JP2012523418A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012523418A5 JP2012523418A5 JP2012504788A JP2012504788A JP2012523418A5 JP 2012523418 A5 JP2012523418 A5 JP 2012523418A5 JP 2012504788 A JP2012504788 A JP 2012504788A JP 2012504788 A JP2012504788 A JP 2012504788A JP 2012523418 A5 JP2012523418 A5 JP 2012523418A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- arylalkyl
- cycloalkyl
- heteroarylalkyl
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 60
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 42
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 40
- 125000003710 aryl alkyl group Chemical group 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 33
- 125000003118 aryl group Chemical group 0.000 claims 31
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 29
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 27
- 125000000753 cycloalkyl group Chemical group 0.000 claims 27
- 238000000034 method Methods 0.000 claims 25
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 17
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 16
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 14
- 230000002401 inhibitory effect Effects 0.000 claims 14
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 208000024827 Alzheimer disease Diseases 0.000 claims 8
- 230000006999 cognitive decline Effects 0.000 claims 8
- 208000010877 cognitive disease Diseases 0.000 claims 8
- 238000001228 spectrum Methods 0.000 claims 8
- 230000006933 amyloid-beta aggregation Effects 0.000 claims 6
- 230000003941 amyloidogenesis Effects 0.000 claims 6
- 210000002569 neuron Anatomy 0.000 claims 6
- 239000010649 ginger oil Substances 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 238000004587 chromatography analysis Methods 0.000 claims 4
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 4
- 238000005576 amination reaction Methods 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- YMVFJGSXZNNUDW-UHFFFAOYSA-N (4-chlorophenyl)methanamine Chemical compound NCC1=CC=C(Cl)C=C1 YMVFJGSXZNNUDW-UHFFFAOYSA-N 0.000 claims 2
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims 2
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- PRDBLLIPPDOICK-UHFFFAOYSA-N [4-(trifluoromethyl)phenyl]methanamine Chemical compound NCC1=CC=C(C(F)(F)F)C=C1 PRDBLLIPPDOICK-UHFFFAOYSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 230000003942 amyloidogenic effect Effects 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 239000012043 crude product Substances 0.000 claims 2
- 230000007774 longterm Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 2
- JWMMMNZRBWMHKZ-UHFFFAOYSA-N 2-methoxy-4-[3-[[4-(trifluoromethyl)phenyl]methylamino]butyl]phenol Chemical compound C1=C(O)C(OC)=CC(CCC(C)NCC=2C=CC(=CC=2)C(F)(F)F)=C1 JWMMMNZRBWMHKZ-UHFFFAOYSA-N 0.000 claims 1
- RWINHBJFJJHNKQ-UHFFFAOYSA-N 4-[3-[(4-chlorophenyl)methylamino]butyl]-2-methoxyphenol Chemical compound C1=C(O)C(OC)=CC(CCC(C)NCC=2C=CC(Cl)=CC=2)=C1 RWINHBJFJJHNKQ-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 0 C*c1c(*)c(*)c(*)c(*)c1* Chemical compound C*c1c(*)c(*)c(*)c(*)c1* 0.000 description 5
- 102000011040 TRPV Cation Channels Human genes 0.000 description 2
- 108010062740 TRPV Cation Channels Proteins 0.000 description 2
- 239000000556 agonist Substances 0.000 description 1
- 235000002780 gingerol Nutrition 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16798409P | 2009-04-09 | 2009-04-09 | |
| US61/167,984 | 2009-04-09 | ||
| US30866710P | 2010-02-26 | 2010-02-26 | |
| US61/308,667 | 2010-02-26 | ||
