JP2012531409A - Ｎｓａｉｄ関連潰瘍を発症するリスクがある患者の処置方法 - Google Patents

Ｎｓａｉｄ関連潰瘍を発症するリスクがある患者の処置方法 Download PDF

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Publication number
JP2012531409A
JP2012531409A JP2012517454A JP2012517454A JP2012531409A JP 2012531409 A JP2012531409 A JP 2012531409A JP 2012517454 A JP2012517454 A JP 2012517454A JP 2012517454 A JP2012517454 A JP 2012517454A JP 2012531409 A JP2012531409 A JP 2012531409A
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Prior art keywords
patient
pharmaceutically acceptable
acceptable salt
dosage form
unit dosage
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Pending
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JP2012517454A
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Japanese (ja)
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JP2012531409A5 (enExample
Inventor
ブライアン・アルト
クララ・ワン
エーバールダス・オールマンズ
ジョン・アール・プラチェツカ
マーク・ソステク
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2012531409A publication Critical patent/JP2012531409A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012517454A 2009-06-25 2010-06-23 Ｎｓａｉｄ関連潰瘍を発症するリスクがある患者の処置方法 Pending JP2012531409A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22042009P 2009-06-25 2009-06-25
US61/220,420 2009-06-25
US22597009P 2009-07-16 2009-07-16
US61/225,970 2009-07-16
US31052510P 2010-03-04 2010-03-04
US61/310,525 2010-03-04
PCT/SE2010/050712 WO2010151216A1 (en) 2009-06-25 2010-06-23 Method for treating a patient at risk for developing an nsaid-associated ulcer

Publications (2)

Publication Number Publication Date
JP2012531409A true JP2012531409A (ja) 2012-12-10
JP2012531409A5 JP2012531409A5 (enExample) 2013-08-01

Family

ID=43381035

Family Applications (1)

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JP2012517454A Pending JP2012531409A (ja) 2009-06-25 2010-06-23 Ｎｓａｉｄ関連潰瘍を発症するリスクがある患者の処置方法

Country Status (13)

Country Link
US (3) US8945621B2 (enExample)
EP (1) EP2445499A4 (enExample)
JP (1) JP2012531409A (enExample)
KR (1) KR20120030106A (enExample)
CN (1) CN102481293A (enExample)
AU (1) AU2010263304A1 (enExample)
CA (1) CA2764963C (enExample)
EA (1) EA201290026A1 (enExample)
IL (1) IL216877A0 (enExample)
MA (1) MA33553B1 (enExample)
MX (1) MX2011013467A (enExample)
SG (1) SG176724A1 (enExample)
WO (1) WO2010151216A1 (enExample)

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JPN6014027342; Ｐｈｉｌｉｐ　Ｂ．　Ｍｉｎｅｒ，　ｅｔ　ａｌ．: 'Ｇａｓｔｒｉｃ　Ａｃｉｄ　Ｓｕｐｐｒｅｓｓｉｏｎ　ｗｉｔｈ　ＰＮ４００，　ａ　Ｓｉｎｇｌｅ-Ｔａｂｌｅｔ，　Ｍｕｌｔｉｌａｙｅｒ，　Ｆｉｘｅｄ-Ｄｏｓｅ　Ｆｏｒｍｕｌａｔｉｏｎ　Ｃｏｍｂｉｎｉｎｇ　Ａ' Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ １３６（５），　Ｓｕｐｐｌｅｍｅｎｔ　１, 200905, Ａ-６１１ *
JPN6014027343; Ｐｈｉｌｉｐ　Ｂ．　Ｍｉｎｅｒ，　ｅｔ　ａｌ．: 'Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ　ｏｆ　Ｎａｐｒｏｘｅｎ　ａｎｄ　Ｅｓｏｍｅｐｒａｚｏｌｅ　ｉｎ　ＰＮ４００，　ａ　Ｓｉｎｇｌｅ-Ｔａｂｌｅｔ，　Ｍｕｌｔｉｌａｙｅｒ　Ｆｏｒｍｕｌａｔｉｏｎ　ｏｆ　Ｅ' Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ １３６（５），　Ｓｕｐｐｌｅｍｅｎｔ　１, 200905, Ａ-６１２ *
JPN6014027344; 'Ａ　１２-ｍｏｎｔｈ，　Ｐｈａｓｅ　３，　Ｏｐｅｎ-ｌａｂｅｌ，　Ｍｕｌｔｉ-ｃｅｎｔｅｒ　Ｓｔｕｄｙ　ｔｏ　Ｅｖａｌｕａｔｅ　ｔｈｅ　Ｌｏｎｇ-ｔｅｒｍ　Ｓａｆｅｔｙ　ｏｆ　ＰＮ４００　（ＶＩＭＯＶ' ＣｌｉｎｉｃａｌＴｒｉａｌｓ．ｇｏｖ , 2007 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024501536A (ja) * 2020-12-30 2024-01-12 エイチケー イノ．エヌ コーポレーション テゴプラザンおよび非ステロイド性抗炎症薬を含有する医薬組成物
JP7566164B2 (ja) 2020-12-30 2024-10-11 エイチケー イノ．エヌ コーポレーション テゴプラザンおよび非ステロイド性抗炎症薬を含有する医薬組成物

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AU2010263304A1 (en) 2012-02-02
US20150202193A1 (en) 2015-07-23
KR20120030106A (ko) 2012-03-27
CA2764963C (en) 2016-11-01
WO2010151216A1 (en) 2010-12-29
US20160166558A1 (en) 2016-06-16
IL216877A0 (en) 2012-02-29
MX2011013467A (es) 2012-02-13
EP2445499A1 (en) 2012-05-02
EP2445499A4 (en) 2013-02-27
US20100330179A1 (en) 2010-12-30
SG176724A1 (en) 2012-01-30
MA33553B1 (fr) 2012-09-01

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