|
US4284412A
(en)
|
1979-07-13 |
1981-08-18 |
Ortho Diagnostics, Inc. |
Method and apparatus for automated identification and enumeration of specified blood cell subclasses
|
|
US4498766A
(en)
|
1982-03-25 |
1985-02-12 |
Becton, Dickinson And Company |
Light beam focal spot elongation in flow cytometry devices
|
|
US4661913A
(en)
*
|
1984-09-11 |
1987-04-28 |
Becton, Dickinson And Company |
Apparatus and method for the detection and classification of articles using flow cytometry techniques
|
|
US4883750A
(en)
|
1984-12-13 |
1989-11-28 |
Applied Biosystems, Inc. |
Detection of specific sequences in nucleic acids
|
|
US4774189A
(en)
|
1984-12-24 |
1988-09-27 |
Flow Cytometry Standards Corp. |
Fluorescent calibration microbeads simulating stained cells
|
|
US4767206A
(en)
|
1984-12-24 |
1988-08-30 |
Flow Cytometry Standards Corporation |
Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof
|
|
US4857451A
(en)
|
1984-12-24 |
1989-08-15 |
Flow Cytometry Standards Corporation |
Method of compensating and calibrating a flow cytometer, and microbead standards kit therefor
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4989977A
(en)
*
|
1985-07-29 |
1991-02-05 |
Becton, Dickinson And Company |
Flow cytometry apparatus with improved light beam adjustment
|
|
US4682195A
(en)
|
1985-09-30 |
1987-07-21 |
General Electric Company |
Insulated gate device with configured emitter contact pad
|
|
US4959463A
(en)
|
1985-10-15 |
1990-09-25 |
Genentech, Inc. |
Intermediates
|
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
|
US4714682A
(en)
|
1985-12-11 |
1987-12-22 |
Flow Cytometry Standards Corporation |
Fluorescent calibration microbeads simulating stained cells
|
|
ATE88761T1
(de)
|
1986-01-10 |
1993-05-15 |
Amoco Corp |
Kompetitiver homogener test.
|
|
US4851331A
(en)
*
|
1986-05-16 |
1989-07-25 |
Allied Corporation |
Method and kit for polynucleotide assay including primer-dependant DNA polymerase
|
|
EP0266032A1
(en)
|
1986-08-29 |
1988-05-04 |
Beecham Group Plc |
Modified fibrinolytic enzyme
|
|
AU622104B2
(en)
|
1987-03-11 |
1992-04-02 |
Sangtec Molecular Diagnostics Ab |
Method of assaying of nucleic acids, a reagent combination and kit therefore
|
|
US4816571A
(en)
|
1987-06-04 |
1989-03-28 |
Applied Biosystems, Inc. |
Chemical capping by phosphitylation during oligonucleotide synthesis
|
|
IL86724A
(en)
|
1987-06-19 |
1995-01-24 |
Siska Diagnostics Inc |
Methods and kits for amplification and testing of nucleic acid sequences
|
|
US4942124A
(en)
|
1987-08-11 |
1990-07-17 |
President And Fellows Of Harvard College |
Multiplex sequencing
|
|
CA1323293C
(en)
|
1987-12-11 |
1993-10-19 |
Keith C. Backman |
Assay using template-dependent nucleic acid probe reorganization
|
|
EP0359789B1
(en)
|
1988-01-21 |
1993-08-04 |
Genentech, Inc. |
Amplification and detection of nucleic acid sequences
|
|
CA1340807C
(en)
|
1988-02-24 |
1999-11-02 |
Lawrence T. Malek |
Nucleic acid amplification process
|
|
IE61148B1
(en)
|
1988-03-10 |
1994-10-05 |
Ici Plc |
Method of detecting nucleotide sequences
|
|
US5932413A
(en)
|
1988-04-01 |
1999-08-03 |
Celebuski; Joseph Eugene |
DNA probe assay using neutrally charged probe strands
|
|
US5602244A
(en)
|
1988-05-26 |
1997-02-11 |
Competitive Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5858652A
(en)
|
1988-08-30 |
1999-01-12 |
Abbott Laboratories |
Detection and amplification of target nucleic acid sequences
|
|
US5639611A
(en)
|
1988-12-12 |
1997-06-17 |
City Of Hope |
Allele specific polymerase chain reaction
|
|
US4932207A
(en)
|
1988-12-28 |
1990-06-12 |
Sundstrand Corporation |
Segmented seal plate for a turbine engine
|
|
US5856092A
(en)
|
1989-02-13 |
1999-01-05 |
Geneco Pty Ltd |
Detection of a nucleic acid sequence or a change therein
|
|
US5141813A
(en)
