AR076305A1 - Composiciones de capsulas biodisponibles de compuesto alfa-(n-sulfonamido) acetamida amorfo - Google Patents
Composiciones de capsulas biodisponibles de compuesto alfa-(n-sulfonamido) acetamida amorfoInfo
- Publication number
- AR076305A1 AR076305A1 ARP100101257A ARP100101257A AR076305A1 AR 076305 A1 AR076305 A1 AR 076305A1 AR P100101257 A ARP100101257 A AR P100101257A AR P100101257 A ARP100101257 A AR P100101257A AR 076305 A1 AR076305 A1 AR 076305A1
- Authority
- AR
- Argentina
- Prior art keywords
- peg
- pvp
- capsule
- polyethylene glycol
- pharmaceutical
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000002131 composite material Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 9
- 229920001223 polyethylene glycol Polymers 0.000 abstract 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 4
- 229920001531 copovidone Polymers 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 3
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 abstract 2
- 229930003427 Vitamin E Natural products 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 2
- 239000007903 gelatin capsule Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 229920002689 polyvinyl acetate Polymers 0.000 abstract 2
- 239000011118 polyvinyl acetate Substances 0.000 abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 2
- 229940046009 vitamin E Drugs 0.000 abstract 2
- 235000019165 vitamin E Nutrition 0.000 abstract 2
- 239000011709 vitamin E Substances 0.000 abstract 2
- 229920002534 Polyethylene Glycol 1450 Polymers 0.000 abstract 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16906109P | 2009-04-14 | 2009-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076305A1 true AR076305A1 (es) | 2011-06-01 |
Family
ID=42235859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101257A AR076305A1 (es) | 2009-04-14 | 2010-04-14 | Composiciones de capsulas biodisponibles de compuesto alfa-(n-sulfonamido) acetamida amorfo |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8252821B2 (enExample) |
| EP (1) | EP2419090B1 (enExample) |
| JP (1) | JP2012524092A (enExample) |
| KR (1) | KR20120022766A (enExample) |
| CN (1) | CN102395361A (enExample) |
| AR (1) | AR076305A1 (enExample) |
| AU (1) | AU2010236602A1 (enExample) |
| BR (1) | BRPI1015483A2 (enExample) |
| CA (1) | CA2758847A1 (enExample) |
| EA (1) | EA201101286A1 (enExample) |
| MX (1) | MX2011010514A (enExample) |
| NZ (1) | NZ595335A (enExample) |
| TW (1) | TW201041609A (enExample) |
| WO (1) | WO2010120755A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60232276D1 (de) | 2001-12-20 | 2009-06-18 | Bristol Myers Squibb Co | Alpha-(n-sulfonamid)acetamidderivate als beta-amyloidinhibitoren |
| US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
| US7977362B2 (en) | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
| CN102577156B (zh) | 2009-10-02 | 2016-01-20 | Lg电子株式会社 | 用于下行链路参考信号的发送方法和装置 |
| RU2618456C2 (ru) | 2010-12-16 | 2017-05-03 | Плэтформ Брайтворкс Ту, Лтд | Фармацевтические препараты азолов для парентерального введения и способы их получения и применения для лечения заболеваний, чувствительных к азольным соединениям |
| HUE034480T2 (en) | 2011-04-28 | 2018-02-28 | Platform Brightworks Two Ltd | Improved parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same |
| US20130302414A1 (en) * | 2012-05-07 | 2013-11-14 | Bristol-Myers Squibb Company | Solubilized capsule formulation of 1,1-dimethylethyl [(1s)-1-carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| MX2021010144A (es) * | 2019-02-22 | 2021-09-14 | Janssen Pharmaceutica Nv | Formulaciones farmaceuticas. |
| KR20210151880A (ko) | 2019-04-11 | 2021-12-14 | 얀센 파마슈티카 엔.브이. | Malt1 억제제로서의 피리딘 고리 함유 유도체 |
| EP4199911A1 (en) * | 2020-08-21 | 2023-06-28 | JANSSEN Pharmaceutica NV | Pharmaceutical formulations comprising a malt1 inhibitor and a mixture of polyethylene glycol with a fatty acid |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5274094A (en) | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| GB9202791D0 (en) | 1992-02-11 | 1992-03-25 | British Bio Technology | Compounds |
| DK0874836T3 (da) | 1995-11-17 | 2003-02-10 | Warner Lambert Co | Sulfonamidinhibitorer af matrix metalloproteinaser |
| CZ16899A3 (cs) | 1996-07-22 | 1999-08-11 | Monsanto Company | Thiolsulfonamidové inhibitory metaloproteázy |
| CA2264718C (en) * | 1996-09-01 | 2006-05-30 | Pharmos Corporation | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
