JP2012521215A5 - - Google Patents
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- JP2012521215A5 JP2012521215A5 JP2012501965A JP2012501965A JP2012521215A5 JP 2012521215 A5 JP2012521215 A5 JP 2012521215A5 JP 2012501965 A JP2012501965 A JP 2012501965A JP 2012501965 A JP2012501965 A JP 2012501965A JP 2012521215 A5 JP2012521215 A5 JP 2012521215A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- phenotype
- cell
- suspension
- nkt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000822 natural killer cell Anatomy 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 15
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 14
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 12
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 12
- 210000000581 natural killer T-cell Anatomy 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 239000000725 suspension Substances 0.000 claims 4
- 102000000588 Interleukin-2 Human genes 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 239000006285 cell suspension Substances 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims 2
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 231100000263 cytotoxicity test Toxicity 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000004976 peripheral blood cell Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000012467 final product Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16359009P | 2009-03-26 | 2009-03-26 | |
| US61/163,590 | 2009-03-26 | ||
| PCT/SE2010/050333 WO2010110734A1 (en) | 2009-03-26 | 2010-03-25 | Expansion of nk cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015254493A Division JP2016105713A (ja) | 2009-03-26 | 2015-12-25 | Ｎｋ細胞の増殖 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012521215A JP2012521215A (ja) | 2012-09-13 |
| JP2012521215A5 true JP2012521215A5 (https=) | 2013-04-25 |
Family
ID=42781254
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501965A Pending JP2012521215A (ja) | 2009-03-26 | 2010-03-25 | Ｎｋ細胞の増殖 |
| JP2015254493A Pending JP2016105713A (ja) | 2009-03-26 | 2015-12-25 | Ｎｋ細胞の増殖 |
| JP2017208238A Active JP6574823B2 (ja) | 2009-03-26 | 2017-10-27 | Ｎｋ細胞の増殖 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015254493A Pending JP2016105713A (ja) | 2009-03-26 | 2015-12-25 | Ｎｋ細胞の増殖 |
| JP2017208238A Active JP6574823B2 (ja) | 2009-03-26 | 2017-10-27 | Ｎｋ細胞の増殖 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8877182B2 (https=) |
| EP (1) | EP2411507B1 (https=) |
| JP (3) | JP2012521215A (https=) |
| KR (1) | KR101881520B1 (https=) |
| CN (1) | CN102428173B (https=) |
| DK (1) | DK2411507T3 (https=) |
| ES (1) | ES2763169T3 (https=) |
| PL (1) | PL2411507T3 (https=) |
| PT (1) | PT2411507T (https=) |
| WO (1) | WO2010110734A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2536242C2 (ru) | 2007-09-28 | 2014-12-20 | Антродженезис Корпорейшн | Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| JP5572863B2 (ja) | 2011-06-24 | 2014-08-20 | 国立大学法人九州大学 | Ｎｋ細胞の増幅方法 |
| ES2652666T3 (es) * | 2011-12-22 | 2018-02-05 | Mogam Biotechnology Institute | Procedimiento de producción de linfocitos citolíticos naturales, linfocitos citolíticos naturales producidos de este modo y composición para el tratamiento de cánceres y enfermedades infecciosas que contienen los mismos |
| US10066207B2 (en) | 2012-04-18 | 2018-09-04 | Board Of Trustees Of Michigan State University | Natural killer cells with enhanced immune response |
| KR101525199B1 (ko) * | 2012-09-13 | 2015-06-04 | (주)케이셀바이오 | 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법 |
| CN102994449A (zh) * | 2012-12-13 | 2013-03-27 | 上海柯莱逊生物技术有限公司 | 一种体外扩增nk细胞的方法 |
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| AU2014215458A1 (en) | 2013-02-05 | 2015-08-13 | Anthrogenesis Corporation | Natural killer cells from placenta |
| HK1215860A1 (zh) * | 2013-03-27 | 2016-09-23 | Biotherapy Institute Of Japan | Nk细胞强化型血液制剂的制造方法 |
| US10260038B2 (en) | 2013-05-10 | 2019-04-16 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| WO2015125113A1 (en) * | 2014-02-21 | 2015-08-27 | Dr. Reddy's Laboratories Limited | Method of culturing high cell density pbmc's |
| CN105002139B (zh) * | 2014-04-25 | 2019-02-01 | 中国医学科学院肿瘤医院 | 一种cd3+cd8+cd56+t细胞亚型促进nk细胞增殖的方法 |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| CN104357390B (zh) * | 2014-10-15 | 2017-07-07 | 恒瑞源正（深圳）生物科技有限公司 | 同时扩增cd3+cd56+cik细胞和cd3‑cd56+nk细胞的方法 |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| CN108289909A (zh) | 2015-10-19 | 2018-07-17 | 巴尔的摩马里兰大学 | 用于产生工程改造的人原代血液树突细胞系的方法 |
| CN105624109B (zh) * | 2016-02-26 | 2019-07-12 | 广州赛莱拉干细胞科技股份有限公司 | 一种使用生物反应器培养nkt细胞的方法 |
| CN107779434A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 高效扩增人外周血nk细胞的实验方法 |
| CN110546265A (zh) | 2017-02-09 | 2019-12-06 | 因达普塔治疗公司 | 工程化自然杀伤(nk)细胞及其组合物和方法 |