| US30909110P | 2010-03-01 | 2010-03-01 | |
| US61/309,091 | 2010-03-01 | ||
| PCT/US2010/030130 WO2010118055A1 (en) | 2009-04-09 | 2010-04-06 | Inhibitors of cognitive decline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012523418A JP2012523418A (ja) | 2012-10-04 |
| JP2012523418A5 true JP2012523418A5 (https=) | 2013-05-23 |
Family
ID=42936539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012504788A Pending JP2012523418A (ja) | 2009-04-09 | 2010-04-06 | 認知機能低下の阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8765816B2 (https=) |
| EP (1) | EP2416795B1 (https=) |
| JP (1) | JP2012523418A (https=) |
| CN (2) | CN105968022A (https=) |
| AU (2) | AU2010234518A1 (https=) |
| BR (1) | BRPI1007624A2 (https=) |
| DK (1) | DK2416795T3 (https=) |
| ES (1) | ES2545795T3 (https=) |
| IL (1) | IL215645A0 (https=) |
| RU (1) | RU2595720C2 (https=) |
| SG (2) | SG176772A1 (https=) |
| WO (1) | WO2010118055A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2545795T3 (es) | 2009-04-09 | 2015-09-15 | Cognition Therapeutics, Inc. | Inhibidores del deterioro cognitivo |
| CN102595884B (zh) | 2009-07-31 | 2014-12-03 | 考格尼申治疗股份有限公司 | 认知衰退的抑制剂 |
| BR112013019775A2 (pt) | 2011-02-02 | 2017-04-18 | Cognition Therapeutics Inc | composto, composição farmacêutica e método para tratar declínio cognitivo ou doença de alzheimer em um paciente |
| EP2747768A4 (en) * | 2011-08-25 | 2015-10-21 | Cognition Therapeutics Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| EP2747759A4 (en) * | 2011-08-25 | 2015-05-13 | Cognition Therapeutics Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| JP2015512383A (ja) | 2012-03-20 | 2015-04-27 | アダムド エスピー．ゼット オー．オー．Ａｄａｍｅｄ Ｓｐ．Ｚ Ｏ．Ｏ． | Ｃｎｓ疾患の処置のためのベンジルアミンのスルホンアミド誘導体 |
| PL3062791T3 (pl) | 2013-10-28 | 2020-06-15 | Drexel University | Nowoczesne terapie zaburzeń uwagi i zaburzeń poznawczych oraz otępienia związanych z zaburzeniem neurodegeneracyjnym |
| RU2692258C2 (ru) | 2014-01-31 | 2019-06-24 | Когнишн Терапьютикс, Инк. | Композиции изоиндолина и способы лечения нейродегенеративного заболевания |
| DK3634394T3 (da) | 2017-05-15 | 2026-03-02 | Cognition Therapeutics Inc | Sammensætninger til behandling af neurogenerative sygdomme |
| US12352719B2 (en) | 2019-09-20 | 2025-07-08 | KYCERA AVX Components Corporation | Somatic cell-based electrical biosensor |
| IL298323B2 (en) | 2020-05-20 | 2023-10-01 | Univ Illinois | A method for treating lysosomal storage disease using histatin peptides |
| WO2026030341A1 (en) | 2024-07-29 | 2026-02-05 | Cognition Therapeutics, Inc. | Zervimesine for treating neurodegenerative disease |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4321386A (en) * | 1981-01-28 | 1982-03-23 | Mead Johnson & Company | Quaternary piperidinium halides |
| JPS62283922A (ja) * | 1986-05-30 | 1987-12-09 | Tsumura Juntendo Inc | 血小板凝集抑制剤 |
| US4697024A (en) | 1986-11-24 | 1987-09-29 | Merrell Dow Pharmaceuticals Inc. | Medroxalol intermediates |
| JPH01180822A (ja) * | 1988-01-12 | 1989-07-18 | Dainippon Pharmaceut Co Ltd | 抗遅延型アレルギー剤 |
| CA2071897A1 (en) | 1989-12-28 | 1991-06-29 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
| DE4000610A1 (de) | 1990-01-11 | 1991-07-18 | Knoll Ag | Verfahren zur herstellung von optisch aktiven 3-amino-1-arylbutanen und 3-benzylamino-1-arylbutanen |
| JP2818958B2 (ja) * | 1990-02-23 | 1998-10-30 | 塩野義製薬株式会社 | ４―（４―アルコキシフェニル）―２―ブチルアミン誘導体およびその製造法 |
| DE4142366A1 (de) | 1991-07-15 | 1993-06-24 | Thomae Gmbh Dr K | Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US6011068A (en) * | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| CN1192011C (zh) * | 1991-08-23 | 2005-03-09 | Nps药物有限公司 | 对钙受体具活性的芳烷基胺化合物 |
