JP2018535684A5 - - Google Patents
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- Publication number
- JP2018535684A5 JP2018535684A5 JP2018528746A JP2018528746A JP2018535684A5 JP 2018535684 A5 JP2018535684 A5 JP 2018535684A5 JP 2018528746 A JP2018528746 A JP 2018528746A JP 2018528746 A JP2018528746 A JP 2018528746A JP 2018535684 A5 JP2018535684 A5 JP 2018535684A5
- Authority
- JP
- Japan
- Prior art keywords
- microrna
- mirna
- seq
- use according
- adult stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002679 microRNA Substances 0.000 claims 22
- 108700011259 MicroRNAs Proteins 0.000 claims 11
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 10
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 10
- 210000004504 adult stem cell Anatomy 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 4
- 108091030789 miR-302 stem-loop Proteins 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 210000001236 prokaryotic cell Anatomy 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 claims 2
- 208000032544 Cicatrix Diseases 0.000 claims 2
- 241000701022 Cytomegalovirus Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000008929 regeneration Effects 0.000 claims 2
- 238000011069 regeneration method Methods 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 230000037387 scars Effects 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000013043 chemical agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 108091084454 miR-302a stem-loop Proteins 0.000 claims 1
- 108091050195 miR-302b stem-loop Proteins 0.000 claims 1
- 108091056763 miR-302c stem-loop Proteins 0.000 claims 1
- 108091053185 miR-302d stem-loop Proteins 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562262280P | 2015-12-02 | 2015-12-02 | |
| US62/262,280 | 2015-12-02 | ||
| US15/048,964 US10519440B2 (en) | 2012-08-10 | 2016-02-19 | Composition and method of using miR-302 precursors as drugs for treating Alzheimer's diseases |
| US15/048,964 | 2016-02-19 | ||
| US15/167,226 | 2016-05-27 | ||
| US15/167,226 US9879263B2 (en) | 2011-08-12 | 2016-05-27 | Use of microRNA precursors as drugs for inducing CD34-positive adult stem cell expansion |
| PCT/US2016/049583 WO2017095489A1 (en) | 2015-12-02 | 2016-08-31 | Use of microrna precursors as drugs for inducing cd34-positive adult stem cell expansion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018535684A JP2018535684A (ja) | 2018-12-06 |
| JP2018535684A5 true JP2018535684A5 (enExample) | 2019-10-10 |
Family
ID=56896813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528746A Pending JP2018535684A (ja) | 2015-12-02 | 2016-08-31 | ＣＤ３４陽性成体幹細胞の増殖を誘導する薬物としてのｍｉｃｒｏＲＮＡ前駆体の使用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3384026A1 (enExample) |
| JP (1) | JP2018535684A (enExample) |
| CN (1) | CN108431227A (enExample) |
| TW (1) | TWI720075B (enExample) |
| WO (1) | WO2017095489A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11624067B2 (en) | 2008-05-07 | 2023-04-11 | Shi-Lung Lin | In-vitro induction of adult stem cell expansion and derivation |
| EP3818158B1 (en) * | 2018-07-02 | 2025-10-08 | Shi-Lung Lin | In-vitro induction of adult stem cell expansion and derivation |
| CN112430596B (zh) * | 2019-08-26 | 2025-10-28 | 中国科学院上海营养与健康研究所 | 一类小rna分子及其类似物在抗衰老中的应用 |
| US20220396778A1 (en) * | 2021-06-12 | 2022-12-15 | Shi-Lung Lin | Novel RNA Composition and Production Method for Use in iPS Cell Generation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103495A (en) | 1997-04-16 | 2000-08-15 | Unigene Laboratories, Inc. | Direct expression of peptides into culture media |
| US9453219B2 (en) | 2003-05-15 | 2016-09-27 | Mello Biotech Taiwan Co., Ltd. | Cosmetic designs and products using intronic RNA |
| MX2007007591A (es) | 2004-12-22 | 2007-07-25 | Ambrx Inc | Metodos para expresion y purificacion de hormona de crecimiento humano recombinante. |
| JP5945385B2 (ja) * | 2008-01-16 | 2016-07-05 | リン、シー−ランLIN, Shi−Lung | 誘導性組換えｒｎａ因子を用いた腫瘍のない多能性胚性幹様細胞の生成 |
| US9422559B2 (en) * | 2010-06-02 | 2016-08-23 | Shi-Lung Lin | Production and utilization of a novel anti-cancer drug in therapy |
| US9879263B2 (en) * | 2011-08-12 | 2018-01-30 | Mello Biotechnology, Inc. | Use of microRNA precursors as drugs for inducing CD34-positive adult stem cell expansion |
| JP6185468B2 (ja) * | 2011-08-12 | 2017-08-23 | メロ バイオテクノロジー インコーポレイテッドＭｅｌｌｏ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，Ｉｎｃ． | 原核細胞内においてヘアピン様ｒｎａを発現させる方法及び組成物 |
| WO2014026189A2 (en) * | 2012-08-10 | 2014-02-13 | Shi-Lung Lin | Production and utilization of a novel anti-cancer drug in therapy |
| US10196662B2 (en) * | 2012-08-10 | 2019-02-05 | Mello Biotechnology, Inc. | Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors |
-
2016
- 2016-08-31 JP JP2018528746A patent/JP2018535684A/ja active Pending
- 2016-08-31 CN CN201680070742.9A patent/CN108431227A/zh active Pending
- 2016-08-31 WO PCT/US2016/049583 patent/WO2017095489A1/en not_active Ceased
- 2016-08-31 EP EP16763666.1A patent/EP3384026A1/en not_active Withdrawn
- 2016-12-02 TW TW105139971A patent/TWI720075B/zh active
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