JP2013106616A5 - - Google Patents
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- JP2013106616A5 JP2013106616A5 JP2013040650A JP2013040650A JP2013106616A5 JP 2013106616 A5 JP2013106616 A5 JP 2013106616A5 JP 2013040650 A JP2013040650 A JP 2013040650A JP 2013040650 A JP2013040650 A JP 2013040650A JP 2013106616 A5 JP2013106616 A5 JP 2013106616A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- oligopeptide
- cell culture
- culture medium
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002609 medium Substances 0.000 claims 10
- 239000006143 cell culture medium Substances 0.000 claims 8
- 108010038807 Oligopeptides Proteins 0.000 claims 6
- 102000015636 Oligopeptides Human genes 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 229920000768 polyamine Polymers 0.000 claims 4
- 108010024636 Glutathione Proteins 0.000 claims 2
- VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims 2
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims 2
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims 2
- QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 claims 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 239000005700 Putrescine Substances 0.000 claims 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 claims 1
- QYPPJABKJHAVHS-UHFFFAOYSA-P agmatinium(2+) Chemical compound NC(=[NH2+])NCCCC[NH3+] QYPPJABKJHAVHS-UHFFFAOYSA-P 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 239000012928 buffer substance Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940063673 spermidine Drugs 0.000 claims 1
- 229940063675 spermine Drugs 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75641906P | 2006-01-04 | 2006-01-04 | |
| US60/756,419 | 2006-01-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548995A Division JP5259418B2 (ja) | 2006-01-04 | 2007-01-03 | 無オリゴペプチド細胞培地 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014210677A Division JP2015006209A (ja) | 2006-01-04 | 2014-10-15 | 無オリゴペプチド細胞培地 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013106616A JP2013106616A (ja) | 2013-06-06 |
| JP2013106616A5 true JP2013106616A5 (https=) | 2014-05-08 |
Family
ID=37942126
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548995A Active JP5259418B2 (ja) | 2006-01-04 | 2007-01-03 | 無オリゴペプチド細胞培地 |
| JP2013040650A Withdrawn JP2013106616A (ja) | 2006-01-04 | 2013-03-01 | 無オリゴペプチド細胞培地 |
| JP2014210677A Withdrawn JP2015006209A (ja) | 2006-01-04 | 2014-10-15 | 無オリゴペプチド細胞培地 |
| JP2016254914A Active JP6567490B2 (ja) | 2006-01-04 | 2016-12-28 | 無オリゴペプチド細胞培地 |
| JP2018001241A Withdrawn JP2018075032A (ja) | 2006-01-04 | 2018-01-09 | 無オリゴペプチド細胞培地 |
| JP2019216735A Active JP7134157B2 (ja) | 2006-01-04 | 2019-11-29 | 無オリゴペプチド細胞培地 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548995A Active JP5259418B2 (ja) | 2006-01-04 | 2007-01-03 | 無オリゴペプチド細胞培地 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014210677A Withdrawn JP2015006209A (ja) | 2006-01-04 | 2014-10-15 | 無オリゴペプチド細胞培地 |
| JP2016254914A Active JP6567490B2 (ja) | 2006-01-04 | 2016-12-28 | 無オリゴペプチド細胞培地 |
| JP2018001241A Withdrawn JP2018075032A (ja) | 2006-01-04 | 2018-01-09 | 無オリゴペプチド細胞培地 |
| JP2019216735A Active JP7134157B2 (ja) | 2006-01-04 | 2019-11-29 | 無オリゴペプチド細胞培地 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20070212770A1 (https=) |
| EP (4) | EP3653699A1 (https=) |
| JP (6) | JP5259418B2 (https=) |
| KR (2) | KR101422435B1 (https=) |
