HRP20100340T1 - Polipeptidi koji imaju antimikrobno djelovanje i polinukleotidi koji ih kodiraju - Google Patents
Polipeptidi koji imaju antimikrobno djelovanje i polinukleotidi koji ih kodiraju Download PDFInfo
- Publication number
- HRP20100340T1 HRP20100340T1 HR20100340T HRP20100340T HRP20100340T1 HR P20100340 T1 HRP20100340 T1 HR P20100340T1 HR 20100340 T HR20100340 T HR 20100340T HR P20100340 T HRP20100340 T HR P20100340T HR P20100340 T1 HRP20100340 T1 HR P20100340T1
- Authority
- HR
- Croatia
- Prior art keywords
- polypeptide according
- seq
- polypeptide
- acid sequence
- amino acids
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims abstract 22
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 22
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 22
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract 7
- 102000040430 polynucleotide Human genes 0.000 title claims 3
- 108091033319 polynucleotide Proteins 0.000 title claims 3
- 239000002157 polynucleotide Substances 0.000 title claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims abstract 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 8
- 150000001413 amino acids Chemical class 0.000 claims abstract 8
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000004599 antimicrobial Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Polipeptid koji ima antimikrobnu aktivnost, naznačen time što sadrži aminokiselinsku sekvencu koja ima najmanje 70% identičnosti sa aminokiselinama 1 do 21 iz SEQ ID NO: 2. Patent sadrži još 17 patentnih zahtjeva.
Claims (18)
1. Polipeptid koji ima antimikrobnu aktivnost, naznačen time što sadrži aminokiselinsku sekvencu koja ima najmanje 70% identičnosti sa aminokiselinama 1 do 21 iz SEQ ID NO: 2.
2. Polipeptid prema patentnom zahtjevu 1, naznačen time što aminokiselinska sekvenca ima najmanje 75% identičnosti sa aminokiselinama 1 do 21 iz SEQ ID NO:2.
3. Polipeptid prema bilo kojem od patentnih zahtjeva 1-2, naznačen time što aminokiselinska sekvenca ima najmanje 80% identičnosti sa aminokiselinama 1 do 21 iz SEQ ID NO: 2.
4. Polipeptid prema bilo kojem od patentnih zahtjeva 1-3, naznačen time što aminokiselinska sekvenca ima najmanje 85% identičnosti sa aminokiselinama 1 do 21 iz SEQ ID NO: 2.
5. Polipeptid prema bilo kojem od patentnih zahtjeva 1-4, naznačen time što aminokiselinska sekvenca ima najmanje 90% identičnosti sa aminokiselinama 1 do 21 iz SEQ ID NO: 2.
6. Polipeptid prema bilo kojem od patentnih zahtjeva 1-5, naznačen time što aminokiselinska sekvenca ima najmanje 95% identičnosti sa aminokiselinama 1 do 21 iz SEQ ID NO: 2.
7. Polipeptid prema patentnom zahtjevu 1, naznačen time što sadrži aminokiselinsku sekvencu SEQ ID NO: 2.
8. Polipeptid prema patentnom zahtjevu 7, naznačen time što se sastoji iz SEQ ID NO: 2.
9. Polipeptid prema patentnom zahtjevu 7, naznačen time što se sastoji od aminokiselina 1 do 21 iz SEQ ID NO: 2.
10. Izolirani polinukleotid naznačen time što sadrži nukleotidnu sekvencu koja kodira polipeptid prema bilo kojem od patentnih zahtjeva 1-9.
11. Konstrukt nukleinske kiseline, naznačen time što sadrži polinukleotid prema patentnom zahtjevu 10 funkcionalno vezan za jednu ili više kontrolnih sekvenci koje usmjeravaju proizvodnju polipeptida u ekspresijskom domaćinu.
12. Rekombinantni ekspresijski vektor, naznačen time što sadrži konstrukt nukleinske kiseline prema patentnom zahtjevu 11.
13. Rekombinantna stanica domaćin, naznačena time što sadrži konstrukt nukleinske kiseline prema patentnom zahtjevu 11.
14. Postupak za proizvodnju polipeptida prema bilo kojem od patentnih zahtjeva 1-9, naznačen time što sadrži
(a) kultivaciju stanice koja je u obliku svog divljeg tipa sposobna da proizvede polipeptid, ili kultivaciju stanice domaćina koja sadrži konstrukt nukleinske kiseline koji sadrži nukleotidnu sekvencu koja kodira polipeptid, pod uvjetima koji su pogodni za proizvodnju polipeptida; i
(b) rekuperiranje polipeptida.
15. Kompozicija, naznačena time što sadrži antimikrobni polipeptid prema bilo kojem od patentnih zahtjeva 1-9 i farmaceutski prihvatljiv nosač.
16. In vitro postupak za ubijanje ili inhibiciju rasta mikrobnih stanica, naznačen time što sadrži dovođenje u dodir mikrobnih stanica sa antimikrobnim polipeptidom prema bilo kojem od patentnih zahtjeva 1-9.
17. Antimikrobni polipeptid prema bilo kojem od patentnih zahtjeva 1-9, naznačen time što se koristi za primjenu kao lijek.
18. Primjena antimikrobnog polipeptida prema bilo kojem od patentnih zahtjeva 1-9, naznačen time što se koristi u pripremi veterinarskog ili humanog terapeutskog sredstva za liječenje mikorbne infekcije.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501190 | 2005-08-26 | ||
| PCT/EP2006/065561 WO2007023163A1 (en) | 2005-08-26 | 2006-08-22 | Polypeptides having antimicrobial activity and polynucleotides encoding same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100340T1 true HRP20100340T1 (hr) | 2010-07-31 |
Family
ID=37056517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100340T HRP20100340T1 (hr) | 2005-08-26 | 2010-06-15 | Polipeptidi koji imaju antimikrobno djelovanje i polinukleotidi koji ih kodiraju |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7745576B2 (hr) |
| EP (1) | EP1922333B1 (hr) |
| JP (2) | JP2009507474A (hr) |
| KR (1) | KR101362710B1 (hr) |
| CN (2) | CN102643337A (hr) |
| AP (1) | AP2008004415A0 (hr) |
| AR (1) | AR055394A1 (hr) |
| AT (1) | ATE462720T1 (hr) |
| AU (1) | AU2006283904B2 (hr) |
| BR (1) | BRPI0614968A2 (hr) |
| CA (1) | CA2620125C (hr) |
| CY (1) | CY1110024T1 (hr) |
| DE (1) | DE602006013330D1 (hr) |
| DK (1) | DK1922333T3 (hr) |
| ES (1) | ES2343586T3 (hr) |
| HR (1) | HRP20100340T1 (hr) |
| IL (1) | IL189135A0 (hr) |
| MX (1) | MX2008002485A (hr) |
| NO (1) | NO20081470L (hr) |
| NZ (1) | NZ565926A (hr) |
| PL (1) | PL1922333T3 (hr) |
| PT (1) | PT1922333E (hr) |
| RS (1) | RS51325B (hr) |
| RU (1) | RU2512525C2 (hr) |
| SI (1) | SI1922333T1 (hr) |
| TW (1) | TWI386416B (hr) |
| WO (1) | WO2007023163A1 (hr) |
| ZA (1) | ZA200801426B (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006013330D1 (de) * | 2005-08-26 | 2010-05-12 | Novozymes Adenium Biotech As | Polypeptide mit antimikrobieller aktivität und diese kodierende polynukleotide |
| TW200804594A (en) * | 2005-12-14 | 2008-01-16 | Novozymes As | Polypeptides having antimicrobial activity and polynucleotides encoding same |
| EP2248893A1 (en) | 2009-05-06 | 2010-11-10 | Novozymes A/S | DFPase Enzymes from Octopus Vulgaris |
| US8653024B2 (en) | 2009-12-11 | 2014-02-18 | Adenium Biotech Aps | Use of AMPs for treatment of UTI/cystitis |
| EP2336155A1 (en) | 2009-12-21 | 2011-06-22 | Centre National de la Recherche Scientifique (CNRS) | Antimicrobial peptides |
| US8835604B2 (en) * | 2010-06-12 | 2014-09-16 | Adenium Biotech Aos | Antimicrobial peptide variants and polynucleotides encoding same |
| US20130303726A1 (en) * | 2012-04-17 | 2013-11-14 | Chiesi Farmaceutici S.P.A. | Method for the preparation of surfactant peptides |
| US8670119B1 (en) | 2013-01-30 | 2014-03-11 | Hewlett-Packard Development Company, L.P. | Apparatus having surface-enhanced spectroscopy modules |
| CN106146629B (zh) * | 2015-04-21 | 2020-03-31 | 中国农业科学院饲料研究所 | 一组胰蛋白酶抗性抗菌肽及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| DK0765394T3 (da) | 1994-06-03 | 2001-12-10 | Novozymes As | Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse |
| AU2705895A (en) | 1994-06-30 | 1996-01-25 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
| AU6188599A (en) | 1998-10-26 | 2000-05-15 | Novozymes A/S | Constructing and screening a dna library of interest in filamentous fungal cells |
| CN100532561C (zh) | 1999-03-22 | 2009-08-26 | 诺沃奇梅兹有限公司 | 新的葡糖淀粉酶及编码它的核酸序列 |
| US6337317B1 (en) * | 2000-06-27 | 2002-01-08 | The University Of British Columbia | Antimicrobial peptides and methods of use thereof |
