ATE430161T1 - Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendung - Google Patents

Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendung

Info

Publication number
ATE430161T1
ATE430161T1 AT01980380T AT01980380T ATE430161T1 AT E430161 T1 ATE430161 T1 AT E430161T1 AT 01980380 T AT01980380 T AT 01980380T AT 01980380 T AT01980380 T AT 01980380T AT E430161 T1 ATE430161 T1 AT E430161T1
Authority
AT
Austria
Prior art keywords
peptide
hsp70
stimulates
present
cell activity
Prior art date
Application number
AT01980380T
Other languages
English (en)
Inventor
Gabriele Multhoff
Original Assignee
Multimmune Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Multimmune Gmbh filed Critical Multimmune Gmbh
Application granted granted Critical
Publication of ATE430161T1 publication Critical patent/ATE430161T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/07—Heat shock proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01980380T 2000-09-13 2001-09-13 Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendung ATE430161T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00119933 2000-09-13
PCT/EP2001/010593 WO2002022656A2 (en) 2000-09-13 2001-09-13 An hsp70 peptide stimulating natural killer (nk) cell activity and uses thereof
BE2009/0695A BE1019732A4 (fr) 2000-09-13 2009-11-12 Peptide de hsp70 simulant l'activite de cellules tueuses naturelles (nk) et ses utilisations.

Publications (1)

Publication Number Publication Date
ATE430161T1 true ATE430161T1 (de) 2009-05-15

Family

ID=47436345

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01980380T ATE430161T1 (de) 2000-09-13 2001-09-13 Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendung

Country Status (8)

Country Link
US (2) US7517948B2 (de)
EP (1) EP1319023B8 (de)
AT (1) ATE430161T1 (de)
AU (1) AU2002212236A1 (de)
BE (1) BE1019732A4 (de)
DE (1) DE60138558D1 (de)
ES (1) ES2326114T3 (de)
WO (1) WO2002022656A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022656A2 (en) * 2000-09-13 2002-03-21 Gabriele Multhoff An hsp70 peptide stimulating natural killer (nk) cell activity and uses thereof
IL148401A0 (en) * 2002-02-26 2002-09-12 Hadasit Med Res Service Hsp70-derived peptides and uses thereof in the diagnosis and treatment of autoimmune diseases
ATE457349T1 (de) * 2002-08-23 2010-02-15 Multhoff Gabriele Prof Dr Granzyme b als ein hsp70/hsp70 peptid-abhängige apoptoseauslöser in tumorzellen
WO2005054868A1 (en) * 2003-12-05 2005-06-16 Multimmune Gmbh Compositions and methods for the treatment and diagnosis of neoplastic and infectious diseases
ES2484340T3 (es) * 2003-12-05 2014-08-11 Multimmune Gmbh Anticuerpos anti hsp70 terapéuticos y diagnósticos
CA2702370A1 (en) * 2006-11-14 2008-05-22 Ralf Dressel Compositions and methods for immunotherapy
GB0705626D0 (en) * 2007-03-23 2007-05-02 Royal Veterinary College Method for enhancing sperm survival
HUE025852T2 (en) 2008-06-26 2016-04-28 Orphazyme Aps Use of HSP70 to regulate enzyme activity
WO2012023631A1 (ja) * 2010-08-19 2012-02-23 株式会社Eci ヒートショックプロテイン（ｈｓｐ）とｅｃｉ３０１ポリペプチドを含む癌細胞の増殖を抑制するための医薬組成物ならびにそれを用いた癌の治療方法
RU2013125923A (ru) 2010-11-30 2015-01-10 Орфазиме Апс СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
US20160000777A1 (en) * 2013-02-21 2016-01-07 University Of Rochester Methods of using histamine receptor agonists and antagonists
PL3193840T3 (pl) 2014-09-15 2021-12-06 Orphazyme A/S Preparat arimoklomolu
CA3116265A1 (en) 2014-10-07 2016-04-14 Cytlimic Inc. Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell
MX2017009181A (es) 2015-01-26 2017-11-22 Cellectis Receptores de antigenos quimericos de cadena sencilla especificos de anti-cll1 para inmunoterapia de cancer.
EP3797794A1 (de) 2015-04-07 2021-03-31 Cytlimic Inc. Medizin enthaltend einen toll like rezeptor 3 agonisten und ein lag-3 protein
WO2017156461A2 (en) 2016-03-10 2017-09-14 Aperisys, Inc. Antigen-binding fusion proteins with modified hsp70 domains
EP3442530A1 (de) 2016-04-13 2019-02-20 Orphazyme A/S Hitzeschockproteinen und cholesterinhomöostase
RS61291B1 (sr) 2016-04-29 2021-02-26 Orphazyme As Arimoklomol za lečenje poremećaja povezanih sa glukocerebrozidazom
WO2018037042A1 (en) * 2016-08-23 2018-03-01 Aimvion A/S Novel immunostimulating peptides
CN106317216B (zh) * 2016-09-21 2019-07-19 南京农业大学 一种促进h9n2禽流感疫苗免疫效果的活性肽及应用
WO2018070069A1 (ja) 2016-10-11 2018-04-19 サイトリミック株式会社 医薬
US12053505B2 (en) * 2017-08-31 2024-08-06 Multimmune Gmbh Hsp70 based combination therapy
MX2023005954A (es) 2020-11-19 2023-09-04 Zevra Denmark As Procesos para preparar citrato de arimoclomol e intermediarios del mismo.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268478B1 (en) * 1996-02-12 2001-07-31 Cedars-Sinai Medical Center Intracellular vitamin D binding protein
DE59912185D1 (de) 1998-03-27 2005-07-21 Multhoff Gabriele Verwendung von hsp70 protein
CN1057363C (zh) 1998-07-10 2000-10-11 贺德新 一种液压挤扩装置
DE69941156D1 (de) * 1998-11-24 2009-09-03 Bristol Myers Squibb Co Intranukleärer, gerichteter transport von verbindungen durch das 70kd-hitzeschockprotein
WO2002022656A2 (en) * 2000-09-13 2002-03-21 Gabriele Multhoff An hsp70 peptide stimulating natural killer (nk) cell activity and uses thereof

Also Published As

Publication number Publication date
EP1319023A2 (de) 2003-06-18
US7517948B2 (en) 2009-04-14
ES2326114T3 (es) 2009-10-01
US20090239802A1 (en) 2009-09-24
AU2002212236A1 (en) 2002-03-26
DE60138558D1 (de) 2009-06-10
EP1319023B1 (de) 2009-04-29
WO2002022656A3 (en) 2002-09-26
US7745399B2 (en) 2010-06-29
US20040063173A1 (en) 2004-04-01
BE1019732A4 (fr) 2012-12-04
EP1319023B8 (de) 2009-07-15
WO2002022656A2 (en) 2002-03-21

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