JP2012521191A5 - - Google Patents
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- JP2012521191A5 JP2012521191A5 JP2011551173A JP2011551173A JP2012521191A5 JP 2012521191 A5 JP2012521191 A5 JP 2012521191A5 JP 2011551173 A JP2011551173 A JP 2011551173A JP 2011551173 A JP2011551173 A JP 2011551173A JP 2012521191 A5 JP2012521191 A5 JP 2012521191A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- sequence provided
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000003042 antagnostic effect Effects 0.000 claims 12
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 7
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 7
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 6
- 102000050320 human TNFRSF4 Human genes 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 230000001575 pathological effect Effects 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 229920001427 mPEG Polymers 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920002859 polyalkenylene Polymers 0.000 claims 1
- 229920001281 polyalkylene Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15303809P | 2009-02-17 | 2009-02-17 | |
| US61/153,038 | 2009-02-17 | ||
| PCT/US2010/024377 WO2010096418A2 (en) | 2009-02-17 | 2010-02-17 | Antibody molecules having specificity for human ox40 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015063849A Division JP2015171362A (ja) | 2009-02-17 | 2015-03-26 | ヒトｏｘ４０に対する特異性を有する抗体分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521191A JP2012521191A (ja) | 2012-09-13 |
| JP2012521191A5 true JP2012521191A5 (https=) | 2014-04-17 |
| JP5782385B2 JP5782385B2 (ja) | 2015-09-24 |
Family
ID=42634416
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551173A Expired - Fee Related JP5782385B2 (ja) | 2009-02-17 | 2010-02-17 | ヒトｏｘ４０に対する特異性を有する抗体分子 |
| JP2015063849A Pending JP2015171362A (ja) | 2009-02-17 | 2015-03-26 | ヒトｏｘ４０に対する特異性を有する抗体分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015063849A Pending JP2015171362A (ja) | 2009-02-17 | 2015-03-26 | ヒトｏｘ４０に対する特異性を有する抗体分子 |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US8614295B2 (https=) |
| EP (1) | EP2398498B1 (https=) |
| JP (2) | JP5782385B2 (https=) |
| KR (1) | KR101761929B1 (https=) |
| CN (1) | CN102741287B (https=) |
| AR (1) | AR075504A1 (https=) |
| AU (1) | AU2010216152B2 (https=) |
| BR (1) | BRPI1008692B8 (https=) |
| CA (1) | CA2751477C (https=) |
| CL (1) | CL2011001994A1 (https=) |
| CO (1) | CO6410312A2 (https=) |
| CY (1) | CY1121431T1 (https=) |
| DK (1) | DK2398498T3 (https=) |
| EA (1) | EA037792B1 (https=) |
| ES (1) | ES2699716T3 (https=) |
| HR (1) | HRP20181932T1 (https=) |
| HU (1) | HUE042114T2 (https=) |
| IL (1) | IL214282A (https=) |
| LT (1) | LT2398498T (https=) |
| MA (1) | MA33122B1 (https=) |
| MX (1) | MX2011008697A (https=) |
| MY (1) | MY157473A (https=) |
| NZ (1) | NZ594315A (https=) |
| PE (1) | PE20120211A1 (https=) |
| PL (1) | PL2398498T3 (https=) |
| PT (1) | PT2398498T (https=) |
| SG (3) | SG2014014708A (https=) |
| SI (1) | SI2398498T1 (https=) |
| TN (1) | TN2011000374A1 (https=) |
| TW (1) | TWI476281B (https=) |
| UA (1) | UA107341C2 (https=) |
| UY (1) | UY32451A (https=) |
| WO (1) | WO2010096418A2 (https=) |
| ZA (1) | ZA201105500B (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ594315A (en) * | 2009-02-17 | 2013-05-31 | Ucb Pharma Sa | Antibody molecules having specificity for human ox40 |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| CA2809089C (en) | 2010-08-23 | 2018-12-18 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| CA2860170C (en) | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| WO2013008171A1 (en) * | 2011-07-11 | 2013-01-17 | Glenmark Pharmaceuticals S.A. | Antibodies that bind to ox40 and their uses |
| CA2845810C (en) * | 2011-08-23 | 2017-03-28 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| UA112203C2 (uk) * | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| WO2013068571A1 (en) * | 2011-11-11 | 2013-05-16 | Ucb Pharma S.A. | Albumin binding antibodies and binding fragments thereof |
