JP2013126995A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013126995A5 JP2013126995A5 JP2013027479A JP2013027479A JP2013126995A5 JP 2013126995 A5 JP2013126995 A5 JP 2013126995A5 JP 2013027479 A JP2013027479 A JP 2013027479A JP 2013027479 A JP2013027479 A JP 2013027479A JP 2013126995 A5 JP2013126995 A5 JP 2013126995A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- helix
- amino acid
- isolated polypeptide
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 229920001184 polypeptide Polymers 0.000 claims 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 8
- 102000036693 Thrombopoietin Human genes 0.000 claims 6
- 108010041111 Thrombopoietin Proteins 0.000 claims 6
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 claims 5
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102000000646 Interleukin-3 Human genes 0.000 claims 4
- 108010002386 Interleukin-3 Proteins 0.000 claims 4
- 102000004058 Leukemia inhibitory factor Human genes 0.000 claims 4
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 4
- 229940076264 interleukin-3 Drugs 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101800002011 Amphipathic peptide Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 201000006306 Cor pulmonale Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 208000012931 Urologic disease Diseases 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 108091006116 chimeric peptides Proteins 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001120 cytoprotective effect Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 230000006371 metabolic abnormality Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 208000017443 reproductive system disease Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 208000014001 urinary system disease Diseases 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70574105P | 2005-08-05 | 2005-08-05 | |
| US60/705,741 | 2005-08-05 | ||
| US70627605P | 2005-08-08 | 2005-08-08 | |
| US60/706,276 | 2005-08-08 | ||
| US83173706P | 2006-07-18 | 2006-07-18 | |
| US60/831,737 | 2006-07-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525285A Division JP5274253B2 (ja) | 2005-08-05 | 2006-08-07 | 組織保護ペプチド及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015020020A Division JP6158235B2 (ja) | 2005-08-05 | 2015-02-04 | 組織保護ペプチド及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013126995A JP2013126995A (ja) | 2013-06-27 |
| JP2013126995A5 true JP2013126995A5 (enExample) | 2013-08-08 |
| JP5918155B2 JP5918155B2 (ja) | 2016-05-18 |
Family
ID=37728020
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525285A Expired - Fee Related JP5274253B2 (ja) | 2005-08-05 | 2006-08-07 | 組織保護ペプチド及びその使用 |
| JP2013027479A Expired - Fee Related JP5918155B2 (ja) | 2005-08-05 | 2013-02-15 | 組織保護ペプチド及びその使用 |
| JP2015020020A Expired - Fee Related JP6158235B2 (ja) | 2005-08-05 | 2015-02-04 | 組織保護ペプチド及びその使用 |
| JP2016114010A Expired - Fee Related JP6491621B2 (ja) | 2005-08-05 | 2016-06-08 | 組織保護ペプチド及びその使用 |
| JP2018071318A Pending JP2018134084A (ja) | 2005-08-05 | 2018-04-03 | 組織保護ペプチド及びその使用 |
| JP2020013151A Pending JP2020078317A (ja) | 2005-08-05 | 2020-01-30 | 組織保護ペプチド及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525285A Expired - Fee Related JP5274253B2 (ja) | 2005-08-05 | 2006-08-07 | 組織保護ペプチド及びその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015020020A Expired - Fee Related JP6158235B2 (ja) | 2005-08-05 | 2015-02-04 | 組織保護ペプチド及びその使用 |
| JP2016114010A Expired - Fee Related JP6491621B2 (ja) | 2005-08-05 | 2016-06-08 | 組織保護ペプチド及びその使用 |
| JP2018071318A Pending JP2018134084A (ja) | 2005-08-05 | 2018-04-03 | 組織保護ペプチド及びその使用 |
| JP2020013151A Pending JP2020078317A (ja) | 2005-08-05 | 2020-01-30 | 組織保護ペプチド及びその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US8071554B2 (enExample) |
| EP (5) | EP2540309B1 (enExample) |
| JP (6) | JP5274253B2 (enExample) |
| KR (7) | KR20180067735A (enExample) |
| CN (2) | CN101378772B (enExample) |
| AU (1) | AU2006278264B2 (enExample) |
| BR (1) | BRPI0614529A8 (enExample) |
| CA (3) | CA2982909A1 (enExample) |
| DK (3) | DK2594279T3 (enExample) |
| EA (1) | EA015672B1 (enExample) |
| ES (3) | ES2653790T3 (enExample) |
| HU (3) | HUE035793T2 (enExample) |
| IL (3) | IL189287A (enExample) |
| IN (1) | IN2014CN02050A (enExample) |
| LT (2) | LT2540309T (enExample) |
| MX (3) | MX364100B (enExample) |
| NO (1) | NO20081112L (enExample) |
| NZ (1) | NZ565937A (enExample) |
| PL (3) | PL2540309T3 (enExample) |
| PT (3) | PT2371855E (enExample) |
| SG (2) | SG10201805825SA (enExample) |
| SI (3) | SI2594279T1 (enExample) |
| UA (1) | UA100222C2 (enExample) |
| WO (1) | WO2007019545A2 (enExample) |
| ZA (1) | ZA201101890B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| WO2007052154A2 (en) | 2005-04-29 | 2007-05-10 | University Of Medicine And Dentistry Of New Jersey | Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators |
| US9585932B2 (en) * | 2005-04-29 | 2017-03-07 | Peter C. Dowling | Use of EPO-derived peptide fragments for the treatment of neurodegenerative disorders |
| US9345745B2 (en) | 2005-04-29 | 2016-05-24 | Bo Wang | Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides |
| PT2371855E (pt) | 2005-08-05 | 2015-11-03 | Araim Pharmaceuticals Inc | Péptidos protetores de tecidos e suas utilizações |
| CA2654154A1 (en) * | 2006-06-07 | 2007-12-13 | The University Of Tokushima | Treatment of ischemic diseases using erythropoietin |
| DK2081956T3 (da) * | 2006-11-13 | 2013-06-24 | Charite Universitaetsmedizin | FREMGANGSMÅDE TIL CELLEDYRKNING OG FREMGANGSMÅDE TIL BEHANDLING OMFATTENDE EN vEPO-PROTEINVARIANT |
| AU2016203452B2 (en) * | 2008-01-22 | 2018-02-22 | Araim Pharmaceuticals, Inc. | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
| AU2014203195B2 (en) * | 2008-01-22 | 2016-03-31 | Araim Pharmaceuticals, Inc. | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
| SG10201604530SA (en) * | 2008-01-22 | 2016-07-28 | Araim Pharmaceuticals Inc | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
| US8791234B2 (en) * | 2010-10-14 | 2014-07-29 | Rutgers, The State University Of New Jersey | Intestinal peptide targeting ligands |
| US9566349B2 (en) * | 2010-10-14 | 2017-02-14 | Rutgers, The State University Of New Jersey | Intestinal peptide targeting ligands |
| CN102180948A (zh) * | 2011-03-03 | 2011-09-14 | 复旦大学附属中山医院 | 一种具有肾脏保护作用的短肽及其制备方法和应用 |
| CN102212111B (zh) * | 2011-05-05 | 2014-04-30 | 中国人民解放军第三军医大学 | 小分子多肽和小分子多肽脂质体及其运用 |
| CA2843014C (en) * | 2011-07-27 | 2020-01-21 | Neumedicines, Inc. | Use of il-12 to generate endogenous erythropoietin |
| US20140249573A1 (en) * | 2011-09-20 | 2014-09-04 | A.A. Cash Technology Ltd. | Methods and devices for occluding blood flow to an organ |
| KR101148191B1 (ko) * | 2011-09-27 | 2012-05-23 | 김후정 | 에리스로포이에틴-유래 펩타이드 및 그 용도 |
| WO2013158871A1 (en) | 2012-04-20 | 2013-10-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of erythropoietin and derivatives for treating hypertension |
