CN101801369B - 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 - Google Patents

磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 Download PDF

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CN101801369B
CN101801369B CN2008801015774A CN200880101577A CN101801369B CN 101801369 B CN101801369 B CN 101801369B CN 2008801015774 A CN2008801015774 A CN 2008801015774A CN 200880101577 A CN200880101577 A CN 200880101577A CN 101801369 B CN101801369 B CN 101801369B
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platinum
substituted
cancer
complex
compositions
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CN101801369A (zh
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拉廷德拉·N·博斯
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Ohio University
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Ohio University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2008801015774A 2007-08-06 2008-08-06 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 Active CN101801369B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95412607P 2007-08-06 2007-08-06
US60/954,126 2007-08-06
US97392607P 2007-09-20 2007-09-20
US60/973,926 2007-09-20
PCT/US2008/072398 WO2009021082A2 (en) 2007-08-06 2008-08-06 Phosphaplatins and their use in the treatment of cancers resistant to cisplantin and carboplatin

Publications (2)

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CN101801369A CN101801369A (zh) 2010-08-11
CN101801369B true CN101801369B (zh) 2012-09-19

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CN2008801015774A Active CN101801369B (zh) 2007-08-06 2008-08-06 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途

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US (4) US7700649B2 (enExample)
EP (2) EP2173337B1 (enExample)
JP (2) JP5385274B2 (enExample)
CN (1) CN101801369B (enExample)
CY (1) CY1115504T1 (enExample)
DK (1) DK2173337T3 (enExample)
ES (1) ES2495743T3 (enExample)
HR (1) HRP20140808T1 (enExample)
PL (1) PL2173337T3 (enExample)
PT (1) PT2173337E (enExample)
SI (1) SI2173337T1 (enExample)
WO (2) WO2009021081A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801369B (zh) 2007-08-06 2012-09-19 俄亥俄大学 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途
PT2575802T (pt) * 2010-06-04 2016-12-27 Univ Ohio Fosfaplatinas e sua utilização para o tratamento de cancros
CA2818933A1 (en) * 2011-01-12 2012-07-19 Ohio University Phosphaplatins having anti-angiogenic, anti-metastatic, and pro-apoptotic properties and uses thereof
WO2013009511A1 (en) 2011-07-08 2013-01-17 Dow Global Technologies Llc Polyethylene blend composition suitable for blown film, method of producing the same, and films made therefrom
JP6027619B2 (ja) 2011-10-05 2016-11-16 ラシンドラ・エヌ・ボーズ ホスファプラチン系抗腫瘍剤の大規模調製のための効率的プロセス
CA2851254A1 (en) * 2011-10-05 2013-04-11 The University Of Houston System Efficient processes for large scale preparation of phophaplatins antitumor agents
AU2012325819B2 (en) 2011-10-20 2017-08-03 Nerium Biotechnology, Inc. Therapeutic combination for the treatment of cancer
EP2855496B1 (en) * 2012-05-24 2016-12-14 Phosplatin Therapeutics LLC Synthetic and purification methods for phosphaplatin compounds and uses thereof
WO2014130776A1 (en) 2013-02-22 2014-08-28 University Of Houston Phosphaplatins as neuroprotective agents
US20150231151A1 (en) * 2014-02-19 2015-08-20 University Of Houston System Compositions and methods for the treatment of neurodegenerative diseases
KR102412203B1 (ko) 2014-06-11 2022-06-23 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 백금 내성을 극복하는데 이용하기 위한 텍사피린-pt(iv) 접합체 및 조성물
WO2017116356A1 (en) 2015-12-30 2017-07-06 Atilim Universitesi Dna targeted mono and heterodinuclear complexes
KR102718532B1 (ko) * 2017-01-06 2024-10-21 프로몬토리 테라퓨틱스 인코포레이티드 뼈 또는 혈액 암의 치료를 위한 치료제로서의 포스파플라틴 화합물
JP7381083B2 (ja) * 2017-09-08 2023-11-15 フォスプラティン テラピューティクス インコーポレイテッド 免疫調節剤としてのホスファプラチン化合物およびその治療的使用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234500A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
EP0409527A2 (en) * 1989-07-18 1991-01-23 Engelhard Corporation Cis-diamineplatinum complexes with methanediphosphonate and substituted methanediphosphonate ligands as antitumor agents
WO2005000858A2 (en) * 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291027A (en) * 1979-03-07 1981-09-22 Engelhard Minerals & Chemicals Corp. Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes
WO2009008345A1 (ja) * 2007-07-06 2009-01-15 Tmrc Co., Ltd. 金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体
CN101801369B (zh) 2007-08-06 2012-09-19 俄亥俄大学 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234500A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
EP0409527A2 (en) * 1989-07-18 1991-01-23 Engelhard Corporation Cis-diamineplatinum complexes with methanediphosphonate and substituted methanediphosphonate ligands as antitumor agents
WO2005000858A2 (en) * 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes

Also Published As

Publication number Publication date
EP2173337A4 (en) 2010-10-27
US7700649B2 (en) 2010-04-20
JP2013227218A (ja) 2013-11-07
EP2173337A2 (en) 2010-04-14
ES2495743T3 (es) 2014-09-17
US20110313182A1 (en) 2011-12-22
US8445710B2 (en) 2013-05-21
SI2173337T1 (sl) 2014-10-30
DK2173337T3 (da) 2014-09-15
PL2173337T3 (pl) 2014-11-28
WO2009021082A3 (en) 2009-04-23
JP5647300B2 (ja) 2014-12-24
JP5385274B2 (ja) 2014-01-08
WO2009021081A3 (en) 2009-05-07
CN101801369A (zh) 2010-08-11
US20090042838A1 (en) 2009-02-12
US20130237503A1 (en) 2013-09-12
PT2173337E (pt) 2014-09-03
US8653132B2 (en) 2014-02-18
EP2173337B1 (en) 2014-07-30
CY1115504T1 (el) 2017-01-04
US8034964B2 (en) 2011-10-11
JP2010535803A (ja) 2010-11-25
WO2009021081A2 (en) 2009-02-12
HRP20140808T1 (hr) 2014-10-24
HK1143551A1 (en) 2011-01-07
EP2668949A1 (en) 2013-12-04
WO2009021082A2 (en) 2009-02-12
US20100233293A1 (en) 2010-09-16

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