JP2012513481A5 - - Google Patents
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- JP2012513481A5 JP2012513481A5 JP2011543689A JP2011543689A JP2012513481A5 JP 2012513481 A5 JP2012513481 A5 JP 2012513481A5 JP 2011543689 A JP2011543689 A JP 2011543689A JP 2011543689 A JP2011543689 A JP 2011543689A JP 2012513481 A5 JP2012513481 A5 JP 2012513481A5
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- 125000000217 alkyl group Chemical group 0.000 claims 25
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 239000012453 solvate Substances 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000003107 substituted aryl group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 208000037906 ischaemic injury Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000030833 cell death Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- -1 8-quinolyl Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 206010019196 Head injury Diseases 0.000 claims 2
- 206010040070 Septic Shock Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 230000036303 septic shock Effects 0.000 claims 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010049565 Muscle fatigue Diseases 0.000 claims 1
- 206010031264 Osteonecrosis Diseases 0.000 claims 1
- 208000016222 Pancreatic disease Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 210000000713 mesentery Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 230000021597 necroptosis Effects 0.000 claims 1
- 230000016273 neuron death Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 CN(C(C(*)(**)N1*)=O)C1=S Chemical compound CN(C(C(*)(**)N1*)=O)C1=S 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14061508P | 2008-12-23 | 2008-12-23 | |
| US61/140,615 | 2008-12-23 | ||
| PCT/US2009/069483 WO2010075561A1 (en) | 2008-12-23 | 2009-12-23 | Small molecule inhibitors of necroptosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230271A Division JP6178777B2 (ja) | 2008-12-23 | 2014-11-13 | ネクロトーシスの小分子阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012513481A JP2012513481A (ja) | 2012-06-14 |
| JP2012513481A5 true JP2012513481A5 (https=) | 2013-02-14 |
Family
ID=42288162
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011543689A Pending JP2012513481A (ja) | 2008-12-23 | 2009-12-23 | ネクロトーシスの小分子阻害剤 |
| JP2014230271A Expired - Fee Related JP6178777B2 (ja) | 2008-12-23 | 2014-11-13 | ネクロトーシスの小分子阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230271A Expired - Fee Related JP6178777B2 (ja) | 2008-12-23 | 2014-11-13 | ネクロトーシスの小分子阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20120122889A1 (https=) |
| EP (2) | EP3000468A1 (https=) |
| JP (2) | JP2012513481A (https=) |
| CN (2) | CN102316735A (https=) |
| AU (2) | AU2009329879A1 (https=) |
| BR (1) | BRPI0923126A2 (https=) |
| CA (1) | CA2772760A1 (https=) |
| HK (2) | HK1212973A1 (https=) |
| WO (1) | WO2010075561A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2384753T1 (sl) | 2003-08-29 | 2016-06-30 | The Brigham And Women's Hospital, Inc. | Hidantoinski derivati kot inhibitorji celične nekroze |
| US20090099242A1 (en) | 2007-08-15 | 2009-04-16 | Cuny Gregory D | Heterocyclic inhibitors of necroptosis |
| CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| CA2772760A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
| CA2794153C (en) | 2010-03-25 | 2018-01-02 | Glaxosmithkline Llc | Substituted indoline derivatives as perk inhibitors |
| IT1401146B1 (it) | 2010-07-27 | 2013-07-12 | Gnosis Spa | Composizione comprendente shellac e/o un suo sale e sodio amido glicolato |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| WO2012125544A2 (en) | 2011-03-11 | 2012-09-20 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
