JP2012512178A - リゾホスファチジン酸受容体のアンタゴニスト - Google Patents
リゾホスファチジン酸受容体のアンタゴニスト Download PDFInfo
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- JP2012512178A JP2012512178A JP2011540973A JP2011540973A JP2012512178A JP 2012512178 A JP2012512178 A JP 2012512178A JP 2011540973 A JP2011540973 A JP 2011540973A JP 2011540973 A JP2011540973 A JP 2011540973A JP 2012512178 A JP2012512178 A JP 2012512178A
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- Prior art keywords
- phenyl
- methyl
- compound
- biphenyl
- isoxazol
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- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US12256808P | 2008-12-15 | 2008-12-15 | |
| US61/122,568 | 2008-12-15 | ||
| PCT/US2009/068106 WO2010077883A2 (en) | 2008-12-15 | 2009-12-15 | Antagonists of lysophosphatidic acid receptors |
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| JP2012512178A true JP2012512178A (ja) | 2012-05-31 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013506695A (ja) * | 2009-10-01 | 2013-02-28 | アミラ ファーマシューティカルス，インコーポレーテッド | リゾホスファチジン酸受容体アンタゴニストとしての化合物 |
| WO2017086430A1 (ja) * | 2015-11-20 | 2017-05-26 | 宇部興産株式会社 | Ｎａｓｈの治療又は予防のための医薬組成物 |
| JP2023544476A (ja) * | 2020-08-11 | 2023-10-24 | ビバ スター バイオサイエンシズ リミテッド | Ｌｐａ受容体アンタゴニストとしてのトリアゾール－ピリジニル置換アザシクロヘキシル酢酸化合物 |
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| JP5692746B2 (ja) * | 2008-08-07 | 2015-04-01 | 国立大学法人 長崎大学 | 全身性疼痛症候群の治療または予防薬 |
| US8455499B2 (en) | 2008-12-11 | 2013-06-04 | Amira Pharmaceuticals, Inc. | Alkyne antagonists of lysophosphatidic acid receptors |
| GB2466121B (en) | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| WO2011017350A2 (en) | 2009-08-04 | 2011-02-10 | Amira Pharmaceuticals, Inc. | Compounds as lysophosphatidic acid receptor antagonists |
| GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| ES2530345T3 (es) | 2010-09-02 | 2015-03-02 | Merck Patent Gmbh | Derivados de pirazolopiridinona como antagonistas del receptor del LPA |
| EP3360552A1 (en) * | 2010-12-07 | 2018-08-15 | Amira Pharmaceuticals, Inc. | Polycyclic lpa1 antagonist and uses thereof |
| EA201390821A1 (ru) * | 2010-12-07 | 2013-10-30 | Амира Фармасьютикалс, Инк. | Антагонисты рецепторов лизофосфатидной кислоты и их применение |
| US8785442B2 (en) | 2011-01-30 | 2014-07-22 | Curegenix, Inc. | Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof |
| CN103596947A (zh) * | 2011-04-05 | 2014-02-19 | 艾米拉医药股份有限公司 | 用于治疗纤维化、疼痛、癌症和呼吸、过敏性、神经系统疾病或心血管疾病的基于3-或5-联苯-4-基异噁唑的化合物 |
| HK1199259A1 (en) | 2011-08-15 | 2015-06-26 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
| WO2013070879A1 (en) * | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Methods for treating spinal cord injury with lpa receptor antagonists |
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| US20140329871A1 (en) * | 2011-12-04 | 2014-11-06 | Angion Biomedica Corp. | Small molecule anti-fibrotic compounds and uses thereof |
| UA109868C2 (ru) * | 2012-06-20 | 2015-10-12 | Ф. Хоффманн-Ля Рош Аг | Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar) |
| SG11201407229UA (en) * | 2012-06-20 | 2014-12-30 | Hoffmann La Roche | Substituted pyrazole compounds as lpar antagonists |
| WO2014104372A1 (ja) * | 2012-12-28 | 2014-07-03 | 宇部興産株式会社 | ハロゲン置換へテロ環化合物 |
| CN110201144B (zh) * | 2013-03-15 | 2024-01-02 | 得克萨斯州大学系统董事会 | 用Nutlin-3a和肽抑制肺纤维化 |
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| AU2016270373A1 (en) | 2015-06-05 | 2018-01-04 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
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| CN117562896B (zh) * | 2023-11-23 | 2024-04-26 | 中国人民解放军海军军医大学第二附属医院 | Lpar拮抗剂在制备多发性骨髓瘤car t细胞联合治疗药物中的应用 |
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- 2009-12-15 BR BRPI0923512A patent/BRPI0923512A2/pt not_active IP Right Cessation
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- 2009-12-15 CN CN2009801506164A patent/CN102245584A/zh active Pending
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| JP2013506695A (ja) * | 2009-10-01 | 2013-02-28 | アミラ ファーマシューティカルス，インコーポレーテッド | リゾホスファチジン酸受容体アンタゴニストとしての化合物 |
| WO2017086430A1 (ja) * | 2015-11-20 | 2017-05-26 | 宇部興産株式会社 | Ｎａｓｈの治療又は予防のための医薬組成物 |
| CN108348610A (zh) * | 2015-11-20 | 2018-07-31 | 宇部兴产株式会社 | 用于治疗或预防nash的医药组合物 |
| JP2023544476A (ja) * | 2020-08-11 | 2023-10-24 | ビバ スター バイオサイエンシズ リミテッド | Ｌｐａ受容体アンタゴニストとしてのトリアゾール－ピリジニル置換アザシクロヘキシル酢酸化合物 |
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