina e carboplatina |
US20110092465A1 (en) * | 2009-10-21 | 2011-04-21 | Syracuse University | Monomeric pyrophosphate complexes and methods of treatment using the complexes |
SG185722A1 (en) | 2010-06-04 | 2013-01-30 | Univ Ohio | Phosphaplatins and their use for treatment of cancers |
-
2012
- 2012-10-05 US US13/646,152 patent/US9012669B2/en not_active Expired - Fee Related
- 2012-10-05 MX MX2014004181A patent/MX357865B/es active IP Right Grant
- 2012-10-05 JP JP2014534791A patent/JP6027619B2/ja not_active Expired - Fee Related
- 2012-10-05 EP EP12838315.5A patent/EP2763537B1/en not_active Not-in-force
-
2015
- 2015-01-12 HK HK15100298.2A patent/HK1199795A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX357865B (es) | 2018-07-25 |
HK1199795A1 (en) | 2015-07-24 |
EP2763537A4 (en) | 2015-03-25 |
US20130165680A1 (en) | 2013-06-27 |
JP2014534189A (ja) | 2014-12-18 |
EP2763537B1 (en) | 2018-01-10 |
US9012669B2 (en) | 2015-04-21 |
JP6027619B2 (ja) | 2016-11-16 |
EP2763537A1 (en) | 2014-08-13 |
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Legal Events
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FG | Grant or registration |