JP2012522018A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012522018A5 JP2012522018A5 JP2012502314A JP2012502314A JP2012522018A5 JP 2012522018 A5 JP2012522018 A5 JP 2012522018A5 JP 2012502314 A JP2012502314 A JP 2012502314A JP 2012502314 A JP2012502314 A JP 2012502314A JP 2012522018 A5 JP2012522018 A5 JP 2012522018A5
- Authority
- JP
- Japan
- Prior art keywords
- inhalation
- dry powder
- powder suitable
- salt
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 claims 36
- 235000002639 sodium chloride Nutrition 0.000 claims 18
- 229910052751 metal Inorganic materials 0.000 claims 12
- 239000002184 metal Substances 0.000 claims 12
- 239000002245 particle Substances 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- -1 cation salt Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical group [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 6
- 150000001768 cations Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 4
- 159000000000 sodium salts Chemical class 0.000 claims 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims 3
- 239000001354 calcium citrate Substances 0.000 claims 3
- 229960004256 calcium citrate Drugs 0.000 claims 3
- 159000000007 calcium salts Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 235000013337 tricalcium citrate Nutrition 0.000 claims 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000001110 calcium chloride Substances 0.000 claims 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims 2
- 229960002713 calcium chloride Drugs 0.000 claims 2
- 235000011148 calcium chloride Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000001509 sodium citrate Substances 0.000 claims 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 2
- 235000011152 sodium sulphate Nutrition 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 230000003068 static effect Effects 0.000 claims 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 230000009798 acute exacerbation Effects 0.000 claims 1
- 238000005349 anion exchange Methods 0.000 claims 1
- 159000000009 barium salts Chemical class 0.000 claims 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims 1
- 239000001639 calcium acetate Substances 0.000 claims 1
- 235000011092 calcium acetate Nutrition 0.000 claims 1
- 229960005147 calcium acetate Drugs 0.000 claims 1
- 239000004227 calcium gluconate Substances 0.000 claims 1
- 235000013927 calcium gluconate Nutrition 0.000 claims 1
- 229960004494 calcium gluconate Drugs 0.000 claims 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims 1
- 239000001527 calcium lactate Substances 0.000 claims 1
- 235000011086 calcium lactate Nutrition 0.000 claims 1
- 229960002401 calcium lactate Drugs 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 229940095672 calcium sulfate Drugs 0.000 claims 1
- 235000011132 calcium sulphate Nutrition 0.000 claims 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- 229910003002 lithium salt Inorganic materials 0.000 claims 1
- 159000000002 lithium salts Chemical group 0.000 claims 1
- 159000000003 magnesium salts Chemical class 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 235000011083 sodium citrates Nutrition 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- 229940005581 sodium lactate Drugs 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16376309P | 2009-03-26 | 2009-03-26 | |
| US16377209P | 2009-03-26 | 2009-03-26 | |
| US16376709P | 2009-03-26 | 2009-03-26 | |
| US61/163,772 | 2009-03-26 | ||
| US61/163,767 | 2009-03-26 | ||
| US61/163,763 | 2009-03-26 | ||
| US25576409P | 2009-10-28 | 2009-10-28 | |
| US61/255,764 | 2009-10-28 | ||
| US26774709P | 2009-12-08 | 2009-12-08 | |
| US61/267,747 | 2009-12-08 | ||
| US29809210P | 2010-01-25 | 2010-01-25 | |
| US61/298,092 | 2010-01-25 | ||
| US30581910P | 2010-02-18 | 2010-02-18 | |
| US61/305,819 | 2010-02-18 | ||
| PCT/US2010/028961 WO2010111680A2 (en) | 2009-03-26 | 2010-03-26 | Dry powder formulations and methods for treating pulmonary diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014256325A Division JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522018A JP2012522018A (ja) | 2012-09-20 |
| JP2012522018A5 true JP2012522018A5 (enExample) | 2013-05-23 |
| JP5671001B2 JP5671001B2 (ja) | 2015-02-18 |
Family
ID=42635067
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502314A Active JP5671001B2 (ja) | 2009-03-26 | 2010-03-26 | 肺疾患を治療するための乾燥粉末製剤および方法 |
| JP2014256325A Active JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014256325A Active JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20120064126A1 (enExample) |
| EP (2) | EP2410981B2 (enExample) |
| JP (2) | JP5671001B2 (enExample) |
| KR (1) | KR101639098B1 (enExample) |
| CN (2) | CN102497853B (enExample) |
| AU (1) | AU2010229668C1 (enExample) |
| BR (1) | BRPI1011721B1 (enExample) |
| CA (1) | CA2754691C (enExample) |
| DK (1) | DK2410981T4 (enExample) |
| ES (1) | ES2625260T5 (enExample) |
| IL (1) | IL215276A (enExample) |
| MX (1) | MX354829B (enExample) |
| PT (1) | PT2410981T (enExample) |
| RU (1) | RU2577698C2 (enExample) |
| WO (1) | WO2010111680A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101639098B1 (ko) | 2009-03-26 | 2016-07-12 | 풀매트릭스 오퍼레이팅 컴퍼니, 인크 | 폐 질환 치료용 건조 분말 제형 및 방법 |
| GB0918450D0 (en) * | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| US9061352B2 (en) | 2010-08-30 | 2015-06-23 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US8758824B2 (en) | 2010-08-30 | 2014-06-24 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
| RU2640921C2 (ru) | 2010-09-29 | 2018-01-12 | Пулмэтрикс, Инк. | Катионы одновалентных металлов сухих порошков для ингаляций |
| PT2621488T (pt) | 2010-09-29 | 2019-02-12 | Pulmatrix Operating Co Inc | Pós secos catiónicos |
| WO2012058719A1 (en) * | 2010-11-02 | 2012-05-10 | The Universtity Of Sydney | Inhalable compositions |
| US9572774B2 (en) | 2011-05-19 | 2017-02-21 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
| BR112013029803B1 (pt) | 2011-05-19 | 2021-07-13 | Savara, Inc | Composições de vancomicina em pó seco |
| US20140336159A1 (en) | 2011-10-07 | 2014-11-13 | Pulmatrix, Inc. | Methods for treating and diagnosing respiratory tract infections |
| NZ722952A (en) | 2012-02-28 | 2018-12-21 | Iceutica Holdings Inc | Inhalable pharmaceutical compositions |
| JP2015509788A (ja) * | 2012-02-29 | 2015-04-02 | パルマトリックス，インコーポレイテッド | 吸入に適した乾燥粉末 |
| BR112015002270B1 (pt) * | 2012-08-01 | 2020-02-11 | Purac Biochem B.V. | Pó de lactato e método para a preparação do mesmo |
| US8545878B1 (en) | 2012-11-09 | 2013-10-01 | Civitas Therapeutics, Inc. | Capsules containing high doses of levodopa for pulmonary use |
| WO2014074797A1 (en) | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| EP2769630B1 (en) | 2013-02-26 | 2016-04-27 | Purac Biochem N.V. | Improved nisin production process |
| EP2754356A1 (en) | 2013-01-15 | 2014-07-16 | Purac Biochem N.V. | Improved nisin production process |
| WO2014165303A1 (en) | 2013-04-01 | 2014-10-09 | Pulmatrix, Inc. | Tiotropium dry powders |
| US10149823B2 (en) | 2013-04-30 | 2018-12-11 | Otitopic Inc. | Dry powder formulations and methods of use |
| US10736840B2 (en) * | 2013-09-03 | 2020-08-11 | Georgia Tech Research Corporation | Thermally stable vaccine formulations and microneedles |
| CA2965759C (en) | 2014-10-31 | 2023-12-12 | Glaxosmithkline Intellectual Property Development Limited | Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials |
| US10046007B2 (en) | 2015-06-24 | 2018-08-14 | Prescient Pharma, Llc | Compositions and methods for treatment of short telomere disorders |
| US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
| WO2017210658A1 (en) | 2016-06-03 | 2017-12-07 | Otitopic Inc. | Dry powder formulations for inhalation |
| AU2017318672B2 (en) | 2016-09-01 | 2022-03-10 | Nutrition 21, Llc | Magnesium biotinate compositions and methods of use |
| EP3846825A4 (en) | 2018-09-05 | 2022-11-02 | Sensory Cloud, LLC | FORMULATIONS AND COMPOSITIONS FOR ORTHO- AND/OR RETRO-NASAL DELIVERY AND RELATED SYSTEMS, METHODS AND ARTICLES |
| JP2022515314A (ja) | 2018-11-02 | 2022-02-18 | ニュートリション・２１，エルエルシー | イノシトール安定化アルギニンケイ酸塩複合体及びイノシトールを含有するビデオゲームプレーヤーの認知機能を改善するための組成物 |
| IL294021A (en) * | 2019-12-16 | 2022-08-01 | Nutrition 21 Llc | Methods of production of arginine-silicate complexes |
| CN119013010A (zh) * | 2021-12-16 | 2024-11-22 | 艾维尔勒斯生物公司 | 用于治疗慢性肺病的可吸入或可摄入的乳酸组合物 |
| CN119894498A (zh) * | 2022-09-02 | 2025-04-25 | 莉塔护理有限公司 | 用于治疗呼吸道感染的药物干粉组合物和方法 |
Family Cites Families (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US4233405A (en) | 1979-10-10 | 1980-11-11 | Rohm And Haas Company | Process for spray drying enzymes |
| US4637815A (en) | 1985-08-06 | 1987-01-20 | Lemole Gerald M | Irrigational hemostatic solution |
| US5511726A (en) | 1988-09-23 | 1996-04-30 | Battelle Memorial Institute | Nebulizer device |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| GB2265845B (en) | 1991-11-12 | 1996-05-01 | Medix Ltd | A nebuliser and nebuliser control system |
| US5466680A (en) * | 1992-03-26 | 1995-11-14 | Cytologics, Inc. | Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US6098620A (en) | 1993-01-29 | 2000-08-08 | Aradigm Corporation | Device for aerosolizing narcotics |
| US5724957A (en) | 1993-01-29 | 1998-03-10 | Aradigm Corporation | Intrapulmonary delivery of narcotics |
| NZ328476A (en) | 1993-06-24 | 1999-05-28 | Astra Ab | Use of a two component insulin preparation in an inhalation device |
| AUPM411494A0 (en) | 1994-02-25 | 1994-03-24 | Central Sydney Area Health Service | Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum |
| JP3414539B2 (ja) | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US5747002A (en) | 1995-04-05 | 1998-05-05 | Genentech, Inc. | Preparation of sodium chloride aerosol formulations |
| US5612053A (en) | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| SK284448B6 (sk) | 1995-04-14 | 2005-04-01 | Glaxo Wellcome Inc. | Merací dávkovací inhalátor |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| WO1996032096A1 (en) | 1995-04-14 | 1996-10-17 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US5628984A (en) | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| US6315983B1 (en) * | 1996-01-24 | 2001-11-13 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for the production of powdered pulmonary surfactant preparations |