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
|
GB8920097D0
(en)
*
|
1989-09-06 |
1989-10-18 |
Ici Plc |
Amplification processes
|
|
US5137806A
(en)
*
|
1989-12-11 |
1992-08-11 |
Board Of Regents, The University Of Texas System |
Methods and compositions for the detection of sequences in selected DNA molecules
|
|
US5160974A
(en)
*
|
1990-06-25 |
1992-11-03 |
Flow Science, Inc. |
Closed sample cell for use in flow cytometry
|
|
US5645987A
(en)
|
1990-09-21 |
1997-07-08 |
Amgen Inc. |
Enzymatic synthesis of oligonucleotides
|
|
US5478722A
(en)
*
|
1991-02-17 |
1995-12-26 |
The Curators Of The University Of Missouri |
Preserved cell preparations for flow cytometry and immunology
|
|
US5766855A
(en)
|
1991-05-24 |
1998-06-16 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity and sequence specificity
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
DK51092D0
(da)
|
1991-05-24 |
1992-04-15 |
Ole Buchardt |
Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
|
|
US5846717A
(en)
|
1996-01-24 |
1998-12-08 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
|
US5846708A
(en)
|
1991-11-19 |
1998-12-08 |
Massachusetts Institiute Of Technology |
Optical and electrical methods and apparatus for molecule detection
|
|
DE4204650C1
(enExample)
|
1992-02-15 |
1993-07-08 |
Hoffmeister, Helmut, Dr., 4400 Muenster, De |
|
|
EP1382386A3
(en)
|
1992-02-19 |
2004-12-01 |
The Public Health Research Institute Of The City Of New York, Inc. |
Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
|
|
ES2082256T3
(es)
*
|
1992-03-23 |
1996-03-16 |
Hoffmann La Roche |
Metodo de deteccion del adn.
|
|
JP3633932B2
(ja)
|
1992-04-01 |
2005-03-30 |
ザ ジョーンズ ホプキンズ ユニバーシティー スクール オブ メディシン |
糞便試料から単離した哺乳類の核酸を検出する方法、およびその検出用試薬
|
|
US5428148A
(en)
|
1992-04-24 |
1995-06-27 |
Beckman Instruments, Inc. |
N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
|
|
GB9211979D0
(en)
|
1992-06-05 |
1992-07-15 |
Buchard Ole |
Uses of nucleic acid analogues
|
|
US5843640A
(en)
|
1992-06-19 |
1998-12-01 |
Northwestern University |
Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
|
|
US5861244A
(en)
|
1992-10-29 |
1999-01-19 |
Profile Diagnostic Sciences, Inc. |
Genetic sequence assay using DNA triple strand formation
|
|
US5658751A
(en)
|
1993-04-13 |
1997-08-19 |
Molecular Probes, Inc. |
Substituted unsymmetrical cyanine dyes with selected permeability
|
|
GB9311386D0
(en)
|
1993-06-02 |
1993-07-21 |
Pna Diagnostics As |
Nucleic acid analogue assay procedures
|
|
US5846709A
(en)
|
1993-06-15 |
1998-12-08 |
Imclone Systems Incorporated |
Chemical process for amplifying and detecting nucleic acid sequences
|
|
US5837832A
(en)
|
1993-06-25 |
1998-11-17 |
Affymetrix, Inc. |
Arrays of nucleic acid probes on biological chips
|
|
FR2708288B1
(fr)
|
1993-07-26 |
1995-09-01 |
Bio Merieux |
Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
|
|
US5925517A
(en)
|
1993-11-12 |
1999-07-20 |
The Public Health Research Institute Of The City Of New York, Inc. |
Detectably labeled dual conformation oligonucleotide probes, assays and kits
|
|
CA2137728C
(en)
*
|
1993-12-14 |
1998-07-14 |
William E. Keating |
Enzymatic removal of non-target nucleic acid from biological samples
|
|
DE69432919T2
(de)
|
1993-12-28 |
2004-05-27 |
Tanabe Seiyaku Co., Ltd. |
Verfahren für den Nachweis spezifischer Polynukleotiden
|
|
US5928905A
(en)
|
1995-04-18 |
1999-07-27 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
|
AU707391B2
(en)
|
1994-05-28 |
1999-07-08 |
Tepnel Medical Limited |
Producing copies of nucleic acids
|
|
US5942391A
(en)
|
1994-06-22 |
1999-08-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method: ramification-extension amplification method (RAM)
|
|
ATE226983T1
(de)
|
1994-08-19 |
2002-11-15 |
Pe Corp Ny |
Gekoppeltes ampflikation- und ligationverfahren
