CY1112439T1 - Μεταλλαγμα fsh-γλυκοζυλιωσης - Google Patents

Μεταλλαγμα fsh-γλυκοζυλιωσης

Info

Publication number
CY1112439T1
CY1112439T1 CY20111100704T CY111100704T CY1112439T1 CY 1112439 T1 CY1112439 T1 CY 1112439T1 CY 20111100704 T CY20111100704 T CY 20111100704T CY 111100704 T CY111100704 T CY 111100704T CY 1112439 T1 CY1112439 T1 CY 1112439T1
Authority
CY
Cyprus
Prior art keywords
fsh
glycosylation
switch
mutant
lifes
Prior art date
Application number
CY20111100704T
Other languages
English (en)
Inventor
Louise M Garone
Stephen J Arkinstall
William H Brondyk
Robert K Campbell
Xuliang Jiang
Sean D Mckenna
Mark Tepper
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of CY1112439T1 publication Critical patent/CY1112439T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Περιγράφεται νέο FSH μετάλλαγμα με αυξημένη γλυκοζυλίωση και μακρύτερο χρόνο ζωής για χρήση στην επαγωγή ωοθυλακιογένεσης σε ασθενείς ανθρώπους. To FSH μετάλλαγμα επιτρέπει τη χρήση μικρότερων αθροιστικών δόσεων της FSH για την επίτευξη του ίδιου ή καλύτερο κλινικού αποτελέσματος.
CY20111100704T 2003-09-02 2011-07-19 Μεταλλαγμα fsh-γλυκοζυλιωσης CY1112439T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49980203P 2003-09-02 2003-09-02
EP04783331A EP1694271B1 (en) 2003-09-02 2004-09-02 Fsh glycosylation mutant

Publications (1)

Publication Number Publication Date
CY1112439T1 true CY1112439T1 (el) 2015-12-09

Family

ID=34272871

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100704T CY1112439T1 (el) 2003-09-02 2011-07-19 Μεταλλαγμα fsh-γλυκοζυλιωσης

Country Status (24)

Country Link
US (1) US7700112B2 (el)
EP (1) EP1694271B1 (el)
JP (1) JP4653090B2 (el)
KR (1) KR101099809B1 (el)
CN (1) CN1984926B (el)
AT (1) ATE511829T1 (el)
AU (1) AU2004268683B2 (el)
BR (1) BRPI0413206A (el)
CA (1) CA2535522A1 (el)
CY (1) CY1112439T1 (el)
DK (1) DK1694271T3 (el)
EA (1) EA012175B1 (el)
ES (1) ES2367784T3 (el)
HK (1) HK1101315A1 (el)
HR (1) HRP20110430T1 (el)
IL (1) IL174037A0 (el)
MX (1) MXPA06002119A (el)
NO (1) NO20061446L (el)
PL (1) PL1694271T3 (el)
PT (1) PT1694271E (el)
SI (1) SI1694271T1 (el)
UA (1) UA88879C2 (el)
WO (1) WO2005020934A2 (el)
ZA (1) ZA200601803B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1917276T3 (en) 2005-08-26 2018-05-07 Ares Trading Sa Process for Preparation of Glycosylated Interferon Beta
CA2625978A1 (en) 2005-12-09 2007-06-14 Ares Trading S.A. Method for purifying fsh or a fsh mutant
EP1976872B1 (en) * 2005-12-22 2015-06-17 Merck Serono SA Fsh mutants
EP1981908B1 (en) * 2006-01-17 2010-11-10 Merck Serono SA Novel fsh glycosylation variant d3n
EP2479564A3 (en) * 2007-03-26 2012-09-26 Novartis AG Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
AR081755A1 (es) 2010-04-02 2012-10-17 Hanmi Holdings Co Ltd Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
CN108676096B (zh) * 2018-05-22 2022-03-29 北京伟杰信生物科技有限公司 重组猪fsh-ctp融合蛋白及其制备方法与应用
WO2021092358A1 (en) * 2019-11-06 2021-05-14 The Regents Of The University Of Colorado, A Body Corporate Modified follicle-stimulating hormone and methods of using the same
CN114213523B (zh) * 2021-11-15 2024-07-09 广州源博医药科技有限公司 一种用于重组蛋白的高糖基化修饰序列及其重组猪促卵泡激素和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US5156957A (en) * 1983-11-02 1992-10-20 Genzyme Corporation Follicle stimulating hormone
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4845077A (en) * 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
US4589402A (en) * 1984-07-26 1986-05-20 Serono Laboratories, Inc. Method of in vitro fertilization
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
US5338835A (en) * 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
US6407205B1 (en) * 1997-06-04 2002-06-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College FSH-releasing peptides
US6653286B1 (en) * 1997-06-20 2003-11-25 Akzo Nobel Nv Gonadotropin releasing hormone antagonist
JP4511042B2 (ja) * 1998-08-07 2010-07-28 メルク セローノ ソシエテ アノニム 不妊症の治療のためのｆｓｈ模倣物
WO2001054715A1 (en) * 2000-01-27 2001-08-02 Applied Research Systems Ars Holding N.V. Use of fsh for treating infertility
US20020127652A1 (en) * 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
WO2001058493A1 (en) * 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
IL161541A0 (en) * 2001-10-22 2004-09-27 Applied Research Systems Mutant glycoproteins

Also Published As

Publication number Publication date
NO20061446L (no) 2006-03-30
AU2004268683B2 (en) 2010-06-24
AU2004268683A2 (en) 2005-03-10
DK1694271T3 (da) 2011-09-12
IL174037A0 (en) 2006-08-01
CN1984926A (zh) 2007-06-20
EA012175B1 (ru) 2009-08-28
EA200600526A1 (ru) 2007-04-27
WO2005020934A3 (en) 2007-02-15
UA88879C2 (en) 2009-12-10
MXPA06002119A (es) 2006-05-31
KR20070029620A (ko) 2007-03-14
JP4653090B2 (ja) 2011-03-16
US7700112B2 (en) 2010-04-20
CA2535522A1 (en) 2005-03-10
PT1694271E (pt) 2011-07-07
KR101099809B1 (ko) 2011-12-27
ES2367784T3 (es) 2011-11-08
ZA200601803B (en) 2007-05-30
BRPI0413206A (pt) 2006-10-03
SI1694271T1 (sl) 2011-08-31
ATE511829T1 (de) 2011-06-15
HRP20110430T1 (hr) 2011-07-31
AU2004268683A1 (en) 2005-03-10
EP1694271A2 (en) 2006-08-30
JP2007508245A (ja) 2007-04-05
CN1984926B (zh) 2012-04-11
PL1694271T3 (pl) 2011-11-30
EP1694271B1 (en) 2011-06-08
HK1101315A1 (en) 2007-10-12
US20050100989A1 (en) 2005-05-12
WO2005020934A2 (en) 2005-03-10

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