SI1537204T1 - Granzim b kot povzročitelj apoptoze odvisen od peptida Hsp Hsp v tumorskih celicah - Google Patents
Granzim b kot povzročitelj apoptoze odvisen od peptida Hsp Hsp v tumorskih celicahInfo
- Publication number
- SI1537204T1 SI1537204T1 SI200331798T SI200331798T SI1537204T1 SI 1537204 T1 SI1537204 T1 SI 1537204T1 SI 200331798 T SI200331798 T SI 200331798T SI 200331798 T SI200331798 T SI 200331798T SI 1537204 T1 SI1537204 T1 SI 1537204T1
- Authority
- SI
- Slovenia
- Prior art keywords
- hsp70
- granzyme
- tumor cells
- apoptosis
- cells
- Prior art date
Links
- 102000001398 Granzyme Human genes 0.000 title abstract 3
- 108060005986 Granzyme Proteins 0.000 title abstract 3
- 210000004881 tumor cell Anatomy 0.000 title abstract 2
- 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 title 2
- 101150031823 HSP70 gene Proteins 0.000 title 2
- 101150052825 dnaK gene Proteins 0.000 title 2
- 230000006907 apoptotic process Effects 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 239000000411 inducer Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464476—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6467—Granzymes, e.g. granzyme A (3.4.21.78); granzyme B (3.4.21.79)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/50—Colon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/07—Heat shock proteins
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02018284 | 2002-08-23 | ||
| PCT/EP2003/009341 WO2004018002A2 (en) | 2002-08-23 | 2003-08-22 | Use of granzyme b as an hsp70/hsp70 peptide dependent inducer of apoptosis in tumor cells |
| EP03792414A EP1537204B1 (en) | 2002-08-23 | 2003-08-22 | Granzyme b as an hsp70/hsp70 peptide dependent inducer of apoptosis in tumor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1537204T1 true SI1537204T1 (sl) | 2010-06-30 |
Family
ID=31896833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331798T SI1537204T1 (sl) | 2002-08-23 | 2003-08-22 | Granzim b kot povzročitelj apoptoze odvisen od peptida Hsp Hsp v tumorskih celicah |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7722863B2 (sl) |
| EP (1) | EP1537204B1 (sl) |
| JP (1) | JP4699755B2 (sl) |
| AT (1) | ATE457349T1 (sl) |
| AU (1) | AU2003260452A1 (sl) |
| CA (1) | CA2535952A1 (sl) |
| CY (1) | CY1110005T1 (sl) |
| DE (1) | DE60331228D1 (sl) |
| DK (1) | DK1537204T3 (sl) |
| ES (1) | ES2340270T3 (sl) |
| PT (1) | PT1537204E (sl) |
| SI (1) | SI1537204T1 (sl) |
| WO (1) | WO2004018002A2 (sl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010509257A (ja) * | 2006-11-14 | 2010-03-25 | ゲオルグ−アウグスト−ウニヴェルズテート ゲッティンゲン シュティフトゥング オッフェントリヒェン レヒツ | 免疫療法のための組成物および方法 |
| KR101192724B1 (ko) | 2010-02-04 | 2012-10-18 | 한국생명공학연구원 | 마이크로알엔에이의 발현을 조절하여 ｎｋ 세포를 활성화시키는 방법 |
| SG187846A1 (en) | 2010-08-20 | 2013-03-28 | Immunovative Therapies Ltd | Cells expressing th1 characteristics and cytolytic properties |
| US11559590B2 (en) | 2016-07-01 | 2023-01-24 | The General Hospital Corporation | Granzyme B directed imaging and therapy |
| WO2019043170A1 (en) * | 2017-08-31 | 2019-03-07 | Multimmune Gmbh | POLY THERAPY BASED ON HSP70 |
| CN115477705B (zh) * | 2021-06-16 | 2024-02-23 | 四川大学华西医院 | 一种基于颗粒酶b构建的嵌合抗原受体免疫细胞制备及其应用 |
| CN115305238B (zh) * | 2022-09-19 | 2023-11-17 | 杭州凤喆凰生物科技有限公司 | 一种提高自然杀伤细胞杀伤力的成分在自然杀伤细胞培养中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6130087A (en) * | 1996-10-07 | 2000-10-10 | Fordham University | Methods for generating cytotoxic T cells in vitro |
| EP1007723A4 (en) * | 1997-08-18 | 2001-11-28 | Blood Res Center | METHOD OF USING GRANZYMES AND FIXING MOLECULES THEREOF FOR TREATING DISEASES CHARACTERIZED BY ABNORMAL APOPTOSIS |
| EP1056877A1 (en) * | 1998-02-27 | 2000-12-06 | Boehringer Ingelheim Pharmaceuticals Inc. | Self-regulated apoptosis of inflammatory cells by gene therapy |
| DE19813759C1 (de) * | 1998-03-27 | 1999-07-15 | Gsf Forschungszentrum Umwelt | Verfahren zur Induktion einer durch NK-Zellen vermittelten Immunantwort |
| CA2325735C (en) * | 1998-03-27 | 2013-06-04 | Gabriele Multhoff | Hsp70 protein for the treatment of tumours, cancer or infectious diseases through nk-cell activation |
| FR2792205B1 (fr) * | 1999-04-19 | 2001-07-27 | Inst Nat Sante Rech Med | Composition pharmaceutique comprenant des cellules nkt activees par des pim, et son utilisation en therapie |
| WO2001080880A2 (de) * | 2000-04-22 | 2001-11-01 | Stefan Barth | Apoptotika |
| WO2001091798A2 (en) * | 2000-06-01 | 2001-12-06 | Universite Catholique De Louvain | Tumor activated prodrug compounds |
| US20040014652A1 (en) * | 2000-06-01 | 2004-01-22 | Andre Trouet | Tumor activated prodrug compounds and methods of making and using the same |
| DE60138558D1 (de) * | 2000-09-13 | 2009-06-10 | Multimmune Gmbh | Peptid aus hsp70 welches nk zellaktivtät stimuliert und seine verwendung |
| WO2003007889A2 (en) * | 2001-07-17 | 2003-01-30 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
-
2003
- 2003-08-22 ES ES03792414T patent/ES2340270T3/es not_active Expired - Lifetime
- 2003-08-22 SI SI200331798T patent/SI1537204T1/sl unknown
- 2003-08-22 WO PCT/EP2003/009341 patent/WO2004018002A2/en active Application Filing
- 2003-08-22 DE DE60331228T patent/DE60331228D1/de not_active Expired - Lifetime
- 2003-08-22 AU AU2003260452A patent/AU2003260452A1/en not_active Abandoned
- 2003-08-22 AT AT03792414T patent/ATE457349T1/de active
- 2003-08-22 CA CA002535952A patent/CA2535952A1/en not_active Abandoned
- 2003-08-22 JP JP2004530248A patent/JP4699755B2/ja not_active Expired - Fee Related
- 2003-08-22 US US10/526,586 patent/US7722863B2/en not_active Expired - Fee Related
- 2003-08-22 EP EP03792414A patent/EP1537204B1/en not_active Expired - Lifetime
- 2003-08-22 PT PT03792414T patent/PT1537204E/pt unknown
- 2003-08-22 DK DK03792414.9T patent/DK1537204T3/da active
-
2010
- 2010-05-10 CY CY20101100406T patent/CY1110005T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004018002A3 (en) | 2004-06-17 |
| CA2535952A1 (en) | 2004-03-04 |
| AU2003260452A1 (en) | 2004-03-11 |
| CY1110005T1 (el) | 2015-01-14 |
| ATE457349T1 (de) | 2010-02-15 |
| EP1537204A2 (en) | 2005-06-08 |
| EP1537204B1 (en) | 2010-02-10 |
| DE60331228D1 (de) | 2010-03-25 |
| US20060111285A1 (en) | 2006-05-25 |
| PT1537204E (pt) | 2010-05-05 |
| JP2006507810A (ja) | 2006-03-09 |
| US7722863B2 (en) | 2010-05-25 |
| JP4699755B2 (ja) | 2011-06-15 |
| WO2004018002A2 (en) | 2004-03-04 |
| DK1537204T3 (da) | 2010-06-07 |
| AU2003260452A8 (en) | 2004-03-11 |
| ES2340270T3 (es) | 2010-06-01 |
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