DE60138558D1 - Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendung - Google Patents
Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendungInfo
- Publication number
- DE60138558D1 DE60138558D1 DE60138558T DE60138558T DE60138558D1 DE 60138558 D1 DE60138558 D1 DE 60138558D1 DE 60138558 T DE60138558 T DE 60138558T DE 60138558 T DE60138558 T DE 60138558T DE 60138558 D1 DE60138558 D1 DE 60138558D1
- Authority
- DE
- Germany
- Prior art keywords
- peptide
- paces
- cell activity
- present
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 10
- 210000000822 natural killer cell Anatomy 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 101710163595 Chaperone protein DnaK Proteins 0.000 title 1
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 title 1
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 230000004927 fusion Effects 0.000 abstract 2
- 230000003308 immunostimulating effect Effects 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/07—Heat shock proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00119933 | 2000-09-13 | ||
PCT/EP2001/010593 WO2002022656A2 (en) | 2000-09-13 | 2001-09-13 | An hsp70 peptide stimulating natural killer (nk) cell activity and uses thereof |
BE2009/0695A BE1019732A4 (fr) | 2000-09-13 | 2009-11-12 | Peptide de hsp70 simulant l'activite de cellules tueuses naturelles (nk) et ses utilisations. |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60138558D1 true DE60138558D1 (de) | 2009-06-10 |
Family
ID=47436345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60138558T Expired - Lifetime DE60138558D1 (de) | 2000-09-13 | 2001-09-13 | Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendung |
Country Status (8)
Country | Link |
---|---|
US (2) | US7517948B2 (de) |
EP (1) | EP1319023B8 (de) |
AT (1) | ATE430161T1 (de) |
AU (1) | AU2002212236A1 (de) |
BE (1) | BE1019732A4 (de) |
DE (1) | DE60138558D1 (de) |
ES (1) | ES2326114T3 (de) |
WO (1) | WO2002022656A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7517948B2 (en) * | 2000-09-13 | 2009-04-14 | Multimmune Gmbh | Hsp70 peptide stimulating natural killer (NK) cell activity and uses thereof |
IL148401A0 (en) * | 2002-02-26 | 2002-09-12 | Hadasit Med Res Service | Hsp70-derived peptides and uses thereof in the diagnosis and treatment of autoimmune diseases |
SI1537204T1 (sl) * | 2002-08-23 | 2010-06-30 | Gabriele Prof Dr Multhoff | Granzim b kot povzročitelj apoptoze odvisen od peptida Hsp Hsp v tumorskih celicah |
JP4898452B2 (ja) * | 2003-12-05 | 2012-03-14 | マルチミューン ジーエムビーエイチ | 治療および診断用抗Hsp70抗体 |
WO2005054868A1 (en) * | 2003-12-05 | 2005-06-16 | Multimmune Gmbh | Compositions and methods for the treatment and diagnosis of neoplastic and infectious diseases |
JP2010509257A (ja) * | 2006-11-14 | 2010-03-25 | ゲオルグ−アウグスト−ウニヴェルズテート ゲッティンゲン シュティフトゥング オッフェントリヒェン レヒツ | 免疫療法のための組成物および方法 |
GB0705626D0 (en) * | 2007-03-23 | 2007-05-02 | Royal Veterinary College | Method for enhancing sperm survival |
ES2532083T3 (es) | 2008-06-26 | 2015-03-24 | Orphazyme Aps | Uso de Hsp70 como regulador de la actividad enzimática |
WO2012023631A1 (ja) * | 2010-08-19 | 2012-02-23 | 株式会社Eci | ヒートショックプロテイン(hsp)とeci301ポリペプチドを含む癌細胞の増殖を抑制するための医薬組成物ならびにそれを用いた癌の治療方法 |
CN103338784A (zh) | 2010-11-30 | 2013-10-02 | 奥菲泽米有限公司 | 用于增加Hsp70细胞内活性的方法 |
WO2014130759A1 (en) * | 2013-02-21 | 2014-08-28 | University Of Rochester | Methods of using histamine receptor agonists and antagonists |
JP6678676B2 (ja) | 2014-09-15 | 2020-04-08 | オーファザイム エー/エス | アリモクロモル製剤 |