| CN (2) | CN102643777A (https=) |
| AU (1) | AU2007204044B2 (https=) |
| CA (1) | CA2633306A1 (https=) |
| CY (1) | CY1119046T1 (https=) |
| DK (3) | DK1974014T3 (https=) |
| ES (3) | ES2474573T3 (https=) |
| HU (1) | HUE032744T2 (https=) |
| LT (1) | LT1974014T (https=) |
| PL (3) | PL3121266T3 (https=) |
| PT (3) | PT2522717E (https=) |
| RU (3) | RU2486236C2 (https=) |
| SI (1) | SI2522717T1 (https=) |
| WO (1) | WO2007077217A2 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3653699A1 (en) | 2006-01-04 | 2020-05-20 | Baxalta Incorporated | Oligopeptide-free cell culture media |
| PL2235197T3 (pl) | 2007-12-27 | 2018-01-31 | Baxalta GmbH | Sposoby hodowli komórek |
| ES2735173T3 (es) * | 2007-12-31 | 2019-12-16 | Baxalta GmbH | Furina recombinante sustancialmente libre de proteína animal y métodos para producir la misma |
| JP5431361B2 (ja) * | 2008-01-09 | 2014-03-05 | セルカ ゲーエムベーハー | 改善された培養培地添加物及びそれを用いる方法 |
| AU2009244776B2 (en) * | 2008-02-25 | 2013-03-07 | Nanotherapeutics, Inc. | Method for producing continuous cell lines |
| CA2742107A1 (en) | 2008-11-12 | 2010-05-20 | Baxter International Inc. | Method of producing serum-free insulin-free factor vii |
| US8580554B2 (en) * | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| CN104962539B (zh) | 2009-07-31 | 2019-09-17 | 百深公司 | 用于adamts蛋白表达的细胞培养基 |
| HUE028688T2 (en) | 2009-09-21 | 2017-01-30 | Baxalta GmbH | Stabilized liquid and lyophilized adamts13 formulations |
| SG185037A1 (en) | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell culture medium |
| CA2805557A1 (en) | 2010-07-08 | 2012-01-12 | Baxter International Inc. | Method of producing recombinant high molecular weight vwf in cell culture |
| CA2810731A1 (en) | 2010-09-17 | 2012-03-22 | Baxter International Inc. | Stabilization of immunoglobulins and other proteins through aqueous formulation with sodium chloride at weak acidic to neutral ph |
| BR112013010362A2 (pt) | 2010-10-27 | 2016-08-02 | Baxter Healthcare Sa | métodos para induzir uma tolerância imune a fviii, para fazer um peptídeo fviii, e para identificar uma célula t específica de peptídeo fvii, peptídeo, composição, e, proteína de fusão |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| ES2682249T3 (es) | 2011-06-10 | 2018-09-19 | Baxalta GmbH | Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| EP2906683B1 (en) | 2012-10-15 | 2017-05-31 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| AR095196A1 (es) * | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| KR101641655B1 (ko) * | 2014-01-08 | 2016-07-21 | 서울대학교산학협력단 | 스퍼미딘 또는 스퍼민을 이용함으로써 생육 저해제에 대한 내성이 증진된 효모의 배양방법 |
| JP6801930B2 (ja) * | 2015-03-17 | 2020-12-16 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | ジアミノブタンの調製のためのプロセス |
| JP6624985B2 (ja) * | 2015-03-27 | 2019-12-25 | 日清ファルマ株式会社 | ポリアミン高含有酵母 |
| TW202440904A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（二） |
| WO2017093482A1 (en) | 2015-12-02 | 2017-06-08 | Csl Behring Recombinant Facility Ag | Improved media for the expression of recombinant vitamin k-dependent proteins |
| CN106635953B (zh) * | 2016-12-13 | 2021-02-19 | 昆明润什生物科技有限公司 | 无血清无蛋白细胞培养基 |
| KR102659791B1 (ko) * | 2017-07-06 | 2024-04-23 | 리제너론 파마슈티칼스 인코포레이티드 | 당단백질을 만들기 위한 세포 배양 과정 |
| US20190091298A1 (en) | 2017-07-07 | 2019-03-28 | Baxalta Incorporated | Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant vwf |
