JP2012522018A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012522018A5 JP2012522018A5 JP2012502314A JP2012502314A JP2012522018A5 JP 2012522018 A5 JP2012522018 A5 JP 2012522018A5 JP 2012502314 A JP2012502314 A JP 2012502314A JP 2012502314 A JP2012502314 A JP 2012502314A JP 2012522018 A5 JP2012522018 A5 JP 2012522018A5
- Authority
- JP
- Japan
- Prior art keywords
- inhalation
- dry powder
- powder suitable
- salt
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 claims 36
- 235000002639 sodium chloride Nutrition 0.000 claims 18
- 229910052751 metal Inorganic materials 0.000 claims 12
- 239000002184 metal Substances 0.000 claims 12
- 239000002245 particle Substances 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- -1 cation salt Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical group [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 6
- 150000001768 cations Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 4
- 159000000000 sodium salts Chemical class 0.000 claims 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims 3
- 239000001354 calcium citrate Substances 0.000 claims 3
- 229960004256 calcium citrate Drugs 0.000 claims 3
- 159000000007 calcium salts Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 235000013337 tricalcium citrate Nutrition 0.000 claims 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000001110 calcium chloride Substances 0.000 claims 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims 2
- 229960002713 calcium chloride Drugs 0.000 claims 2
- 235000011148 calcium chloride Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000001509 sodium citrate Substances 0.000 claims 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 2
- 235000011152 sodium sulphate Nutrition 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 230000003068 static effect Effects 0.000 claims 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 230000009798 acute exacerbation Effects 0.000 claims 1
- 238000005349 anion exchange Methods 0.000 claims 1
- 159000000009 barium salts Chemical class 0.000 claims 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims 1
- 239000001639 calcium acetate Substances 0.000 claims 1
- 235000011092 calcium acetate Nutrition 0.000 claims 1
- 229960005147 calcium acetate Drugs 0.000 claims 1
- 239000004227 calcium gluconate Substances 0.000 claims 1
- 235000013927 calcium gluconate Nutrition 0.000 claims 1
- 229960004494 calcium gluconate Drugs 0.000 claims 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims 1
- 239000001527 calcium lactate Substances 0.000 claims 1
- 235000011086 calcium lactate Nutrition 0.000 claims 1
- 229960002401 calcium lactate Drugs 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 229940095672 calcium sulfate Drugs 0.000 claims 1
- 235000011132 calcium sulphate Nutrition 0.000 claims 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- 229910003002 lithium salt Inorganic materials 0.000 claims 1
- 159000000002 lithium salts Chemical group 0.000 claims 1
- 159000000003 magnesium salts Chemical class 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 235000011083 sodium citrates Nutrition 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- 229940005581 sodium lactate Drugs 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16376709P | 2009-03-26 | 2009-03-26 | |
| US16376309P | 2009-03-26 | 2009-03-26 | |
