ES2495743T3 - Fosfaplatinos y su uso en el tratamiento de cánceres resistentes a cisplatino y carboplatino - Google Patents
Fosfaplatinos y su uso en el tratamiento de cánceres resistentes a cisplatino y carboplatino Download PDFInfo
- Publication number
- ES2495743T3 ES2495743T3 ES08797320.2T ES08797320T ES2495743T3 ES 2495743 T3 ES2495743 T3 ES 2495743T3 ES 08797320 T ES08797320 T ES 08797320T ES 2495743 T3 ES2495743 T3 ES 2495743T3
- Authority
- ES
- Spain
- Prior art keywords
- phosphaplatins
- carboplatin
- cisplatin
- treatment
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 229960004562 carboplatin Drugs 0.000 title 1
- 190000008236 carboplatin Chemical compound 0.000 title 1
- 229960004316 cisplatin Drugs 0.000 title 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 title 1
- RCSSYAPRDMUESK-UHFFFAOYSA-L [Pt+2].OP(O)(=O)OP(=O)([O-])[O-] Chemical compound [Pt+2].OP(O)(=O)OP(=O)([O-])[O-] RCSSYAPRDMUESK-UHFFFAOYSA-L 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 2
- -1 aliphatic amines Chemical class 0.000 abstract 2
- 229940061720 alpha hydroxy acid Drugs 0.000 abstract 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95412607P | 2007-08-06 | 2007-08-06 | |
| US954126P | 2007-08-06 | ||
| US97392607P | 2007-09-20 | 2007-09-20 | |
| US973926P | 2007-09-20 | ||
| PCT/US2008/072398 WO2009021082A2 (en) | 2007-08-06 | 2008-08-06 | Phosphaplatins and their use in the treatment of cancers resistant to cisplantin and carboplatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2495743T3 true ES2495743T3 (es) | 2014-09-17 |
Family
ID=40342030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08797320.2T Active ES2495743T3 (es) | 2007-08-06 | 2008-08-06 | Fosfaplatinos y su uso en el tratamiento de cánceres resistentes a cisplatino y carboplatino |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7700649B2 (enExample) |
| EP (2) | EP2173337B1 (enExample) |
| JP (2) | JP5385274B2 (enExample) |
| CN (1) | CN101801369B (enExample) |
| CY (1) | CY1115504T1 (enExample) |
| DK (1) | DK2173337T3 (enExample) |
| ES (1) | ES2495743T3 (enExample) |
| HR (1) | HRP20140808T1 (enExample) |
| PL (1) | PL2173337T3 (enExample) |
| PT (1) | PT2173337E (enExample) |
| SI (1) | SI2173337T1 (enExample) |
| WO (2) | WO2009021081A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101801369B (zh) | 2007-08-06 | 2012-09-19 | 俄亥俄大学 | 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 |
| PT2575802T (pt) * | 2010-06-04 | 2016-12-27 | Univ Ohio | Fosfaplatinas e sua utilização para o tratamento de cancros |
| CA2818933A1 (en) * | 2011-01-12 | 2012-07-19 | Ohio University | Phosphaplatins having anti-angiogenic, anti-metastatic, and pro-apoptotic properties and uses thereof |
| WO2013009511A1 (en) | 2011-07-08 | 2013-01-17 | Dow Global Technologies Llc | Polyethylene blend composition suitable for blown film, method of producing the same, and films made therefrom |
| JP6027619B2 (ja) | 2011-10-05 | 2016-11-16 | ラシンドラ・エヌ・ボーズ | ホスファプラチン系抗腫瘍剤の大規模調製のための効率的プロセス |
| CA2851254A1 (en) * | 2011-10-05 | 2013-04-11 | The University Of Houston System | Efficient processes for large scale preparation of phophaplatins antitumor agents |
| AU2012325819B2 (en) | 2011-10-20 | 2017-08-03 | Nerium Biotechnology, Inc. | Therapeutic combination for the treatment of cancer |
| EP2855496B1 (en) * | 2012-05-24 | 2016-12-14 | Phosplatin Therapeutics LLC | Synthetic and purification methods for phosphaplatin compounds and uses thereof |
| WO2014130776A1 (en) | 2013-02-22 | 2014-08-28 | University Of Houston | Phosphaplatins as neuroprotective agents |
| US20150231151A1 (en) * | 2014-02-19 | 2015-08-20 | University Of Houston System | Compositions and methods for the treatment of neurodegenerative diseases |
| KR102412203B1 (ko) | 2014-06-11 | 2022-06-23 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 백금 내성을 극복하는데 이용하기 위한 텍사피린-pt(iv) 접합체 및 조성물 |
| WO2017116356A1 (en) | 2015-12-30 | 2017-07-06 | Atilim Universitesi | Dna targeted mono and heterodinuclear complexes |
| KR102718532B1 (ko) * | 2017-01-06 | 2024-10-21 | 프로몬토리 테라퓨틱스 인코포레이티드 | 뼈 또는 혈액 암의 치료를 위한 치료제로서의 포스파플라틴 화합물 |
| JP7381083B2 (ja) * | 2017-09-08 | 2023-11-15 | フォスプラティン テラピューティクス インコーポレイテッド | 免疫調節剤としてのホスファプラチン化合物およびその治療的使用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234500A (en) * | 1979-03-07 | 1980-11-18 | Engelhard Minerals & Chemicals Corporation | Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes |
| US4291027A (en) * | 1979-03-07 | 1981-09-22 | Engelhard Minerals & Chemicals Corp. | Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes |
| CA2017739A1 (en) * | 1989-07-18 | 1991-01-18 | Engelhard Corporation | Cis-diamineplatinum complexes with methanediphosphonate and substituted methanediphosphonate ligands as antitumor agents |
| WO2005000858A2 (en) * | 2003-06-27 | 2005-01-06 | Akira Odani | Bisphosphonate complexes |
| WO2009008345A1 (ja) * | 2007-07-06 | 2009-01-15 | Tmrc Co., Ltd. | 金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体 |
| CN101801369B (zh) | 2007-08-06 | 2012-09-19 | 俄亥俄大学 | 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 |
-
2008
- 2008-08-06 CN CN2008801015774A patent/CN101801369B/zh active Active
- 2008-08-06 SI SI200831280T patent/SI2173337T1/sl unknown
- 2008-08-06 PL PL08797320T patent/PL2173337T3/pl unknown
- 2008-08-06 HR HRP20140808AT patent/HRP20140808T1/hr unknown
- 2008-08-06 ES ES08797320.2T patent/ES2495743T3/es active Active
- 2008-08-06 US US12/187,376 patent/US7700649B2/en active Active
- 2008-08-06 PT PT87973202T patent/PT2173337E/pt unknown
- 2008-08-06 WO PCT/US2008/072397 patent/WO2009021081A2/en not_active Ceased
- 2008-08-06 EP EP08797320.2A patent/EP2173337B1/en active Active
- 2008-08-06 DK DK08797320.2T patent/DK2173337T3/da active
- 2008-08-06 EP EP13182512.7A patent/EP2668949A1/en not_active Withdrawn
- 2008-08-06 WO PCT/US2008/072398 patent/WO2009021082A2/en not_active Ceased
- 2008-08-06 JP JP2010520294A patent/JP5385274B2/ja active Active
-
2010
- 2010-03-11 US US12/722,189 patent/US8034964B2/en active Active
-
2011
- 2011-08-30 US US13/221,458 patent/US8445710B2/en active Active
-
2013
- 2013-03-15 US US13/842,885 patent/US8653132B2/en active Active
- 2013-06-07 JP JP2013120309A patent/JP5647300B2/ja active Active
-
2014
- 2014-08-27 CY CY20141100686T patent/CY1115504T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2173337A4 (en) | 2010-10-27 |
| US7700649B2 (en) | 2010-04-20 |
| JP2013227218A (ja) | 2013-11-07 |
| EP2173337A2 (en) | 2010-04-14 |
| US20110313182A1 (en) | 2011-12-22 |