| WO2013086419A1 (en) * | 2011-12-09 | 2013-06-13 | California Institute Of Technology | Polymer scaffolds and their use in the treatment of vision loss |
| EP3508215A3 (en) | 2012-12-03 | 2019-10-02 | Bristol-Myers Squibb Company | Enhancing anti-cancer activity of immunomodulatory fc fusion proteins |
| SG10201708048XA (en) | 2013-03-18 | 2017-10-30 | Biocerox Prod Bv | Humanized anti-cd134 (ox40) antibodies and uses thereof |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| CA2942245C (en) * | 2014-03-12 | 2021-11-02 | Yeda Research And Development Co. Ltd. | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| EP3322443A1 (en) * | 2015-07-13 | 2018-05-23 | Yeda Research and Development Co. Ltd | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| WO2015140638A1 (en) * | 2014-03-18 | 2015-09-24 | Korea Advanced Institute Of Science And Technology (Kaist) | Glycosylated vegf decoy receptor fusion protein |
| KR20160146747A (ko) | 2014-03-31 | 2016-12-21 | 제넨테크, 인크. | 항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법 |
| WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| SI3148579T1 (sl) | 2014-05-28 | 2021-07-30 | Agenus Inc. | Proti GITR antitelesa in postopki z njihovo uporabo |
| TW201619200A (zh) * | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| SI3242890T1 (sl) * | 2015-01-08 | 2020-01-31 | BioNTech SE | Agonistična sredstva, ki vežejo receptorje TNF |
| US9512229B2 (en) | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| KR20250005465A (ko) | 2015-03-03 | 2025-01-09 | 키맵 리미티드 | 항체, 용도 및 방법 |
| WO2016145085A2 (en) | 2015-03-09 | 2016-09-15 | Celldex Therapeutics, Inc. | Cd27 agonists |
| GB201506868D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| SG11201708804WA (en) | 2015-05-07 | 2017-11-29 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
| DK3303396T5 (da) | 2015-05-29 | 2024-10-07 | Bristol Myers Squibb Co | Antistoffer mod ox40 og anvendelser deraf |
| US10526413B2 (en) * | 2015-10-02 | 2020-01-07 | Hoffmann-La Roche Inc. | Bispecific antibodies specific for OX40 |
| WO2017063162A1 (zh) * | 2015-10-15 | 2017-04-20 | 苏州丁孚靶点生物技术有限公司 | 抗ox40抗体及其应用 |
| CN108883173B (zh) | 2015-12-02 | 2022-09-06 | 阿吉纳斯公司 | 抗体和其使用方法 |
| KR20180098671A (ko) | 2016-01-11 | 2018-09-04 | 인히브릭스, 인크. | 다가 및 다중특이적 ox40-결합 융합 단백질 |
| WO2017134292A1 (en) * | 2016-02-04 | 2017-08-10 | Glenmark Pharmaceuticals S.A. | Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
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| IL317989A (en) | 2016-08-17 | 2025-02-01 | Compugen Ltd | Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof |
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| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| JP7348072B2 (ja) | 2017-06-01 | 2023-09-20 | コンピュジェン リミテッド | 三重併用抗体療法 |
| CN111201035A (zh) | 2017-06-19 | 2020-05-26 | 梅迪塞纳医疗股份有限公司 | Il-2超激动剂、激动剂及其融合体的用途和方法 |
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| EP3860653A1 (en) | 2018-10-05 | 2021-08-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and systems for controlling the agonistic properties of antibody variable domains by light |
| US10442866B1 (en) * | 2019-01-23 | 2019-10-15 | Beijing Mabworks Biotech Co. Ltd | Antibodies binding OX40 and uses thereof |
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| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
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| US20250249278A1 (en) | 2022-04-14 | 2025-08-07 | Institut National de la Santé et de la Recherche Médicale | Methods for controlling the tumor cell killing by light |
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| US12195546B2 (en) | 2022-12-19 | 2025-01-14 | Sanofi | CD28/OX40 bispecific antibodies |
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