CN102245584A - 溶血磷脂酶受体的拮抗剂 - Google Patents

溶血磷脂酶受体的拮抗剂 Download PDF

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Publication number
CN102245584A
CN102245584A CN2009801506164A CN200980150616A CN102245584A CN 102245584 A CN102245584 A CN 102245584A CN 2009801506164 A CN2009801506164 A CN 2009801506164A CN 200980150616 A CN200980150616 A CN 200980150616A CN 102245584 A CN102245584 A CN 102245584A
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phenyl
methyl
compound
biphenyl
isoxazol
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Pending
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CN2009801506164A
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Chinese (zh)
Inventor
王博韦
约翰·霍华德·哈钦森
托马斯·乔恩·赛德尔斯
珍妮·M·阿鲁达
杰弗里·罗杰·罗普
蒂莫西·帕尔
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Amira Pharmaceuticals Inc
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Amira Pharmaceuticals Inc
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Publication of CN102245584A publication Critical patent/CN102245584A/zh
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    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801506164A 2008-12-15 2009-12-15 溶血磷脂酶受体的拮抗剂 Pending CN102245584A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12256808P 2008-12-15 2008-12-15
US61/122,568 2008-12-15
PCT/US2009/068106 WO2010077883A2 (en) 2008-12-15 2009-12-15 Antagonists of lysophosphatidic acid receptors

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CN102245584A true CN102245584A (zh) 2011-11-16

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US (4) US20110301211A1 (https=)
EP (1) EP2358688B1 (https=)
JP (1) JP2012512178A (https=)
KR (1) KR101323054B1 (https=)
CN (1) CN102245584A (https=)
AR (1) AR074676A1 (https=)
AU (1) AU2009333275B2 (https=)
BR (1) BRPI0923512A2 (https=)
CA (1) CA2744221C (https=)
EA (1) EA201100691A1 (https=)
GB (1) GB2466121B (https=)
IL (1) IL212779A (https=)
MX (1) MX2011006407A (https=)
SG (1) SG172163A1 (https=)
TW (1) TWI415841B (https=)
UY (1) UY32327A (https=)
WO (2) WO2010077883A2 (https=)
ZA (1) ZA201103945B (https=)

Cited By (7)

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CN104411690A (zh) * 2012-06-20 2015-03-11 霍夫曼-拉罗奇有限公司 作为lpar拮抗剂的取代的吡唑化合物
CN104411692A (zh) * 2012-06-20 2015-03-11 霍夫曼-拉罗奇有限公司 作为lpar拮抗剂的n-烷基三唑化合物
CN104884447A (zh) * 2012-12-28 2015-09-02 宇部兴产株式会社 卤素取代杂环化合物
CN105061346A (zh) * 2009-06-03 2015-11-18 艾米拉医药股份有限公司 溶血磷脂酸受体的多环拮抗剂
CN115181069A (zh) * 2022-07-15 2022-10-14 天津医科大学眼科医院 一种防治近视的化合物
CN116236486A (zh) * 2023-03-30 2023-06-09 复旦大学附属中山医院 髓过氧化物酶抑制剂在制备心脏保护药物中的应用
CN117562896A (zh) * 2023-11-23 2024-02-20 中国人民解放军海军军医大学第二附属医院 Lpar拮抗剂在制备多发性骨髓瘤car t细胞联合治疗药物中的应用

Families Citing this family (37)

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WO2010016590A1 (ja) 2008-08-07 2010-02-11 国立大学法人 長崎大学 全身性疼痛症候群の治療または予防薬
US8455499B2 (en) 2008-12-11 2013-06-04 Amira Pharmaceuticals, Inc. Alkyne antagonists of lysophosphatidic acid receptors
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
CN102574822A (zh) 2009-08-04 2012-07-11 阿米拉制药公司 作为溶血磷脂酸受体拮抗剂的化合物
GB2474120B (en) * 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
JP6039559B2 (ja) 2010-09-02 2016-12-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｌｐａ受容体アンタゴニストとしてのピラゾロピリジノン誘導体
DK2648726T3 (da) 2010-12-07 2018-07-16 Amira Pharmaceuticals Inc Polycyklisk lpa1-antagonist og anvendelser deraf
KR20130126659A (ko) * 2010-12-07 2013-11-20 아미라 파마슈티칼스 인코포레이티드 리소포스파티드산 수용체 길항제 및 섬유증 치료에서의 그의 용도
US8785442B2 (en) 2011-01-30 2014-07-22 Curegenix, Inc. Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof
WO2012138797A1 (en) * 2011-04-05 2012-10-11 Amira Pharmaceuticals, Inc. 3- or 5 - bi phenyl - 4 - ylisoxazole - based compounds useful for the treatment of fibrosis, pain, cancer and respiratory, allergic, nervous system or cardiovascular disorders
JP2014525932A (ja) 2011-08-15 2014-10-02 インターミューン， インコーポレイテッド リゾホスファチド酸レセプターアンタゴニスト
WO2013070879A1 (en) * 2011-11-10 2013-05-16 Bristol-Myers Squibb Company Methods for treating spinal cord injury with lpa receptor antagonists
JP2015504307A (ja) 2011-11-22 2015-02-12 インターミューン， インコーポレイテッド 特発性肺線維症を診断および治療する方法
US20140329871A1 (en) * 2011-12-04 2014-11-06 Angion Biomedica Corp. Small molecule anti-fibrotic compounds and uses thereof
CN110201144B (zh) 2013-03-15 2024-01-02 得克萨斯州大学系统董事会 用Nutlin-3a和肽抑制肺纤维化
WO2014145873A2 (en) 2013-03-15 2014-09-18 Epigen Biosciences, Inc. Heterocyclic compounds useful in the treatment of disease
WO2015102856A1 (en) * 2013-12-30 2015-07-09 Rxbio Inc. Crystalline salts of (z)-o-octadec-9-en-1-yl o,o-dihydrogen phosphorothioate
RU2689315C2 (ru) * 2014-06-27 2019-05-27 Убе Индастриз, Лтд. Соль гетероциклического соединения, замещенного галогеном
AU2016270373A1 (en) 2015-06-05 2018-01-04 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
EP3378491A4 (en) * 2015-11-20 2019-07-17 UBE Industries, Ltd. PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF NASH
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2019041340A1 (en) 2017-09-04 2019-03-07 Eli Lilly And Company LYSOPHOSPHATIDE ACID RECEPTOR 1 RECEPTOR INHIBITORS (LPAR1)
US11447475B2 (en) 2017-12-19 2022-09-20 Bristol-Myers Squibb Company Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists
EP3849580A4 (en) 2018-09-10 2022-06-15 Lung Therapeutics, Inc. MODIFIED PEPTIDE FRAGMENTS OF CAV-1 PROTEIN AND THEIR USE IN THE TREATMENT OF FIBROSIS
EP4058144A1 (en) 2019-11-15 2022-09-21 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
TWI843503B (zh) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
EP4161936A1 (en) 2020-06-03 2023-04-12 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
WO2022006470A1 (en) 2020-07-01 2022-01-06 Vanderbilt University Methods of treatment for a kidney disease
WO2022034568A1 (en) * 2020-08-11 2022-02-17 Viva Star Biosciences Limited Triazole-pyridinyl substituted azacyclohexyl acetic acid compounds as lpa receptor antagonists
WO2022240879A1 (en) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
KR20240007233A (ko) 2021-05-13 2024-01-16 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
WO2023107938A1 (en) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物
WO2025235487A1 (en) * 2024-05-06 2025-11-13 Ohio State Innovation Foundation Lpa receptor antagonist-derived lipid compounds and uses thereof

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