JP2018535684A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018535684A5 JP2018535684A5 JP2018528746A JP2018528746A JP2018535684A5 JP 2018535684 A5 JP2018535684 A5 JP 2018535684A5 JP 2018528746 A JP2018528746 A JP 2018528746A JP 2018528746 A JP2018528746 A JP 2018528746A JP 2018535684 A5 JP2018535684 A5 JP 2018535684A5
- Authority
- JP
- Japan
- Prior art keywords
- microrna
- mirna
- seq
- use according
- adult stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002679 microRNA Substances 0.000 claims 22
- 108700011259 MicroRNAs Proteins 0.000 claims 11
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 10
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 10
- 210000004504 adult stem cell Anatomy 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 4
- 108091030789 miR-302 stem-loop Proteins 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 210000001236 prokaryotic cell Anatomy 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 claims 2
- 208000032544 Cicatrix Diseases 0.000 claims 2
- 241000701022 Cytomegalovirus Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000008929 regeneration Effects 0.000 claims 2
- 238000011069 regeneration method Methods 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 230000037387 scars Effects 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000013043 chemical agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 108091084454 miR-302a stem-loop Proteins 0.000 claims 1
- 108091050195 miR-302b stem-loop Proteins 0.000 claims 1
- 108091056763 miR-302c stem-loop Proteins 0.000 claims 1
- 108091053185 miR-302d stem-loop Proteins 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562262280P | 2015-12-02 | 2015-12-02 | |
| US62/262,280 | 2015-12-02 | ||
| US15/048,964 | 2016-02-19 | ||
| US15/048,964 US10519440B2 (en) | 2012-08-10 | 2016-02-19 | Composition and method of using miR-302 precursors as drugs for treating Alzheimer's diseases |
| US15/167,226 US9879263B2 (en) | 2011-08-12 | 2016-05-27 | Use of microRNA precursors as drugs for inducing CD34-positive adult stem cell expansion |
| US15/167,226 | 2016-05-27 | ||
| PCT/US2016/049583 WO2017095489A1 (en) | 2015-12-02 | 2016-08-31 | Use of microrna precursors as drugs for inducing cd34-positive adult stem cell expansion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018535684A JP2018535684A (ja) | 2018-12-06 |
| JP2018535684A5 true JP2018535684A5 (enExample) | 2019-10-10 |
Family
ID=56896813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528746A Pending JP2018535684A (ja) | 2015-12-02 | 2016-08-31 | ＣＤ３４陽性成体幹細胞の増殖を誘導する薬物としてのｍｉｃｒｏＲＮＡ前駆体の使用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3384026A1 (enExample) |
| JP (1) | JP2018535684A (enExample) |
| CN (1) | CN108431227A (enExample) |
| TW (1) | TWI720075B (enExample) |
| WO (1) | WO2017095489A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11624067B2 (en) | 2008-05-07 | 2023-04-11 | Shi-Lung Lin | In-vitro induction of adult stem cell expansion and derivation |
| JP7718819B2 (ja) * | 2018-07-02 | 2025-08-05 | リン、シー－ラン | 成体幹細胞の拡大と誘導のインビトロでの誘発 |
| CN112430596B (zh) * | 2019-08-26 | 2025-10-28 | 中国科学院上海营养与健康研究所 | 一类小rna分子及其类似物在抗衰老中的应用 |
| US20220396778A1 (en) * | 2021-06-12 | 2022-12-15 | Shi-Lung Lin | Novel RNA Composition and Production Method for Use in iPS Cell Generation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE484572T1 (de) | 1997-04-16 | 2010-10-15 | Unigene Lab Inc | Direkte expression von peptiden ins kulturmedium |
| US9453219B2 (en) | 2003-05-15 | 2016-09-27 | Mello Biotech Taiwan Co., Ltd. | Cosmetic designs and products using intronic RNA |
| US8080391B2 (en) | 2004-12-22 | 2011-12-20 | Ambrx, Inc. | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer |
| CN101970664B (zh) * | 2008-01-16 | 2013-08-21 | 林希龙 | 使用可诱导的重组核糖核酸因子生成不含肿瘤的类胚胎干细胞的多能性细胞 |
| US9879263B2 (en) * | 2011-08-12 | 2018-01-30 | Mello Biotechnology, Inc. | Use of microRNA precursors as drugs for inducing CD34-positive adult stem cell expansion |
| US9422559B2 (en) * | 2010-06-02 | 2016-08-23 | Shi-Lung Lin | Production and utilization of a novel anti-cancer drug in therapy |
| WO2013025248A1 (en) * | 2011-08-12 | 2013-02-21 | Mello Biotechnology, Inc. | Inducable expression from the eukaryotic pol -2 promoter in prokaryotes |
| WO2014026189A2 (en) * | 2012-08-10 | 2014-02-13 | Shi-Lung Lin | Production and utilization of a novel anti-cancer drug in therapy |
| US10196662B2 (en) * | 2012-08-10 | 2019-02-05 | Mello Biotechnology, Inc. | Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors |
-
2016
- 2016-08-31 WO PCT/US2016/049583 patent/WO2017095489A1/en not_active Ceased
- 2016-08-31 JP JP2018528746A patent/JP2018535684A/ja active Pending
- 2016-08-31 CN CN201680070742.9A patent/CN108431227A/zh active Pending
- 2016-08-31 EP EP16763666.1A patent/EP3384026A1/en not_active Withdrawn
- 2016-12-02 TW TW105139971A patent/TWI720075B/zh active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ruan et al. | Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries | |
| Hussen et al. | Revolutionizing medicine: recent developments and future prospects in stem-cell therapy | |
| JP7235702B2 (ja) | 核酸生成及び送達のための方法及び製品 | |
| ES2886480T3 (es) | Métodos y composiciones para el tratamiento guiado por ARN de una infección por VIH | |
| JP2022000470A (ja) | 核酸製品及びその投与方法 | |
| JP2018535684A5 (enExample) | ||
| JP2018520646A5 (enExample) | ||
| JP2012041342A5 (enExample) | ||
| AU2018240515A1 (en) | Nucleic acids encoding CRISPR-associated proteins and uses thereof | |
| MX2018011384A (es) | Arn de replicacion en trans. | |
| WO2017077329A3 (en) | Nucleic acids, peptides and methods | |
| JP2013126995A5 (enExample) | ||
| WO2011139379A3 (en) | A method of treating patients undergoing protein replacement therapy, gene replacement therapy, or other therapeutic modalities | |
| Kim et al. | Recent advances in gene therapy for cardiac tissue regeneration | |
| IN2014CN04734A (enExample) | ||
| Choong et al. | The roles of non-coding RNAs in cardiac regenerative medicine | |
| De Lázaro et al. | Engineering cell fate for tissue regeneration by in vivo transdifferentiation | |
| Zarudnaya et al. | Phylogenetic study on structural elements of HIV-1 poly (A) region. 1. PolyA and DSE hairpins | |
| Miura et al. | Cell-based and extracellular vesicle-based MSC therapies for acute radiation syndrome affecting organ systems | |
| Bao et al. | Genetically modified cell membrane proteins in tissue engineering and regenerative medicine | |
| Thi et al. | RNA therapeutics for regenerative medicine | |
| KR20220063252A (ko) | 혈관형성 섬유아세포 | |
| JPWO2017073689A1 (ja) | Ｄｎａ損傷を修復するｒｎａ分子 | |
| Gugjoo et al. | Mesenchymal stem cell genetic engineering and regenerative medicine | |
| Uspenskaya et al. | Intercellular Transport of Mitochondria: Molecular Mechanisms and Role in Maintaining Energy Homeostasis in Tissues |