| US16377209P | 2009-03-26 | 2009-03-26 | |
| US61/163,763 | 2009-03-26 | ||
| US61/163,767 | 2009-03-26 | ||
| US61/163,772 | 2009-03-26 | ||
| US25576409P | 2009-10-28 | 2009-10-28 | |
| US61/255,764 | 2009-10-28 | ||
| US26774709P | 2009-12-08 | 2009-12-08 | |
| US61/267,747 | 2009-12-08 | ||
| US29809210P | 2010-01-25 | 2010-01-25 | |
| US61/298,092 | 2010-01-25 | ||
| US30581910P | 2010-02-18 | 2010-02-18 | |
| US61/305,819 | 2010-02-18 | ||
| PCT/US2010/028961 WO2010111680A2 (en) | 2009-03-26 | 2010-03-26 | Dry powder formulations and methods for treating pulmonary diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014256325A Division JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522018A JP2012522018A (ja) | 2012-09-20 |
| JP2012522018A5 true JP2012522018A5 (enExample) | 2013-05-23 |
| JP5671001B2 JP5671001B2 (ja) | 2015-02-18 |
Family
ID=42635067
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502314A Active JP5671001B2 (ja) | 2009-03-26 | 2010-03-26 | 肺疾患を治療するための乾燥粉末製剤および方法 |
| JP2014256325A Active JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014256325A Active JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20120064126A1 (enExample) |
| EP (2) | EP3184099A1 (enExample) |
| JP (2) | JP5671001B2 (enExample) |
| KR (1) | KR101639098B1 (enExample) |
| CN (2) | CN102497853B (enExample) |
| AU (1) | AU2010229668C1 (enExample) |
| BR (1) | BRPI1011721B1 (enExample) |
| CA (1) | CA2754691C (enExample) |
| DK (1) | DK2410981T4 (enExample) |
| ES (1) | ES2625260T5 (enExample) |
| IL (1) | IL215276A (enExample) |
| MX (1) | MX354829B (enExample) |
| PT (1) | PT2410981T (enExample) |
| RU (1) | RU2577698C2 (enExample) |
| WO (1) | WO2010111680A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5671001B2 (ja) | 2009-03-26 | 2015-02-18 | パルマトリックス，インコーポレイテッド | 肺疾患を治療するための乾燥粉末製剤および方法 |
| GB0918450D0 (en) * | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| WO2012030664A1 (en) * | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US8758824B2 (en) | 2010-08-30 | 2014-06-24 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
| EP4008326A1 (en) | 2010-09-29 | 2022-06-08 | Pulmatrix Operating Company, Inc. | Monovalent metal cation dry powders for inhalation |
| PT2621488T (pt) * | 2010-09-29 | 2019-02-12 | Pulmatrix Operating Co Inc | Pós secos catiónicos |
| WO2012058719A1 (en) * | 2010-11-02 | 2012-05-10 | The Universtity Of Sydney | Inhalable compositions |
| US9572774B2 (en) | 2011-05-19 | 2017-02-21 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
| SG195038A1 (en) | 2011-05-19 | 2013-12-30 | Savara Inc | Dry powder vancomycin compositions and associated methods |
| US20140336159A1 (en) | 2011-10-07 | 2014-11-13 | Pulmatrix, Inc. | Methods for treating and diagnosing respiratory tract infections |
| CN107875127A (zh) * | 2012-02-28 | 2018-04-06 | 艾塞尤提卡控股公司 | 可吸入药物组合物 |
| US20150136130A1 (en) | 2012-02-29 | 2015-05-21 | Pulmatrix, Inc. | Inhalable dry powders |
| ES2604855T3 (es) | 2012-08-01 | 2017-03-09 | Purac Biochem Bv | Polvo de lactato y procedimiento de preparación del mismo |
| BR112015010601B1 (pt) | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | Composição farmacêutica e uso da composição |
| US8545878B1 (en) | 2012-11-09 | 2013-10-01 | Civitas Therapeutics, Inc. | Capsules containing high doses of levodopa for pulmonary use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| EP2754356A1 (en) | 2013-01-15 | 2014-07-16 | Purac Biochem N.V. | Improved nisin production process |
| EP2769630B1 (en) | 2013-02-26 | 2016-04-27 | Purac Biochem N.V. | Improved nisin production process |
| KR20150135328A (ko) | 2013-04-01 | 2015-12-02 | 풀매트릭스 인코퍼레이티드 | 티오트로피움 건조 분말 |
| CN105473133A (zh) * | 2013-04-30 | 2016-04-06 | 欧缇托匹克公司 | 干粉制剂及使用方法 |
| JP6611720B2 (ja) * | 2013-09-03 | 2019-11-27 | ジョージア テック リサーチ コーポレイション | 熱安定性ワクチン製剤及びマイクロニードル |
| AU2015338717B2 (en) | 2014-10-31 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
| US10046007B2 (en) | 2015-06-24 | 2018-08-14 | Prescient Pharma, Llc | Compositions and methods for treatment of short telomere disorders |
| US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
| EP3463378A4 (en) | 2016-06-03 | 2020-01-08 | Otitopic Inc. | DRY POWDER FORMULAS FOR INHALATION |
| GB2568849B (en) | 2016-09-01 | 2022-08-10 | Nutrition 21 Llc | Magnesium biotinate compositions and methods of use |
| US12337064B2 (en) | 2018-09-05 | 2025-06-24 | Sensory Cloud, Inc. | Formulations and compositions for ortho- and/or retro-nasal delivery and associated systems, methods and articles |
| CN113329680A (zh) | 2018-11-02 | 2021-08-31 | 营养21有限责任公司 | 用于改善视频游戏者认知功能的含有肌醇稳定的精氨酸硅酸盐复合物和肌醇的组合物 |
| GB2613672A (en) * | 2019-12-16 | 2023-06-14 | Nutrition 21 Llc | Methods of production of aginine-silicate complexes |
| CN119013010A (zh) * | 2021-12-16 | 2024-11-22 | 艾维尔勒斯生物公司 | 用于治疗慢性肺病的可吸入或可摄入的乳酸组合物 |
| AU2022476747A1 (en) * | 2022-09-02 | 2025-02-06 | Liita Care Aps | Pharmaceutical dry powder composition and methods for treating respiratory tract infections |
| WO2025264889A1 (en) * | 2024-06-19 | 2025-12-26 | Pharmosa Biopharm Inc. | Nebulizer kits and uses thereof |
Family Cites Families (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US4233405A (en) | 1979-10-10 | 1980-11-11 | Rohm And Haas Company | Process for spray drying enzymes |
| US4637815A (en) | 1985-08-06 | 1987-01-20 | Lemole Gerald M | Irrigational hemostatic solution |
| US5511726A (en) | 1988-09-23 | 1996-04-30 | Battelle Memorial Institute | Nebulizer device |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| GB2265845B (en) | 1991-11-12 | 1996-05-01 | Medix Ltd | A nebuliser and nebuliser control system |
| US5466680A (en) * | 1992-03-26 | 1995-11-14 | Cytologics, Inc. | Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US5724957A (en) | 1993-01-29 | 1998-03-10 | Aradigm Corporation | Intrapulmonary delivery of narcotics |
| US6098620A (en) | 1993-01-29 | 2000-08-08 | Aradigm Corporation | Device for aerosolizing narcotics |
| NZ328476A (en) | 1993-06-24 | 1999-05-28 | Astra Ab | Use of a two component insulin preparation in an inhalation device |
| AUPM411494A0 (en) | 1994-02-25 | 1994-03-24 | Central Sydney Area Health Service | Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum |
| JP3414539B2 (ja) | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US5747002A (en) | 1995-04-05 | 1998-05-05 | Genentech, Inc. | Preparation of sodium chloride aerosol formulations |
| US5612053A (en) | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
| MX9707862A (es) | 1995-04-14 | 1997-11-29 | Glaxo Wellcome Inc | Inhalador de dosis medida para el propionato de fluticasona. |