| CA3069295A1 (en) | 2017-07-07 | 2019-01-10 | Baxalta Incorporated | Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf |
| CA3094644A1 (en) | 2018-03-21 | 2019-09-26 | Baxalta Incorporated | Separation of vwf and vwf propeptide by chromatographic methods |
| LT3781941T (lt) | 2018-04-20 | 2026-04-10 | Janssen Biotech, Inc. | Chromatografijos kolonėlės kvalifikavimas gamybos būduose, skirtuose anti-tnf antikūnų kompozicijoms gaminti |
| CN108872758B (zh) * | 2018-05-10 | 2019-06-28 | 江苏大学 | 一种电子元器件寿命检测装置 |
| EA202191352A1 (ru) | 2018-11-13 | 2021-08-11 | Янссен Байотек, Инк. | Контроль содержания микроэлементов-металлов во время продукции антител к cd38 |
| MX2021006115A (es) | 2019-01-17 | 2021-07-07 | Boehringer Ingelheim Animal Health Usa Inc | Medio libre de suero para produccion de vacuna aviar y usos del mismo. |
| US12128090B2 (en) | 2019-02-01 | 2024-10-29 | Takeda Pharmaceutical Company Limited | Methods of prophylactic treatment using recombinant VWF (rVWF) |
| CA3133381A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
| KR20210141976A (ko) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | 항-tnf 항체 조성물의 제조 방법 |
| JP7662529B2 (ja) | 2019-03-14 | 2025-04-15 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｔｎｆ抗体組成物を産生するための方法 |
| KR20210141990A (ko) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법 |
| WO2020201296A1 (en) | 2019-04-01 | 2020-10-08 | The Automation Partnership (Cambridge) Ltd. | Operation process for a cell cultivation system |
| US20220401524A1 (en) | 2019-09-11 | 2022-12-22 | Takeda Pharmaceutical Company Limited | Methods of treatment related to complexes of von willebrand factor and complement c1q |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| EP4056678A4 (en) | 2019-11-05 | 2023-12-06 | Ajinomoto Co., Inc. | Method for producing protein |
| US11180540B2 (en) | 2019-12-06 | 2021-11-23 | Regeneron Pharmaceuticals, Inc. | Anti-VEGF protein compositions and methods for producing the same |
| KR20220150303A (ko) | 2020-02-04 | 2022-11-10 | 다케다 야쿠힌 고교 가부시키가이샤 | 재조합 vwf의 투여에 의한 중증 폰 빌레브란트병 환자의 월경과다 치료 |
| WO2021198781A2 (en) | 2020-04-02 | 2021-10-07 | Takeda Pharmaceutical Company Limited | Adamts13 variant, compositions, and uses thereof |
| JP2023525034A (ja) | 2020-05-08 | 2023-06-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆトラップおよびミニトラップならびに眼障害およびがんの治療方法 |
| KR20230134117A (ko) | 2021-01-20 | 2023-09-20 | 리제너론 파마슈티칼스 인코포레이티드 | 세포 배양물에서 단백질 역가를 개선시키는 방법 |
| CN113151183A (zh) * | 2021-04-21 | 2021-07-23 | 赵峻岭 | 一种促进蛋白表达的培养基添加物及其应用 |
| IL309987A (en) | 2021-07-09 | 2024-03-01 | Janssen Biotech Inc | Production methods for the production of anti-IL12/IL23 antibody compositions |
| AU2022308201A1 (en) | 2021-07-09 | 2024-02-22 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
| WO2023167847A2 (en) | 2022-03-02 | 2023-09-07 | Regeneron Pharmaceuticals, Inc. | Bioreactor for antibody production |
| CA3266599A1 (en) | 2022-09-07 | 2024-11-07 | Quantitative Biosciences, Inc. | UNIQUE VARIABLE DOMAIN ANTIBODIES SPECIFIC TO FENTANYL AND USE IN A CONTINUOUS AGGLUTINATION TEST |
| WO2025053166A1 (ja) * | 2023-09-05 | 2025-03-13 | 味の素株式会社 | 培地組成物 |
| WO2025128343A1 (en) | 2023-12-11 | 2025-06-19 | Just-Evotec Biologics, Inc. | Protein expression using trans-splicing and split selectable markers |