|
|
US5574146A
(en)
|
1994-08-30 |
1996-11-12 |
Beckman Instruments, Inc. |
Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
|
|
US5599668A
(en)
|
1994-09-22 |
1997-02-04 |
Abbott Laboratories |
Light scattering optical waveguide method for detecting specific binding events
|
|
US5554744A
(en)
|
1994-09-23 |
1996-09-10 |
Hybridon, Inc. |
Method for loading solid supports for nucleic acid synthesis
|
|
US5604097A
(en)
*
|
1994-10-13 |
1997-02-18 |
Spectragen, Inc. |
Methods for sorting polynucleotides using oligonucleotide tags
|
|
FR2726277B1
(fr)
|
1994-10-28 |
1996-12-27 |
Bio Merieux |
Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
|
|
EP0709466B1
(en)
|
1994-10-28 |
2006-09-27 |
Gen-Probe Incorporated |
Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences
|
|
US5935825A
(en)
|
1994-11-18 |
1999-08-10 |
Shimadzu Corporation |
Process and reagent for amplifying nucleic acid sequences
|
|
US5843650A
(en)
|
1995-05-01 |
1998-12-01 |
Segev; David |
Nucleic acid detection and amplification by chemical linkage of oligonucleotides
|
|
US5929227A
(en)
|
1995-07-12 |
1999-07-27 |
The Regents Of The University Of California |
Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
|
|
US5916779A
(en)
|
1995-09-21 |
1999-06-29 |
Becton, Dickinson And Company |
Strand displacement amplification of RNA targets
|
|
US5981180A
(en)
*
|
1995-10-11 |
1999-11-09 |
Luminex Corporation |
Multiplexed analysis of clinical specimens apparatus and methods
|
|
US5736330A
(en)
|
1995-10-11 |
1998-04-07 |
Luminex Corporation |
Method and compositions for flow cytometric determination of DNA sequences
|
|
US5705629A
(en)
|
1995-10-20 |
1998-01-06 |
Hybridon, Inc. |
Methods for H-phosphonate synthesis of mono- and oligonucleotides
|
|
US5866331A
(en)
|
1995-10-20 |
1999-02-02 |
University Of Massachusetts |
Single molecule detection by in situ hybridization
|
|
US5612473A
(en)
|
1996-01-16 |
1997-03-18 |
Gull Laboratories |
Methods, kits and solutions for preparing sample material for nucleic acid amplification
|
|
AU735440B2
(en)
|
1996-02-09 |
2001-07-05 |
Cornell Research Foundation Inc. |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
|
US5928906A
(en)
|
1996-05-09 |
1999-07-27 |
Sequenom, Inc. |
Process for direct sequencing during template amplification
|
|
US5912124A
(en)
|
1996-06-14 |
1999-06-15 |
Sarnoff Corporation |
Padlock probe detection
|
|
US5939291A
(en)
|
1996-06-14 |
1999-08-17 |
Sarnoff Corporation |
Microfluidic method for nucleic acid amplification
|
|
US5866336A
(en)
*
|
1996-07-16 |
1999-02-02 |
Oncor, Inc. |
Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
|
|
US6117635A
(en)
|
1996-07-16 |
2000-09-12 |
Intergen Company |
Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
|
|
US5853990A
(en)
|
1996-07-26 |
1998-12-29 |
Edward E. Winger |
Real time homogeneous nucleotide assay
|
|
CA2744096C
(en)
|
1996-07-31 |
2013-07-30 |
Laboratory Corporation Of America Holdings |
Biomarkers and targets for diagnosis, prognosis and management of prostate disease
|
|
US5849546A
(en)
|
1996-09-13 |
1998-12-15 |
Epicentre Technologies Corporation |
Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
|
|
US5853992A
(en)
|
1996-10-04 |
1998-12-29 |
The Regents Of The University Of California |
Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels
|
|
US5853993A
(en)
|
1996-10-21 |
1998-12-29 |
Hewlett-Packard Company |
Signal enhancement method and kit
|
|
US5908845A
(en)
|
1996-10-30 |
1999-06-01 |
Segev; David |
Polyether nucleic acids
|
|
US5905024A
(en)
|
1996-12-17 |
1999-05-18 |
University Of Chicago |
Method for performing site-specific affinity fractionation for use in DNA sequencing
|
|
US5846729A
(en)
|
1997-02-27 |
1998-12-08 |
Lorne Park Research, Inc. |