| AU706195B2 (en) | 1995-04-14 | 1999-06-10 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US5628984A (en) | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| CZ292186B6 (cs) * | 1996-01-24 | 2003-08-13 | Altana Pharma Ag | Způsob výroby práškového prostředku s obsahem plicní povrchově aktivní látky, práškový prostředek a jeho použití |
| GB9606677D0 (en) | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| ATE248583T1 (de) | 1997-09-29 | 2003-09-15 | Nektar Therapeutics | In dosierinhalatoren verwendbare, stabilisierte zubereitungen |
| GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
| WO2000000215A1 (en) | 1998-06-29 | 2000-01-06 | Inhale Therapeutic Systems, Inc. | Particulate delivery systems and methods of use |
| GB9814172D0 (en) | 1998-06-30 | 1998-08-26 | Andaris Ltd | Formulation for inhalation |
| ATE308976T1 (de) * | 1998-11-10 | 2005-11-15 | Altana Pharma Ag | Lungensurfactant zubereitungen enthaltendes behandlungset |
| US6926911B1 (en) | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| US6355271B1 (en) | 1999-02-03 | 2002-03-12 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of manufacture and use |
| US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| GB9916316D0 (en) * | 1999-07-12 | 1999-09-15 | Quadrant Holdings Cambridge | Dry powder compositions |
| DE60017152D1 (de) * | 1999-08-25 | 2005-02-03 | Advanced Inhalation Res Inc | Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| DE60025019T2 (de) | 1999-10-29 | 2006-08-24 | Nektar Therapeutics, San Carlos | Trockenpulverzusammensetzungen mit verbesserter dispersivität |
| SK284948B6 (sk) | 2000-04-06 | 2006-03-02 | Zentiva, A. S. | Liečivý prípravok s obsahom vápnika alebo zmesi vápnika a vitamínu D, alebo zmesi vápnika a horčíka v novej liekovej forme |
| EP1276495B1 (en) * | 2000-04-12 | 2006-04-19 | ALTANA Pharma AG | Use of recombinant pulmonary surfactant for the early treatment of acute pulmonary diseases |
| PT1280520E (pt) * | 2000-05-10 | 2014-12-16 | Novartis Ag | Pós à base de fosfolípidos para administração de fármacos |
| ES2292598T3 (es) | 2000-06-27 | 2008-03-16 | Vectura Limited | Metodo para producir particulas para usar en una composicion farmaceutica. |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| EP2283817B1 (en) | 2000-11-30 | 2016-05-18 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| DK2301524T3 (da) | 2000-12-27 | 2013-07-15 | Gilead Sciences Inc | Inhalerbar aztreonam uden arginin til behandling og forebyggelse af bakterielle lungeinfektioner |
| US20020141946A1 (en) * | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| US6766799B2 (en) | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
| US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| WO2003035028A1 (en) | 2001-10-19 | 2003-05-01 | Nektar Therapeutics | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
| CA2465675C (en) * | 2001-11-20 | 2008-06-10 | Advanced Inhalation Research, Inc. | Improved particulate compositions for pulmonary delivery |
| IL161446A0 (en) | 2001-11-26 | 2004-09-27 | Daiichi Suntory Pharma Co Ltd | Medicinal compositions for nasal absorption |
| WO2003072080A1 (en) | 2002-02-22 | 2003-09-04 | Advanced Inhalation Research, Inc. | Inhalable formulations for sustained release |
| US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| SI2630954T1 (sl) | 2002-03-20 | 2017-02-28 | Civitas Therapeutics, Inc. | Pulmonalno dovajanje za levodopo |
| GB0207906D0 (en) | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and mometasone aerosol formulations |