| WO2025210223A1 (en) * | 2024-04-04 | 2025-10-09 | Sartorius Xell GmbH | Methods for viral vector production with reduced host cell aggregation and methods for dissolving host cell aggregates |
| WO2026058210A1 (en) | 2024-09-12 | 2026-03-19 | Janssen Biotech, Inc. | Model system and biomarkers to prevent lactate runaway |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT165999B (de) | 1947-06-26 | 1950-05-25 | Delle Atel Const Electr | Einirchtung zum Schutz von Drehstrommotoren gegen Überstrom |
| US4443540A (en) * | 1980-05-09 | 1984-04-17 | University Of Illinois Foundation | Protein hydrolysis |
| DK207980A (da) * | 1980-05-13 | 1981-11-14 | Novo Industri As | Fremgangsmaade til fremstilling af et skumnings- eller emulgeringsmiddel paa sojaproteinbasis |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| FR2543158B1 (fr) | 1983-03-24 | 1985-11-15 | Inst Nat Sante Rech Med | Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu |
| US4767704A (en) * | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| FI86885C (fi) | 1984-04-20 | 1992-10-26 | Genentech Inc | Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill |
| ATE89314T1 (de) | 1985-02-13 | 1993-05-15 | Scios Nova Inc | Menschlicher metallothionein ii-promotor in saeugetierexpressionssystemen. |
| US4978616A (en) * | 1985-02-28 | 1990-12-18 | Verax Corporation | Fluidized cell cultivation process |
| DE3787805T2 (de) | 1986-08-04 | 1994-02-10 | Garvan Inst Med Res | Serumfreies gewebekulturmedium, das ein polymerzellenschutzmittel enthält. |
| US5045468A (en) | 1986-12-12 | 1991-09-03 | Cell Enterprises, Inc. | Protein-free culture medium which promotes hybridoma growth |
| AU627427B2 (en) | 1987-06-30 | 1992-08-27 | Amgen, Inc. | Production of kallikrein |
| JP2507882B2 (ja) | 1988-02-17 | 1996-06-19 | 工業技術院長 | 外部増殖因子非依存性増殖良好細胞株の製造法 |
| US6048728A (en) * | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| US5573937A (en) * | 1989-12-07 | 1996-11-12 | Snow Brand Milk Products Co., Ltd. | Serum free culture medium |
| SE465222C5 (sv) | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| DK0512066T3 (da) | 1990-01-22 | 1996-12-02 | Us Health | CO2-uafhængigt vækstmedium til opretholdelse og opformering af celler |
| JP2844484B2 (ja) | 1990-02-22 | 1999-01-06 | 味の素株式会社 | 組換え蛋白質の生産方法 |
| JP2859679B2 (ja) | 1990-03-01 | 1999-02-17 | 協和醗酵工業株式会社 | 新規細胞株 |
| US5378612A (en) * | 1990-05-11 | 1995-01-03 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Culture medium for production of recombinant protein |
| JP2696001B2 (ja) | 1991-04-15 | 1998-01-14 | 財団法人化学及血清療法研究所 | 組換え蛋白質産生用培地 |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| AU643077B2 (en) | 1990-10-19 | 1993-11-04 | Unilever Plc | Detergent compositions |
| JPH04228066A (ja) | 1990-10-23 | 1992-08-18 | Rikagaku Kenkyusho | 外来遺伝子発現用培養細胞 |
| EP0531562A1 (de) * | 1991-09-11 | 1993-03-17 | Doerr, Hans-Wilhelm, Prof. Dr. med. | Kultivierung von Säugetierzellen |
| CA2078721A1 (en) | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
| JPH05123178A (ja) | 1991-11-01 | 1993-05-21 | Ajinomoto Co Inc | Ｌ−フエニルアラニンの製造法 |
| AU7895898A (en) | 1993-04-26 | 1998-10-08 | Hans Wolf | Mammal cell lines and method of obtaining glycoproteins |
| DE4313620A1 (de) | 1993-04-26 | 1994-10-27 | Biotechnolog Forschung Gmbh | Hamsterzellinien und Verfahren zur Glykoproteingewinnung |
| GB9311132D0 (en) * | 1993-05-28 | 1993-07-14 | Eisai London Res Lab Ltd | Control of cell death |