| KR102660336B1 (ko) | 2017-03-27 | 2024-04-26 | 내셔널 유니버시티 오브 싱가포르 | 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| EP3633029A4 (en) | 2017-05-26 | 2021-06-09 | Green Cross Lab Cell Corporation | METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL |
| CN107541491A (zh) * | 2017-10-12 | 2018-01-05 | 广州金晟生物科技有限公司 | 一种nk细胞体外培养方法 |
| KR102265437B1 (ko) * | 2017-11-24 | 2021-06-15 | 의료법인 성광의료재단 | Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법 |
| CN108060130B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 控制培养箱适于免疫细胞的诱导扩增的方法 |
| CN108192868B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 免疫细胞的诱导扩增方法 |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| US20230181635A1 (en) * | 2018-03-13 | 2023-06-15 | Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz | Anti-cxcr4 antibody combined with activated and expanded natural killer cells for cancer immunotherapy |
| KR102232321B1 (ko) * | 2018-03-23 | 2021-03-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| WO2019182392A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| CN112055717B (zh) | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子 |
| GB201807050D0 (en) * | 2018-04-30 | 2018-06-13 | Cellprotect Nordic Pharmaceuticals Ab | Medical uses |
| KR102069704B1 (ko) * | 2018-05-16 | 2020-01-23 | 고려대학교 산학협력단 | Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법 |
| US20210207097A1 (en) * | 2018-05-31 | 2021-07-08 | Korea University Research And Business Foundation | Expansion and culture of human-derived natural killer cells by using igfbp2 |
| CN110628715B (zh) * | 2018-06-21 | 2022-11-25 | 精准生技股份有限公司 | 体外扩增自然杀手细胞及自然杀手t细胞的方法及其医药组成物 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| MY199770A (en) | 2018-11-14 | 2023-11-22 | Green Cross Lab Cell Corp | Method for culturing cord blood-derived natural killer cells using transformed t cells |
| US12410402B2 (en) | 2018-11-21 | 2025-09-09 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (NK) cell subset and related compositions and methods |
| US12590148B2 (en) | 2018-11-26 | 2026-03-31 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| JP2022525928A (ja) * | 2019-03-21 | 2022-05-20 | ガミダ セル リミテッド | 併用療法における移植に適したｎｋ細胞画分の増殖及び増殖ｎｋ細胞画分の使用 |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| AU2019456283B2 (en) * | 2019-07-08 | 2023-06-08 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| EP4096688A1 (en) | 2020-01-28 | 2022-12-07 | Sorrento Therapeutics, Inc. | Natural killer cells for treatment of coronavirus infection |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| EP4277638A4 (en) * | 2021-01-12 | 2024-12-04 | Hadasit Medical Research Services&Development Ltd. | ENHANCED ADOPTIVE CELL TRANSFER THERAPY FOR CANCER |
| GB202115389D0 (en) | 2021-10-26 | 2021-12-08 | XNK Therapeutics AB | Methods |
| WO2023081813A1 (en) | 2021-11-05 | 2023-05-11 | St. Jude Children's Research Hospital, Inc. | Zip cytokine receptors |
| EP4536687A1 (en) | 2022-06-08 | 2025-04-16 | St. Jude Children's Research Hospital, Inc. | Disruption of kdm4a in t cells to enhance immunotherapy |
| WO2024059787A1 (en) | 2022-09-16 | 2024-03-21 | St. Jude Children's Research Hospital, Inc. | Disruption of asxl1 in t cells to enhance immunotherapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2425801A (en) | 1999-11-24 | 2001-06-04 | Ernest G. Hope | Anti-angiogenic cellular agent for cancer therapy |
| US20030119185A1 (en) * | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| AU2001262697A1 (en) * | 2000-06-06 | 2001-12-17 | Kirin Beer Kabushiki Kaisha | Method of amplifying natural killer t cells |
| US20030068306A1 (en) * | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
| WO2006009731A1 (en) * | 2004-06-18 | 2006-01-26 | Genentech, Inc. | Methods of using apo2l receptor agonists and nk cell activators |
| EP3072522B1 (en) | 2005-01-06 | 2019-04-24 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| JP4953403B2 (ja) * | 2007-11-05 | 2012-06-13 | 恒雄 倉持 | がん免疫療法用細胞の製造方法 |
| US20090123442A1 (en) * | 2007-11-09 | 2009-05-14 | Avaris Ab | Expanded nk cells |
| KR20090127974A (ko) * | 2008-06-10 | 2009-12-15 | 주식회사 엔케이바이오 | 자기활성화 림프구 배양용 배지 조성물 |
-
2010
- 2010-03-25 US US13/260,004 patent/US8877182B2/en active Active
- 2010-03-25 WO PCT/SE2010/050333 patent/WO2010110734A1/en not_active Ceased
- 2010-03-25 EP EP10756430.4A patent/EP2411507B1/en active Active
- 2010-03-25 DK DK10756430.4T patent/DK2411507T3/da active
- 2010-03-25 ES ES10756430T patent/ES2763169T3/es active Active
- 2010-03-25 CN CN201080021237.8A patent/CN102428173B/zh active Active
- 2010-03-25 PT PT107564304T patent/PT2411507T/pt unknown
- 2010-03-25 KR KR1020117025234A patent/KR101881520B1/ko active Active
- 2010-03-25 PL PL10756430T patent/PL2411507T3/pl unknown
- 2010-03-25 JP JP2012501965A patent/JP2012521215A/ja active Pending
-
2015
- 2015-12-25 JP JP2015254493A patent/JP2016105713A/ja active Pending
-
2017
- 2017-10-27 JP JP2017208238A patent/JP6574823B2/ja active Active
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