AU2010234518A1 - Inhibitors of cognitive decline - Google Patents

Inhibitors of cognitive decline Download PDF

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Publication number
AU2010234518A1
AU2010234518A1 AU2010234518A AU2010234518A AU2010234518A1 AU 2010234518 A1 AU2010234518 A1 AU 2010234518A1 AU 2010234518 A AU2010234518 A AU 2010234518A AU 2010234518 A AU2010234518 A AU 2010234518A AU 2010234518 A1 AU2010234518 A1 AU 2010234518A1
Authority
AU
Australia
Prior art keywords
alkyl
compound
pharmaceutically acceptable
acceptable salt
haloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010234518A
Other languages
English (en)
Inventor
Susan Catalano
Gilbert M. Rishton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cognition Therapeutics Inc
Original Assignee
Cognition Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cognition Therapeutics Inc filed Critical Cognition Therapeutics Inc
Publication of AU2010234518A1 publication Critical patent/AU2010234518A1/en
Priority to AU2015242954A priority Critical patent/AU2015242954B2/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2010234518A 2009-04-09 2010-04-06 Inhibitors of cognitive decline Abandoned AU2010234518A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2015242954A AU2015242954B2 (en) 2009-04-09 2015-10-12 Inhibitors of cognitive decline

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16798409P 2009-04-09 2009-04-09
US61/167,984 2009-04-09
US30866710P 2010-02-26 2010-02-26
US61/308,667 2010-02-26
US30909110P 2010-03-01 2010-03-01
US61/309,091 2010-03-01
PCT/US2010/030130 WO2010118055A1 (en) 2009-04-09 2010-04-06 Inhibitors of cognitive decline

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015242954A Division AU2015242954B2 (en) 2009-04-09 2015-10-12 Inhibitors of cognitive decline

Publications (1)

Publication Number Publication Date
AU2010234518A1 true AU2010234518A1 (en) 2012-02-02

Family

ID=42936539

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2010234518A Abandoned AU2010234518A1 (en) 2009-04-09 2010-04-06 Inhibitors of cognitive decline
AU2015242954A Ceased AU2015242954B2 (en) 2009-04-09 2015-10-12 Inhibitors of cognitive decline

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2015242954A Ceased AU2015242954B2 (en) 2009-04-09 2015-10-12 Inhibitors of cognitive decline

Country Status (12)

Country Link
US (3) US8765816B2 (https=)
EP (1) EP2416795B1 (https=)
JP (1) JP2012523418A (https=)
CN (2) CN105968022A (https=)
AU (2) AU2010234518A1 (https=)
BR (1) BRPI1007624A2 (https=)
DK (1) DK2416795T3 (https=)
ES (1) ES2545795T3 (https=)
IL (1) IL215645A0 (https=)
RU (1) RU2595720C2 (https=)
SG (2) SG10201404913QA (https=)
WO (1) WO2010118055A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201404913QA (en) 2009-04-09 2014-11-27 Cognition Therapeutics Inc Inhibitors of cognitive decline
RU2012107457A (ru) 2009-07-31 2013-09-10 Когнишн Терапьютикс, Инк. Ингибиторы ухудшения когнитивных способностей
US9499462B2 (en) 2011-02-02 2016-11-22 Cognition Therapeutics, Inc. Isolated compounds from turmeric oil and methods of use
RU2014111079A (ru) * 2011-08-25 2015-09-27 Когнишн Терапьютикс, Инк. Композиции и способы для лечения нейродегенеративного заболевания
CA2846611A1 (en) * 2011-08-25 2013-02-28 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
CA2866910A1 (en) 2012-03-20 2013-09-26 Adamed Sp. Z O.O. Sulphonamide derivatives of benzylamine for the treatment of cns diseases
WO2015066019A1 (en) 2013-10-28 2015-05-07 Drexel University Novel treatments for attention and cognitive disorders, and for dementia associated with a neurodegenerative disorder
DK3099296T3 (en) 2014-01-31 2019-04-15 Cognition Therapeutics Inc ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
EP3634394B1 (en) 2017-05-15 2025-12-24 Cognition Therapeutics, Inc. Compositions for treating neurodegenerative diseases
WO2021055670A1 (en) 2019-09-20 2021-03-25 Avx Corporation Somatic cell-based electrical biosensor
IL298323B2 (en) 2020-05-20 2023-10-01 Univ Illinois A method for treating lysosomal storage disease using histatin peptides
WO2026030341A1 (en) 2024-07-29 2026-02-05 Cognition Therapeutics, Inc. Zervimesine for treating neurodegenerative disease

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Also Published As

Publication number Publication date
HK1167323A1 (en) 2013-01-04
AU2015242954A1 (en) 2015-10-29
RU2011145321A (ru) 2013-05-20
US20120095105A1 (en) 2012-04-19
BRPI1007624A2 (pt) 2016-07-26
CN102458435A (zh) 2012-05-16
IL215645A0 (en) 2012-01-31
ES2545795T3 (es) 2015-09-15
EP2416795B1 (en) 2015-06-03
RU2595720C2 (ru) 2016-08-27
US9365491B2 (en) 2016-06-14
US8765816B2 (en) 2014-07-01
AU2015242954B2 (en) 2016-08-25
SG10201404913QA (en) 2014-11-27
SG176772A1 (en) 2012-01-30
US20140371324A1 (en) 2014-12-18
JP2012523418A (ja) 2012-10-04
WO2010118055A1 (en) 2010-10-14
EP2416795A1 (en) 2012-02-15
EP2416795A4 (en) 2013-12-25
CN105968022A (zh) 2016-09-28
US20160355458A1 (en) 2016-12-08
DK2416795T3 (en) 2015-08-31

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Legal Events

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Free format text: THE TIME IN WHICH TO ENTER THE NATIONAL PHASE HAS BEEN EXTENDED TO 09 DEC 2011.

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NA Applications received for extensions of time, section 223

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NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO PAY A CONTINUATION FEE AND GAIN ACCEPTANCE HAS BEEN EXTENDED TO 06 NOV 2015 .

MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted