JP2012524092A - アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物 - Google Patents

アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物 Download PDF

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Publication number
JP2012524092A
JP2012524092A JP2012506123A JP2012506123A JP2012524092A JP 2012524092 A JP2012524092 A JP 2012524092A JP 2012506123 A JP2012506123 A JP 2012506123A JP 2012506123 A JP2012506123 A JP 2012506123A JP 2012524092 A JP2012524092 A JP 2012524092A
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JP
Japan
Prior art keywords
capsule
peg
pharmaceutical composition
crystallization inhibitor
trifluoropentanamide
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Pending
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JP2012506123A
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English (en)
Japanese (ja)
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JP2012524092A5 (enExample
Inventor
サチン・チャンドラン
ラジェシュ・バブラル・ガンジー
ジャクアン・カラニ・レボンズ
ロバート・ケビン・パーローン
クリストファー・ピー・プライス
クリシュナスワミー・スリニバス・ラガーバン
イスマト・ウラー
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2012524092A publication Critical patent/JP2012524092A/ja
Publication of JP2012524092A5 publication Critical patent/JP2012524092A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2012506123A 2009-04-14 2010-04-13 アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物 Pending JP2012524092A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16906109P 2009-04-14 2009-04-14
US61/169,061 2009-04-14
PCT/US2010/030862 WO2010120755A1 (en) 2009-04-14 2010-04-13 Bioavailable capsule compositions of amorphous alpha-(n-sulfonamido)acetamide compound

Publications (2)

Publication Number Publication Date
JP2012524092A true JP2012524092A (ja) 2012-10-11
JP2012524092A5 JP2012524092A5 (enExample) 2013-03-28

Family

ID=42235859

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012506123A Pending JP2012524092A (ja) 2009-04-14 2010-04-13 アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物

Country Status (14)

Country Link
US (1) US8252821B2 (enExample)
EP (1) EP2419090B1 (enExample)
JP (1) JP2012524092A (enExample)
KR (1) KR20120022766A (enExample)
CN (1) CN102395361A (enExample)
AR (1) AR076305A1 (enExample)
AU (1) AU2010236602A1 (enExample)
BR (1) BRPI1015483A2 (enExample)
CA (1) CA2758847A1 (enExample)
EA (1) EA201101286A1 (enExample)
MX (1) MX2011010514A (enExample)
NZ (1) NZ595335A (enExample)
TW (1) TW201041609A (enExample)
WO (1) WO2010120755A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8934446B2 (en) 2009-10-02 2015-01-13 Lg Electronics Inc. Transmission method and device for a downlink reference signal
JP2022523371A (ja) * 2019-02-22 2022-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 医薬製剤

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NZ533603A (en) 2001-12-20 2007-02-23 Bristol Myers Squibb Co Alpha-(N-sulphonamido)acetamide derivatives as beta-amyloid inhibitors used for treating Alzheimer's Disease and Down's syndrome
US8044077B2 (en) 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
NZ613167A (en) * 2010-12-16 2015-09-25 Univ Texas Azole pharmaceutical formulations for parenteral administration and methods for preparing and using the same as treatment of diseases sensitive to azole compounds
US9364433B2 (en) 2011-04-28 2016-06-14 Borje S. Andersson Parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same
US20130302414A1 (en) * 2012-05-07 2013-11-14 Bristol-Myers Squibb Company Solubilized capsule formulation of 1,1-dimethylethyl [(1s)-1-carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
BR112021019799A2 (pt) 2019-04-11 2021-12-07 Janssen Pharmaceutica Nv Derivados contendo anéis de piridina como inibidores de malt1
JP2023538099A (ja) * 2020-08-21 2023-09-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｍａｌｔ１阻害剤と、ポリエチレングリコールの脂肪酸との混合物と、を含む、医薬製剤

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JP2001523221A (ja) * 1996-09-01 2001-11-20 ファーモス コーポレイション 親油性物質の促進された生物学的利用能のための固形共沈物
JP2005506990A (ja) * 2001-10-19 2005-03-10 アイソテクニカ インコーポレーテッド 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
JP2007535545A (ja) * 2004-04-28 2007-12-06 プロキャリア・インコーポレーテッド 難吸収性薬剤の経口投与のための製剤

