HRP20110430T1 - Fsh glikozilacijski mutant - Google Patents
Fsh glikozilacijski mutant Download PDFInfo
- Publication number
- HRP20110430T1 HRP20110430T1 HR20110430T HRP20110430T HRP20110430T1 HR P20110430 T1 HRP20110430 T1 HR P20110430T1 HR 20110430 T HR20110430 T HR 20110430T HR P20110430 T HRP20110430 T HR P20110430T HR P20110430 T1 HRP20110430 T1 HR P20110430T1
- Authority
- HR
- Croatia
- Prior art keywords
- fsh
- seq
- sequence
- vector
- mutant
- Prior art date
Links
- 230000013595 glycosylation Effects 0.000 title abstract 2
- 238000006206 glycosylation reaction Methods 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 claims abstract 3
- 210000004027 cell Anatomy 0.000 claims 7
- 239000013598 vector Substances 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 6
- 102000002287 alpha Subunit Glycoprotein Hormones Human genes 0.000 claims 4
- 108010000732 alpha Subunit Glycoprotein Hormones Proteins 0.000 claims 4
- 102000035824 beta Subunit Follicle Stimulating Hormone Human genes 0.000 claims 4
- 108010081485 beta Subunit Follicle Stimulating Hormone Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 206010033266 Ovarian Hyperstimulation Syndrome Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000001186 cumulative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Rekombinantni FSH, naznačen time da FSH alfa podjedinica sadrži sekvencu sa SEQ ID NO: 3 i pri čemu FSH beta podjedinica sadrži sekvencu sa SEQ ID NO: 4. Patent sadrži još 12 patentnih zahtjeva.
Claims (13)
1. Rekombinantni FSH, naznačen time da FSH alfa podjedinica sadrži sekvencu sa SEQ ID NO: 3 i pri čemu FSH beta podjedinica sadrži sekvencu sa SEQ ID NO: 4.
2. Rekombinantni FSH prema zahtjevu 1 naznačen time da N55 iz beta podjedinice je glikoziliran.
3. Vektor koji kodira FSH alfa podjedinicu naznačen time da obuhvaća sekvencu sa SEQ ID NO:3 i FSH beta podjedinicu koja obuhvaća sekvencu sa SEQ ID NO: 4.
4. Vektor prema zahtjevu 3, naznačen time da navedeni vektor je ekspresijski vektor.
5. Izolirana stanica naznačena time da sadrži vektor prema zahtjevu 4.
6. Izolirana stanica naznačena time da sadrži prvi vektor koji obuhvaća DNA koji kodira FSH alfa podjedinicu koja obuhvaća sekvencu sa SEQ ID NO: 3 i drugi vektor obuhvaća DNA koji kodira FSH beta podjedinicu koja obuhvaća sekvencu sa SEQ ID NO: 4.
7. Stanica prema zahtjevu 6, naznačena time da prvi i drugi vektori su ekspresijski vektori.
8. Stanica prema zahtjevu 7, naznačena time da stanica je stanica sisavca.
9. Postupak za dobivanje FSH mutanta naznačen time da obuhvaća:
(a) pružanje stanica sisavca, pri čemu stanice sadrže prvi ekspresijski vektor i drugi ekspresijski vektor; i
(b) induciranja ekspresije FSH mutanta, pri čemu prvi ekspresijski vektor kodira FSH alfa podjedinicu koja obuhvaća sekvencu sa SEQ ID NO:3 i pri čemu drugi ekspresijski vektor kodira FSH beta podjedinicu koja obuhvaća sekvencu sa SEQ ID NO:4 i pri čemu su stanice sposobne za glikoziliranje proteina.
10. Pripravak naznačen time da sadrži rekombinantni FSH prema zahtjevu 1 i farmaceutski prihvatljiv nosač ili pomoćnu tvar.
11. Rekombinantni FSH mutant prema zahtjevu 1 naznačen time da je za upotrebu kod postupka liječenja neplodne životinje.
12. Rekombinantni FSH mutant prema zahtjevu 1 naznačen time da je za upotrebu kod postupka stimulacije folikulogeneze kod sisavca.
