JP2012518648A5 - - Google Patents
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- Publication number
- JP2012518648A5 JP2012518648A5 JP2011551272A JP2011551272A JP2012518648A5 JP 2012518648 A5 JP2012518648 A5 JP 2012518648A5 JP 2011551272 A JP2011551272 A JP 2011551272A JP 2011551272 A JP2011551272 A JP 2011551272A JP 2012518648 A5 JP2012518648 A5 JP 2012518648A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- virus
- composition according
- substituted
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 26
- 241000700605 Viruses Species 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 206010061192 Haemorrhagic fever Diseases 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 241000712892 Arenaviridae Species 0.000 claims 2
- 201000009695 Argentine hemorrhagic fever Diseases 0.000 claims 2
- LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 claims 2
- 206010023927 Lassa fever Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical compound OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- OLYHECNPMKMYII-LXTVHRRPSA-N (2r,3r,4r,5s)-2-(hydroxymethyl)-1-(6-propoxyhexyl)piperidine-3,4,5-triol Chemical compound CCCOCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO OLYHECNPMKMYII-LXTVHRRPSA-N 0.000 claims 1
- 241000190711 Amapari mammarenavirus Species 0.000 claims 1
- 208000003829 American Hemorrhagic Fever Diseases 0.000 claims 1
- 208000034200 Bolivian hemorrhagic fever Diseases 0.000 claims 1
- 241000659008 Chapare mammarenavirus Species 0.000 claims 1
- 206010008761 Choriomeningitis lymphocytic Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000555269 Ippy mammarenavirus Species 0.000 claims 1
- 241000712890 Junin mammarenavirus Species 0.000 claims 1
- 241000712902 Lassa mammarenavirus Species 0.000 claims 1
- 241000190596 Latino mammarenavirus Species 0.000 claims 1
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 1
- 241000712898 Machupo mammarenavirus Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000712897 Mopeia mammarenavirus Species 0.000 claims 1
- -1 N- {4'- azido-2'-nitrophenyl} -6-aminohexyl Chemical group 0.000 claims 1
- 241000190594 Parana mammarenavirus Species 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 241000192617 Sabia mammarenavirus Species 0.000 claims 1
- 241000712908 Tacaribe mammarenavirus Species 0.000 claims 1
- 241000190592 Tamiami mammarenavirus Species 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 208000001419 lymphocytic choriomeningitis Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20239109P | 2009-02-24 | 2009-02-24 | |
| US61/202,391 | 2009-02-24 | ||
| US27225109P | 2009-09-04 | 2009-09-04 | |
| US61/272,251 | 2009-09-04 | ||
| PCT/US2010/024914 WO2010099064A1 (en) | 2009-02-24 | 2010-02-22 | Iminosugars and methods of treating arenaviral infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518648A JP2012518648A (ja) | 2012-08-16 |
| JP2012518648A5 true JP2012518648A5 (enExample) | 2013-03-21 |
| JP5951996B2 JP5951996B2 (ja) | 2016-07-13 |
Family
ID=42665853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551272A Expired - Fee Related JP5951996B2 (ja) | 2009-02-24 | 2010-02-22 | イミノ糖及びアレナウイルス感染症を治療する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100222384A1 (enExample) |
| EP (1) | EP2400843B1 (enExample) |
| JP (1) | JP5951996B2 (enExample) |
| KR (2) | KR20170117614A (enExample) |
| CN (1) | CN102625660B (enExample) |
| CA (1) | CA2753194A1 (enExample) |
| ES (1) | ES2562635T3 (enExample) |
| WO (1) | WO2010099064A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2398321B1 (en) | 2009-02-23 | 2015-11-25 | United Therapeutics Corporation | Iminosugars and methods of treating viral diseases |
| JP2015518896A (ja) | 2012-06-06 | 2015-07-06 | ユニザー ヴィロロジー，エルエルシー | 新規イミノ糖およびそれらの用途 |
| CN102775384B (zh) * | 2012-07-27 | 2015-05-27 | 中国科学院化学研究所 | 小钩树碱i和j类似物及其制备方法与应用 |
| US20160075651A1 (en) * | 2013-05-02 | 2016-03-17 | Unither Virology, Llc | Glycolipid inhibition using iminosugars |
| EP3046558B1 (en) | 2013-09-16 | 2019-08-14 | Emergent Virology LLC | Deoxynojirimycin derivatives and methods of their using |
| IT202000008917A1 (it) * | 2020-04-24 | 2021-10-24 | Biovalley Invest Partner S R L | Composizioni antivirali |