| KR20160052537A (ko) * | 2013-07-17 | 2016-05-12 | 아라임 파마슈티칼즈, 인크. | 조직 손상과 연관된 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
| CN104744593A (zh) * | 2013-12-25 | 2015-07-01 | 深圳先进技术研究院 | 一种抗肿瘤血管生成免疫复合肽及其制备方法和应用 |
| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| KR20150130616A (ko) * | 2014-05-13 | 2015-11-24 | (주)케어젠 | 피부상태 개선 활성을 갖는 펩타이드 및 이의 용도 |
| CN105837662A (zh) * | 2014-06-22 | 2016-08-10 | 马恒标 | 组织保护活性多肽sl3及其应用 |
| MX391259B (es) | 2015-10-14 | 2025-03-21 | X Therma Inc | Composiciones y métodos para reducir la formación de cristales de hielo. |
| JP2019523633A (ja) | 2016-04-29 | 2019-08-29 | アライム ファーマシューティカルズ，インコーポレーテッド | 組織の損傷に関連した疾患及び障害を予防及び治療する組織保護ペプチド |
| US10456346B2 (en) | 2016-11-10 | 2019-10-29 | Asc Regenity Ltd. | Cosmetic formulations for topical applications containing erythropoietin-derived molecules |
| KR101965814B1 (ko) | 2017-02-27 | 2019-08-13 | 재단법인 대구경북과학기술원 | 에리스로포이에틴 유래 펩티드의 세포손상방지에 효과를 통한 활용 |
| US11260101B2 (en) | 2017-02-28 | 2022-03-01 | Jinan University | Repair peptide for use in promoting post-traumatic tissue repair and regeneration, and application thereof |
| CN108503690B (zh) * | 2017-02-28 | 2020-07-03 | 暨南大学 | 一种促进创伤后组织修复与再生的修复肽及其应用 |
| EP3761959A4 (en) * | 2018-04-08 | 2022-03-02 | Brim Biotechnology, Inc. | APPLICATION OF PEDF DERIVED SHORT PEPTIDES IN TENDON HEALING |
| KR102300060B1 (ko) | 2018-06-12 | 2021-09-08 | 주식회사 엘지에너지솔루션 | 2열 터미널 구조의 pcb 다이렉트 커넥터 |
| CN120267815A (zh) | 2018-09-10 | 2025-07-08 | 冷泉港实验室 | 用于治疗胰腺炎的方法 |
| CN112390877B (zh) * | 2019-08-16 | 2022-10-04 | 董红燕 | Pedf衍生多肽组合物及其在制备保护肺损伤药物中的应用 |
| CN118255845B (zh) * | 2022-12-27 | 2025-07-11 | 上海瑞吉康生物医药有限公司 | 相分离逆转多肽的变体及其应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
| US4558006A (en) | 1983-02-04 | 1985-12-10 | Kirin-Amgen, Inc. | A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin |
| US5051448A (en) | 1984-07-24 | 1991-09-24 | The Mclean Hospital Corporation | GABA esters and GABA analog esters |
| US4704355A (en) | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5498694A (en) | 1989-05-25 | 1996-03-12 | La Jolla Cancer Research Foundation | Peptides of the cytoplasmic domain of integrin |
| DE3924746A1 (de) | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper |
| WO1991004014A1 (en) | 1989-09-21 | 1991-04-04 | Synergen, Inc. | Method for transporting compositions across the blood brain barrier |
| US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
| US6140120A (en) * | 1993-02-12 | 2000-10-31 | Board Of Trustees Of Leland Stanford Jr. University | Regulated transcription of targeted genes and other biological events |
| US5559103A (en) | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
| US5700909A (en) | 1993-07-30 | 1997-12-23 | The Regents Of The University Of California | Prosaposin and cytokine-derived peptides |
| US5571787A (en) | 1993-07-30 | 1996-11-05 | Myelos Corporation | Prosaposin as a neurotrophic factor |
| WO1995021919A2 (en) * | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| ITFI940106A1 (it) * | 1994-05-27 | 1995-11-27 | Menarini Ricerche Sud Spa | Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica |
| US5576423A (en) | 1994-12-02 | 1996-11-19 | Schering Corporation | Antibodies to the slam protein expressed on activated T cells |
| EP0886648B8 (en) * | 1995-06-07 | 2004-03-03 | Ortho Pharmaceutical Corporation | Compounds and peptides that bind to the erythropoietin receptor |
| JP2001524944A (ja) * | 1997-03-05 | 2001-12-04 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 神経障害性疼痛の緩和方法 |