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NZ321293A (en) 1995-11-17 2001-04-27 Warner Lambert Co Sulfonamide inhibitors of matrix metalloproteinases
CZ16899A3 (cs) 1996-07-22 1999-08-11 Monsanto Company Thiolsulfonamidové inhibitory metaloproteázy
JPH11343279A (ja) 1998-03-16 1999-12-14 Shionogi & Co Ltd スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤
US6313123B1 (en) 1999-01-27 2001-11-06 American Cyanamid Company Acetylenic sulfonamide thiol tace inhibitors
JP2002535386A (ja) 1999-01-27 2002-10-22 アメリカン・サイアナミド・カンパニー アセチレンスルホンアミドチオールｔａｃｅインヒビター
NZ514453A (en) 1999-02-26 2003-04-29 Merck & Co Inc Novel sulfonamide compounds and uses thereof
NZ533603A (en) 2001-12-20 2007-02-23 Bristol Myers Squibb Co Alpha-(N-sulphonamido)acetamide derivatives as beta-amyloid inhibitors used for treating Alzheimer's Disease and Down's syndrome
RU2342374C2 (ru) 2003-03-31 2008-12-27 Уайт Фтор- и трифторалкилсодержащие гетероциклические сульфонамидные ингибиторы образования бета-амилоида и их производные
RU2364587C2 (ru) 2003-10-29 2009-08-20 Элан Фармасьютикалз, Инк. N-замещенные бензолсульфонамиды
US7163942B2 (en) 2004-04-01 2007-01-16 Pfizer Inc. Sulfonamide compounds for the treatment of neurodegenerative disorders
JP4845883B2 (ja) 2004-07-13 2011-12-28 エフ．ホフマン−ラ ロシュ アーゲー スルホンアミド誘導体
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TW200732295A (en) 2006-02-17 2007-09-01 Wyeth Corp Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
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US8084477B2 (en) 2007-10-31 2011-12-27 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
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KR20110133046A (ko) 2009-03-19 2011-12-09 브리스톨-마이어스 스큅 컴퍼니 베타 아밀로이드 펩티드 생성의 억제제로서의 신규 알파-(ｎ-술폰아미도)아세트아미드 화합물
US8044077B2 (en) 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US20110071199A1 (en) 2009-03-20 2011-03-24 Bristol-Myers Squibb Company Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease
TW201043269A (en) 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound

Patent Citations (3)

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JP2001523221A (ja) * 1996-09-01 2001-11-20 ファーモス コーポレイション 親油性物質の促進された生物学的利用能のための固形共沈物
JP2005506990A (ja) * 2001-10-19 2005-03-10 アイソテクニカ インコーポレーテッド 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
JP2007535545A (ja) * 2004-04-28 2007-12-06 プロキャリア・インコーポレーテッド 難吸収性薬剤の経口投与のための製剤

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JPN6014008835; Ｉｍｂｉｍｂｏ　ＢＰ: 'Ａｌｚｈｅｉｍｅｒ'ｓ　ｄｉｓｅａｓｅ：　gamma-ｓｅｃｒｅｔａｓｅ　ｉｎｈｉｂｉｔｏｒｓ' Ｄｒｕｇ　Ｄｉｓｃｏｖｅｒｙ　Ｔｏｄａｙ：　Ｔｈｅｒａｐｅｕｔｉｃ　Ｓｔｒａｔｅｇｉｅｓ Ｖｏｌ．５　Ｎｏ．３, 2008, ｐｐ．１６９-１７５ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8934446B2 (en) 2009-10-02 2015-01-13 Lg Electronics Inc. Transmission method and device for a downlink reference signal
US9313003B2 (en) 2009-10-02 2016-04-12 Lg Electronics Inc. Transmission method and device for a downlink reference signal
JP2022523371A (ja) * 2019-02-22 2022-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 医薬製剤

Also Published As

Publication number Publication date
US20100260837A1 (en) 2010-10-14
TW201041609A (en) 2010-12-01
BRPI1015483A2 (pt) 2016-04-26
CN102395361A (zh) 2012-03-28
AR076305A1 (es) 2011-06-01
WO2010120755A1 (en) 2010-10-21
NZ595335A (en) 2013-03-28
CA2758847A1 (en) 2010-10-21
AU2010236602A1 (en) 2011-10-13
EP2419090A1 (en) 2012-02-22
EA201101286A1 (ru) 2012-04-30
US8252821B2 (en) 2012-08-28
MX2011010514A (es) 2011-11-29
EP2419090B1 (en) 2013-02-13
KR20120022766A (ko) 2012-03-12

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