HK1215860A1 - 細胞强化型血液製劑的製造方法 - Google Patents
細胞强化型血液製劑的製造方法Info
- Publication number
- HK1215860A1 HK1215860A1 HK16103832.8A HK16103832A HK1215860A1 HK 1215860 A1 HK1215860 A1 HK 1215860A1 HK 16103832 A HK16103832 A HK 16103832A HK 1215860 A1 HK1215860 A1 HK 1215860A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cell
- producing
- blood product
- enhancing blood
- enhancing
- Prior art date
Links
- 239000010836 blood and blood product Substances 0.000 title 1
- 229940125691 blood product Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/72—Undefined extracts from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1164—NK cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2013/059037 WO2014155572A1 (ja) | 2013-03-27 | 2013-03-27 | Nk細胞強化型血液製剤の製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1215860A1 true HK1215860A1 (zh) | 2016-09-23 |
Family
ID=51622649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16103832.8A HK1215860A1 (zh) | 2013-03-27 | 2016-04-05 | 細胞强化型血液製劑的製造方法 |
Country Status (4)
Country | Link |
---|---|
US (2) | US20160075996A1 (zh) |
CN (1) | CN105101978B (zh) |
HK (1) | HK1215860A1 (zh) |
WO (1) | WO2014155572A1 (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014155572A1 (ja) * | 2013-03-27 | 2014-10-02 | 株式会社日本バイオセラピー研究所 | Nk細胞強化型血液製剤の製造方法 |
US10760054B2 (en) | 2014-12-29 | 2020-09-01 | Restem Llc | Natural killer cells and methods for enhancing viability, proliferation and cytotoxicity of same following cryopreservation |
CN105176926A (zh) * | 2015-09-22 | 2015-12-23 | 上海柯莱逊生物技术有限公司 | 一种体外培养扩增nk细胞的方法 |
CN105462924B (zh) * | 2015-12-04 | 2019-01-18 | 广州赛莱拉干细胞科技股份有限公司 | Nk细胞的培养方法及无血清培养基组合 |
CN107267454A (zh) * | 2016-04-07 | 2017-10-20 | 北京京蒙高科干细胞技术有限公司 | 一种脐血nk细胞的体外扩增方法及其试剂盒与应用 |
CN105754942A (zh) * | 2016-05-18 | 2016-07-13 | 天津普瑞赛尔生物科技有限公司 | 一种体外扩增nk细胞的方法及其获得的nk细胞 |
CN107574148B (zh) * | 2016-07-05 | 2020-08-11 | 拜西欧斯(北京)生物技术有限公司 | 一种自然杀伤细胞(nk细胞)培养基及其制备方法 |
CN106148282B (zh) * | 2016-07-29 | 2020-04-03 | 北京时合生物科技有限公司 | 一种自然杀伤细胞的培养方法 |
CN108251365B (zh) * | 2016-12-28 | 2020-10-16 | 华南生物医药研究院 | 免疫细胞培养基体系 |
CN106754704B (zh) * | 2016-12-28 | 2020-10-16 | 华南生物医药研究院 | 免疫细胞体外诱导扩增的方法 |
CN107083362A (zh) * | 2017-06-19 | 2017-08-22 | 金浩范 | 一种自体nk细胞制备方法及实施该方法的试剂盒 |
JP2020530486A (ja) * | 2017-08-04 | 2020-10-22 | トゥルティノ バイオサイエンシズ インコーポレイテッド | 免疫細胞を活性化させる方法 |
CN107884250A (zh) * | 2017-11-13 | 2018-04-06 | 深圳博大博聚科技有限公司 | 一种基于细胞计数板的染脱色方法 |
JP6977969B2 (ja) * | 2019-03-22 | 2021-12-08 | 株式会社ガイアバイオメディシン | 免疫細胞提供システム |
CN110564683A (zh) * | 2019-05-16 | 2019-12-13 | 安徽瑞达健康产业有限公司 | 一种γδT细胞和NK细胞共培养诱导扩增的方法 |
US20210008110A1 (en) * | 2019-06-14 | 2021-01-14 | Serhat Gumrukcu | Activated lymphocytic cells and methods of using the same to treat cancer and infectious conditions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030068306A1 (en) * | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
CN101386840A (zh) * | 2008-10-31 | 2009-03-18 | 江苏省人民医院 | Cd3-cd56+nk细胞高效扩增培养系统的构建方法 |
JP2012521215A (ja) * | 2009-03-26 | 2012-09-13 | アヴァリス・アクチエボラーグ | Nk細胞の増殖 |
US20120308986A1 (en) * | 2010-02-08 | 2012-12-06 | Biotherapy Institute Of Japan | Method for producing nk cell-enriched blood product |
CN102586185A (zh) * | 2012-03-12 | 2012-07-18 | 浙江中赢方舟生物工程股份有限公司 | 一种k562细胞扩增激活nk细胞的方法 |
WO2014155572A1 (ja) * | 2013-03-27 | 2014-10-02 | 株式会社日本バイオセラピー研究所 | Nk細胞強化型血液製剤の製造方法 |
-
2013
- 2013-03-27 WO PCT/JP2013/059037 patent/WO2014155572A1/ja active Application Filing
- 2013-03-27 CN CN201380075111.2A patent/CN105101978B/zh active Active
- 2013-03-27 US US14/780,394 patent/US20160075996A1/en not_active Abandoned
-
2016
- 2016-04-05 HK HK16103832.8A patent/HK1215860A1/zh unknown
-
2019
- 2019-03-15 US US16/354,605 patent/US20190211308A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN105101978A (zh) | 2015-11-25 |
CN105101978B (zh) | 2019-11-01 |
US20190211308A1 (en) | 2019-07-11 |
US20160075996A1 (en) | 2016-03-17 |
WO2014155572A1 (ja) | 2014-10-02 |
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