| KR101410332B1 (ko) | 2012-02-29 | 2014-06-24 | 코아스템(주) | 중간엽 기질세포 배양용 항산화 조성물 및 이의 용도 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| TWI648274B (zh) | 2013-02-15 | 2019-01-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 （二） |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ａｍｐｋを活性化させるインダゾール化合物 |
| US9725452B2 (en) | 2013-03-15 | 2017-08-08 | Presidents And Fellows Of Harvard College | Substituted indoles and pyrroles as RIP kinase inhibitors |
| CN103396376B (zh) * | 2013-07-31 | 2016-08-10 | 杨文茂 | 一种抗菌抗癌活性化合物 |
| JP6307088B2 (ja) * | 2013-10-23 | 2018-04-04 | 中外製薬株式会社 | キナゾリノンおよびイソキノリノン誘導体 |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| EP3229807A4 (en) * | 2014-12-11 | 2018-10-17 | President and Fellows of Harvard College | Inhibitors of cellular necrosis and related methods |
| AU2015371822B2 (en) * | 2014-12-24 | 2020-04-09 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
| HK1244792B (en) * | 2014-12-24 | 2019-07-12 | 北京生命科学研究所 | Necrosis inhibitors |
| AR103297A1 (es) | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| HK1248220A1 (zh) | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 喹唑啉酮和偶氮喹唑啉作为泛特丁胺蛋白酶7抑制剂 |
| US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| EP3253765A1 (en) | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
| DE102015212208A1 (de) | 2015-04-24 | 2016-10-27 | Ihp Gmbh-Innovations For High Performance Microelectronics / Leibniz-Institut Für Innovative Mikroelektronik | Hochgeschwindigkeits-Germanium-PIN-Fotodiode |
| TWI730959B (zh) | 2015-05-19 | 2021-06-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺 |
| EP3317278B1 (en) | 2015-07-01 | 2021-04-14 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| US11168068B2 (en) | 2016-07-18 | 2021-11-09 | Janssen Pharmaceutica Nv | Tau PET imaging ligands |
| IL247368A0 (en) | 2016-08-18 | 2016-11-30 | Yeda Res & Dev | Diagnostic and therapeutic uses of exosomes |
| EP3585782A1 (en) | 2017-02-27 | 2020-01-01 | GlaxoSmithKline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| KR20200118422A (ko) * | 2017-12-31 | 2020-10-15 | 에버그린 바이오사이언시즈 | 동결보존용 조성물 및 이의 사용 방법 |
| CN109078187B (zh) * | 2018-08-02 | 2021-04-20 | 中国人民解放军第四军医大学 | 胰腺GnIH受体功能调节剂制备治疗2型糖尿病药物的应用 |
| WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
| EP3883918B1 (en) | 2018-11-20 | 2023-07-19 | Sironax Ltd | Rip1 inhibitors |
| SG11202105250TA (en) * | 2018-11-20 | 2021-06-29 | Sironax Ltd | Cyclic Ureas |
| CN111978311B (zh) * | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| IL291665B2 (en) | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| JP2023502514A (ja) | 2019-11-26 | 2023-01-24 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 疾患の処置のための受容体相互作用プロテインキナーゼｉの阻害剤 |
| CN115697991B (zh) * | 2020-05-20 | 2024-11-22 | 维泰瑞隆有限公司 | 哌嗪环状脲 |
| CA3183661A1 (en) * | 2020-05-20 | 2021-11-25 | Sironax Ltd. | Receptor-interacting protein 1 inhibitors including piperazine heterocyclic amide ureas |
| US20230265094A1 (en) * | 2020-06-12 | 2023-08-24 | Merck Sharp & Dohme Llc | Ripk1 inhibitors and methods of use |
| DK4168401T3 (da) * | 2020-06-19 | 2026-04-13 | Anaxis Pharma Pty Ltd | Sulfonamidforbindelser |
| CA3218159A1 (en) | 2021-05-20 | 2022-11-24 | Zhaolan ZHANG | Rip1 modulators including azetidine cyclic ureas, preparations, and uses thereof |
| CN117304110A (zh) * | 2023-09-21 | 2023-12-29 | 宁夏医科大学 | 一种化合物及其制备方法和用途 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577420A (en) * | 1968-01-05 | 1971-05-04 | Pfizer | Certain 4-aminofuro(2,3-d)pyrimidines |
| BE789948A (fr) | 1971-10-13 | 1973-04-11 | Sandoz Sa | Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments |
| JPS5113156B2 (https=) | 1972-10-21 | 1976-04-26 | ||
| US4016037A (en) | 1975-10-15 | 1977-04-05 | Ajinomoto Co., Inc. | Method for producing L-amino acid |
