JP2012512178A - リゾホスファチジン酸受容体のアンタゴニスト - Google Patents
リゾホスファチジン酸受容体のアンタゴニスト Download PDFInfo
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- JP2012512178A JP2012512178A JP2011540973A JP2011540973A JP2012512178A JP 2012512178 A JP2012512178 A JP 2012512178A JP 2011540973 A JP2011540973 A JP 2011540973A JP 2011540973 A JP2011540973 A JP 2011540973A JP 2012512178 A JP2012512178 A JP 2012512178A
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- Prior art keywords
- phenyl
- methyl
- compound
- biphenyl
- isoxazol
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
- Health & Medical Sciences (AREA)
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- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12256808P | 2008-12-15 | 2008-12-15 | |
| US61/122,568 | 2008-12-15 | ||
| PCT/US2009/068106 WO2010077883A2 (en) | 2008-12-15 | 2009-12-15 | Antagonists of lysophosphatidic acid receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512178A true JP2012512178A (ja) | 2012-05-31 |
| JP2012512178A5 JP2012512178A5 (https=) | 2013-02-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540973A Pending JP2012512178A (ja) | 2008-12-15 | 2009-12-15 | リゾホスファチジン酸受容体のアンタゴニスト |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20110301211A1 (https=) |
| EP (1) | EP2358688B1 (https=) |
| JP (1) | JP2012512178A (https=) |
| KR (1) | KR101323054B1 (https=) |
| CN (1) | CN102245584A (https=) |
| AR (1) | AR074676A1 (https=) |
| AU (1) | AU2009333275B2 (https=) |
| BR (1) | BRPI0923512A2 (https=) |
| CA (1) | CA2744221C (https=) |
| EA (1) | EA201100691A1 (https=) |
| GB (1) | GB2466121B (https=) |
| IL (1) | IL212779A (https=) |
| MX (1) | MX2011006407A (https=) |
| SG (1) | SG172163A1 (https=) |
| TW (1) | TWI415841B (https=) |
| UY (1) | UY32327A (https=) |
| WO (2) | WO2010077883A2 (https=) |
| ZA (1) | ZA201103945B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013506695A (ja) * | 2009-10-01 | 2013-02-28 | アミラ ファーマシューティカルス，インコーポレーテッド | リゾホスファチジン酸受容体アンタゴニストとしての化合物 |
| WO2017086430A1 (ja) * | 2015-11-20 | 2017-05-26 | 宇部興産株式会社 | Ｎａｓｈの治療又は予防のための医薬組成物 |
| JP2023544476A (ja) * | 2020-08-11 | 2023-10-24 | ビバ スター バイオサイエンシズ リミテッド | Ｌｐａ受容体アンタゴニストとしてのトリアゾール－ピリジニル置換アザシクロヘキシル酢酸化合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010016590A1 (ja) | 2008-08-07 | 2010-02-11 | 国立大学法人 長崎大学 | 全身性疼痛症候群の治療または予防薬 |
| US8455499B2 (en) | 2008-12-11 | 2013-06-04 | Amira Pharmaceuticals, Inc. | Alkyne antagonists of lysophosphatidic acid receptors |
| GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| GB2470833B (en) * | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| CN102574822A (zh) | 2009-08-04 | 2012-07-11 | 阿米拉制药公司 | 作为溶血磷脂酸受体拮抗剂的化合物 |
| GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| JP6039559B2 (ja) | 2010-09-02 | 2016-12-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｌｐａ受容体アンタゴニストとしてのピラゾロピリジノン誘導体 |
| DK2648726T3 (da) | 2010-12-07 | 2018-07-16 | Amira Pharmaceuticals Inc | Polycyklisk lpa1-antagonist og anvendelser deraf |
| KR20130126659A (ko) * | 2010-12-07 | 2013-11-20 | 아미라 파마슈티칼스 인코포레이티드 | 리소포스파티드산 수용체 길항제 및 섬유증 치료에서의 그의 용도 |
| US8785442B2 (en) | 2011-01-30 | 2014-07-22 | Curegenix, Inc. | Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof |
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| JP2014525932A (ja) | 2011-08-15 | 2014-10-02 | インターミューン， インコーポレイテッド | リゾホスファチド酸レセプターアンタゴニスト |
| WO2013070879A1 (en) * | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Methods for treating spinal cord injury with lpa receptor antagonists |
| JP2015504307A (ja) | 2011-11-22 | 2015-02-12 | インターミューン， インコーポレイテッド | 特発性肺線維症を診断および治療する方法 |
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| SG11201407229UA (en) * | 2012-06-20 | 2014-12-30 | Hoffmann La Roche | Substituted pyrazole compounds as lpar antagonists |
| JP2015520202A (ja) * | 2012-06-20 | 2015-07-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｌｐａｒ拮抗薬としてのｎ−アルキルトリアゾール化合物 |
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| CN118236373A (zh) * | 2023-11-23 | 2024-06-25 | 中国人民解放军海军军医大学第二附属医院 | 一种lpar拮抗剂在制备多发性骨髓瘤car t细胞联合治疗药物中的应用 |
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| CN108348610A (zh) * | 2015-11-20 | 2018-07-31 | 宇部兴产株式会社 | 用于治疗或预防nash的医药组合物 |
| JP2023544476A (ja) * | 2020-08-11 | 2023-10-24 | ビバ スター バイオサイエンシズ リミテッド | Ｌｐａ受容体アンタゴニストとしてのトリアゾール－ピリジニル置換アザシクロヘキシル酢酸化合物 |
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