AR076305A1 - Composiciones de capsulas biodisponibles de compuesto alfa-(n-sulfonamido) acetamida amorfo - Google Patents
Composiciones de capsulas biodisponibles de compuesto alfa-(n-sulfonamido) acetamida amorfoInfo
- Publication number
- AR076305A1 AR076305A1 ARP100101257A ARP100101257A AR076305A1 AR 076305 A1 AR076305 A1 AR 076305A1 AR P100101257 A ARP100101257 A AR P100101257A AR P100101257 A ARP100101257 A AR P100101257A AR 076305 A1 AR076305 A1 AR 076305A1
- Authority
- AR
- Argentina
- Prior art keywords
- peg
- pvp
- capsule
- polyethylene glycol
- pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Composiciones farmacéuticas en cápsulas que contienen el compuesto activo (2R)-2-[[(4-clorofenil)sulfonil][[2-fluoro-4-(1,2,4-oxadiazol-3-iI)fenil]metil]amino]-5,5,5-trifluoropentanamida, y polietilenglicol (PEG), Vitamina E succinato de polietilenglicol, polivinilpirrolidona (PVP) o copovidona (PVP-acetato de polivinilo), con o sin ácido cítrico. Reivindicacion 1: Una composicion caracterizada porque comprende aproximadamente de 0,1 a 20% de (2R)2-[[(4-clorofenil)sulfonil][[2-fluoro-4-(1,2,4-oxadiazol-3-iI)fenil]metil]amino]-5,5,5-trifluoropentanamida, hasta aproximadamente 90% de polietilenglicol (PEG) y hasta aproximadamente 90% de Vitamina E succinato de polietilenglicol (TPGS), aproximadamente de 0,1 a 20% de un miembro inhibidor de la cristalizacion seleccionado del grupo constituido por polivinilpirrolidona (PVP) y copovidona (PVP-acetato de polivinilo); y aproximadamente de 0,05 a 5% de ácido cítrico. Reivindicacion 6: La composicion farmacéutica de la reivindicacion 3, caracterizada porque dicho PEG es PEG 1450. Reivindicacion 11: La cápsula farmacéutica de la reivindicacion 10, caracterizada porque dicha cápsula es una cápsula de gelatina dura. Reivindicacion 19: La composicion farmacéutica de la reivindicacion 15, caracterizada porque dicho PEG es PEG 400. Reivindicacion 23: La cápsula farmacéutica de la reivindicacion 22, caracterizada porque dicha capsula es una cápsula de gelatina blanda. Reivindicacion 28: Un procedimiento de fabricacion de una composicion farmacéutica, caracterizado porque comprende disolver (2R)-2-[[(4-clorofenil)sulfonil][[2-fluoro-4-(1,2,4-oxadiazol-3-iI)fenil]metil]amino]-5,5,5-trifluoropentanamida en una mezcla de PEG, TPGS y un miembro inhibidor de la cristalizacion seleccionado del grupo constituido por PVP y copovidona.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16906109P | 2009-04-14 | 2009-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR076305A1 true AR076305A1 (es) | 2011-06-01 |
Family
ID=42235859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101257A AR076305A1 (es) | 2009-04-14 | 2010-04-14 | Composiciones de capsulas biodisponibles de compuesto alfa-(n-sulfonamido) acetamida amorfo |
Country Status (14)
Country | Link |
---|---|
US (1) | US8252821B2 (es) |
EP (1) | EP2419090B1 (es) |
JP (1) | JP2012524092A (es) |
KR (1) | KR20120022766A (es) |
CN (1) | CN102395361A (es) |
AR (1) | AR076305A1 (es) |
AU (1) | AU2010236602A1 (es) |
BR (1) | BRPI1015483A2 (es) |
CA (1) | CA2758847A1 (es) |
EA (1) | EA201101286A1 (es) |
MX (1) | MX2011010514A (es) |
NZ (1) | NZ595335A (es) |
TW (1) | TW201041609A (es) |
WO (1) | WO2010120755A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS51155B (sr) | 2001-12-20 | 2010-10-31 | Bristol-Myers Squibb Company | DERIVATI α -(N-SULFONAMIDO)ACETAMIDA KAO INHIBITORI β -AMILOIDA |
US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
US7977362B2 (en) | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
JP2013507033A (ja) | 2009-10-02 | 2013-02-28 | エルジー エレクトロニクス インコーポレイティド | ダウンリンク参照信号の転送方法及び装置 |
RU2618456C2 (ru) * | 2010-12-16 | 2017-05-03 | Плэтформ Брайтворкс Ту, Лтд | Фармацевтические препараты азолов для парентерального введения и способы их получения и применения для лечения заболеваний, чувствительных к азольным соединениям |
EP3238709B1 (en) | 2011-04-28 | 2020-07-01 | Platform Brightworks Two, Ltd. | Improved parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same |
US20130302414A1 (en) * | 2012-05-07 | 2013-11-14 | Bristol-Myers Squibb Company | Solubilized capsule formulation of 1,1-dimethylethyl [(1s)-1-carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate |
SG11202109102PA (en) * | 2019-02-22 | 2021-09-29 | Janssen Pharmaceutica Nv | Pharmaceutical formulations |
CN115884773A (zh) * | 2020-08-21 | 2023-03-31 | 詹森药业有限公司 | 药物制剂 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
GB9202791D0 (en) * | 1992-02-11 | 1992-03-25 | British Bio Technology | Compounds |
BR9611487A (pt) * | 1995-11-17 | 1999-01-19 | Warner Lambert Co | Inibidores de sulfonamida de metaloproteinases de matriz |