| US4110536A (en) * | 1977-04-18 | 1978-08-29 | Miles Laboratories, Inc. | Derivatives of 5-(indol-3-yl)hydantoin |
| DE2728523C2 (de) | 1977-06-23 | 1986-02-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | 4-Methyl-1,2,3-thiadiazol-5-carbonsäure-(cyclohexylmethyl)-amid, Mittel mit herbizider und wachstumsregulatorischer Wirkung enthaltend diese Verbindung sowie Verfahren zu seiner Herstellung |
| JPS5810074B2 (ja) | 1979-07-18 | 1983-02-24 | 味の素株式会社 | 新規微生物 |
| US4332952A (en) | 1980-07-28 | 1982-06-01 | Pfizer Inc. | Hypoglycemic 5-substituted oxazolidine-2,4-diones |
| GB2080803B (en) | 1980-07-28 | 1984-01-18 | Pfizer | Hypoglycemic 5-substituted oxazolidine-2,4-diones |
| DE3567460D1 (en) | 1984-06-07 | 1989-02-16 | Pfizer Ltd | Dihydropyridines |
| JPS6122081A (ja) | 1984-07-10 | 1986-01-30 | Mitsui Toatsu Chem Inc | ヒダントイン化合物の製造法 |
| CA1292840C (en) | 1985-09-26 | 1991-12-03 | David Harry Hawke | Sequencing of peptides |
| IE62214B1 (en) | 1988-05-25 | 1995-01-11 | Warner Lambert Co | Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents |
| JPH0219363A (ja) | 1988-07-06 | 1990-01-23 | Fujisawa Pharmaceut Co Ltd | イミダゾリジン誘導体 |
| WO1990004183A1 (en) | 1988-10-07 | 1990-04-19 | Commonwealth Scientific And Industrial Research Organisation | Method for preparation of thiohydantoins and for protein sequence analysis |
| DE58905691D1 (de) | 1989-01-02 | 1993-10-28 | Ruetgerswerke Ag | Verfahren zur Herstellung von L-alpha-Aminosäuren. |
| JPH054910A (ja) | 1990-07-31 | 1993-01-14 | Nikka Chem Co Ltd | 化粧料組成物 |
| CA2088195A1 (en) | 1990-08-31 | 1992-03-01 | David C. Horwell | Cholecystokinin antagonists, their preparation and therapeutic use |
| NZ242065A (en) | 1991-03-26 | 1996-06-25 | Csl Ltd | Delayed release implant having a degradable or rupturable polymeric coating |
| US5693643A (en) | 1991-09-16 | 1997-12-02 | Merck & Co., Inc. | Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists |
| CH683995A5 (fr) | 1991-12-02 | 1994-06-30 | Nestle Sa | (Alcoxy-1-éthenyl)-2-pyrroline-1 et procédé de préparation d'acétyl-2-pyrroline-1. |
| EP0545478A1 (en) | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclic compounds as tachykinin antagonists |
| AU4424496A (en) | 1995-03-27 | 1996-10-16 | Warner-Lambert Company | A method for the synthesis of mixtures of compounds |
| US6166054A (en) | 1995-03-31 | 2000-12-26 | Nihon Nohyaku Co., Ltd. | Agricultural and horticultural disease controller and a method for controlling the diseases |
| US6846839B1 (en) | 1995-06-07 | 2005-01-25 | Sugen, Inc. | Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis |
| US5962478A (en) * | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
| FR2750862B1 (fr) * | 1996-07-12 | 1998-10-16 | Dupin Jean Pierre | Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques |
| AU725138B2 (en) | 1996-09-30 | 2000-10-05 | Nihon Nohyaku Co., Ltd. | 1,2,3-thiadiazole derivatives and salts thereof, disease controlling agents for agricultural and horticultural use, and method for the use thereof |
| US6355664B1 (en) * | 1997-03-03 | 2002-03-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease |
| PL336580A1 (en) | 1997-03-03 | 2000-07-03 | Boehringer Ingelheim Pharma | Fine-molecular compounds useful in treating inflammatory diseases |
| BR9809598A (pt) * | 1997-05-08 | 2000-07-04 | Agrevo Uk Ltd | Uso de compostos, e, composto. |
| EP0976326B1 (en) | 1998-07-30 | 2003-05-02 | Nihon Nohyaku Co., Ltd. | Fungicidal composition containing a 1,2,3-tiadiazole derivative and its use |
| WO2001028493A2 (en) | 1999-10-15 | 2001-04-26 | President And Fellows Of Harvard College | Small molecule inhibitors of necrosis |