13. Rekombinantni FSH mutant prema zahtjevu 1 naznačen time da je za upotrebu kod postupka induciranja hiperstimulacije jajnika kod sisavca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49980203P | 2003-09-02 | 2003-09-02 | |
PCT/US2004/029042 WO2005020934A2 (en) | 2003-09-02 | 2004-09-02 | Fsh glycosylation mutant |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110430T1 true HRP20110430T1 (hr) | 2011-07-31 |
Family
ID=34272871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110430T HRP20110430T1 (hr) | 2003-09-02 | 2011-06-08 | Fsh glikozilacijski mutant |
Country Status (24)
Country | Link |
---|---|
US (1) | US7700112B2 (hr) |
EP (1) | EP1694271B1 (hr) |
JP (1) | JP4653090B2 (hr) |
KR (1) | KR101099809B1 (hr) |
CN (1) | CN1984926B (hr) |
AT (1) | ATE511829T1 (hr) |
AU (1) | AU2004268683B2 (hr) |
BR (1) | BRPI0413206A (hr) |
CA (1) | CA2535522A1 (hr) |
CY (1) | CY1112439T1 (hr) |
DK (1) | DK1694271T3 (hr) |
EA (1) | EA012175B1 (hr) |
ES (1) | ES2367784T3 (hr) |
HK (1) | HK1101315A1 (hr) |
HR (1) | HRP20110430T1 (hr) |
IL (1) | IL174037A0 (hr) |
MX (1) | MXPA06002119A (hr) |
NO (1) | NO20061446L (hr) |
PL (1) | PL1694271T3 (hr) |
PT (1) | PT1694271E (hr) |
SI (1) | SI1694271T1 (hr) |
UA (1) | UA88879C2 (hr) |
WO (1) | WO2005020934A2 (hr) |
ZA (1) | ZA200601803B (hr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1917276T1 (en) | 2005-08-26 | 2018-05-31 | Ares Trading S.A. | PROCEDURE FOR PREPARATION OF GLYCOSYLATED INTERFERONE BETA |
US8604175B2 (en) | 2005-12-09 | 2013-12-10 | Ares Trading S.A. | Method for purifying FSH or a FSH mutant |
WO2008010840A2 (en) * | 2005-12-22 | 2008-01-24 | Laboratoires Serono S.A. | Fsh mutants |
EA013974B1 (ru) * | 2006-01-17 | 2010-08-30 | Мерк Сероно С.А. | Мутантный fsh и способы его применения |
CN101679525B (zh) * | 2007-03-26 | 2013-06-19 | 诺瓦提斯公司 | 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签 |
AR081755A1 (es) | 2010-04-02 | 2012-10-17 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo |
CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
CA3160345A1 (en) * | 2019-11-06 | 2021-05-14 | The Regents Of The University Of Colorado, A Body Corporate | Modified follicle-stimulating hormone and methods of using the same |
CN114213523B (zh) * | 2021-11-15 | 2024-07-09 | 广州源博医药科技有限公司 | 一种用于重组蛋白的高糖基化修饰序列及其重组猪促卵泡激素和应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5156957A (en) | 1983-11-02 | 1992-10-20 | Genzyme Corporation | Follicle stimulating hormone |
US5639639A (en) | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
US4840896A (en) | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
US4845077A (en) | 1984-04-03 | 1989-07-04 | Serono Laboratories, Inc. | Method of inducing ovulation |
US4589402A (en) | 1984-07-26 | 1986-05-20 | Serono Laboratories, Inc. | Method of in vitro fertilization |
US5338835A (en) | 1989-02-21 | 1994-08-16 | Washington University | CTP-extended form of FSH |
EP0461200B1 (en) | 1989-02-21 | 1997-01-22 | Washington University | Modified forms of reproductive hormones |
US5508261A (en) | 1991-06-18 | 1996-04-16 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same |
US6407205B1 (en) | 1997-06-04 | 2002-06-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | FSH-releasing peptides |
AU8727798A (en) * | 1997-06-20 | 1999-01-04 | Akzo Nobel N.V. | Gonadotropin releasing hormone antagonist |