| GB9606677D0 (en) | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| NZ503464A (en) | 1997-09-29 | 2002-05-31 | Inhale Therapeutic Syst | Perforated microparticles containing a bioactive agent for pulmonary delivery |
| GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
| WO2000000215A1 (en) | 1998-06-29 | 2000-01-06 | Inhale Therapeutic Systems, Inc. | Particulate delivery systems and methods of use |
| GB9814172D0 (en) | 1998-06-30 | 1998-08-26 | Andaris Ltd | Formulation for inhalation |
| DE69928279T2 (de) * | 1998-11-10 | 2006-08-17 | Altana Pharma Ag | Lungensurfactant zubereitungen enthaltendes behandlungset |
| US6926911B1 (en) | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| MXPA01007895A (es) | 1999-02-03 | 2003-07-21 | Biosante Pharmaceuticals Inc | Particulas terapeuticas de fosfato de calcio, metodos de manufactura y usos. |
| US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| GB9916316D0 (en) * | 1999-07-12 | 1999-09-15 | Quadrant Holdings Cambridge | Dry powder compositions |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| CA2383491A1 (en) † | 1999-08-25 | 2001-03-01 | Advanced Inhalation Research, Inc. | Large porous particles by spray-drying |
| EP1666028B1 (en) | 1999-10-29 | 2010-03-24 | Novartis AG | Dry powder compositions having improved dispersivity |
| SK284948B6 (sk) | 2000-04-06 | 2006-03-02 | Zentiva, A. S. | Liečivý prípravok s obsahom vápnika alebo zmesi vápnika a vitamínu D, alebo zmesi vápnika a horčíka v novej liekovej forme |
| CA2405811C (en) * | 2000-04-12 | 2011-09-27 | Altana Pharma Ag | Novel use of pulmonary surfactant for the prophylaxis or early treatment of acute pulmonary diseases |
| CA2382133C (en) † | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| ATE378039T1 (de) | 2000-06-27 | 2007-11-15 | Vectura Ltd | Herstellungsverfahren für partikel zur verwendung in einer arzneizusammensetzung |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| EP2298285A3 (en) | 2000-11-30 | 2011-07-27 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| PT2301524E (pt) | 2000-12-27 | 2013-07-10 | Gilead Sciences Inc | Aztreonam inalável sem arginina para tratamento e prevenção de infecções bacterianas pulmonares |
| US20020141946A1 (en) | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| US6766799B2 (en) | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
| US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| WO2003035028A1 (en) | 2001-10-19 | 2003-05-01 | Nektar Therapeutics | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
| ES2415654T3 (es) * | 2001-11-20 | 2013-07-26 | Civitas Therapeutics, Inc. | Composiciones particuladas mejoradas para suministro pulmonar |
| EP1466610A4 (en) | 2001-11-26 | 2007-03-21 | Daiichi Asubio Pharma Co Ltd | MEDICAL COMPOSITIONS FOR RECEIVING VIA THE NOSE |
| US20030232019A1 (en) | 2002-02-22 | 2003-12-18 | Advanced Inhalation Research, Inc. | Inhalable formulations for sustained release |
| US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| DK1531798T3 (da) | 2002-03-20 | 2012-08-13 | Civitas Therapeutics Inc | Pulmonal frigørelse af Levodopa |
| GB0207906D0 (en) | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and mometasone aerosol formulations |
| CA2488976C (en) † | 2002-06-28 | 2009-08-25 | Advanced Inhalation Research, Inc. | Inhalable epinephrine |
| US7112572B2 (en) * | 2002-09-09 | 2006-09-26 | Trigen Limited | Multivalent metal salts of boronic acids |
| AU2003279070A1 (en) * | 2002-09-30 | 2004-04-23 | Acusphere Inc | Sustained release porous microparticles for inhalation |
| US7534781B2 (en) | 2003-03-21 | 2009-05-19 | Dsm Ip Assets B.V. | Crystalline amoxicillin trihydrate powder |
| CN1194062C (zh) | 2003-04-04 | 2005-03-23 | 王泽斌 | 一种融雪融冰组合物及其制备方法和应用 |
| EP1617834B1 (en) | 2003-05-01 | 2006-09-27 | Innogene Kalbiotech Pte. Ltd. | Use of a pharmaceutical composition containing lactic acid or lactate and potassium for treating brain edema or brain injury |
| JP2009514779A (ja) * | 2003-07-11 | 2009-04-09 | グラクソ グループ リミテッド | 医薬製剤 |
| DE10339197A1 (de) * | 2003-08-22 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität |
| GB0324897D0 (en) | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Composition |
| GB0324918D0 (en) * | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Composition |
| KR20050056622A (ko) | 2003-12-10 | 2005-06-16 | 주식회사 대우일렉트로닉스 | 플레쉬롬 다운로드 장치 |
| US7192919B2 (en) * | 2004-01-07 | 2007-03-20 | Stelios Tzannis | Sustained release compositions for delivery of pharmaceutical proteins |
| US20050207983A1 (en) | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| SE528121C2 (sv) | 2004-03-29 | 2006-09-05 | Mederio Ag | Preparering av torrpulver för på förhand uppmätt DPI |
| WO2005094869A1 (en) | 2004-03-30 | 2005-10-13 | Malcolm King | Compositions and methods for improved mucus function |
| US20050281740A1 (en) | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
| RU2007106714A (ru) | 2004-07-26 | 2008-09-10 | Байер Шеринг Фарма Аг (De) | Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц |
| JP2008513444A (ja) * | 2004-09-20 | 2008-05-01 | コラス ファーマ インコーポレイテッド | リドカイン及び他の局所麻酔剤の標的運搬並びに咳そう及び咳の発作の処置のための方法 |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| EP1888257A1 (en) | 2005-05-05 | 2008-02-20 | Pulmatrix, Inc. | Ultrasonic aerosol generator |
| EP2308469A1 (en) * | 2005-05-18 | 2011-04-13 | Pulmatrix, Inc. | Formulations for alteration of biophysical properties of mucosal lining |
| US7838532B2 (en) | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| GB0520794D0 (en) | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
| GB0523576D0 (en) | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
| GB0625322D0 (en) | 2006-12-19 | 2007-01-24 | Pharmakodex Ltd | Pharmaceutical compositions |
| WO2009037503A2 (en) | 2007-09-18 | 2009-03-26 | Astrazeneca Ab | New combination - 012 for the treatment of respiratory diseases |
| DK2252275T3 (en) | 2008-02-13 | 2018-03-05 | Univ Texas | CREATED NON-OPEN FLOCKS OF ANISOTROPIC PARTICLES FOR IMPROVED TRANSPORT INTO THE Lungs |
| EP2098219A1 (en) | 2008-03-05 | 2009-09-09 | PARI Pharma GmbH | Macrolide compositions having improved taste and stability |
| KR101621986B1 (ko) | 2008-05-15 | 2016-05-17 | 노파르티스 아게 | 플루오로퀴놀론의 폐 전달 |
| GB0818476D0 (en) | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
| JP2012522009A (ja) | 2009-03-26 | 2012-09-20 | パルマトリックス，インコーポレイテッド | 肺炎および人工呼吸器関連気管気管支炎を治療および予防するための方法 |
| WO2010111650A2 (en) | 2009-03-26 | 2010-09-30 | Pulmatrix, Inc. | Calcium citrate and calcium lactate formulations for alteration of biophysical properties of mucosal lining |
| KR101639098B1 (ko) | 2009-03-26 | 2016-07-12 | 풀매트릭스 오퍼레이팅 컴퍼니, 인크 | 폐 질환 치료용 건조 분말 제형 및 방법 |
| ES2379775T3 (es) | 2009-03-26 | 2012-05-03 | Pulmatrix, Inc. | Formulaciones farmacéuticas y métodos para tratar infecciones del aparato respiratorio |
| CN102448438A (zh) | 2009-03-26 | 2012-05-09 | 普马特里克斯公司 | 抗流行性感冒调配物及方法 |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| PT106094A (pt) | 2012-01-13 | 2013-07-15 | Hovione Farmaciencia S A | Administração por inalação de formulações com dose elevada |
-
2010
- 2010-03-26 KR KR1020117024843A patent/KR101639098B1/ko active Active
- 2010-03-26 MX MX2011009957A patent/MX354829B/es active IP Right Grant
- 2010-03-26 CN CN201080023554.3A patent/CN102497853B/zh not_active Expired - Fee Related
- 2010-03-26 CN CN201810147094.3A patent/CN108434126B/zh active Active
- 2010-03-26 ES ES10713283T patent/ES2625260T5/es active Active
- 2010-03-26 US US13/259,635 patent/US20120064126A1/en not_active Abandoned
- 2010-03-26 WO PCT/US2010/028961 patent/WO2010111680A2/en not_active Ceased
- 2010-03-26 AU AU2010229668A patent/AU2010229668C1/en active Active
- 2010-03-26 CA CA2754691A patent/CA2754691C/en active Active
- 2010-03-26 PT PT107132839T patent/PT2410981T/pt unknown
- 2010-03-26 RU RU2011137960/15A patent/RU2577698C2/ru active
- 2010-03-26 JP JP2012502314A patent/JP5671001B2/ja active Active
- 2010-03-26 BR BRPI1011721-0A patent/BRPI1011721B1/pt active IP Right Grant
- 2010-03-26 EP EP10713283.9A patent/EP2410981B2/en active Active
- 2010-03-26 DK DK10713283.9T patent/DK2410981T4/da active
- 2010-03-26 EP EP17000124.2A patent/EP3184099A1/en active Pending
-
2011
- 2011-09-21 IL IL215276A patent/IL215276A/en active IP Right Grant
-
2014
- 2014-12-18 JP JP2014256325A patent/JP5964939B2/ja active Active
-
2015
- 2015-03-25 US US14/667,857 patent/US9119778B2/en active Active
- 2015-07-21 US US14/804,940 patent/US9238005B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012522018A5 (enExample) | ||
| RU2011137960A (ru) | Сухие порошкообразные составы и способы лечения легочных заболеваний | |
| JP2013508344A5 (enExample) | ||
| RU2017145305A (ru) | Аморфный карбонат кальция, стабилизированный полифосфатами или бисфосфонатами | |
| JP6140198B2 (ja) | 酸と金属との錯体の粉体組成物およびその製造法 | |
| JP2014524442A5 (enExample) | ||
| TW201127407A (en) | Carnitine granulate and methods for its production | |
| JP2004525108A5 (enExample) | ||
| JP2017532374A5 (enExample) | ||
| MX2013013135A (es) | Proceso para producir un material inorganico particulado. | |
| WO2003070023A1 (en) | Amino acid powder and process for producing the same | |
| ES2689517T3 (es) | Método para la fabricación de sal mineral y producto de sal mineral | |
| CN101730704A (zh) | S-腺苷甲硫氨酸的稳定的盐及其制备方法 | |
| CN104027313A (zh) | 一种含布洛芬的磷酸八钙双层复合颗粒的制备方法 | |
| WO2017013542A1 (en) | Product based on iron bis-glycinate chelate and alginic acid and/or water-soluble salts thereof, formulations thereof, and pharmaceutical uses thereof | |
| JP2017530988A5 (enExample) | ||
| JP6562336B2 (ja) | 透析用ａ剤に使用される造粒物の製造方法 | |
| CN102976962A (zh) | L-鸟氨酸阿司匹林复盐及其制备方法和应用 | |
| JP2010540440A5 (enExample) | ||
| Bernardo et al. | Naproxen/layered double hydroxide composites for tissue-engineering applications: Physicochemical characterization and biological evaluation | |
| CN104432095A (zh) | 一种肌酸速溶粉及其制备方法 | |
| KR20180091689A (ko) | 무정형 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법 | |
| JP2011045473A5 (enExample) | ||
| JP4062719B2 (ja) | 固形重曹透析用剤およびその製造方法 | |
| JP6435161B2 (ja) | アミノ酸含有組成物 |