| US7153943B2 (en) * | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
| US7270809B2 (en) * | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
| PL352223A1 (en) * | 1999-04-13 | 2003-08-11 | Kenneth S Warren Inst | Modulation of excitable tissue function by peripherally administered erythropoietin |
| WO2001083548A1 (en) * | 2000-04-28 | 2001-11-08 | Effector Cell Institute | Novel derivative of cell chemotactic factor |
| AU2002233230B2 (en) * | 2000-12-20 | 2007-02-01 | F. Hoffmann-La Roche Ag | Erythropoietin conjugates |
| US20030072737A1 (en) | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| PA8536201A1 (es) | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina |
| RU2003125654A (ru) * | 2001-02-06 | 2005-03-10 | Мерк Патент ГмбХ (DE) | Модифицированный эритропоэтин (еро) с уменьшенной иммуногенностью |
| DE60232870D1 (de) * | 2001-04-04 | 2009-08-20 | Genodyssee | Neue polynukleotide und polypeptide des erythropoietingens |
| KR100467751B1 (ko) * | 2001-12-03 | 2005-01-24 | 씨제이 주식회사 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
| US7300915B2 (en) * | 2002-06-05 | 2007-11-27 | The Regents Of The University Of California | Use of erythropoietin and erythropoietin mimetics for the treatment of neuropathic pain |
| CA2491567A1 (en) | 2002-07-01 | 2004-01-08 | The Kenneth S. Warren Institute, Inc. | Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs |
| KR100478455B1 (ko) | 2002-08-19 | 2005-03-22 | 삼성전자주식회사 | 전자렌지 |
| ZA200505423B (en) | 2002-09-09 | 2008-08-27 | Warren Pharmaceuticals Inc | Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin |
| EP1578432A4 (en) * | 2002-10-03 | 2008-07-30 | Epimmune Inc | HLA BINDING PEPTIDES AND USES THEREOF |
| JP2004305006A (ja) * | 2003-04-01 | 2004-11-04 | Japan Science & Technology Agency | 人工調製肺サーファクタント |
| CN103230415B (zh) * | 2003-04-25 | 2016-05-04 | 匹兹堡大学联邦制高等教育 | 用于促进和增强神经修复和再生的肌肉来源的细胞（mdc） |
| US7718363B2 (en) | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
| CN1882355A (zh) | 2003-09-09 | 2006-12-20 | 沃伦药品公司 | 保持内源性促红细胞生成素组织保护活性的长效促红细胞生成素 |
| KR20070008519A (ko) | 2003-09-29 | 2007-01-17 | 워렌 파마슈티칼즈 인코포레이티드 | 패혈증 및 유착 형성의 치료 및 예방용 조직 보호성사이토카인 |
| US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
| US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| WO2007010552A2 (en) | 2005-03-17 | 2007-01-25 | Serum Institute Of India Limited | N- terminal peg conjugate of erythropoietin |
| US9345745B2 (en) | 2005-04-29 | 2016-05-24 | Bo Wang | Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides |
| WO2007052154A2 (en) | 2005-04-29 | 2007-05-10 | University Of Medicine And Dentistry Of New Jersey | Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators |
| EP2377884A1 (en) | 2005-05-10 | 2011-10-19 | Neoloch Aps | Neuritogenic peptides |
| EP1736481A1 (en) | 2005-05-13 | 2006-12-27 | Charite Universitätsmedizin-Berlin | Erythropoietin variants |
| PT2371855E (pt) * | 2005-08-05 | 2015-11-03 | Araim Pharmaceuticals Inc | Péptidos protetores de tecidos e suas utilizações |
| ATE554186T1 (de) | 2007-11-29 | 2012-05-15 | Molecular Health Gmbh | Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendung |
| SG10201604530SA (en) | 2008-01-22 | 2016-07-28 | Araim Pharmaceuticals Inc | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
| CA2725601A1 (en) * | 2008-04-28 | 2009-11-05 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
| WO2011022056A2 (en) | 2009-08-18 | 2011-02-24 | Medical College Of Georgia Research Institute, Inc. | PEPTIDE MODULATORS OF THE δPKC INTERACTION WITH THE D SUBUNIT OF F1FO ATP SYNTHASE/ATPASE AND USES THEREOF |
-
2006
- 2006-08-07 PT PT111631941T patent/PT2371855E/pt unknown
- 2006-08-07 ES ES12175366.9T patent/ES2653790T3/es active Active
- 2006-08-07 DK DK12175366.9T patent/DK2594279T3/en active
- 2006-08-07 IN IN2050CHN2014 patent/IN2014CN02050A/en unknown
- 2006-08-07 CA CA2982909A patent/CA2982909A1/en not_active Abandoned
- 2006-08-07 EP EP12175352.9A patent/EP2540309B1/en active Active
- 2006-08-07 KR KR1020187016750A patent/KR20180067735A/ko not_active Ceased
- 2006-08-07 SG SG10201805825SA patent/SG10201805825SA/en unknown
- 2006-08-07 KR KR1020177005579A patent/KR20170027868A/ko not_active Ceased
- 2006-08-07 MX MX2016004825A patent/MX364100B/es unknown
- 2006-08-07 UA UAA200802850A patent/UA100222C2/uk unknown
- 2006-08-07 PT PT121753529T patent/PT2540309T/pt unknown
- 2006-08-07 JP JP2008525285A patent/JP5274253B2/ja not_active Expired - Fee Related
- 2006-08-07 PL PL12175352T patent/PL2540309T3/pl unknown
- 2006-08-07 AU AU2006278264A patent/AU2006278264B2/en not_active Ceased
- 2006-08-07 KR KR1020197019568A patent/KR20190084136A/ko not_active Ceased
- 2006-08-07 PL PL11163194T patent/PL2371855T3/pl unknown
- 2006-08-07 NZ NZ565937A patent/NZ565937A/en not_active IP Right Cessation
- 2006-08-07 KR KR1020087005373A patent/KR101626153B1/ko not_active Expired - Fee Related
- 2006-08-07 LT LTEP12175352.9T patent/LT2540309T/lt unknown
- 2006-08-07 SG SG2014007868A patent/SG2014007868A/en unknown
- 2006-08-07 CA CA2618396A patent/CA2618396C/en not_active Expired - Fee Related
- 2006-08-07 SI SI200632230T patent/SI2594279T1/en unknown
- 2006-08-07 MX MX2014011168A patent/MX339613B/es unknown
- 2006-08-07 BR BRPI0614529A patent/BRPI0614529A8/pt not_active Application Discontinuation
- 2006-08-07 HU HUE12175352A patent/HUE035793T2/en unknown
- 2006-08-07 EP EP06801051A patent/EP1924276A4/en not_active Withdrawn
- 2006-08-07 CA CA3079319A patent/CA3079319A1/en not_active Abandoned
- 2006-08-07 EP EP12175366.9A patent/EP2594279B1/en active Active
- 2006-08-07 SI SI200632233T patent/SI2540309T1/en unknown
- 2006-08-07 LT LTEP12175366.9T patent/LT2594279T/lt unknown
- 2006-08-07 MX MX2008001509A patent/MX2008001509A/es active IP Right Grant
- 2006-08-07 ES ES12175352.9T patent/ES2653864T3/es active Active
- 2006-08-07 KR KR1020207016998A patent/KR20200072568A/ko not_active Ceased
- 2006-08-07 EP EP17202352.5A patent/EP3363451A1/en not_active Withdrawn
- 2006-08-07 DK DK11163194.1T patent/DK2371855T3/en active
- 2006-08-07 CN CN2006800348244A patent/CN101378772B/zh not_active Expired - Fee Related
- 2006-08-07 PT PT121753669T patent/PT2594279T/pt unknown
- 2006-08-07 HU HUE11163194A patent/HUE026444T2/en unknown
- 2006-08-07 WO PCT/US2006/031061 patent/WO2007019545A2/en not_active Ceased
- 2006-08-07 ES ES11163194.1T patent/ES2550055T3/es active Active
- 2006-08-07 KR KR1020137016015A patent/KR101713368B1/ko not_active Expired - Fee Related
- 2006-08-07 KR KR1020187030050A patent/KR20180116475A/ko not_active Ceased
- 2006-08-07 CN CN201310529242.5A patent/CN103724418B/zh not_active Expired - Fee Related
- 2006-08-07 SI SI200631979T patent/SI2371855T1/sl unknown
- 2006-08-07 HU HUE12175366A patent/HUE035655T2/en unknown
- 2006-08-07 DK DK12175352.9T patent/DK2540309T3/en active
- 2006-08-07 EP EP11163194.1A patent/EP2371855B1/en active Active
- 2006-08-07 US US11/997,898 patent/US8071554B2/en not_active Expired - Fee Related