| US5405637A (en) | 1993-06-30 | 1995-04-11 | Bristol-Myers Squibb Company | Milk protein partial hydrolysate and infant formula containing same |
| JP2766165B2 (ja) | 1993-08-02 | 1998-06-18 | 株式会社バイオポリマー・リサーチ | バクテリアセルロースの製造方法 |
| US5445956A (en) * | 1993-08-13 | 1995-08-29 | The Regents Of The University Of California | Recombinant soluble epoxide hydrolase |
| EP0653487A1 (de) | 1993-11-07 | 1995-05-17 | Ferruccio Dr. Messi | Serum- und proteinfrei wachsende Zellen |
| US5719050A (en) * | 1993-12-24 | 1998-02-17 | Eiken Chemical Co., Ltd. | Animal cell culturing media containing N-acetyl-L-glutamic acid |
| US5498599A (en) * | 1994-01-21 | 1996-03-12 | Amgen Inc. | Methods for stimulating platelet production |
| EP0666312A1 (en) | 1994-02-08 | 1995-08-09 | Wolfgang A. Renner | Process for the improvement of mammalian cell growth |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5789247A (en) * | 1994-04-01 | 1998-08-04 | Ballay; Annick | Expression in non-tumoral human lymphoblastoid lines with an integrative vector |
| WO1996007730A2 (de) | 1994-09-09 | 1996-03-14 | Renner Wolfgang A | Chemisches verfahren zur förderung der proliferation von tierischen zellen |
| ES2378409T3 (es) | 1994-11-10 | 2012-04-12 | Baxter Healthcare S.A. | Método para producir sustancias biológicas en cultivo sin proteínas |
| AT403167B (de) | 1994-11-14 | 1997-11-25 | Immuno Ag | Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems |
| EP0799310A1 (en) | 1994-12-16 | 1997-10-08 | Novartis AG | Production of recombinant secretory component |
| DE69608668T2 (de) | 1995-02-23 | 2001-02-01 | Quest International B.V., Naarden | Peptide für gewebe- und zellkulturmedien |
| US5741705A (en) * | 1995-02-23 | 1998-04-21 | Quest International Flavors & Food Ingredients Company, Division Of Indopco, Inc. | Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides |
| WO1996040866A1 (en) | 1995-06-07 | 1996-12-19 | Novartis Ag | Serum-free media for primitive hematopoietic cells and methods of use thereof |
| AUPN442295A0 (en) | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
| US5851800A (en) * | 1996-05-14 | 1998-12-22 | Pharmacia & Upjohn Ab | Process for producing a protein |
| WO1998008935A1 (en) | 1996-08-30 | 1998-03-05 | The University Of North Carolina At Chapel Hill | Immortalized human hepatic cell line |
| EP1482031B1 (en) | 1996-08-30 | 2015-10-28 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
| JP4543402B2 (ja) | 1996-10-10 | 2010-09-15 | ライフ テクノロジーズ コーポレーション | 植物由来栄養素を含む動物細胞培養培地 |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| ATE372376T1 (de) | 1997-05-28 | 2007-09-15 | Novartis Vaccines & Diagnostic | Kulturmedium mit sojabohnenextrakt als aminosäuren-quelle und ohne proteinkomplexe tierischen ursprungs |
| AT407255B (de) * | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US6475725B1 (en) * | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| EP0986644B1 (de) | 1997-07-23 | 2006-10-04 | Boehringer Mannheim GmbH | Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren |
| AU731857B2 (en) | 1997-11-20 | 2001-04-05 | Weyerhaeuser Company | Nutritive media and manufactured seeds comprising same |
| WO1999035242A1 (en) * | 1998-01-12 | 1999-07-15 | Betagene, Inc. | Media for neuroendocrine cells |
| FR2775983B1 (fr) | 1998-03-13 | 2000-11-10 | Pasteur Merieux Serums Vacc | Milieu et procede de propagation et de multiplication virales |
| WO1999057246A1 (en) | 1998-05-01 | 1999-11-11 | Life Technologies, Inc. | Animal cell culture media comprising non-animal or plant-derived nutrients |
| US6537782B1 (en) * | 1998-06-01 | 2003-03-25 | Chugai Seiyaku Kabushiki Kaisha | Media for culturing animal cells and process for producing protein by using the same |
| US6406909B1 (en) | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
| JP4266055B2 (ja) | 1999-03-04 | 2009-05-20 | 雪印乳業株式会社 | ポリアミン組成物の製造法 |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| ATE330003T1 (de) | 1999-08-05 | 2006-07-15 | Baxter Ag | Rekombinanter stabiler zellklon, seine herstellung und verwendung |
| WO2001014529A1 (en) | 1999-08-25 | 2001-03-01 | Immunex Corporation | Compositions and methods for improved cell culture |
| US6596526B1 (en) * | 2000-06-09 | 2003-07-22 | Baxter Aktiengesellschaft | Furin polypeptides with improved characteristics |
| US7494659B2 (en) | 2000-09-25 | 2009-02-24 | Polymun Scientific Immunbiologische Forschung Gmbh | Live attenuated influenza vaccine |
| EP1208966A1 (en) | 2000-11-27 | 2002-05-29 | Cheng-Kun Liao | Manufacturing process of patio tabletop glass with broken protection |
| DE10059175A1 (de) | 2000-11-29 | 2002-06-20 | Siemens Ag | Verfahren und Vorrichtung zur Anrufumleitung mittels eines Stellvertreters in einem Kommunikationssystem |
| US20030096414A1 (en) | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
| US6734289B2 (en) * | 2001-03-29 | 2004-05-11 | The University Of Chicago | Gastrokines and derived peptides including inhibitors |
| AU2002316230A1 (en) | 2001-06-13 | 2002-12-23 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
| US7037658B2 (en) * | 2001-08-16 | 2006-05-02 | Regents Of University Of Michigan | Methods and compositions for detecting variant ADAMTS13 genes |
| EP1434857B1 (en) | 2001-10-02 | 2007-08-01 | Novo Nordisk Health Care AG | Method for production of recombinant proteins in eukaryote cells |
| US20030104527A1 (en) * | 2001-12-03 | 2003-06-05 | National Research Council Of Canada | Methylotrophic bacterium for the production of recombinant proteins and other products |
| DE10161412A1 (de) | 2001-12-13 | 2003-07-03 | Aventis Pharma Gmbh | Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität |
| PT2287288E (pt) | 2002-07-09 | 2012-12-10 | Baxter Int | Meio isento de proteína animal para cultura de células |
| FR2846005B1 (fr) | 2002-10-16 | 2006-06-23 | Maco Pharma Sa | Composition pour milieu biologique comprenant de l'erythorbate de sodium |
| FR2846004B1 (fr) | 2002-10-16 | 2006-06-23 | Maco Pharma Sa | Composition pour culture de cellules notamment animales ou de tissus, comprenant du polyethylene glycol |
| DE10333675A1 (de) | 2003-07-24 | 2005-03-03 | Aventis Pharma Deutschland Gmbh | Perfusionsverfahren für die Produktion von Erythropoietin |
| JP4740138B2 (ja) | 2003-10-10 | 2011-08-03 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 真核生物細胞におけるポリペプチドの大規模生産方法及びそれに適した培養容器 |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US20060094104A1 (en) * | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| EP1812557A4 (en) | 2004-10-29 | 2009-11-04 | Centocor Ortho Biotech Inc | COMPOSITIONS OF CHEMICALLY DEFINED MEDIA |
| EP3653699A1 (en) | 2006-01-04 | 2020-05-20 | Baxalta Incorporated | Oligopeptide-free cell culture media |
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