| US6756394B1 (en) | 1999-10-15 | 2004-06-29 | President And Fellow Of Harvard College | Small molecule inhibitors of necrosis |
| US6706766B2 (en) | 1999-12-13 | 2004-03-16 | President And Fellows Of Harvard College | Small molecules used to increase cell death |
| US20030087949A1 (en) | 2000-03-30 | 2003-05-08 | Mikiko Sodeoka | Indolylpyrrole derivatives and cell death inhibitors |
| US20020155172A1 (en) | 2000-04-07 | 2002-10-24 | Junying Yuan | Methods and compounds for decreasing cell toxicity or death |
| GB0011071D0 (en) | 2000-05-08 | 2000-06-28 | Novartis Ag | Organic compounds |
| DE10031390A1 (de) * | 2000-07-03 | 2002-01-17 | Knoll Ag | Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie |
| JP2002105081A (ja) * | 2000-07-28 | 2002-04-10 | Nikken Chem Co Ltd | 新規チオフェンニ環化合物 |
| AU2002220241A1 (en) * | 2000-12-01 | 2002-06-11 | Iconix Pharmaceuticals, Inc. | Parb inhibitors |
| JP4529338B2 (ja) | 2001-03-08 | 2010-08-25 | 味の素株式会社 | ヒダントイナーゼをコードするｄｎａ、ｎ−カルバミル−ｌ−アミノ酸ハイドロラーゼをコードするｄｎａ、組み換えｄｎａ、形質転換された細胞、タンパク質の製造方法および光学活性アミノ酸の製造方法 |
| US7868204B2 (en) * | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| DE10150325A1 (de) | 2001-10-15 | 2003-04-24 | Degussa | Verfahren zur Herstellung oder Beschichtung von Granulaten, Vorrichtung zur Durchführung des Verfahrens und hiernach erhältliche Granulate |
| EP1442039A1 (en) * | 2001-10-31 | 2004-08-04 | Bayer HealthCare AG | Pyrimido (4,5-b) indole derivatives |
| MXPA04004830A (es) | 2001-11-22 | 2004-07-30 | Ono Pharmaceutical Co | Compuestos derivados de piperidin-2-ona, y composiciones farmaceuticas que los contienen como ingredientes activos. |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| JP3659224B2 (ja) | 2001-12-26 | 2005-06-15 | 村田機械株式会社 | インターネットファクシミリ装置 |
| US7189856B2 (en) | 2001-12-28 | 2007-03-13 | Gideon Shapiro | Non-peptide somatostatin receptor ligands |
| FR2850652B1 (fr) | 2003-01-31 | 2008-05-30 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| GB0302671D0 (en) | 2003-02-06 | 2003-03-12 | Astrazeneca Ab | Pharmaceutical formulations |
| US7320986B2 (en) | 2003-03-07 | 2008-01-22 | Abbott Labortories | Fused tri and tetra-cyclic pyrazole kinase inhibitors |
| WO2004094409A1 (en) * | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Novel ido inhibitors and methods of use |
| CN101265254A (zh) * | 2003-03-27 | 2008-09-17 | 兰肯瑙医学研究所 | 新型ido抑制剂及其使用方法 |
| US7465739B2 (en) | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| SI2384753T1 (sl) | 2003-08-29 | 2016-06-30 | The Brigham And Women's Hospital, Inc. | Hidantoinski derivati kot inhibitorji celične nekroze |
| WO2005028664A2 (en) | 2003-09-17 | 2005-03-31 | University Of Massachusetts | Modulation of programmed necrosis |
| DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| US6887993B1 (en) | 2003-11-12 | 2005-05-03 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
| JP2007529422A (ja) * | 2004-01-29 | 2007-10-25 | エリクシアー ファーマシューティカルズ， インコーポレイテッド | 抗ウイルス治療 |
| JP5134248B2 (ja) * | 2004-02-19 | 2013-01-30 | バイエル・ファルマ・アクチェンゲゼルシャフト | ジヒドロピリジノン誘導体 |
| WO2005082887A1 (ja) * | 2004-02-26 | 2005-09-09 | Aska Pharmaceutical Co., Ltd. | ピリミジン誘導体 |
| WO2005115147A2 (en) | 2004-05-18 | 2005-12-08 | Merck & Co., Inc. | Hiv reverse transcriptase inhibitors |
| SG155188A1 (en) | 2004-07-30 | 2009-09-30 | Exelixis Inc | Pyrrole derivatives as pharmaceutical agents |
| JP2008517061A (ja) * | 2004-10-20 | 2008-05-22 | コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー | 抗腫瘍剤としての化合物及びそれらの使用 |
| EP1851213A4 (en) | 2005-02-10 | 2010-10-06 | Merck Sharp & Dohme | INHIBITORS OF MITOTIC KINESINE |
| KR20080066949A (ko) * | 2005-10-11 | 2008-07-17 | 인터뮨, 인크. | 바이러스 복제 억제제 |
| US20090022694A1 (en) * | 2005-10-18 | 2009-01-22 | Distefano Peter | Sirt1 inhibition |