- 2006-08-07 PL PL12175366T patent/PL2594279T3/pl unknown
- 2006-08-07 EA EA200800536A patent/EA015672B1/ru not_active IP Right Cessation
-
2008
- 2008-02-05 IL IL189287A patent/IL189287A/en active IP Right Grant
- 2008-03-03 NO NO20081112A patent/NO20081112L/no not_active Application Discontinuation
-
2011
- 2011-03-11 ZA ZA2011/01890A patent/ZA201101890B/en unknown
- 2011-10-20 US US13/278,131 patent/US8716245B2/en not_active Expired - Fee Related
-
2012
- 2012-04-16 US US13/448,345 patent/US8673861B2/en not_active Expired - Fee Related
-
2013
- 2013-02-15 JP JP2013027479A patent/JP5918155B2/ja not_active Expired - Fee Related
-
2014
- 2014-04-08 US US14/248,030 patent/US9340598B2/en not_active Expired - Fee Related
-
2015
- 2015-02-04 JP JP2015020020A patent/JP6158235B2/ja not_active Expired - Fee Related
- 2015-02-10 US US14/618,873 patent/US20150152156A1/en not_active Abandoned
- 2015-06-29 IL IL239695A patent/IL239695A0/en active IP Right Grant
-
2016
- 2016-05-05 US US15/147,848 patent/US10100096B2/en not_active Expired - Fee Related
- 2016-06-08 JP JP2016114010A patent/JP6491621B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-03 JP JP2018071318A patent/JP2018134084A/ja active Pending
- 2018-08-23 IL IL261346A patent/IL261346A/en unknown
- 2018-09-25 US US16/141,724 patent/US20190016769A1/en not_active Abandoned
-
2020
- 2020-01-30 JP JP2020013151A patent/JP2020078317A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013126995A5 (enExample) | ||
| JP2009508471A5 (enExample) | ||
| JP7285220B2 (ja) | 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 | |
| SI2594279T1 (en) | Tissue protective peptides and their uses | |
| RU2648950C2 (ru) | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение | |
| JP2020040969A5 (enExample) | ||
| US20190016781A1 (en) | Polynucleotides encoding immune modulating polypeptides | |
| Kumar et al. | IL-22: an evolutionary missing-link authenticating the role of the immune system in tissue regeneration | |
| WO2009100253A8 (en) | Rescue of photoreceptors by intravitreal administration of an expression vector encoding a therapeutic protein | |
| NZ587105A (en) | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage | |
| JP2016196480A5 (enExample) | ||
| BRPI0415563A (pt) | método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional | |
| BR112021003410A2 (pt) | anticorpos de domínio único anti-bcma, grupo de genes dos ditos anticorpos, polipeptídeo, vetor de expressão, célula hospedeira, receptor de antígeno quimérico, célula t modificada pelo mesmo, composição farmacêutica e usos dos ditos anticorpos | |
| JP2013530965A5 (enExample) | ||
| CN114573709B (zh) | 携带趋化因子受体且靶向msln抗原的car t免疫细胞的制备及其用途 | |
| JP2016514672A (ja) | 抗原およびアジュバントとしてのインターロイキン−２３を有するワクチン | |
| EP2412723B1 (en) | Modified sodium iodide symporter proteins and uses thereof | |
| CN114438106B (zh) | Rv2779c基因及其表达产物作为抗结核分枝杆菌靶点的应用 | |
| ES2390967T3 (es) | Epítopo/péptido reconocido por LTC específico para Ep-CAM con restricción por ALH-A2402 y su utilización | |
| JP2018535684A5 (enExample) | ||
| CN109200271A (zh) | 一种蛋白质及其在调控巨噬细胞免疫功能方面的应用 | |
| JP2009542631A (ja) | 自己免疫疾患、アレルギー性疾患及び炎症性疾患治療用薬剤組成物、並びにその伝達方法 | |
| HRP20100340T1 (hr) | Polipeptidi koji imaju antimikrobno djelovanje i polinukleotidi koji ih kodiraju | |
| CN116478932A (zh) | 基因修饰的免疫细胞及其应用 | |
| Wang et al. | Interferons as negative regulators of ILC2s in allergic lung inflammation and respiratory viral infections |