AU2015329070B2 (en) | 2014-10-07 | 2018-11-22 | Nec Corporation | Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell |
RU2732925C2 (ru) | 2015-01-26 | 2020-09-24 | Селлектис | МАт-НАПРАВЛЯЕМЫЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРНЫЕ СИСТЕМЫ ДЛЯ СОРТИРОВКИ/ИСТОЩЕНИЯ СКОНСТРУИРОВАННЫХ ИММУННЫХ КЛЕТОК |
TWI738646B (zh) | 2015-04-07 | 2021-09-11 | 日商賽多利克公司 | 醫藥組成物 |
MX2018010961A (es) * | 2016-03-10 | 2019-03-28 | Aperisys Inc | Proteínas de fusión de unión a antígeno con dominios de proteína de choque térmico de 70 kilodaltons (hsp70) modificada. |
EP3442530A1 (de) | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Hitzeschockproteinen und cholesterinhomöostase |
WO2017186919A1 (en) | 2016-04-29 | 2017-11-02 | Orphazyme Aps | Arimoclomol for treating glucocerebrosidase associated disorders |
EP3504224A1 (de) * | 2016-08-23 | 2019-07-03 | Aimvion A/S | Neuartige immunstimulierende peptide |
CN106317216B (zh) * | 2016-09-21 | 2019-07-19 | 南京农业大学 | 一种促进h9n2禽流感疫苗免疫效果的活性肽及应用 |
EP3527216B1 (de) | 2016-10-11 | 2024-02-14 | NEC Corporation | Arzneimittel, das einen toll-like-rezeptor-agonist, lag-3-protein, ein derivat des hsp70 peptids und ein derivat des gpc3 peptids |
EP3675877A1 (de) * | 2017-08-31 | 2020-07-08 | Multimmune GmbH | Hsp70-basierte kombinationstherapie |
IL303026A (en) | 2020-11-19 | 2023-07-01 | Zevra Denmark As | Processes for preparing arimoclomol citrate and its intermediates |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6268478B1 (en) * | 1996-02-12 | 2001-07-31 | Cedars-Sinai Medical Center | Intracellular vitamin D binding protein |
WO1999049881A2 (de) * | 1998-03-27 | 1999-10-07 | Gabriele Multhoff | Verwendung von hsp70 protein |
CN1057363C (zh) | 1998-07-10 | 2000-10-11 | 贺德新 | 一种液压挤扩装置 |
JP4892132B2 (ja) * | 1998-11-24 | 2012-03-07 | ブリストル−マイヤーズ スクイブ カンパニー | 70kD熱ショック蛋白による化合物の細胞内標的輸送 |
US7517948B2 (en) * | 2000-09-13 | 2009-04-14 | Multimmune Gmbh | Hsp70 peptide stimulating natural killer (NK) cell activity and uses thereof |
-
2001
- 2001-09-13 US US10/380,408 patent/US7517948B2/en not_active Expired - Lifetime
- 2001-09-13 AU AU2002212236A patent/AU2002212236A1/en not_active Abandoned
- 2001-09-13 AT AT01980380T patent/ATE430161T1/de active
- 2001-09-13 ES ES01980380T patent/ES2326114T3/es not_active Expired - Lifetime
- 2001-09-13 EP EP01980380A patent/EP1319023B8/de not_active Expired - Lifetime
- 2001-09-13 DE DE60138558T patent/DE60138558D1/de not_active Expired - Lifetime
- 2001-09-13 WO PCT/EP2001/010593 patent/WO2002022656A2/en active Application Filing
-
2009
- 2009-03-02 US US12/395,818 patent/US7745399B2/en not_active Expired - Fee Related
- 2009-11-12 BE BE2009/0695A patent/BE1019732A4/fr active
Also Published As
Publication number | Publication date |
---|---|
US7745399B2 (en) | 2010-06-29 |
US20090239802A1 (en) | 2009-09-24 |
EP1319023A2 (de) | 2003-06-18 |
ATE430161T1 (de) | 2009-05-15 |
US20040063173A1 (en) | 2004-04-01 |
BE1019732A4 (fr) | 2012-12-04 |
EP1319023B1 (de) | 2009-04-29 |
EP1319023B8 (de) | 2009-07-15 |
US7517948B2 (en) | 2009-04-14 |
ES2326114T3 (es) | 2009-10-01 |
AU2002212236A1 (en) | 2002-03-26 |
WO2002022656A2 (en) | 2002-03-21 |
WO2002022656A3 (en) | 2002-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: MULTIMMUNE GMBH C/O STRAHLENTHERAPIE DER TU MU, DE |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: MULTIMMUNE GMBH, 80634 MUENCHEN, DE |
|
8364 | No opposition during term of opposition |