Assaying nucleotides in solution using a fluorescent intensity quenching effect
|
|
US5837860A
(en)
|
1997-03-05 |
1998-11-17 |
Molecular Tool, Inc. |
Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
|
|
US5849497A
(en)
|
1997-04-03 |
1998-12-15 |
The Research Foundation Of State University Of New York |
Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker
|
|
US5846726A
(en)
|
1997-05-13 |
1998-12-08 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
|
US5928869A
(en)
|
1997-05-30 |
1999-07-27 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
|
US5866366A
(en)
|
1997-07-01 |
1999-02-02 |
Smithkline Beecham Corporation |
gidB
|
|
US5916776A
(en)
|
1997-08-27 |
1999-06-29 |
Sarnoff Corporation |
Amplification method for a polynucleotide
|
|
US5935791A
(en)
|
1997-09-23 |
1999-08-10 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
|
US5932451A
(en)
|
1997-11-19 |
1999-08-03 |
Incyte Pharmaceuticals, Inc. |
Method for unbiased mRNA amplification
|
|
GB9812768D0
(en)
*
|
1998-06-13 |
1998-08-12 |
Zeneca Ltd |
Methods
|
|
GB9902971D0
(en)
|
1999-02-11 |
1999-03-31 |
Zeneca Ltd |
Assay
|
|
US6964847B1
(en)
*
|
1999-07-14 |
2005-11-15 |
Packard Biosciences Company |
Derivative nucleic acids and uses thereof
|
|
US6287778B1
(en)
*
|
1999-10-19 |
2001-09-11 |
Affymetrix, Inc. |
Allele detection using primer extension with sequence-coded identity tags
|
|
US7838225B2
(en)
|
1999-10-29 |
2010-11-23 |
Hologic, Inc. |
Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
|
|
JP2003521252A
(ja)
*
|
2000-02-07 |
2003-07-15 |
イルミナ インコーポレイテッド |
ユニバーサルプライミングを用いる核酸検出方法
|
|
US20050106564A1
(en)
*
|
2000-06-02 |
2005-05-19 |
Hechinger Mark K. |
One-step, no-wash multiplex bead-based flow cytometric assay
|
|
WO2001094625A2
(en)
|
2000-06-06 |
2001-12-13 |
Tm Bioscience Corporation |
Capture moieties for nucleic acids and uses thereof
|
|
BRPI0206746B8
(pt)
|
2001-01-25 |
2021-07-27 |
Luminex Molecular Diagnostics Inc |
composição compreendendo conjuntos de moléculas para uso como rótulos ou complementos de rótulo, kit para classificação e identificação de polinucleotídeos, método de análise de uma amostra biológica e método para determinação da presença de um alvo
|
|
US7226737B2
(en)
|
2001-01-25 |
2007-06-05 |
Luminex Molecular Diagnostics, Inc. |
Polynucleotides for use as tags and tag complements, manufacture and use thereof
|
|
US20040076994A1
(en)
|
2001-10-26 |
2004-04-22 |
Hidenobu Yaku |
Method of detecting target nucleic acid and nucleic acid probe
|
|
US6803201B2
(en)
*
|
2002-01-24 |
2004-10-12 |
Stratagene |
Compositions and methods for polynucleotide sequence determination
|
|
JP2004205414A
(ja)
|
2002-12-26 |
2004-07-22 |
Institute Of Physical & Chemical Research |
核酸マイクロアレイ、その作製方法及びその使用方法
|
|
US7700750B2
(en)
*
|
2003-01-09 |
2010-04-20 |
Third Wave Technologies, Inc. |
Connexin allele detection assays
|
|
JP2004283024A
(ja)
|
2003-03-19 |
2004-10-14 |
Junsei Chemical Co Ltd |
新規アンチセンスオリゴヌクレオチド及び抗ｈｉｖ剤
|
|
EP1668157A4
(en)
|
2003-07-07 |
2007-10-24 |
One Cell Systems Inc |
HAIRPIN MARKED PROBES AND METHOD OF USE
|
|
WO2005010199A2
(en)
|
2003-07-16 |
2005-02-03 |
Geneohm Sciences, Inc. |
Invasive cleavage reaction with electrochemical readout
|
|
CA2546171A1
(en)
|
2003-11-17 |
2005-05-26 |
Tm Bioscience Corporation |
Method of detecting mutations associated with thrombosis
|
|
JP2005253427A
(ja)
*
|
2004-03-15 |
2005-09-22 |
Aisin Seiki Co Ltd |
核酸検出方法及び核酸単離方法
|
|
CA2479968A1
(en)
|
2004-09-01 |
2006-03-01 |
Keith R. Walley |
Protein c and endothelial protein c receptor polymorphisms as indicators of patient outcome
|
|
ES2292270B1
(es)
|
2004-04-14 |
2009-02-16 |
Oryzon Genomics, S.A. |
Procedimiento para detectar selectivamente acidos nucleicos con estructuras atipicas convertibles en muescas.
|
|
CA2568499A1
(en)
*
|
2004-06-01 |
2005-12-15 |
Tm Bioscience Corporation |
Method of detecting cystic fibrosis associated mutations
|
|
CA2571817A1
(en)
|
2004-06-30 |
2006-01-12 |
Tm Bioscience Pgx, Inc. |
Method of detecting mutations in the gene encoding cytochrome p450-2c9
|
|
JP2008504826A
(ja)
|
2004-06-30 |
2008-02-21 |
ティーエム バイオサイエンス ピージーエクス インコーポレイティッド |
チトクロムｐ４５０−２ｄ６をコードする遺伝子における変異を検出する方法
|
|
US20070259356A1
(en)
*
|
2004-11-04 |
2007-11-08 |
Applera Corporation |
Concatameric Ligation Products: Compositions, Methods and Kits for Same
|
|
WO2006071770A2
(en)
*
|
2004-12-23 |
2006-07-06 |
I-Stat Corporation |
Molecular diagnostics system and methods
|
|
JP2009501532A
(ja)
*
|
2005-07-15 |
2009-01-22 |
アプレラ コーポレーション |
核酸増幅物の検出
|
|
CA2638773A1
(en)
|
2006-01-24 |
2007-08-02 |
The University Of British Columbia |
Vasopressin pathway polymorphisms as indicators of subject outcome in critically ill subjects
|
|
US20070172841A1
(en)
|
2006-01-25 |
2007-07-26 |
Hui Wang |
Probe/target stabilization with add-in oligo
|
|
JP2008048648A
(ja)
|
2006-08-23 |
2008-03-06 |
Institute Of Physical & Chemical Research |
核酸増幅用プライマーセット及び核酸の増幅方法
|
|
EP2079754B1
(en)
*
|
2006-10-04 |
2017-03-15 |
Third Wave Technologies, Inc. |
Snap-back primers and detectable hairpin structures
|
|
EP2099930B1
(en)
|
2006-12-13 |
2015-02-18 |
Luminex Corporation |
Systems and methods for multiplex analysis of pcr in real time
|
|
US7862999B2
(en)
*
|
2007-01-17 |
2011-01-04 |
Affymetrix, Inc. |
Multiplex targeted amplification using flap nuclease
|
|
EP2167685B1
(de)
|
2007-06-13 |
2014-12-17 |
Attomol GmbH Molekulare Diagnostika |
Verfahren und sonden/primersystem zum "real time" nachweis eines nukleinsäuretargets
|
|
EP2215245A2
(en)
*
|
2007-11-02 |
2010-08-11 |
Luminex Molecular Diagnostics, Inc. |
One-step target detection assay
|
|
US8008019B2
(en)
*
|
2007-11-28 |
2011-08-30 |
Luminex Molecular Diagnostics |
Use of dual-tags for the evaluation of genomic variable repeat regions
|
|
JP4744503B2
(ja)
*
|
2007-11-30 |
2011-08-10 |
シャープ株式会社 |
操作処理装置
|
|
US8312249B1
(en)
|
2008-10-10 |
2012-11-13 |
Apple Inc. |
Dynamic trampoline and structured code generation in a signed code environment
|
|
FR2957821B1
(fr)
|
2010-03-24 |
2014-08-29 |
Inst Francais Du Petrole |
Nouvelle zone de regeneration du catalyseur divisee en secteurs pour unites catalytiques regeneratives
|