| WO2007053662A1 (en) * | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Dihydroisoindolones as allosteric modulators of glucokinase |
| WO2007059905A2 (en) * | 2005-11-25 | 2007-05-31 | Develogen Aktiengesellschaft | Thienopyrimidines treating inflammatory diseases |
| EP1968583A4 (en) | 2005-12-20 | 2010-09-15 | Harvard College | COMPOUNDS, SCREENING AND TREATMENT PROCEDURES |
| AR056882A1 (es) | 2006-02-01 | 2007-10-31 | Bayer Cropscience Sa | Derivados del fungicida n- cicloalquil- bencil- amida |
| EP2041141A2 (en) | 2006-07-13 | 2009-04-01 | 4Sc Ag | Benzopyranopyrazoles |
| US20100087453A1 (en) | 2006-10-10 | 2010-04-08 | President And Fellows Of Harvard College | Compounds, screens, and methods of treatment |
| CN100430403C (zh) * | 2006-10-13 | 2008-11-05 | 中国科学院上海有机化学研究所 | 3-芳基-5,6-取代噻吩并嘧啶-4-羰基-2-巯基乙腈、合成方法和用途 |
| CA2670031A1 (en) * | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic metalloprotease inhibitors |
| JP2010528051A (ja) * | 2007-05-23 | 2010-08-19 | シガ・テクノロジーズ・インコーポレーテッド | デング感染症の治療または予防のための抗ウイルス薬 |
| US20090099242A1 (en) | 2007-08-15 | 2009-04-16 | Cuny Gregory D | Heterocyclic inhibitors of necroptosis |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8324227B2 (en) * | 2008-03-03 | 2012-12-04 | Fdc Limited | Thieno[2,3-D]-pyrimidin-4(3H)-one compounds with antifungal properties and process thereof |
| GB0810542D0 (en) | 2008-06-09 | 2008-07-16 | Element Six Production Pty Ltd | Cubic boron nitride compact |
| WO2010075290A1 (en) | 2008-12-22 | 2010-07-01 | President And Fellows Of Harvard College | Unsaturated heterocyclic inhibitors of necroptosis |
| CA2772760A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
| WO2014152182A1 (en) | 2013-03-15 | 2014-09-25 | President And Fellows Of Harvard College | Deuterated heterocyclic inhibitors of necroptosis |
| US9725452B2 (en) | 2013-03-15 | 2017-08-08 | Presidents And Fellows Of Harvard College | Substituted indoles and pyrroles as RIP kinase inhibitors |
| EP3229807A4 (en) | 2014-12-11 | 2018-10-17 | President and Fellows of Harvard College | Inhibitors of cellular necrosis and related methods |
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2009
- 2009-12-23 CA CA2772760A patent/CA2772760A1/en not_active Abandoned
- 2009-12-23 BR BRPI0923126-9A patent/BRPI0923126A2/pt not_active IP Right Cessation
- 2009-12-23 EP EP15001699.6A patent/EP3000468A1/en not_active Withdrawn
- 2009-12-23 CN CN2009801569144A patent/CN102316735A/zh active Pending
- 2009-12-23 CN CN201510081043.1A patent/CN104803986A/zh active Pending
- 2009-12-23 EP EP09835866A patent/EP2381775A4/en not_active Withdrawn
- 2009-12-23 JP JP2011543689A patent/JP2012513481A/ja active Pending
- 2009-12-23 US US13/141,545 patent/US20120122889A1/en not_active Abandoned
- 2009-12-23 AU AU2009329879A patent/AU2009329879A1/en not_active Abandoned
- 2009-12-23 WO PCT/US2009/069483 patent/WO2010075561A1/en not_active Ceased
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2013
- 2013-09-20 US US14/033,176 patent/US9586880B2/en active Active
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2014
- 2014-11-13 JP JP2014230271A patent/JP6178777B2/ja not_active Expired - Fee Related
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2016
- 2016-01-26 HK HK16100821.7A patent/HK1212973A1/zh unknown
- 2016-04-12 AU AU2016202262A patent/AU2016202262A1/en not_active Abandoned
- 2016-09-30 HK HK16111463.7A patent/HK1223272A1/en unknown
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2017
- 2017-02-08 US US15/427,699 patent/US20170305824A1/en not_active Abandoned
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2018
- 2018-08-06 US US16/055,898 patent/US20190135718A1/en not_active Abandoned