| JPH11343279A (ja) | 1998-03-16 | 1999-12-14 | Shionogi & Co Ltd | スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤 |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| PL350420A1 (en) | 1999-01-27 | 2002-12-16 | American Cyanamid Co | Acetylenic sulfonamide thiol tace inhibitors |
| WO2000050391A1 (en) | 1999-02-26 | 2000-08-31 | Merck & Co., Inc. | Novel sulfonamide compounds and uses thereof |
| PT1435910E (pt) * | 2001-10-19 | 2009-09-07 | Isotechnika Inc | Novos pré-concentrados de microemulsão de análogos da ciclosporina |
| DE60232276D1 (de) | 2001-12-20 | 2009-06-18 | Bristol Myers Squibb Co | Alpha-(n-sulfonamid)acetamidderivate als beta-amyloidinhibitoren |
| NZ542468A (en) | 2003-03-31 | 2009-01-31 | Wyeth Corp | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
| JP2007512242A (ja) | 2003-10-29 | 2007-05-17 | イーラン ファーマスーティカルズ、インコーポレイテッド | Ｎ−置換ベンゼンスルホンアミド |
| US7163942B2 (en) | 2004-04-01 | 2007-01-16 | Pfizer Inc. | Sulfonamide compounds for the treatment of neurodegenerative disorders |
| BRPI0510310A (pt) * | 2004-04-28 | 2007-10-16 | Procarrier Inc | formulação oral para aplicação de drogas fracamente absorvidas |
| KR100880972B1 (ko) | 2004-07-13 | 2009-02-03 | 에프. 호프만-라 로슈 아게 | 설폰아마이드 유도체 |
| US7144894B2 (en) | 2004-09-23 | 2006-12-05 | Bristol-Myers Squibb Company | Sulfonamide bicyclic compounds |
| RU2007122450A (ru) * | 2004-12-14 | 2009-01-27 | Вайет (Us) | Применение агониста рецептора 5-нт6 для лечения и профилактики нейродегенеративных заболеваний |
| BRPI0707742A2 (pt) | 2006-02-17 | 2011-05-10 | Wyeth Corp | processo para preparar um composto |
| KR20080093126A (ko) | 2006-02-17 | 2008-10-20 | 와이어쓰 | 술폰아미드 치환된 알코올 및 이의 중간체의 제조 방법 |
| US20090017112A1 (en) * | 2006-03-01 | 2009-01-15 | Roskamp Research Llc | Compounds for Inhibiting Beta-Amyloid Production |
| WO2008112249A1 (en) | 2007-03-13 | 2008-09-18 | Trustees Of Columbia University In The City Of New York | Synergistic interaction of notch-1 inhibitors with glucocorticoids |
| WO2009005688A2 (en) | 2007-06-29 | 2009-01-08 | Trustees Of Columbia University In The City Of New York | Activating mutations in notch-1 |
| US8084477B2 (en) * | 2007-10-31 | 2011-12-27 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
| EP2278878A4 (en) | 2008-05-08 | 2014-08-27 | Bristol Myers Squibb Co | 2-ARYL-GYCINAMID DERIVATIVES |
| JP2012520875A (ja) | 2009-03-19 | 2012-09-10 | ブリストル−マイヤーズ スクイブ カンパニー | ベータアミロイドペプチド産生阻害剤としての新規アルファ−（ｎ−スルホンアミド）アセトアミド化合物 |
| US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
| US7977362B2 (en) | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
| US20110071199A1 (en) | 2009-03-20 | 2011-03-24 | Bristol-Myers Squibb Company | Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease |
| TW201043269A (en) | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
-
2010
- 2010-04-12 US US12/758,385 patent/US8252821B2/en not_active Expired - Fee Related
- 2010-04-13 EA EA201101286A patent/EA201101286A1/ru unknown
- 2010-04-13 JP JP2012506123A patent/JP2012524092A/ja active Pending
- 2010-04-13 CN CN2010800164919A patent/CN102395361A/zh active Pending
- 2010-04-13 NZ NZ595335A patent/NZ595335A/xx not_active IP Right Cessation
- 2010-04-13 MX MX2011010514A patent/MX2011010514A/es active IP Right Grant
- 2010-04-13 AU AU2010236602A patent/AU2010236602A1/en not_active Abandoned
- 2010-04-13 CA CA2758847A patent/CA2758847A1/en not_active Abandoned
- 2010-04-13 BR BRPI1015483A patent/BRPI1015483A2/pt not_active IP Right Cessation
- 2010-04-13 KR KR1020117024036A patent/KR20120022766A/ko not_active Withdrawn
- 2010-04-13 EP EP10714418A patent/EP2419090B1/en not_active Not-in-force
- 2010-04-13 WO PCT/US2010/030862 patent/WO2010120755A1/en not_active Ceased
- 2010-04-14 TW TW099111671A patent/TW201041609A/zh unknown
- 2010-04-14 AR ARP100101257A patent/AR076305A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012524092A (ja) | 2012-10-11 |
| KR20120022766A (ko) | 2012-03-12 |
| US20100260837A1 (en) | 2010-10-14 |
| EP2419090A1 (en) | 2012-02-22 |
| TW201041609A (en) | 2010-12-01 |
| BRPI1015483A2 (pt) | 2016-04-26 |
| NZ595335A (en) | 2013-03-28 |
| EP2419090B1 (en) | 2013-02-13 |
| CN102395361A (zh) | 2012-03-28 |
| MX2011010514A (es) | 2011-11-29 |
| WO2010120755A1 (en) | 2010-10-21 |
| AU2010236602A1 (en) | 2011-10-13 |
| US8252821B2 (en) | 2012-08-28 |
| EA201101286A1 (ru) | 2012-04-30 |
| CA2758847A1 (en) | 2010-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |