JP2012521768A - 抗体−受容体の組み合わせを含む多特異的結合性タンパク質を用いるための組成物および方法 - Google Patents

抗体−受容体の組み合わせを含む多特異的結合性タンパク質を用いるための組成物および方法 Download PDF

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JP2012521768A
JP2012521768A JP2012502294A JP2012502294A JP2012521768A JP 2012521768 A JP2012521768 A JP 2012521768A JP 2012502294 A JP2012502294 A JP 2012502294A JP 2012502294 A JP2012502294 A JP 2012502294A JP 2012521768 A JP2012521768 A JP 2012521768A
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vegf
antibody
cancer
binding protein
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JP2012521768A5 (cg-RX-API-DMAC7.html
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パン・キ
カール・ダブリュー・バークス
パラブル・ブイ・シバクマル
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012502294A 2009-03-27 2010-03-26 抗体−受容体の組み合わせを含む多特異的結合性タンパク質を用いるための組成物および方法 Pending JP2012521768A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16402309P 2009-03-27 2009-03-27
US61/164,023 2009-03-27
PCT/US2010/028877 WO2010111625A1 (en) 2009-03-27 2010-03-26 Compositions and methods for using multispecific-binding proteins comprising an antibody-receptor combination

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JP2012521768A true JP2012521768A (ja) 2012-09-20
JP2012521768A5 JP2012521768A5 (cg-RX-API-DMAC7.html) 2013-05-09

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US (1) US20120134993A1 (cg-RX-API-DMAC7.html)
EP (1) EP2411407A1 (cg-RX-API-DMAC7.html)
JP (1) JP2012521768A (cg-RX-API-DMAC7.html)
KR (1) KR20110134494A (cg-RX-API-DMAC7.html)
CN (1) CN102448984A (cg-RX-API-DMAC7.html)
AU (1) AU2010229705A1 (cg-RX-API-DMAC7.html)
MX (1) MX2011009810A (cg-RX-API-DMAC7.html)
WO (1) WO2010111625A1 (cg-RX-API-DMAC7.html)

Cited By (7)

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JP2017522052A (ja) * 2014-07-21 2017-08-10 曁南大学 ヒトFGFR2c細胞外ドメイン146−356とそれをコードする遺伝子及びそれらの応用
JP2017526635A (ja) * 2014-06-28 2017-09-14 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. デュアルpdgf/vegfアンタゴニスト
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
US11071771B2 (en) 2014-10-17 2021-07-27 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
US11155610B2 (en) 2014-06-28 2021-10-26 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof

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WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
HK1219533A1 (zh) * 2013-03-15 2017-04-07 Intermune, Inc. 蛋白质组学ipf标志物
US9879081B2 (en) 2013-06-25 2018-01-30 Samsung Electronics Co., Ltd. Protein complex, bispecific antibody including the protein complex, and method of preparation thereof
US9920096B2 (en) 2013-06-25 2018-03-20 Sepia Pesquisa E Desenvolvimento Bradykinin receptor modulators and use thereof
KR102060187B1 (ko) 2013-07-19 2019-12-27 삼성전자주식회사 Vegf-c, vegf-d 및/또는 안지오포이에틴-2를 동시에 저해하는 융합 폴리펩타이드 및 이의 용도
LT3041513T (lt) 2013-09-08 2020-11-25 Kodiak Sciences Inc. Viii faktoriaus cviterioninių polimerų konjugatai
EA037920B1 (ru) 2014-09-26 2021-06-07 Янссен Фармацевтика Нв Использование панелей мутантных генов fgfr для выявления онкологических пациентов, которые будут поддаваться лечению ингибитором fgfr
KR102548827B1 (ko) * 2014-12-22 2023-06-30 시스트이뮨, 인코포레이티드 이중특이적 4가 항체 및 이의 제조 및 사용방법
US12428483B2 (en) 2014-12-22 2025-09-30 Systimmune, Inc. Bispecific tetravalent antibodies and methods of making and using thereof
EA201890305A1 (ru) 2015-07-15 2018-07-31 Генмаб А/С Гуманизированные или химерные cd3-антитела
AU2016363668A1 (en) * 2015-11-30 2018-05-24 Pieris Australia Pty Ltd. Novel anti-angiogenic fusion polypeptides
KR20240017129A (ko) 2016-07-14 2024-02-06 젠맵 에이/에스 Cd40 및 cd137에 대한 다중특이적 항체
PL3592769T3 (pl) 2017-03-09 2024-10-14 Genmab A/S Przeciwciała przeciwko PD-L1
IL269645B2 (en) 2017-03-31 2025-05-01 Genmab Holding B V Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
KR20250020679A (ko) 2017-08-04 2025-02-11 젠맵 에이/에스 Pd-l1 및 cd137에 결합하는 결합제 및 그의 용도
CN113260629A (zh) 2018-09-19 2021-08-13 拉法医疗有限公司 用于治疗恶性血液病的新双特异性抗体
WO2020070313A1 (en) 2018-10-04 2020-04-09 Genmab Holding B.V. Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
WO2020094744A1 (en) 2018-11-06 2020-05-14 Genmab A/S Antibody formulation
CN113993893A (zh) 2019-02-01 2022-01-28 拉法医疗有限公司 新cd40结合抗体
NL2022494B1 (en) 2019-02-01 2020-08-19 Lava Therapeutics B V Novel CD40-binding antibodies
JPWO2021010326A1 (cg-RX-API-DMAC7.html) * 2019-07-12 2021-01-21
EP3792283A1 (en) 2019-09-16 2021-03-17 Lava Therapeutics B.V. Treatment of cancer comprising administration of vgamma9vdelta2 t cell receptor binding antibodies
WO2021155916A1 (en) 2020-02-04 2021-08-12 BioNTech SE Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
AU2021236906A1 (en) 2020-03-18 2022-08-18 Genmab A/S Antibodies binding to B7H4
JP2023524149A (ja) 2020-05-08 2023-06-08 ジェンマブ エー/エス Cd3およびcd20に対する二重特異性抗体
CN116323667A (zh) 2020-07-08 2023-06-23 拉法医疗股份有限公司 结合PSMA和γ-δT细胞受体的抗体
US20230287088A1 (en) 2020-08-06 2023-09-14 BioNTech SE Binding agents for coronavirus s protein
BR112023004321A2 (pt) 2020-09-10 2023-04-04 Genmab As Método para tratar linfoma de célula b grande difusa em um sujeito humano
JP2023541858A (ja) 2020-09-10 2023-10-04 ジェンマブ エー/エス 慢性リンパ球性白血病を治療するためのcd3及びcd20に対する二重特異性抗体
KR20230157933A (ko) 2020-12-10 2023-11-17 라바 테라퓨틱스 엔.브이. 감마-델타 t 세포 수용체에 결합하는 항체
CA3209454A1 (en) 2021-02-26 2022-09-01 Robertus Cornelis ROOVERS Antibodies that bind cd123 and gamma-delta t cell receptors
IL308300A (en) 2021-05-07 2024-01-01 Genmab As PHARMACEUTICAL COMPOSITIONS COMPRISING BISPECIFIC ANTIBODIES BINDING TO B7H4 and CD3
IL309319A (en) 2021-06-21 2024-02-01 Genmab As Combined dosage regimen CD137 and PD-L1 binding agents
AU2022344595A1 (en) 2021-09-13 2024-05-02 Janssen Biotech, Inc CD33 X Vδ2 MULTISPECIFIC ANTIBODIES FOR THE TREATMENT OF CANCER
WO2023057571A1 (en) 2021-10-08 2023-04-13 Genmab A/S Antibodies binding to cd30 and cd3
WO2023067138A1 (en) 2021-10-21 2023-04-27 LAVA Therapeutics N.V. Uses of gamma delta t cell activating antibodies
WO2023174521A1 (en) 2022-03-15 2023-09-21 Genmab A/S Binding agents binding to epcam and cd137
EP4285926A1 (en) 2022-05-30 2023-12-06 LAVA Therapeutics N.V. Combination treatment for chronic lymphocytic leukemia
EP4292609A1 (en) 2022-06-15 2023-12-20 LAVA Therapeutics N.V. Compositions comprising antibodies that bind gamma-delta t cell receptors
EP4292610A1 (en) 2022-06-15 2023-12-20 LAVA Therapeutics N.V. Variant antibodies that bind gamma-delta t cell receptors
NL2032398B1 (en) 2022-07-06 2024-01-23 Academisch Ziekenhuis Leiden Bispecific antibody and uses thereof
CN116199744B (zh) * 2023-03-23 2024-06-25 湖南中晟全肽生物科技股份有限公司 一种结合fgfr2受体的多肽及其用途
EP4438624A1 (en) 2023-03-27 2024-10-02 LAVA Therapeutics N.V. Antibodies that bind nectin-4 and gamma-delta t cell receptors
WO2024200573A1 (en) 2023-03-27 2024-10-03 LAVA Therapeutics N.V. Nectin-4 binding agents and methods of use
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JP2025530208A (ja) 2023-06-30 2025-09-11 ジェンマブ エー/エス 線維芽細胞活性化タンパク質アルファおよびデスレセプター4に結合する抗体
WO2025012118A2 (en) 2023-07-07 2025-01-16 LAVA Therapeutics N.V. 5t4 binding agents and methods of use
TW202519261A (zh) 2023-07-27 2025-05-16 荷蘭商拉法醫療公司 用於治療癌症之結合γ-δ T細胞受體之抗體
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017526635A (ja) * 2014-06-28 2017-09-14 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. デュアルpdgf/vegfアンタゴニスト
JP2021091700A (ja) * 2014-06-28 2021-06-17 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. デュアルvegf/pdgfアンタゴニスト
US11155610B2 (en) 2014-06-28 2021-10-26 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
JP7100425B2 (ja) 2014-06-28 2022-07-13 コディアック サイエンシーズ インコーポレイテッド デュアルpdgf/vegfアンタゴニスト
JP7373514B2 (ja) 2014-06-28 2023-11-02 コディアック サイエンシーズ インコーポレイテッド デュアルvegf/pdgfアンタゴニスト
JP2017522052A (ja) * 2014-07-21 2017-08-10 曁南大学 ヒトFGFR2c細胞外ドメイン146−356とそれをコードする遺伝子及びそれらの応用
US11071771B2 (en) 2014-10-17 2021-07-27 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder

Also Published As

Publication number Publication date
MX2011009810A (es) 2011-09-30
WO2010111625A1 (en) 2010-09-30
AU2010229705A1 (en) 2011-10-20
KR20110134494A (ko) 2011-12-14
CN102448984A (zh) 2012-05-09
US20120134993A1 (en) 2012-05-31
EP2411407A1 (en) 2012-02-01

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