| CN1093079A (zh) * | 1993-03-30 | 1994-10-05 | 陈英俊 | 由具有愈创木酚结构之香辛类化合物及其去氢化合物衍生之肾上腺素激性乙型阻断剂 |
| ES2285707T3 (es) * | 1994-10-21 | 2007-11-16 | Nps Pharmaceuticals, Inc. | Compuestos activos frente al receptor de calcio. |
| WO1997030038A1 (en) | 1996-02-15 | 1997-08-21 | Mitsubishi Chemical Corporation | Diarylsultam derivatives |
| US6518315B1 (en) | 1997-10-21 | 2003-02-11 | The University Of Sydney | Medicinal uses of phenylaikanols and derivatives |
| JP2003505508A (ja) * | 1999-07-30 | 2003-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非環式又は環式アミド誘導体 |
| WO2001030335A2 (en) | 1999-10-22 | 2001-05-03 | The Board Of Trustees Of The University Of Illinois | Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease |
| JP4312402B2 (ja) | 2001-07-31 | 2009-08-12 | 有限会社大長企画 | 抗うつ剤、抗更年期障害剤、抗老人性痴呆症剤、抗アルツハイマー剤 |
| US20030073681A1 (en) * | 2001-08-21 | 2003-04-17 | Hauske James R. | 2-substituted piperidines that are ligands for monoamine receptors and transporters |
| US6991814B2 (en) | 2001-12-13 | 2006-01-31 | Council Of Scientific And Industrial Research | Herbal medicaments for the treatment of neurocerebrovascular disorders |
| JP2004002517A (ja) * | 2002-05-31 | 2004-01-08 | Dae Sil Kim | 生姜成分を含む石鹸の組成物及びその製造方法 |
| DE10320560A1 (de) | 2003-05-07 | 2004-01-29 | Brosig, Stefan, Dr. | Mittel zur Bekämpfung der Alzheimer Erkrankung und/oder der Parkinson Krankheit |
| EP1644026A4 (en) | 2003-06-12 | 2007-10-24 | Ms Science Corp | SIGMA LIGANDS FOR NEURONAL REGENERATION AND FUNCTIONAL RECREATION |
| EP1794313B1 (en) | 2004-06-21 | 2013-05-15 | Proteome Sciences Plc | Screening methods using c-abl, fyn and syk in combination with tau protein |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| WO2006027252A1 (en) | 2004-09-10 | 2006-03-16 | Ucb Pharma, Sa | Sigma receptor ligands |
| GB0423356D0 (en) * | 2004-10-21 | 2004-11-24 | Merck Sharp & Dohme | Therapeutic agents |
| WO2006094724A2 (en) | 2005-03-05 | 2006-09-14 | Abbott Gmbh & Co. Kg | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
| KR20080041624A (ko) | 2005-06-15 | 2008-05-13 | 대릭 에스. 에치. 엘. 김 | 베타-아밀로이드 단백질-유발 안질환의 치료 방법 |
| EP1745778A3 (en) | 2005-07-20 | 2007-03-07 | Speedel Experimenta AG | Diaminoalcohols as therapeutic compounds |
| ITRM20060007A1 (it) | 2006-01-05 | 2007-07-06 | Univ Bari | Recettore sigma-2 metodo di screening di ligandi specifici e uso degli stessi in metodi diagnostici o terapeutici |
| KR20090007564A (ko) | 2006-03-17 | 2009-01-19 | 허발사이언스 싱가포르 피티이 리미티드 | 쿠르쿠마 종을 포함한 추출물 및 이를 수득하는 방법 |
| WO2007112288A2 (en) | 2006-03-23 | 2007-10-04 | Mount Sinai School Of Medicine | Cardiovascular composition and use the same for the treatment of alzheimers disease |
| US7561775B2 (en) | 2006-08-22 | 2009-07-14 | Senko Advanced Components, Inc. | Fiber optic protective shutter |
| WO2008042755A2 (en) | 2006-09-29 | 2008-04-10 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| WO2008076262A2 (en) | 2006-12-15 | 2008-06-26 | Merck & Co., Inc. | Receptor for amyloid beta and uses thereof |
| CA2684920A1 (en) | 2007-05-15 | 2008-11-27 | Helicon Therapeutics, Inc. | Methods of treating cognitive disorders by inhibition of gpr12 |
| EP2206707B1 (en) * | 2007-10-24 | 2014-07-23 | Astellas Pharma Inc. | Azolecarboxamide compound or salt thereof |
| WO2009059214A1 (en) | 2007-11-02 | 2009-05-07 | The Regents Of The University Of California | Abeta-binding small molecules |
| WO2010062260A1 (en) | 2008-11-29 | 2010-06-03 | The Thailand Research Fund | Virus and target cell interaction inhibition |
| ES2545795T3 (es) | 2009-04-09 | 2015-09-15 | Cognition Therapeutics, Inc. | Inhibidores del deterioro cognitivo |
| CN102595884B (zh) | 2009-07-31 | 2014-12-03 | 考格尼申治疗股份有限公司 | 认知衰退的抑制剂 |
| WO2011106785A2 (en) | 2010-02-26 | 2011-09-01 | Cognition Therapeutics, Inc. | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| EP2747759A4 (en) | 2011-08-25 | 2015-05-13 | Cognition Therapeutics Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
-
2010
- 2010-04-06 ES ES10762322.5T patent/ES2545795T3/es active Active
- 2010-04-06 BR BRPI1007624A patent/BRPI1007624A2/pt not_active Application Discontinuation
- 2010-04-06 DK DK10762322.5T patent/DK2416795T3/en active
- 2010-04-06 AU AU2010234518A patent/AU2010234518A1/en not_active Abandoned
- 2010-04-06 JP JP2012504788A patent/JP2012523418A/ja active Pending
- 2010-04-06 EP EP10762322.5A patent/EP2416795B1/en active Active
- 2010-04-06 CN CN201610113476.5A patent/CN105968022A/zh active Pending
- 2010-04-06 US US13/263,162 patent/US8765816B2/en active Active
- 2010-04-06 SG SG2011091352A patent/SG176772A1/en unknown
- 2010-04-06 RU RU2011145321/04A patent/RU2595720C2/ru not_active Application Discontinuation
- 2010-04-06 WO PCT/US2010/030130 patent/WO2010118055A1/en not_active Ceased
- 2010-04-06 SG SG10201404913QA patent/SG10201404913QA/en unknown
- 2010-04-06 CN CN2010800257716A patent/CN102458435A/zh active Pending
-
2011
- 2011-10-09 IL IL215645A patent/IL215645A0/en unknown
-
2014
- 2014-06-02 US US14/293,755 patent/US9365491B2/en active Active
-
2015
- 2015-10-12 AU AU2015242954A patent/AU2015242954B2/en not_active Ceased
-
2016
- 2016-06-13 US US15/181,211 patent/US20160355458A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012523418A5 (https=) | ||
| RU2011145321A (ru) | Ингибиторы снижения когнитивных способностей | |
| JPWO2022138987A5 (https=) | ||
| JP2013501006A5 (https=) | ||
| AU2010297557C1 (en) | Lysine specific demethylase-1 inhibitors and their use | |
| RU2003130268A (ru) | Производные 4,5-дигидро-1h-пиразола, обладающие сильной cb1-антагонистической активностью | |
| RU2004114263A (ru) | Производные тиазола, имеющие антагонистичекую агонистическую или частично агонистическую св1-активность | |
| JP7026787B2 (ja) | ヒストン脱アセチル化酵素１および／または２（ｈｄａｃ１－２）の選択的阻害剤としての新規なヘテロアリールアミド誘導体 | |
| CA2457444A1 (en) | 1h-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1- antagonistic activity | |
| JP2021105002A5 (https=) | ||
| JP2020502092A5 (https=) | ||
| JP2013056919A5 (https=) | ||
| CA2456606A1 (en) | 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity | |
| RU2005103244A (ru) | Производные 1h-1,2,4-триазол-3-карбоксамида в качестве лигандов рецептора каннабиноидов (cb1) | |
| JP2013522325A5 (https=) | ||
| US9682950B2 (en) | Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors | |
| WO1996018608A1 (en) | Aniline derivatives having nitrogen monoxide synthase inhibitory activity | |
| JP2017519796A5 (https=) | ||
| JP2023518776A (ja) | シクロスポリン誘導体の調製 | |
| JP2015516968A5 (https=) | ||
| RU2012107457A (ru) | Ингибиторы ухудшения когнитивных способностей | |
| AU2017202849C1 (en) | Potent and Selective Inhibitors of Monoamine Transporters; Method of Making; and Use Thereof | |
| JP2018507230A5 (https=) | ||
| CA2671482A1 (en) | Substituted diazepine sulfonamides as bombesin receptor subtype-3 modulators | |
| WO2007054444A3 (en) | 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives |