JP2012522808A5 - - Google Patents

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Publication number

JP2012522808A5

JP2012522808A5 JP2012503769A JP2012503769A JP2012522808A5 JP 2012522808 A5 JP2012522808 A5 JP 2012522808A5 JP 2012503769 A JP2012503769 A JP 2012503769A JP 2012503769 A JP2012503769 A JP 2012503769A JP 2012522808 A5 JP2012522808 A5 JP 2012522808A5

Authority

JP

Japan

Prior art keywords

amino acid

isolated polypeptide

pharmaceutical composition

staphylococcal

immunogenic composition

Prior art date

2010-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 238000000034 method Methods 0.000 claims description 84
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 67
• 239000000203 mixture Substances 0.000 claims description 63
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 59
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 50
• 229920001184 polypeptide Polymers 0.000 claims description 47
• 235000001014 amino acid Nutrition 0.000 claims description 44
• 206010041925 Staphylococcal infections Diseases 0.000 claims description 30
• 230000002163 immunogen Effects 0.000 claims description 29
• 239000000427 antigen Substances 0.000 claims description 28
• 102000036639 antigens Human genes 0.000 claims description 28
• 108091007433 antigens Proteins 0.000 claims description 28
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 23
• 238000006467 substitution reaction Methods 0.000 claims description 22
• 235000018102 proteins Nutrition 0.000 claims description 21
• 102000004169 proteins and genes Human genes 0.000 claims description 21
• 108090000623 proteins and genes Proteins 0.000 claims description 21
• 239000008194 pharmaceutical composition Substances 0.000 claims description 19
• 238000011282 treatment Methods 0.000 claims description 13
• 239000002671 adjuvant Substances 0.000 claims description 12
• 108060003951 Immunoglobulin Proteins 0.000 claims description 11
• 102000018358 immunoglobulin Human genes 0.000 claims description 11
• 108700035708 EsaB Proteins 0.000 claims description 10
• 241000295644 Staphylococcaceae Species 0.000 claims description 10
• 230000028993 immune response Effects 0.000 claims description 10
• 230000002265 prevention Effects 0.000 claims description 10
• 229960005486 vaccine Drugs 0.000 claims description 9
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
• 150000004676 glycans Chemical class 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 6
• 229920001282 polysaccharide Polymers 0.000 claims description 6
• 239000005017 polysaccharide Substances 0.000 claims description 6
• 241000124008 Mammalia Species 0.000 claims description 5
• 241000191940 Staphylococcus Species 0.000 claims description 5
• 102000039446 nucleic acids Human genes 0.000 claims description 5
• 108020004707 nucleic acids Proteins 0.000 claims description 5
• 150000007523 nucleic acids Chemical class 0.000 claims description 5
• 229920001542 oligosaccharide Polymers 0.000 claims description 4
• 150000002482 oligosaccharides Chemical class 0.000 claims description 4
• 108010047303 von Willebrand Factor Proteins 0.000 claims description 4
• 102100036537 von Willebrand factor Human genes 0.000 claims description 4
• 229960001134 von willebrand factor Drugs 0.000 claims description 4
• 241000894006 Bacteria Species 0.000 claims description 3
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 3
• 241000607142 Salmonella Species 0.000 claims description 3
• 239000003814 drug Substances 0.000 claims description 3
• 230000003053 immunization Effects 0.000 claims description 3
• 230000001939 inductive effect Effects 0.000 claims description 3
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 3
• 229960003085 meticillin Drugs 0.000 claims description 3
• 230000002085 persistent effect Effects 0.000 claims description 3
• 230000001681 protective effect Effects 0.000 claims description 3
• 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 2
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims description 2
• 241000606768 Haemophilus influenzae Species 0.000 claims description 2
• 108010006464 Hemolysin Proteins Proteins 0.000 claims description 2
• 101710188053 Protein D Proteins 0.000 claims description 2
• 101710132893 Resolvase Proteins 0.000 claims description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims description 2
• 229960003983 diphtheria toxoid Drugs 0.000 claims description 2
• 239000012634 fragment Substances 0.000 claims description 2
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims description 2
• 229940047650 haemophilus influenzae Drugs 0.000 claims description 2
• 239000003228 hemolysin Substances 0.000 claims description 2
• 230000035772 mutation Effects 0.000 claims description 2
• 229960000814 tetanus toxoid Drugs 0.000 claims description 2
• 239000003053 toxin Substances 0.000 claims description 2
• 231100000765 toxin Toxicity 0.000 claims description 2
• 108010065152 Coagulase Proteins 0.000 description 15
• 150000001413 amino acids Chemical class 0.000 description 9
• 239000000825 pharmaceutical preparation Substances 0.000 description 4
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 230000002238 attenuated effect Effects 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 208000015339 staphylococcus aureus infection Diseases 0.000 description 1