| KR20250160378A (ko) | 2024-05-06 | 2025-11-13 | 문제정 | 가구재용 서랍 조립시스템 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
| DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
| US5103008A (en) * | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
| US4994572A (en) * | 1989-10-12 | 1991-02-19 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| US5200523A (en) * | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| WO1995022975A1 (en) * | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| JP2001525367A (ja) * | 1997-12-11 | 2001-12-11 | ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニバーシティ・オブ・オックスフォード | 膜関連ウイルス複製の阻害 |
| US6689759B1 (en) * | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| US6610703B1 (en) * | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB9828474D0 (en) * | 1998-12-24 | 1999-02-17 | British Aerospace | Surface topology inspection |
| AU3595500A (en) * | 1999-02-12 | 2000-08-29 | G.D. Searle & Co. | Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| CA2378776A1 (en) * | 1999-07-26 | 2001-02-01 | G.D. Searle & Co. | Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of medicament for the treatment of glycolipid storage diseases |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| US6565487B1 (en) * | 2000-07-17 | 2003-05-20 | Hai Pin Kuo | Exerciser having a forward and rearward adjusting seat |
| ES2619353T3 (es) * | 2003-01-31 | 2017-06-26 | Mount Sinai School Of Medicine Of New York University | Terapia de combinación para tratar trastornos de deficiencia de proteínas |
| US7446098B2 (en) * | 2003-02-18 | 2008-11-04 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiencies |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
| US7524829B2 (en) * | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| GB0501352D0 (en) * | 2005-01-21 | 2005-03-02 | Slingsby Jason H | Use of glycosylation modulators in combination with membrane fusion inhibitors for treatment of infections caused by viruses bearing glycosylated envelope |
| EP2058004A1 (en) * | 2005-03-16 | 2009-05-13 | University of Oxford | Mannose immunogens for HIV-1 |
| CN101355971A (zh) * | 2005-05-17 | 2009-01-28 | 阿米库斯治疗学公司 | 使用1-去氧野尻霉素衍生物治疗庞皮病的方法 |
| JP2008545657A (ja) * | 2005-05-17 | 2008-12-18 | アミカス セラピューティックス インコーポレイテッド | １−デオキシノジリマイシンおよび誘導体を用いるポンペ病の治療方法 |
| KR20080031474A (ko) * | 2005-07-27 | 2008-04-08 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | 안구 질환의 치료를 위한 열충격의 사용 |
| US20100004156A1 (en) * | 2005-07-27 | 2010-01-07 | Shalesh Kaushal | Small Compounds That Correct Protein Misfolding and Uses Thereof |
| US20070244184A1 (en) * | 2006-01-09 | 2007-10-18 | Simon Fraser University | Glycosidase inhibitors and methods of synthesizing same |
| DE602007008870D1 (de) * | 2006-04-24 | 2010-10-14 | Amc Amsterdam | Verbessertes verfahren zur behandlung von cystischer fibrose |
| ES2537572T3 (es) * | 2006-05-24 | 2015-06-09 | United Therapeutics Corporation | Análogos de desoxinojirimicina y D-arabinitol y métodos de uso |
| EP2049126A2 (en) * | 2006-08-02 | 2009-04-22 | United Therapeutics Corporation | Liposome treatment of viral infections |
| WO2008063727A2 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| US20090252785A1 (en) * | 2008-03-26 | 2009-10-08 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| WO2010027996A1 (en) * | 2008-09-02 | 2010-03-11 | Institute For Hepatitis And Virus Research | Novel imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity |
-
2010
- 2010-02-22 CA CA2753194A patent/CA2753194A1/en not_active Abandoned
- 2010-02-22 EP EP10746681.5A patent/EP2400843B1/en not_active Not-in-force
- 2010-02-22 JP JP2011551272A patent/JP5951996B2/ja not_active Expired - Fee Related
- 2010-02-22 KR KR1020177029196A patent/KR20170117614A/ko not_active Ceased
- 2010-02-22 ES ES10746681.5T patent/ES2562635T3/es active Active
- 2010-02-22 CN CN201080017592.8A patent/CN102625660B/zh not_active Expired - Fee Related
- 2010-02-22 WO PCT/US2010/024914 patent/WO2010099064A1/en not_active Ceased
- 2010-02-22 US US12/656,993 patent/US20100222384A1/en not_active Abandoned
- 2010-02-22 KR KR1020117021910A patent/KR101787434B1/ko not_active Expired - Fee Related