| RU2261866C1 (ru) * | 2004-02-10 | 2005-10-10 | Институт Биоорганической химии им. акад. М.М. Шемякина и Ю.А. Овчинникова Российской Академии Наук | ПЕПТИДЫ АРЕНИЦИНЫ, ВЫДЕЛЕННЫЕ ИЗ МОРСКОГО КОЛЬЧАТОГО ЧЕРВЯ ArenicolA marina, ОБЛАДАЮЩИЕ АНТИМИКРОБНЫМ ДЕЙСТВИЕМ |
| US7534762B2 (en) * | 2005-03-18 | 2009-05-19 | Novozymes A/S | Polypeptides having antimicrobial activity and polynucleotides encoding same |
| AR052947A1 (es) * | 2005-03-18 | 2007-04-11 | Novozymes As | Polipeptidos que tienen actividad antimicrobiana y polinucleotidos que codifican para los mismos |
| WO2007009978A1 (en) * | 2005-07-15 | 2007-01-25 | Novozymes A/S | Polypeptides having antimicrobial activity and polynucleotides encoding same |
| DE602006013330D1 (de) * | 2005-08-26 | 2010-05-12 | Novozymes Adenium Biotech As | Polypeptide mit antimikrobieller aktivität und diese kodierende polynukleotide |
| TW200804594A (en) * | 2005-12-14 | 2008-01-16 | Novozymes As | Polypeptides having antimicrobial activity and polynucleotides encoding same |
| RU2316590C1 (ru) * | 2006-06-16 | 2008-02-10 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pE-His8-TrxL-Ar2, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК, СОДЕРЖАЩИЙ АНТИМИКРОБНЫЙ ПЕПТИД АРЕНИЦИН МОРСКОГО КОЛЬЧАТОГО ЧЕРВЯ Arenicola marina, И ШТАММ Escherichia coli BL21(DE3)/pE-His8-TrxL-Ar2 - ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА, СОДЕРЖАЩЕГО АРЕНИЦИН |
| RU2316595C1 (ru) * | 2006-06-16 | 2008-02-10 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | Способ получения антимикробного пептида ареницина |
-
2006
- 2006-08-22 DE DE602006013330T patent/DE602006013330D1/de active Active
- 2006-08-22 CA CA2620125A patent/CA2620125C/en not_active Expired - Fee Related
- 2006-08-22 PL PL06792947T patent/PL1922333T3/pl unknown
- 2006-08-22 AT AT06792947T patent/ATE462720T1/de active
- 2006-08-22 NZ NZ565926A patent/NZ565926A/en not_active IP Right Cessation
- 2006-08-22 JP JP2008527463A patent/JP2009507474A/ja not_active Withdrawn
- 2006-08-22 AP AP2008004415A patent/AP2008004415A0/xx unknown
- 2006-08-22 KR KR1020087005788A patent/KR101362710B1/ko active IP Right Grant
- 2006-08-22 CN CN2012101037428A patent/CN102643337A/zh active Pending
- 2006-08-22 RU RU2008111504/10A patent/RU2512525C2/ru not_active IP Right Cessation
- 2006-08-22 SI SI200630620T patent/SI1922333T1/sl unknown
- 2006-08-22 MX MX2008002485A patent/MX2008002485A/es active IP Right Grant
- 2006-08-22 ES ES06792947T patent/ES2343586T3/es active Active
- 2006-08-22 AU AU2006283904A patent/AU2006283904B2/en not_active Ceased
- 2006-08-22 RS RSP-2010/0262A patent/RS51325B/sr unknown
- 2006-08-22 EP EP06792947A patent/EP1922333B1/en active Active
- 2006-08-22 WO PCT/EP2006/065561 patent/WO2007023163A1/en active Application Filing
- 2006-08-22 BR BRPI0614968-5A patent/BRPI0614968A2/pt not_active Application Discontinuation
- 2006-08-22 PT PT06792947T patent/PT1922333E/pt unknown
- 2006-08-22 DK DK06792947.1T patent/DK1922333T3/da active
- 2006-08-22 CN CN2006800307070A patent/CN101248085B/zh not_active Expired - Fee Related
- 2006-08-25 US US11/509,859 patent/US7745576B2/en not_active Expired - Fee Related
- 2006-08-25 TW TW095131272A patent/TWI386416B/zh not_active IP Right Cessation
- 2006-08-25 AR ARP060103709A patent/AR055394A1/es not_active Application Discontinuation
-
2008
- 2008-01-30 IL IL189135A patent/IL189135A0/en not_active IP Right Cessation
- 2008-02-12 ZA ZA200801426A patent/ZA200801426B/xx unknown
- 2008-03-25 NO NO20081470A patent/NO20081470L/no not_active Application Discontinuation
-
2010
- 2010-05-07 CY CY20101100402T patent/CY1110024T1/el unknown
- 2010-06-15 HR HR20100340T patent/HRP20100340T1/hr unknown
-
2012
- 2012-12-20 JP JP2012278182A patent/JP2013100301A/ja active Pending
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