JP2012530504A5 - - Google Patents
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- Publication number
- JP2012530504A5 JP2012530504A5 JP2012516746A JP2012516746A JP2012530504A5 JP 2012530504 A5 JP2012530504 A5 JP 2012530504A5 JP 2012516746 A JP2012516746 A JP 2012516746A JP 2012516746 A JP2012516746 A JP 2012516746A JP 2012530504 A5 JP2012530504 A5 JP 2012530504A5
- Authority
- JP
- Japan
- Prior art keywords
- rsv
- amino acid
- recombinant
- domain
- rsv antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000725643 Respiratory syncytial virus Species 0.000 claims 43
- 239000000427 antigen Substances 0.000 claims 28
- 102000036639 antigens Human genes 0.000 claims 28
- 108091007433 antigens Proteins 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 150000001413 amino acids Chemical class 0.000 claims 13
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 12
- 230000037430 deletion Effects 0.000 claims 8
- 238000012217 deletion Methods 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 108020001507 fusion proteins Proteins 0.000 claims 6
- 102000037865 fusion proteins Human genes 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000004961 Furin Human genes 0.000 claims 5
- 108090001126 Furin Proteins 0.000 claims 5
- 238000007792 addition Methods 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 230000013595 glycosylation Effects 0.000 claims 4
- 238000006206 glycosylation reaction Methods 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000006229 amino acid addition Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 238000005829 trimerization reaction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21996409P | 2009-06-24 | 2009-06-24 | |
| US61/219,964 | 2009-06-24 | ||
| US33456810P | 2010-05-13 | 2010-05-13 | |
| US61/334,568 | 2010-05-13 | ||
| PCT/EP2010/059008 WO2010149745A1 (en) | 2009-06-24 | 2010-06-24 | Recombinant rsv antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016005403A Division JP2016128457A (ja) | 2009-06-24 | 2016-01-14 | 組換えｒｓｖ抗原 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530504A JP2012530504A (ja) | 2012-12-06 |
| JP2012530504A5 true JP2012530504A5 (OSRAM) | 2013-08-08 |
| JP6062245B2 JP6062245B2 (ja) | 2017-01-18 |
Family
ID=42670494
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516746A Expired - Fee Related JP6062245B2 (ja) | 2009-06-24 | 2010-06-24 | 組換えｒｓｖ抗原 |
| JP2016005403A Pending JP2016128457A (ja) | 2009-06-24 | 2016-01-14 | 組換えｒｓｖ抗原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016005403A Pending JP2016128457A (ja) | 2009-06-24 | 2016-01-14 | 組換えｒｓｖ抗原 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9492531B2 (OSRAM) |
| EP (1) | EP2445526B1 (OSRAM) |
| JP (2) | JP6062245B2 (OSRAM) |
| KR (1) | KR101696002B1 (OSRAM) |
| CN (1) | CN102481359B (OSRAM) |
| AU (2) | AU2010264688A1 (OSRAM) |
| BR (1) | BRPI1015917A2 (OSRAM) |
| CA (1) | CA2766211A1 (OSRAM) |
| CL (1) | CL2011003273A1 (OSRAM) |
| CO (1) | CO6480978A2 (OSRAM) |
| CR (1) | CR20120025A (OSRAM) |
| CY (1) | CY1117673T1 (OSRAM) |
| DK (1) | DK2445526T3 (OSRAM) |
| DO (1) | DOP2011000389A (OSRAM) |
| EA (1) | EA023054B1 (OSRAM) |
| ES (1) | ES2583257T3 (OSRAM) |
| HR (1) | HRP20160798T1 (OSRAM) |
| HU (1) | HUE028085T2 (OSRAM) |
| IL (1) | IL217013B (OSRAM) |
| MA (1) | MA33449B1 (OSRAM) |
| MX (1) | MX2012000035A (OSRAM) |
| PE (1) | PE20121541A1 (OSRAM) |
| PL (1) | PL2445526T3 (OSRAM) |
| PT (1) | PT2445526T (OSRAM) |
| SG (1) | SG176829A1 (OSRAM) |