| US8445710B2 (en) | 2013-05-21 |
| SI2173337T1 (sl) | 2014-10-30 |
| DK2173337T3 (da) | 2014-09-15 |
| PL2173337T3 (pl) | 2014-11-28 |
| WO2009021082A3 (en) | 2009-04-23 |
| JP5647300B2 (ja) | 2014-12-24 |
| JP5385274B2 (ja) | 2014-01-08 |
| WO2009021081A3 (en) | 2009-05-07 |
| CN101801369A (zh) | 2010-08-11 |
| US20090042838A1 (en) | 2009-02-12 |
| US20130237503A1 (en) | 2013-09-12 |
| PT2173337E (pt) | 2014-09-03 |
| US8653132B2 (en) | 2014-02-18 |
| EP2173337B1 (en) | 2014-07-30 |
| CY1115504T1 (el) | 2017-01-04 |
| US8034964B2 (en) | 2011-10-11 |
| JP2010535803A (ja) | 2010-11-25 |
| WO2009021081A2 (en) | 2009-02-12 |
| CN101801369B (zh) | 2012-09-19 |
| HRP20140808T1 (hr) | 2014-10-24 |
| HK1143551A1 (en) | 2011-01-07 |
| EP2668949A1 (en) | 2013-12-04 |
| WO2009021082A2 (en) | 2009-02-12 |
| US20100233293A1 (en) | 2010-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201100969A1 (ru) | Солевые формы органического соединения | |
| ECSP109953A (es) | Derivados de piridazinona | |
| AR047917A1 (es) | Derivados de 4-benzimidazol-2-il-piridazin-3-ona, preparacion de los mismos, y su empleo en medicamentos | |
| ECSP034460A (es) | Nuevos compuestos heterociclicos, su preparacion y su utilizacion como medicamentos, en especial como antibacterianos | |
| ECSP099571A (es) | Derivados pirazólicos como inhibidores de la 11-beta-hsd1 | |
| CR11750A (es) | Pirimidin-5-carboxamidas sustituidas 281 | |
| PA8680701A1 (es) | Derivados de oxindol | |
| ECSP099436A (es) | Acilaminopirazoles como inhibidores de fgfr | |
| BR112013002375A2 (pt) | composto, composição farmacêutica, métodos de tratar um indivíduo para um distúrbio proliferativo de induzir a apoptose das células cancerígenas, e de inibir a atividade de cinase em um mamífero, e, processo de preparação de composto | |
| AR058077A1 (es) | Derivados de acidos fenoxiaceticos | |
| MX2022001789A (es) | Derivados de 2-hidroxicicloalcan-1-carbamoilo. | |
| ES2037753T3 (es) | Compuestos heterociclicos y su preparacion y uso. | |
| CL2023001367A1 (es) | Inhibidores de btk | |
| CY1112451T1 (el) | Μεθοδος για μειωση γαστρεντερικης τοξικοτητας λογω της χορηγησης τεγκαφουρης | |
| AR072228A1 (es) | Derivados de pirimido isoquinolina sustituidos | |
| BRPI0519329A2 (pt) | Ácidos hidroxibifenil carboxÍlicos e derivados, mÉtodos para produÇço dos mesmos e uso dos mesmos | |
| AR056987A1 (es) | Derivados de acetileno | |
| ATE507212T1 (de) | Morpholine als 5ht2c-agonisten | |
| MX2024003028A (es) | Derivados de 6 aza quinolina y usos relacionados. | |
| CY1124702T1 (el) | Μεθοδοι χρησης για παραγωγα τριυποκατεστημενου βενζοτριαζολιου ως αναστολεις διυδροοροτικης οξυγονασης | |
| DOP2025000212A (es) | Derivados de hidroquinazolina para el tratamiento de una enfermedad o un trastorno | |
| UY38971A (es) | Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso | |
| AR084216A1 (es) | Composiciones y metodos para tratar el cancer usando un inhibidor de pi3k e inhibidor de mek, kit | |
| ES2582660T3 (es) | Sidnoniminas - inhibidores específicos de la recaptación de la dopamina y su uso en el tratamiento de los trastornos relacionados con la dopamina | |
| BRPI0615158A8 (pt) | composto, composição farmacêutica, e, métodos para tratar ou prevenir uma doença ou condição, e para preparar um composto. |