BRPI0413206A - mutante de fsh por glicosilação - Google Patents

mutante de fsh por glicosilação

Info

Publication number
BRPI0413206A
BRPI0413206A BRPI0413206-8A BRPI0413206A BRPI0413206A BR PI0413206 A BRPI0413206 A BR PI0413206A BR PI0413206 A BRPI0413206 A BR PI0413206A BR PI0413206 A BRPI0413206 A BR PI0413206A
Authority
BR
Brazil
Prior art keywords
glycosylation
fsh
fsh mutant
mutant
lifes
Prior art date
Application number
BRPI0413206-8A
Other languages
English (en)
Inventor
Louise M Garone
Stephen J Arkinstall
William H Brondyk
Robert K Campbell
Xuliang Jiang
Sean D Mckenna
Mark Tepper
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BRPI0413206A publication Critical patent/BRPI0413206A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"MUTANTE DE FSH POR GLICOSILAçãO". A presente invenção refere-se a um novo mutante de FSH com aumento de glicosilação e meias-vidas mais longas para uso na indução de foliculogênese em pacientes humanos. O mutante de FSH permite o uso de doses cumulativas menores de FSH para obter o mesmo ou melhor resultado clínico.
BRPI0413206-8A 2003-09-02 2004-09-02 mutante de fsh por glicosilação BRPI0413206A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49980203P 2003-09-02 2003-09-02
PCT/US2004/029042 WO2005020934A2 (en) 2003-09-02 2004-09-02 Fsh glycosylation mutant

Publications (1)

Publication Number Publication Date
BRPI0413206A true BRPI0413206A (pt) 2006-10-03

Family

ID=34272871

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413206-8A BRPI0413206A (pt) 2003-09-02 2004-09-02 mutante de fsh por glicosilação

Country Status (24)

Country Link
US (1) US7700112B2 (pt)
EP (1) EP1694271B1 (pt)
JP (1) JP4653090B2 (pt)
KR (1) KR101099809B1 (pt)
CN (1) CN1984926B (pt)
AT (1) ATE511829T1 (pt)
AU (1) AU2004268683B2 (pt)
BR (1) BRPI0413206A (pt)
CA (1) CA2535522A1 (pt)
CY (1) CY1112439T1 (pt)
DK (1) DK1694271T3 (pt)
EA (1) EA012175B1 (pt)
ES (1) ES2367784T3 (pt)
HK (1) HK1101315A1 (pt)
HR (1) HRP20110430T1 (pt)
IL (1) IL174037A0 (pt)
MX (1) MXPA06002119A (pt)
NO (1) NO20061446L (pt)
PL (1) PL1694271T3 (pt)
PT (1) PT1694271E (pt)
SI (1) SI1694271T1 (pt)
UA (1) UA88879C2 (pt)
WO (1) WO2005020934A2 (pt)
ZA (1) ZA200601803B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101282990B (zh) 2005-08-26 2013-04-03 阿雷斯贸易股份有限公司 糖基化干扰素-β的制备方法
JP5199112B2 (ja) * 2005-12-09 2013-05-15 アレス トレーディング ソシエテ アノニム Ｆｓｈ又はｆｓｈ変異体を精製するための方法
KR20080087854A (ko) * 2005-12-22 2008-10-01 라보라토리스 세로노 에스.에이. Ｆｓｈ 변종
EP1981908B1 (en) * 2006-01-17 2010-11-10 Merck Serono SA Novel fsh glycosylation variant d3n
ES2532221T3 (es) * 2007-03-26 2015-03-25 Novartis Ag Biomarcadores de seguridad renal predictiva y señales de biomarcadores para monitorizar la función renal
AR081755A1 (es) 2010-04-02 2012-10-17 Hanmi Holdings Co Ltd Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
CN108676096B (zh) * 2018-05-22 2022-03-29 北京伟杰信生物科技有限公司 重组猪fsh-ctp融合蛋白及其制备方法与应用
WO2021092358A1 (en) * 2019-11-06 2021-05-14 The Regents Of The University Of Colorado, A Body Corporate Modified follicle-stimulating hormone and methods of using the same
CN114213523A (zh) * 2021-11-15 2022-03-22 广州源博医药科技有限公司 一种用于重组蛋白的高糖基化修饰序列及其重组猪促卵泡激素和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840896A (en) 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US5639639A (en) 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US5156957A (en) 1983-11-02 1992-10-20 Genzyme Corporation Follicle stimulating hormone
US4845077A (en) 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
US4589402A (en) 1984-07-26 1986-05-20 Serono Laboratories, Inc. Method of in vitro fertilization
US5338835A (en) 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
CA2053864C (en) 1989-02-21 2001-11-20 Irving Boime Modified forms of reproductive hormones
US5508261A (en) 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
US6407205B1 (en) * 1997-06-04 2002-06-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College FSH-releasing peptides
EP0994718B1 (en) * 1997-06-20 2005-08-17 Akzo Nobel N.V. Gonadotropin releasing hormone antagonist
IL141063A (en) * 1998-08-07 2005-06-19 Applied Research Systems Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility
CA2397680A1 (en) * 2000-01-27 2001-08-02 Applied Research Systems Ars Holding N.V. Use of fsh for treating infertility
US20020127652A1 (en) * 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
AU2001231531A1 (en) * 2000-02-11 2001-08-20 Maxygen Aps Follicle stimulating hormones
AU2002368265B2 (en) 2001-10-22 2007-06-07 Merck Serono Sa Mutant glycoproteins

Also Published As

Publication number Publication date
US20050100989A1 (en) 2005-05-12
MXPA06002119A (es) 2006-05-31
PT1694271E (pt) 2011-07-07
EP1694271A2 (en) 2006-08-30
CA2535522A1 (en) 2005-03-10
AU2004268683A2 (en) 2005-03-10
WO2005020934A3 (en) 2007-02-15
US7700112B2 (en) 2010-04-20
AU2004268683A1 (en) 2005-03-10
JP2007508245A (ja) 2007-04-05
PL1694271T3 (pl) 2011-11-30
AU2004268683B2 (en) 2010-06-24
WO2005020934A2 (en) 2005-03-10
ATE511829T1 (de) 2011-06-15
CY1112439T1 (el) 2015-12-09
IL174037A0 (en) 2006-08-01
HRP20110430T1 (hr) 2011-07-31
CN1984926B (zh) 2012-04-11
SI1694271T1 (sl) 2011-08-31
JP4653090B2 (ja) 2011-03-16
KR101099809B1 (ko) 2011-12-27
NO20061446L (no) 2006-03-30
CN1984926A (zh) 2007-06-20
HK1101315A1 (en) 2007-10-12
ZA200601803B (en) 2007-05-30
DK1694271T3 (da) 2011-09-12
ES2367784T3 (es) 2011-11-08
EA012175B1 (ru) 2009-08-28
EP1694271B1 (en) 2011-06-08
UA88879C2 (en) 2009-12-10
EA200600526A1 (ru) 2007-04-27
KR20070029620A (ko) 2007-03-14

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: LABORATOIRES SERONO S.A. (CH)

Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: MERCK SERONO S.A. (CH)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2269 DE 01/07/2014.