| EP1531794B1 (en) † | 2002-06-28 | 2017-05-10 | Civitas Therapeutics, Inc. | Inhalable epinephrine |
| US20050288253A1 (en) * | 2002-09-09 | 2005-12-29 | Trigen Limited | Boronic acid salts |
| CN1694689A (zh) * | 2002-09-30 | 2005-11-09 | 阿库斯菲尔公司 | 供吸入的缓释多孔微粒 |
| US7534781B2 (en) | 2003-03-21 | 2009-05-19 | Dsm Ip Assets B.V. | Crystalline amoxicillin trihydrate powder |
| CN1194062C (zh) | 2003-04-04 | 2005-03-23 | 王泽斌 | 一种融雪融冰组合物及其制备方法和应用 |
| SI1617834T1 (sl) | 2003-05-01 | 2007-02-28 | Innogene Kalbiotech Pte Ltd | Uporaba farmacevtskega sestavka, ki vsebuje mlecno kislino ali laktat in kalij, za zdravljenje mozganskega edema in mozganske poskodbe |
| EP1646370A1 (en) * | 2003-07-11 | 2006-04-19 | Glaxo Group Limited | Pharmaceutical formulations |
| DE10339197A1 (de) * | 2003-08-22 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität |
| GB0324897D0 (en) | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Composition |
| GB0324918D0 (en) * | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Composition |
| KR20050056622A (ko) | 2003-12-10 | 2005-06-16 | 주식회사 대우일렉트로닉스 | 플레쉬롬 다운로드 장치 |
| WO2005067898A2 (en) * | 2004-01-07 | 2005-07-28 | Nektar Therapeutics | Improved sustained release compositions for pulmonary administration of insulin |
| US20050207983A1 (en) | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| SE528121C2 (sv) | 2004-03-29 | 2006-09-05 | Mederio Ag | Preparering av torrpulver för på förhand uppmätt DPI |
| CA2602596A1 (en) | 2004-03-30 | 2005-10-13 | Malcolm King | Compositions and methods for improved mucus function |
| US20050281740A1 (en) | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
| CA2574958A1 (en) | 2004-07-26 | 2006-02-09 | Cotherix, Inc. | Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation |
| EP1796637A4 (en) * | 2004-09-20 | 2010-01-13 | Gilead Sciences Inc | TARGETED DISTRIBUTION OF LIDOCAINE AND OTHER LOCAL ANESTHETICS AND METHOD OF TREATING COUGH AND LARYNGETIC ATTACKS |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| EP1888257A1 (en) | 2005-05-05 | 2008-02-20 | Pulmatrix, Inc. | Ultrasonic aerosol generator |
| WO2006125153A2 (en) * | 2005-05-18 | 2006-11-23 | Pulmatrix Inc. | Formulations for alteration of biophysical properties of mucosal lining |
| US7838532B2 (en) | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| GB0520794D0 (en) | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
| GB0523576D0 (en) | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
| GB0625322D0 (en) | 2006-12-19 | 2007-01-24 | Pharmakodex Ltd | Pharmaceutical compositions |
| WO2009037503A2 (en) | 2007-09-18 | 2009-03-26 | Astrazeneca Ab | New combination - 012 for the treatment of respiratory diseases |
| EP2252275B1 (en) | 2008-02-13 | 2017-11-29 | Board of Regents, The University of Texas System | Templated open flocs of anisotropic particles for enhanced pulmonary delivery |
| EP2098219A1 (en) | 2008-03-05 | 2009-09-09 | PARI Pharma GmbH | Macrolide compositions having improved taste and stability |
| US8834930B2 (en) | 2008-05-15 | 2014-09-16 | Novartis Ag | Pulmonary delivery of a fluoroquinolone |
| GB0818476D0 (en) | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
| EP2410984A2 (en) | 2009-03-26 | 2012-02-01 | Pulmatrix, Inc. | Anti-influenza formulations and methods |
| JP5671001B2 (ja) | 2009-03-26 | 2015-02-18 | パルマトリックス，インコーポレイテッド | 肺疾患を治療するための乾燥粉末製剤および方法 |
