|
US4284412A
(en)
|
1979-07-13 |
1981-08-18 |
Ortho Diagnostics, Inc. |
Method and apparatus for automated identification and enumeration of specified blood cell subclasses
|
|
US4498766A
(en)
|
1982-03-25 |
1985-02-12 |
Becton, Dickinson And Company |
Light beam focal spot elongation in flow cytometry devices
|
|
US4661913A
(en)
|
1984-09-11 |
1987-04-28 |
Becton, Dickinson And Company |
Apparatus and method for the detection and classification of articles using flow cytometry techniques
|
|
US4883750A
(en)
|
1984-12-13 |
1989-11-28 |
Applied Biosystems, Inc. |
Detection of specific sequences in nucleic acids
|
|
US4774189A
(en)
|
1984-12-24 |
1988-09-27 |
Flow Cytometry Standards Corp. |
Fluorescent calibration microbeads simulating stained cells
|
|
US4857451A
(en)
|
1984-12-24 |
1989-08-15 |
Flow Cytometry Standards Corporation |
Method of compensating and calibrating a flow cytometer, and microbead standards kit therefor
|
|
US4767206A
(en)
|
1984-12-24 |
1988-08-30 |
Flow Cytometry Standards Corporation |
Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4989977A
(en)
|
1985-07-29 |
1991-02-05 |
Becton, Dickinson And Company |
Flow cytometry apparatus with improved light beam adjustment
|
|
US4682195A
(en)
|
1985-09-30 |
1987-07-21 |
General Electric Company |
Insulated gate device with configured emitter contact pad
|
|
US4959463A
(en)
|
1985-10-15 |
1990-09-25 |
Genentech, Inc. |
Intermediates
|
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
|
US4714682A
(en)
|
1985-12-11 |
1987-12-22 |
Flow Cytometry Standards Corporation |
Fluorescent calibration microbeads simulating stained cells
|
|
EP0232967B1
(en)
|
1986-01-10 |
1993-04-28 |
Amoco Corporation |
Competitive homogeneous assay
|
|
US4851331A
(en)
|
1986-05-16 |
1989-07-25 |
Allied Corporation |
Method and kit for polynucleotide assay including primer-dependant DNA polymerase
|
|
EP0266032A1
(en)
|
1986-08-29 |
1988-05-04 |
Beecham Group Plc |
Modified fibrinolytic enzyme
|
|
AU622104B2
(en)
|
1987-03-11 |
1992-04-02 |
Sangtec Molecular Diagnostics Ab |
Method of assaying of nucleic acids, a reagent combination and kit therefore
|
|
US4816571A
(en)
|
1987-06-04 |
1989-03-28 |
Applied Biosystems, Inc. |
Chemical capping by phosphitylation during oligonucleotide synthesis
|
|
IL86724A
(en)
|
1987-06-19 |
1995-01-24 |
Siska Diagnostics Inc |
Methods and kits for amplification and testing of nucleic acid sequences
|
|
US4942124A
(en)
|
1987-08-11 |
1990-07-17 |
President And Fellows Of Harvard College |
Multiplex sequencing
|
|
AU622426B2
(en)
|
1987-12-11 |
1992-04-09 |
Abbott Laboratories |
Assay using template-dependent nucleic acid probe reorganization
|
|
JP2846018B2
(ja)
|
1988-01-21 |
1999-01-13 |
ジェネンテク，インコーポレイテッド |
核酸配列の増幅および検出
|
|
CA1340807C
(en)
|
1988-02-24 |
1999-11-02 |
Lawrence T. Malek |
Nucleic acid amplification process
|
|
IE61148B1
(en)
|
1988-03-10 |
1994-10-05 |
Ici Plc |
Method of detecting nucleotide sequences
|
|
US5932413A
(en)
|
1988-04-01 |
1999-08-03 |
Celebuski; Joseph Eugene |
DNA probe assay using neutrally charged probe strands
|
|
US5602244A
(en)
|
1988-05-26 |
1997-02-11 |
Competitive Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5858652A
(en)
|
1988-08-30 |
1999-01-12 |
Abbott Laboratories |
Detection and amplification of target nucleic acid sequences
|
|
US5639611A
(en)
|
1988-12-12 |
1997-06-17 |
City Of Hope |
Allele specific polymerase chain reaction
|
|
US4932207A
(en)
|
1988-12-28 |
1990-06-12 |
Sundstrand Corporation |
Segmented seal plate for a turbine engine
|
|
US5856092A
(en)
|
1989-02-13 |
1999-01-05 |
Geneco Pty Ltd |
Detection of a nucleic acid sequence or a change therein
|
|
US5141813A
(en)
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
|
GB8920097D0
(en)
|
1989-09-06 |
1989-10-18 |
Ici Plc |
Amplification processes
|
|
US5137806A
(en)
|
1989-12-11 |
1992-08-11 |
Board Of Regents, The University Of Texas System |
Methods and compositions for the detection of sequences in selected DNA molecules
|
|
US5160974A
(en)
|
1990-06-25 |
1992-11-03 |
Flow Science, Inc. |
Closed sample cell for use in flow cytometry
|
|
US5645987A
(en)
|
1990-09-21 |
1997-07-08 |
Amgen Inc. |
Enzymatic synthesis of oligonucleotides
|
|
US5478722A
(en)
|
1991-02-17 |
1995-12-26 |
The Curators Of The University Of Missouri |
Preserved cell preparations for flow cytometry and immunology
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5766855A
(en)
|
1991-05-24 |
1998-06-16 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity and sequence specificity
|
|
DK51092D0
(da)
|
1991-05-24 |
1992-04-15 |
Ole Buchardt |
Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5846717A
(en)
|
1996-01-24 |
1998-12-08 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
|
US5846708A
(en)
|
1991-11-19 |
1998-12-08 |
Massachusetts Institiute Of Technology |
Optical and electrical methods and apparatus for molecule detection
|
|
DE4204650C1
(enExample)
|
1992-02-15 |
1993-07-08 |
Hoffmeister, Helmut, Dr., 4400 Muenster, De |
|
|
AU3728093A
(en)
|
1992-02-19 |
1993-09-13 |
Public Health Research Institute Of The City Of New York, Inc., The |
Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
|
|
DK0566751T3
(da)
|
1992-03-23 |
1996-03-04 |
Hoffmann La Roche |
DNA-påvisningsmetode
|
|
WO1993020235A1
(en)
|
1992-04-01 |
1993-10-14 |
The Johns Hopkins University School Of Medicine |
Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor
|
|
US5428148A
(en)
|
1992-04-24 |
1995-06-27 |
Beckman Instruments, Inc. |
N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
|
|
GB9211979D0
(en)
|
1992-06-05 |
1992-07-15 |
Buchard Ole |
Uses of nucleic acid analogues
|
|
US5843640A
(en)
|
1992-06-19 |
1998-12-01 |
Northwestern University |
Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
|
|
US5861244A
(en)
|
1992-10-29 |
1999-01-19 |
Profile Diagnostic Sciences, Inc. |
Genetic sequence assay using DNA triple strand formation
|
|
US5658751A
(en)
|
1993-04-13 |
1997-08-19 |
Molecular Probes, Inc. |
Substituted unsymmetrical cyanine dyes with selected permeability
|
|
GB9311386D0
(en)
|
1993-06-02 |
1993-07-21 |
Pna Diagnostics As |
Nucleic acid analogue assay procedures
|
|
US5846709A
(en)
|
1993-06-15 |
1998-12-08 |
Imclone Systems Incorporated |
Chemical process for amplifying and detecting nucleic acid sequences
|
|
US5837832A
(en)
|
1993-06-25 |
1998-11-17 |
Affymetrix, Inc. |
Arrays of nucleic acid probes on biological chips
|
|
FR2708288B1
(fr)
|
1993-07-26 |
1995-09-01 |
Bio Merieux |
Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
|
|
US5925517A
(en)
|
1993-11-12 |
1999-07-20 |
The Public Health Research Institute Of The City Of New York, Inc. |
Detectably labeled dual conformation oligonucleotide probes, assays and kits
|
|
CA2137728C
(en)
*
|
1993-12-14 |
1998-07-14 |
William E. Keating |
Enzymatic removal of non-target nucleic acid from biological samples
|
|
DE69432919T2
(de)
|
1993-12-28 |
2004-05-27 |
Tanabe Seiyaku Co., Ltd. |
Verfahren für den Nachweis spezifischer Polynukleotiden
|
|
US5928905A
(en)
|
1995-04-18 |
1999-07-27 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
|
AU707391B2
(en)
|
1994-05-28 |
1999-07-08 |
Tepnel Medical Limited |
Producing copies of nucleic acids
|
|
US5942391A
(en)
|
1994-06-22 |
1999-08-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method: ramification-extension amplification method (RAM)
|
|
CA2195562A1
(en)
|
1994-08-19 |
1996-02-29 |
Pe Corporation (Ny) |
Coupled amplification and ligation method
|
|
US5574146A
(en)
|
1994-08-30 |
1996-11-12 |
Beckman Instruments, Inc. |
Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
|
|
US5599668A
(en)
|
1994-09-22 |
1997-02-04 |
Abbott Laboratories |
Light scattering optical waveguide method for detecting specific binding events
|
|
US5554744A
(en)
|
1994-09-23 |
1996-09-10 |
Hybridon, Inc. |
Method for loading solid supports for nucleic acid synthesis
|
|
US5604097A
(en)
|
1994-10-13 |
1997-02-18 |
Spectragen, Inc. |
Methods for sorting polynucleotides using oligonucleotide tags
|
|
DE69535240T2
(de)
|
1994-10-28 |
2007-06-06 |
Gen-Probe Inc., San Diego |
Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
|
|
FR2726277B1
(fr)
*
|
1994-10-28 |
1996-12-27 |
Bio Merieux |
Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
|
|
US5935825A
(en)
|
1994-11-18 |
1999-08-10 |
Shimadzu Corporation |
Process and reagent for amplifying nucleic acid sequences
|
|
US5843650A
(en)
|
1995-05-01 |
1998-12-01 |
Segev; David |
Nucleic acid detection and amplification by chemical linkage of oligonucleotides
|
|
US5929227A
(en)
|
1995-07-12 |
1999-07-27 |
The Regents Of The University Of California |
Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
|
|
US5916779A
(en)
|
1995-09-21 |
1999-06-29 |
Becton, Dickinson And Company |
Strand displacement amplification of RNA targets
|
|
US5736330A
(en)
|
1995-10-11 |
1998-04-07 |
Luminex Corporation |
Method and compositions for flow cytometric determination of DNA sequences
|
|
US5981180A
(en)
|
1995-10-11 |
1999-11-09 |
Luminex Corporation |
Multiplexed analysis of clinical specimens apparatus and methods
|
|
US5866331A
(en)
|
1995-10-20 |
1999-02-02 |
University Of Massachusetts |
Single molecule detection by in situ hybridization
|
|
US5705629A
(en)
|
1995-10-20 |
1998-01-06 |
Hybridon, Inc. |
Methods for H-phosphonate synthesis of mono- and oligonucleotides
|
|
US5612473A
(en)
|
1996-01-16 |
1997-03-18 |
Gull Laboratories |
Methods, kits and solutions for preparing sample material for nucleic acid amplification
|
|
EP2332957B1
(en)
|
1996-02-09 |
2015-04-08 |
Cornell Research Foundation, Inc. |
Detection of nucleic and acid sequence differences using the ligase detection reaction with addressable arrays
|
|
US5928906A
(en)
|
1996-05-09 |
1999-07-27 |
Sequenom, Inc. |
Process for direct sequencing during template amplification
|
|
US5939291A
(en)
|
1996-06-14 |
1999-08-17 |
Sarnoff Corporation |
Microfluidic method for nucleic acid amplification
|
|
US5912124A
(en)
|
1996-06-14 |
1999-06-15 |
Sarnoff Corporation |
Padlock probe detection
|
|
US5866336A
(en)
|
1996-07-16 |
1999-02-02 |
Oncor, Inc. |
Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
|
|
US6117635A
(en)
|
1996-07-16 |
2000-09-12 |
Intergen Company |
Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
|
|
US5853990A
(en)
|
1996-07-26 |
1998-12-29 |
Edward E. Winger |
Real time homogeneous nucleotide assay
|
|
CA2744096C
(en)
|
1996-07-31 |
2013-07-30 |
Laboratory Corporation Of America Holdings |
Biomarkers and targets for diagnosis, prognosis and management of prostate disease
|
|
US5849546A
(en)
|
1996-09-13 |
1998-12-15 |
Epicentre Technologies Corporation |
Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
|
|
US5853992A
(en)
|
1996-10-04 |
1998-12-29 |
The Regents Of The University Of California |
Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels
|
|
US5853993A
(en)
|
1996-10-21 |
1998-12-29 |
Hewlett-Packard Company |
Signal enhancement method and kit
|
|
US5908845A
(en)
|
1996-10-30 |
1999-06-01 |
Segev; David |
Polyether nucleic acids
|
|
US5905024A
(en)
|
1996-12-17 |
1999-05-18 |
University Of Chicago |
Method for performing site-specific affinity fractionation for use in DNA sequencing
|
|
US5846729A
(en)
|
1997-02-27 |
1998-12-08 |
Lorne Park Research, Inc. |
Assaying nucleotides in solution using a fluorescent intensity quenching effect
|
|
US5837860A
(en)
|
1997-03-05 |
1998-11-17 |
Molecular Tool, Inc. |
Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
|
|
US5849497A
(en)
|
1997-04-03 |
1998-12-15 |
The Research Foundation Of State University Of New York |
Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker
|
|
US5846726A
(en)
|
1997-05-13 |
1998-12-08 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
|
US5928869A
(en)
|
1997-05-30 |
1999-07-27 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
|
US5866366A
(en)
|
1997-07-01 |
1999-02-02 |
Smithkline Beecham Corporation |
gidB
|
|
US5916776A
(en)
|
1997-08-27 |
1999-06-29 |
Sarnoff Corporation |
Amplification method for a polynucleotide
|
|
US5935791A
(en)
|
1997-09-23 |
1999-08-10 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
|
US5932451A
(en)
|
1997-11-19 |
1999-08-03 |
Incyte Pharmaceuticals, Inc. |
Method for unbiased mRNA amplification
|
|
GB9812768D0
(en)
*
|
1998-06-13 |
1998-08-12 |
Zeneca Ltd |
Methods
|
|
GB9902971D0
(en)
|
1999-02-11 |
1999-03-31 |
Zeneca Ltd |
Assay
|
|
US6964847B1
(en)
*
|
1999-07-14 |
2005-11-15 |
Packard Biosciences Company |
Derivative nucleic acids and uses thereof
|
|
US6287778B1
(en)
|
1999-10-19 |
2001-09-11 |
Affymetrix, Inc. |
Allele detection using primer extension with sequence-coded identity tags
|
|
US7838225B2
(en)
|
1999-10-29 |
2010-11-23 |
Hologic, Inc. |
Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
|
|
AU2001238068A1
(en)
*
|
2000-02-07 |
2001-08-14 |
Illumina, Inc. |
Nucleic acid detection methods using universal priming
|
|
US20050106564A1
(en)
|
2000-06-02 |
2005-05-19 |
Hechinger Mark K. |
One-step, no-wash multiplex bead-based flow cytometric assay
|
|
WO2001094625A2
(en)
|
2000-06-06 |
2001-12-13 |
Tm Bioscience Corporation |
Capture moieties for nucleic acids and uses thereof
|
|
US7226737B2
(en)
|
2001-01-25 |
2007-06-05 |
Luminex Molecular Diagnostics, Inc. |
Polynucleotides for use as tags and tag complements, manufacture and use thereof
|
|
JP4422963B2
(ja)
|
2001-01-25 |
2010-03-03 |
ルミネックス モレキュラー ダイアグノスティックス， インク． |
標識および標識補体として使用するための非クロス交雑しているポリヌクレオチドのファミリー、製品、ならびにその使用方法
|
|
JPWO2003035864A1
(ja)
|
2001-10-26 |
2005-02-10 |
松下電器産業株式会社 |
標的核酸の検出方法及び核酸プローブ
|
|
US6803201B2
(en)
|
2002-01-24 |
2004-10-12 |
Stratagene |
Compositions and methods for polynucleotide sequence determination
|
|
JP2004205414A
(ja)
|
2002-12-26 |
2004-07-22 |
Institute Of Physical & Chemical Research |
核酸マイクロアレイ、その作製方法及びその使用方法
|
|
US7700750B2
(en)
*
|
2003-01-09 |
2010-04-20 |
Third Wave Technologies, Inc. |
Connexin allele detection assays
|
|
JP2004283024A
(ja)
|
2003-03-19 |
2004-10-14 |
Junsei Chemical Co Ltd |
新規アンチセンスオリゴヌクレオチド及び抗ｈｉｖ剤
|
|
WO2005007815A2
(en)
|
2003-07-07 |
2005-01-27 |
One Cell Systems, Inc. |
Hairpin-labeled probes and methods of use
|
|
US20070092880A1
(en)
|
2003-07-16 |
2007-04-26 |
Crothers Donald M |
Invasive cleavage reaction with electrochemical readout
|
|
US20070099228A1
(en)
*
|
2004-11-04 |
2007-05-03 |
Applera Corporation |
Concatameric Ligation Products: Compositions, Methods and Kits for Same
|
|
US7879543B2
(en)
|
2003-11-17 |
2011-02-01 |
Luminex Molecular Diagnostics, Inc. |
Method of detecting mutations associated with thrombosis
|
|
JP2005253427A
(ja)
*
|
2004-03-15 |
2005-09-22 |
Aisin Seiki Co Ltd |
核酸検出方法及び核酸単離方法
|
|
CA2479968A1
(en)
|
2004-09-01 |
2006-03-01 |
Keith R. Walley |
Protein c and endothelial protein c receptor polymorphisms as indicators of patient outcome
|
|
ES2292270B1
(es)
|
2004-04-14 |
2009-02-16 |
Oryzon Genomics, S.A. |
Procedimiento para detectar selectivamente acidos nucleicos con estructuras atipicas convertibles en muescas.
|
|
CA2568499A1
(en)
*
|
2004-06-01 |
2005-12-15 |
Tm Bioscience Corporation |
Method of detecting cystic fibrosis associated mutations
|
|
JP2008504826A
(ja)
|
2004-06-30 |
2008-02-21 |
ティーエム バイオサイエンス ピージーエクス インコーポレイティッド |
チトクロムｐ４５０−２ｄ６をコードする遺伝子における変異を検出する方法
|
|
WO2006002525A1
(en)
|
2004-06-30 |
2006-01-12 |
Tm Bioscience Pgx, Inc. |
Method of detecting mutations in the gene encoding cytochrome p450-2c9
|
|
EP2418018B1
(en)
*
|
2004-12-23 |
2013-05-22 |
Abbott Point of Care Inc. |
Methods for the separation nucleic acids
|
|
JP2009501532A
(ja)
*
|
2005-07-15 |
2009-01-22 |
アプレラ コーポレーション |
核酸増幅物の検出
|
|
AU2007209725A1
(en)
|
2006-01-24 |
2007-08-02 |
Sirius Genomics Inc. |
Vasopressin pathway polymorphisms as indicators of subject outcome in critically ill subjects
|
|
US20070172841A1
(en)
|
2006-01-25 |
2007-07-26 |
Hui Wang |
Probe/target stabilization with add-in oligo
|
|
JP2008048648A
(ja)
|
2006-08-23 |
2008-03-06 |
Institute Of Physical & Chemical Research |
核酸増幅用プライマーセット及び核酸の増幅方法
|
|
AU2007307171B2
(en)
|
2006-10-04 |
2012-01-19 |
Third Wave Technologies, Inc. |
Snap-back primers and detectable hairpin structures
|
|
CN102851369B
(zh)
|
2006-12-13 |
2015-01-21 |
卢米耐克斯公司 |
用于实时pcr多重分析的系统和方法
|
|
US7862999B2
(en)
*
|
2007-01-17 |
2011-01-04 |
Affymetrix, Inc. |
Multiplex targeted amplification using flap nuclease
|
|
ES2538100T3
(es)
|
2007-06-13 |
2015-06-17 |
Attomol Gmbh Molekulare Diagnostika |
Procedimiento para la realización y evaluación de ensayos de mezclado y medición para la medición de cinéticas de reacción así como de concentraciones y afinidades de analitos en formato múltiplex
|
|
EP2215245A2
(en)
*
|
2007-11-02 |
2010-08-11 |
Luminex Molecular Diagnostics, Inc. |
One-step target detection assay
|
|
US8008019B2
(en)
*
|
2007-11-28 |
2011-08-30 |
Luminex Molecular Diagnostics |
Use of dual-tags for the evaluation of genomic variable repeat regions
|
|
JP4744503B2
(ja)
|
2007-11-30 |
2011-08-10 |
シャープ株式会社 |
操作処理装置
|
|
US8312249B1
(en)
|
2008-10-10 |
2012-11-13 |
Apple Inc. |
Dynamic trampoline and structured code generation in a signed code environment
|
|
FR2957821B1
(fr)
|
2010-03-24 |
2014-08-29 |
Inst Francais Du Petrole |
Nouvelle zone de regeneration du catalyseur divisee en secteurs pour unites catalytiques regeneratives
|