PT1102763E (pt) * | 1998-08-07 | 2005-01-31 | Applied Research Systems | Mimeticos fsh para o tratamento da infertilidade |
BR0107881A (pt) | 2000-01-27 | 2003-04-01 | Applied Research Systems | Uso de fsh tratamento de infertilidade |
US20020127652A1 (en) * | 2000-02-11 | 2002-09-12 | Schambye Hans Thalsgard | Follicle stimulating hormones |
WO2001058493A1 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
ES2389835T3 (es) | 2001-10-22 | 2012-11-02 | Merck Serono Sa | Glicoproteínas mutantes |
-
2004
- 2004-02-09 UA UAA200603350A patent/UA88879C2/ru unknown
- 2004-09-02 JP JP2006525513A patent/JP4653090B2/ja not_active Expired - Fee Related
- 2004-09-02 EA EA200600526A patent/EA012175B1/ru not_active IP Right Cessation
- 2004-09-02 MX MXPA06002119A patent/MXPA06002119A/es active IP Right Grant
- 2004-09-02 BR BRPI0413206-8A patent/BRPI0413206A/pt not_active IP Right Cessation
- 2004-09-02 ES ES04783331T patent/ES2367784T3/es active Active
- 2004-09-02 KR KR1020067004084A patent/KR101099809B1/ko not_active IP Right Cessation
- 2004-09-02 DK DK04783331.4T patent/DK1694271T3/da active
- 2004-09-02 ZA ZA200601803A patent/ZA200601803B/en unknown
- 2004-09-02 AT AT04783331T patent/ATE511829T1/de active
- 2004-09-02 WO PCT/US2004/029042 patent/WO2005020934A2/en active Application Filing
- 2004-09-02 CA CA002535522A patent/CA2535522A1/en not_active Abandoned
- 2004-09-02 AU AU2004268683A patent/AU2004268683B2/en not_active Ceased
- 2004-09-02 SI SI200431701T patent/SI1694271T1/sl unknown
- 2004-09-02 US US10/934,707 patent/US7700112B2/en not_active Expired - Fee Related
- 2004-09-02 PL PL04783331T patent/PL1694271T3/pl unknown
- 2004-09-02 CN CN2004800326655A patent/CN1984926B/zh not_active Expired - Fee Related
- 2004-09-02 PT PT04783331T patent/PT1694271E/pt unknown
- 2004-09-02 EP EP04783331A patent/EP1694271B1/en active Active
-
2006
- 2006-03-01 IL IL174037A patent/IL174037A0/en unknown
- 2006-03-30 NO NO20061446A patent/NO20061446L/no not_active Application Discontinuation
-
2007
- 2007-08-30 HK HK07109465.0A patent/HK1101315A1/xx not_active IP Right Cessation
-
2011
- 2011-06-08 HR HR20110430T patent/HRP20110430T1/hr unknown
- 2011-07-19 CY CY20111100704T patent/CY1112439T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1694271B1 (en) | 2011-06-08 |
EA012175B1 (ru) | 2009-08-28 |
WO2005020934A2 (en) | 2005-03-10 |
BRPI0413206A (pt) | 2006-10-03 |
UA88879C2 (en) | 2009-12-10 |
CN1984926A (zh) | 2007-06-20 |
ZA200601803B (en) | 2007-05-30 |
MXPA06002119A (es) | 2006-05-31 |
JP4653090B2 (ja) | 2011-03-16 |
US20050100989A1 (en) | 2005-05-12 |
KR20070029620A (ko) | 2007-03-14 |
EA200600526A1 (ru) | 2007-04-27 |
CN1984926B (zh) | 2012-04-11 |
ATE511829T1 (de) | 2011-06-15 |
NO20061446L (no) | 2006-03-30 |
SI1694271T1 (sl) | 2011-08-31 |
HK1101315A1 (en) | 2007-10-12 |
AU2004268683A2 (en) | 2005-03-10 |
WO2005020934A3 (en) | 2007-02-15 |
US7700112B2 (en) | 2010-04-20 |
PT1694271E (pt) | 2011-07-07 |
EP1694271A2 (en) | 2006-08-30 |
DK1694271T3 (da) | 2011-09-12 |
AU2004268683B2 (en) | 2010-06-24 |
PL1694271T3 (pl) | 2011-11-30 |
JP2007508245A (ja) | 2007-04-05 |
AU2004268683A1 (en) | 2005-03-10 |
ES2367784T3 (es) | 2011-11-08 |
IL174037A0 (en) | 2006-08-01 |
CY1112439T1 (el) | 2015-12-09 |
KR101099809B1 (ko) | 2011-12-27 |
CA2535522A1 (en) | 2005-03-10 |
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