CA2260860A1 (en) | 1996-07-22 | 1998-01-29 | Monsanto Company | Thiol sulfonamide metalloprotease inhibitors |
CA2264718C (en) * | 1996-09-01 | 2006-05-30 | Pharmos Corporation | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
JPH11343279A (ja) | 1998-03-16 | 1999-12-14 | Shionogi & Co Ltd | スルホンアミド誘導体およびそれらを含有するTNF―α産生抑制剤 |
WO2000044716A1 (en) | 1999-01-27 | 2000-08-03 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
US6313123B1 (en) * | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
NZ514453A (en) | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
AU2002333098B2 (en) * | 2001-10-19 | 2006-03-16 | Isotechnika Pharma Inc. | Novel cyclosporin analog microemulsion preconcentrates |
RS51155B (sr) | 2001-12-20 | 2010-10-31 | Bristol-Myers Squibb Company | DERIVATI α -(N-SULFONAMIDO)ACETAMIDA KAO INHIBITORI β -AMILOIDA |
KR20060002908A (ko) * | 2003-03-31 | 2006-01-09 | 와이어쓰 | 베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체 |
AU2004285022A1 (en) | 2003-10-29 | 2005-05-12 | Elan Pharmaceuticals, Inc. | N-substituted benzene sulfonamides |
US7163942B2 (en) | 2004-04-01 | 2007-01-16 | Pfizer Inc. | Sulfonamide compounds for the treatment of neurodegenerative disorders |
CA2595116A1 (en) * | 2004-04-28 | 2005-11-10 | Procarrier, Inc. | Oral formulation for delivery of poorly absorbed drugs |
MX2007000468A (es) | 2004-07-13 | 2007-03-08 | Hoffmann La Roche | Derivados de sulfonamida. |
US7144894B2 (en) | 2004-09-23 | 2006-12-05 | Bristol-Myers Squibb Company | Sulfonamide bicyclic compounds |
KR20070088770A (ko) * | 2004-12-14 | 2007-08-29 | 와이어쓰 | 신경변성 장애의 치료 및 예방을 위한 5-ht6 작용제의용도 |
CA2641013A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Methods for preparing sulfonamide substituted alcohols and intermediates thereof |
CA2637615A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
WO2007103683A2 (en) * | 2006-03-01 | 2007-09-13 | Roskamp Research Llc | Compounds for inhibiting beta-amyloid production |
US8633179B2 (en) | 2007-03-13 | 2014-01-21 | The Trustees Of Columbia University In The City Of New York | Synergistic interaction of NOTCH-1 inhibitors with glucocorticoids |
WO2009005688A2 (en) | 2007-06-29 | 2009-01-08 | Trustees Of Columbia University In The City Of New York | Activating mutations in notch-1 |
US8084477B2 (en) | 2007-10-31 | 2011-12-27 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
US20110059940A1 (en) | 2008-05-08 | 2011-03-10 | Bristol- Myers Squibb Company | 2-Aryl Glycinamide Derivatives |
US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
JP2012520875A (ja) | 2009-03-19 | 2012-09-10 | ブリストル−マイヤーズ スクイブ カンパニー | ベータアミロイドペプチド産生阻害剤としての新規アルファ−(n−スルホンアミド)アセトアミド化合物 |
US7977362B2 (en) | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
US20110071199A1 (en) | 2009-03-20 | 2011-03-24 | Bristol-Myers Squibb Company | Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease |
TW201043269A (en) | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
-
2010
- 2010-04-12 US US12/758,385 patent/US8252821B2/en not_active Expired - Fee Related
- 2010-04-13 CA CA2758847A patent/CA2758847A1/en not_active Abandoned
- 2010-04-13 AU AU2010236602A patent/AU2010236602A1/en not_active Abandoned
- 2010-04-13 JP JP2012506123A patent/JP2012524092A/ja active Pending
- 2010-04-13 KR KR1020117024036A patent/KR20120022766A/ko not_active Application Discontinuation
- 2010-04-13 WO PCT/US2010/030862 patent/WO2010120755A1/en active Application Filing
- 2010-04-13 CN CN2010800164919A patent/CN102395361A/zh active Pending
- 2010-04-13 EA EA201101286A patent/EA201101286A1/ru unknown
- 2010-04-13 NZ NZ595335A patent/NZ595335A/xx not_active IP Right Cessation
- 2010-04-13 BR BRPI1015483A patent/BRPI1015483A2/pt not_active IP Right Cessation
- 2010-04-13 EP EP10714418A patent/EP2419090B1/en not_active Not-in-force
- 2010-04-13 MX MX2011010514A patent/MX2011010514A/es active IP Right Grant
- 2010-04-14 AR ARP100101257A patent/AR076305A1/es not_active Application Discontinuation
- 2010-04-14 TW TW099111671A patent/TW201041609A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010236602A1 (en) | 2011-10-13 |
WO2010120755A1 (en) | 2010-10-21 |
EP2419090B1 (en) | 2013-02-13 |
CN102395361A (zh) | 2012-03-28 |
EP2419090A1 (en) | 2012-02-22 |
MX2011010514A (es) | 2011-11-29 |
NZ595335A (en) | 2013-03-28 |
CA2758847A1 (en) | 2010-10-21 |
KR20120022766A (ko) | 2012-03-12 |
BRPI1015483A2 (pt) | 2016-04-26 |
JP2012524092A (ja) | 2012-10-11 |
EA201101286A1 (ru) | 2012-04-30 |
US20100260837A1 (en) | 2010-10-14 |
US8252821B2 (en) | 2012-08-28 |
TW201041609A (en) | 2010-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |