ES2037753T3 - Compuestos heterociclicos y su preparacion y uso. - Google Patents
Compuestos heterociclicos y su preparacion y uso.Info
- Publication number
- ES2037753T3 ES2037753T3 ES198888104379T ES88104379T ES2037753T3 ES 2037753 T3 ES2037753 T3 ES 2037753T3 ES 198888104379 T ES198888104379 T ES 198888104379T ES 88104379 T ES88104379 T ES 88104379T ES 2037753 T3 ES2037753 T3 ES 2037753T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- hetero
- preparation
- chem
- cycle compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
COMPUESTOS DE DIHIDROXIQUINOXALINA QUE TIENEN LA FORMULA (I) DONDE -A- JUNTO CON LOS DOS ATOMOS DE CARBONO DESIGNADOS COMO 1 Y 2 SE ELIGEN DE ENTRE (II), (III) O (IV), R1, R2 Y R3 SON INDEPENDIENTEMENTE H, HALOGENO, CN, NH2, NO2, SO3H, SO2NH2, CONH2. LA INVENCION TAMBIEN SE REFIERE A UN METODO PARA PREPARAR COMPUESTOS, COMPOSICIONES FARMACEUTICAS DE LOS MISMOS Y SU USO. LOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE INDICACIONES PROVOCADAS POR HIPERACTIVIDAD DE LOS NEUROTRANSMISORES EXCITADORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK146787A DK146787A (da) | 1987-03-23 | 1987-03-23 | Heterocykliske forbindelser, deres fremstilling og anvendelse |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2037753T3 true ES2037753T3 (es) | 1993-07-01 |
Family
ID=8105140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198888104379T Expired - Lifetime ES2037753T3 (es) | 1987-03-23 | 1988-03-18 | Compuestos heterociclicos y su preparacion y uso. |
Country Status (18)
Country | Link |
---|---|
US (2) | US4889855A (es) |
EP (1) | EP0283959B1 (es) |
KR (1) | KR960003324B1 (es) |
AT (1) | ATE71090T1 (es) |
AU (1) | AU596737B2 (es) |
CA (1) | CA1315789C (es) |
DE (1) | DE3867268D1 (es) |
DK (1) | DK146787A (es) |
ES (1) | ES2037753T3 (es) |
FI (1) | FI92582C (es) |
GR (1) | GR3003910T3 (es) |
IE (1) | IE60002B1 (es) |
IL (1) | IL85328A (es) |
NO (1) | NO174549C (es) |
NZ (1) | NZ223776A (es) |
PH (1) | PH23979A (es) |
PT (1) | PT87063B (es) |
ZA (1) | ZA881139B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743607A (en) * | 1987-05-29 | 1988-05-10 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic tricyclic imidazolones |
NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
DK160941C (da) * | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
DK716188D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
US5308845A (en) * | 1988-12-22 | 1994-05-03 | Novo Nordisk A/S | Quinoxaline compounds and their preparation and use |
PT99864B (pt) * | 1990-12-21 | 1999-06-30 | Schering Ag | Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato |
DK73091D0 (da) * | 1991-04-22 | 1991-04-22 | Novo Nordisk As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
ATE162075T1 (de) * | 1991-09-09 | 1998-01-15 | Warner Lambert Co | Pharmazeutisches kombinationspräparat, das ein uricosurisches mittel und einen excitatorischen aminosäure-antagonisten enthält |
DE4217952A1 (de) * | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
JP3301024B2 (ja) * | 1992-06-22 | 2002-07-15 | ザ・リージェンツ・オブ・ザ・ユニバーシテイ・オブ・カリフォルニア | グリシンレセプター拮抗物質及びその用途 |
JPH08502483A (ja) | 1992-10-13 | 1996-03-19 | ワーナー−ランバート・コンパニー | 新規なキノキサリンジオン誘導体、それらの製造および使用 |
DK12293D0 (da) * | 1993-02-02 | 1993-02-02 | Novo Nordisk As | Heterocykliske forbindelser og deres fremstilling og anvendelse |
US5843945A (en) * | 1993-05-13 | 1998-12-01 | Neurosearch A/S | AMPA antagonists and a method of treatment |
WO1994026747A1 (en) * | 1993-05-13 | 1994-11-24 | Neurosearch A/S | Ampa antagonists and a method of treatment therewith |
US5631373A (en) | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
DE4436852A1 (de) * | 1994-10-14 | 1996-04-18 | Basf Ag | Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung |
US5721234A (en) * | 1994-12-07 | 1998-02-24 | Warner-Lambert Company | Glutamate receptor antagonists: fused cycloalkylouinoxalinediones |
AU4152296A (en) * | 1994-12-07 | 1996-06-26 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkylquinoxalinediones |
JPH11501619A (ja) * | 1995-02-15 | 1999-02-09 | ベアーズデン バイオ,インコーポレイテッド | アルキルカルボキシアミノ酸−カイネートレセプターのモジュレーター |
AU4423496A (en) | 1995-03-14 | 1996-10-02 | Warner-Lambert Company | Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones |
US5719153A (en) * | 1995-08-15 | 1998-02-17 | American Home Products Corporation | 5H,8H-2-oxa-1,3,5,8-tetraaza-cyclopenta b!-naphthalene-6,7-diones |
AU3571997A (en) * | 1996-08-01 | 1998-02-25 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkyl quinoxalinediones |
FR2752163B1 (fr) * | 1996-08-12 | 1998-10-30 | Pf Medicament | Utilisation de l'efaroxan pour la fabricaton de medicament destine au traitement de la maladie de huntington |
US5968928A (en) * | 1996-09-19 | 1999-10-19 | Warner-Lambert Company | Excitatory amino acid antagonists: fused-azacyclic quinoxalinediones and immunoassays thereof |
EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
WO2023042888A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
WO2023042887A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3431111A (en) * | 1963-06-10 | 1969-03-04 | Eastman Kodak Co | Cyanine dyes |
US3772273A (en) * | 1969-01-17 | 1973-11-13 | Allied Chem | Derivatives of quinoxaline |
US3962440A (en) * | 1973-12-26 | 1976-06-08 | Eli Lilly And Company | Quinoxaline compounds as hypnotic agents |
US4430502A (en) * | 1982-08-13 | 1984-02-07 | The Upjohn Company | Pyridinyl substituted benzimidazoles and quinoxalines |
FR2583751B1 (fr) * | 1985-06-20 | 1989-10-13 | Panmedica | Nouveaux antibacteriens contenant des derives des acides oxo-4-pyridine carboxyliques et leur procede de preparation |
-
1987
- 1987-03-23 DK DK146787A patent/DK146787A/da not_active IP Right Cessation
-
1988
- 1988-02-05 IL IL85328A patent/IL85328A/xx not_active IP Right Cessation
- 1988-02-16 US US07/156,539 patent/US4889855A/en not_active Expired - Lifetime
- 1988-02-18 ZA ZA881139A patent/ZA881139B/xx unknown
- 1988-02-18 IE IE43988A patent/IE60002B1/en not_active IP Right Cessation
- 1988-02-22 FI FI880816A patent/FI92582C/fi not_active IP Right Cessation
- 1988-02-26 PH PH36561A patent/PH23979A/en unknown
- 1988-03-07 NZ NZ223776A patent/NZ223776A/xx unknown
- 1988-03-17 CA CA000561757A patent/CA1315789C/en not_active Expired - Fee Related
- 1988-03-18 AT AT88104379T patent/ATE71090T1/de not_active IP Right Cessation
- 1988-03-18 AU AU13260/88A patent/AU596737B2/en not_active Ceased
- 1988-03-18 DE DE8888104379T patent/DE3867268D1/de not_active Expired - Fee Related
- 1988-03-18 ES ES198888104379T patent/ES2037753T3/es not_active Expired - Lifetime
- 1988-03-18 EP EP88104379A patent/EP0283959B1/en not_active Expired - Lifetime
- 1988-03-22 NO NO881264A patent/NO174549C/no unknown
- 1988-03-22 KR KR1019880003024A patent/KR960003324B1/ko not_active IP Right Cessation
- 1988-03-23 PT PT87063A patent/PT87063B/pt active IP Right Grant
-
1989
- 1989-05-03 US US07/347,141 patent/US4912108A/en not_active Expired - Lifetime
-
1992
- 1992-02-27 GR GR920400325T patent/GR3003910T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US4889855A (en) | 1989-12-26 |
PH23979A (en) | 1990-02-09 |
ZA881139B (en) | 1988-08-15 |
KR960003324B1 (ko) | 1996-03-08 |
AU596737B2 (en) | 1990-05-10 |
FI92582C (fi) | 1994-12-12 |
FI880816A0 (fi) | 1988-02-22 |
AU1326088A (en) | 1988-09-22 |
NO881264L (no) | 1988-09-26 |
CA1315789C (en) | 1993-04-06 |
DK146787D0 (da) | 1987-03-23 |
IE880439L (en) | 1988-09-23 |
FI92582B (fi) | 1994-08-31 |
NO174549C (no) | 1994-05-25 |
IL85328A (en) | 1993-06-10 |
GR3003910T3 (es) | 1993-03-16 |
NO174549B (no) | 1994-02-14 |
ATE71090T1 (de) | 1992-01-15 |
NO881264D0 (no) | 1988-03-22 |
NZ223776A (en) | 1990-10-26 |
PT87063A (pt) | 1988-04-01 |
EP0283959B1 (en) | 1992-01-02 |
DK146787A (da) | 1988-09-24 |
IE60002B1 (en) | 1994-05-18 |
PT87063B (pt) | 1992-07-31 |
FI880816A (fi) | 1988-09-24 |
DE3867268D1 (de) | 1992-02-13 |
EP0283959A1 (en) | 1988-09-28 |
US4912108A (en) | 1990-03-27 |
KR880011125A (ko) | 1988-10-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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