| SI (1) | SI2445526T1 (OSRAM) |
| UA (1) | UA111141C2 (OSRAM) |
| WO (1) | WO2010149745A1 (OSRAM) |
| ZA (1) | ZA201109199B (OSRAM) |
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| ME03442B (me) | 2013-04-25 | 2020-01-20 | Janssen Vaccines & Prevention Bv | Stabilizovani rastvorljivi pre-fuzioni rsv f polipeptidi |
| CN105408348B (zh) | 2013-06-17 | 2021-07-06 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
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| EP3319633B1 (en) | 2015-07-07 | 2020-11-11 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
| SG10202001389PA (en) | 2015-12-23 | 2020-04-29 | Pfizer | Rsv f protein mutants |
| EP3439672B1 (en) | 2016-04-05 | 2020-11-25 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion rsv f protein for use in the prophylaxis of rsv infection |
| IL262109B2 (en) | 2016-04-05 | 2023-04-01 | Janssen Vaccines Prevention B V | vaccine against rsv |
| IL264119B2 (en) | 2016-05-30 | 2023-04-01 | Janssen Vaccines Prevention B V | f proteins of rsv are stabilized before fusion |
| WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| CN107872643A (zh) * | 2016-09-23 | 2018-04-03 | 伊姆西Ip控股有限责任公司 | 用于视频监控系统的故障恢复方法和装置 |
| TWI683826B (zh) * | 2016-11-22 | 2020-02-01 | 國立臺灣大學 | 重組ｒｓｖ抗原 |
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| WO2018211419A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| CA3061278A1 (en) | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| US12016919B2 (en) | 2017-05-30 | 2024-06-25 | Glaxosmithkline Biologicals Sa | Methods for manufacturing an adjuvant |
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| WO2019053109A1 (en) | 2017-09-15 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | METHOD FOR SAFE INDUCTION OF IMMUNITY AGAINST RSV |
| KR102700187B1 (ko) * | 2017-09-29 | 2024-08-28 | 에스케이바이오사이언스(주) | 가용성 변형 호흡기 융합세포 바이러스 (ｒｓｖ) ｆ 단백질 항원 |
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| CN115772230A (zh) * | 2022-07-18 | 2023-03-10 | 青岛硕景生物科技有限公司 | 一种rsv重组抗原、其制备方法及应用 |
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| FR2873378A1 (fr) | 2004-07-23 | 2006-01-27 | Pierre Fabre Medicament Sa | Complexes immunogenes, leur procede de preparation et leur utilisation dans des compositions pharmaceutiques |
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2010
- 2010-06-24 WO PCT/EP2010/059008 patent/WO2010149745A1/en not_active Ceased
- 2010-06-24 US US13/378,391 patent/US9492531B2/en not_active Expired - Fee Related
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- 2010-06-24 ES ES10724879.1T patent/ES2583257T3/es active Active
- 2010-06-24 SG SG2011092319A patent/SG176829A1/en unknown
- 2010-06-24 KR KR1020127001782A patent/KR101696002B1/ko not_active Expired - Fee Related
- 2010-06-24 JP JP2012516746A patent/JP6062245B2/ja not_active Expired - Fee Related
- 2010-06-24 UA UAA201200714A patent/UA111141C2/uk unknown
- 2010-06-24 AU AU2010264688A patent/AU2010264688A1/en not_active Abandoned
- 2010-06-24 PL PL10724879T patent/PL2445526T3/pl unknown
- 2010-06-24 MX MX2012000035A patent/MX2012000035A/es active IP Right Grant
- 2010-06-24 DK DK10724879.1T patent/DK2445526T3/en active
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- 2010-06-24 PE PE2011002168A patent/PE20121541A1/es not_active Application Discontinuation
- 2010-06-24 CN CN201080037770.3A patent/CN102481359B/zh not_active Expired - Fee Related
- 2010-06-24 MA MA34557A patent/MA33449B1/fr unknown
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