| PT2315580E (pt) | 2009-03-26 | 2012-03-28 | Pulmatrix Inc | Formulações farmacêuticas e métodos para o tratamento de infeções do trato respiratório |
| KR20120015295A (ko) | 2009-03-26 | 2012-02-21 | 풀매트릭스 인코퍼레이티드 | 점막 내층의 생물물리학적 성질의 변경을 위한 구연산 칼슘 및 젖산 칼슘 제형 |
| AU2010229721A1 (en) | 2009-03-26 | 2011-10-06 | Pulmatrix, Inc. | Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| PT106094A (pt) | 2012-01-13 | 2013-07-15 | Hovione Farmaciencia S A | Administração por inalação de formulações com dose elevada |
-
2010
- 2010-03-26 JP JP2012502314A patent/JP5671001B2/ja active Active
- 2010-03-26 ES ES10713283T patent/ES2625260T5/es active Active
- 2010-03-26 PT PT107132839T patent/PT2410981T/pt unknown
- 2010-03-26 CN CN201080023554.3A patent/CN102497853B/zh not_active Expired - Fee Related
- 2010-03-26 DK DK10713283.9T patent/DK2410981T4/da active
- 2010-03-26 RU RU2011137960/15A patent/RU2577698C2/ru active
- 2010-03-26 MX MX2011009957A patent/MX354829B/es active IP Right Grant
- 2010-03-26 BR BRPI1011721-0A patent/BRPI1011721B1/pt active IP Right Grant
- 2010-03-26 CA CA2754691A patent/CA2754691C/en active Active
- 2010-03-26 CN CN201810147094.3A patent/CN108434126B/zh active Active
- 2010-03-26 AU AU2010229668A patent/AU2010229668C1/en active Active
- 2010-03-26 KR KR1020117024843A patent/KR101639098B1/ko active Active
- 2010-03-26 EP EP17000124.2A patent/EP3184099A1/en active Pending
- 2010-03-26 US US13/259,635 patent/US20120064126A1/en not_active Abandoned
- 2010-03-26 WO PCT/US2010/028961 patent/WO2010111680A2/en not_active Ceased
- 2010-03-26 EP EP10713283.9A patent/EP2410981B2/en active Active
-
2011
- 2011-09-21 IL IL215276A patent/IL215276A/en active IP Right Grant
-
2014
- 2014-12-18 JP JP2014256325A patent/JP5964939B2/ja active Active
-
2015
- 2015-03-25 US US14/667,857 patent/US9119778B2/en active Active
- 2015-07-21 US US14/804,940 patent/US9238005B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2011137960A (ru) | Сухие порошкообразные составы и способы лечения легочных заболеваний | |
| AU2010229668B9 (en) | Dry powder formulations and methods for treating pulmonary diseases | |
| JP2013508344A5 (enExample) | ||
| KR102082752B1 (ko) | 산과 금속 사이의 복합체의 분말 조성물 및 이의 제조방법 | |
| JP2023549226A5 (enExample) | ||
| JP2016065107A5 (enExample) | ||
| CN102488920B (zh) | 核壳结构的α-半水硫酸钙/羟基磷灰石复合颗粒及制备 | |
| TW201127407A (en) | Carnitine granulate and methods for its production | |
| JP2004525108A5 (enExample) | ||
| KR20120015295A (ko) | 점막 내층의 생물물리학적 성질의 변경을 위한 구연산 칼슘 및 젖산 칼슘 제형 | |
| JP2015510010A5 (enExample) | ||
| JP4482925B2 (ja) | アミノ酸類粉末及びその製造方法 | |
| JP2013507499A5 (enExample) | ||
| MX2013013135A (es) | Proceso para producir un material inorganico particulado. | |
| RU2015130602A (ru) | Соли и кристаллические формы | |
| ES2689517T3 (es) | Método para la fabricación de sal mineral y producto de sal mineral | |
| WO2013107236A1 (zh) | （6s）-5-甲基四氢叶酸盐晶型及其制备方法 | |
| CN101730704A (zh) | S-腺苷甲硫氨酸的稳定的盐及其制备方法 | |
| CN104027313A (zh) | 一种含布洛芬的磷酸八钙双层复合颗粒的制备方法 | |
| JP2015514119A5 (enExample) | ||
| JP2017530988A5 (enExample) | ||
| CN103142607B (zh) | 一种替吉奥胶囊制剂的制备方法 | |
| WO2022120768A1 (zh) | 一种硼硅酸盐生物活性玻璃微纳米颗粒及制备方法和应用 | |
| CN102389107A (zh) | 利用富硅植物制备正硅酸提取液和硅补充剂的方法 | |
| Bernardo et al. | Naproxen/Layered double hydroxide composites for Tissue-Engineering applications: physicochemical characterization and biological evaluation |