JP2012511586A - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP2012511586A
JP2012511586A JP2011540882A JP2011540882A JP2012511586A JP 2012511586 A JP2012511586 A JP 2012511586A JP 2011540882 A JP2011540882 A JP 2011540882A JP 2011540882 A JP2011540882 A JP 2011540882A JP 2012511586 A JP2012511586 A JP 2012511586A
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JP
Japan
Prior art keywords
glp
pharmaceutical composition
human
polypeptide
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011540882A
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English (en)
Japanese (ja)
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JP2012511586A5 (enExample
Inventor
マーク、エイ．ブッシュ
マレー、ダブリュ．スチュワート
ヨンホン、ヤン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
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GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of JP2012511586A publication Critical patent/JP2012511586A/ja
Publication of JP2012511586A5 publication Critical patent/JP2012511586A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2011540882A 2008-12-10 2009-12-10 医薬組成物 Pending JP2012511586A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12122908P 2008-12-10 2008-12-10
US61/121,229 2008-12-10
US15090909P 2009-02-09 2009-02-09
US61/150,909 2009-02-09
US16399509P 2009-03-27 2009-03-27
US61/163,995 2009-03-27
US23872309P 2009-09-01 2009-09-01
US61/238,723 2009-09-01
PCT/US2009/067469 WO2010068735A1 (en) 2008-12-10 2009-12-10 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
JP2012511586A true JP2012511586A (ja) 2012-05-24
JP2012511586A5 JP2012511586A5 (enExample) 2013-01-31

Family

ID=42243062

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011540882A Pending JP2012511586A (ja) 2008-12-10 2009-12-10 医薬組成物

Country Status (14)

Country Link
US (3) US8748377B2 (enExample)
EP (1) EP2373681B1 (enExample)
JP (1) JP2012511586A (enExample)
CY (1) CY1118731T1 (enExample)
DK (1) DK2373681T3 (enExample)
ES (1) ES2620610T3 (enExample)
HR (1) HRP20170478T1 (enExample)
HU (1) HUE031900T2 (enExample)
LT (1) LT2373681T (enExample)
PL (1) PL2373681T3 (enExample)
PT (1) PT2373681T (enExample)
SI (1) SI2373681T1 (enExample)
SM (1) SMT201700189T1 (enExample)
WO (1) WO2010068735A1 (enExample)

Families Citing this family (24)

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LT2373681T (lt) 2008-12-10 2017-04-10 Glaxosmithkline Llc Albiglutido farmacinės kompozicijos
EP2566502A4 (en) * 2010-05-04 2013-10-09 Glaxosmithkline Llc METHODS OF TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND PROVIDING CARDIOVASCULAR PROTECTION
UY34347A (es) 2011-09-26 2013-04-30 Novartis Ag Proteínas de función dual para tratar trastornos metabólicos
DK2866825T3 (da) 2012-07-01 2020-06-08 Novo Nordisk As Anvendelse af langstidsvirkende glp-1-peptider
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
MX362190B (es) 2012-12-21 2019-01-08 Sanofi Sa Agonistas duales de glp1/gip o trigonales de glp1/gip/glucagon.
US9849066B2 (en) 2013-04-24 2017-12-26 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
GEP201706762B (en) 2013-05-28 2017-10-25 Takeda Pharmaceuticals Co Peptide compound
US20140378374A1 (en) * 2013-06-21 2014-12-25 Glaxosmithkline Intellectual Property (No.2) Limited Methods of treatment
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
RU2017101667A (ru) * 2014-06-25 2018-07-26 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Фармацевтические композиции
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
WO2017204219A1 (ja) 2016-05-24 2017-11-30 武田薬品工業株式会社 ペプチド化合物
MY207828A (en) 2017-09-22 2025-03-21 Regeneron Pharma Glucagon-like peptide 1 receptor agonists and uses thereof
MA50358A (fr) 2017-10-12 2020-08-19 Novo Nordisk As Sémaglutide en thérapie médicale
CN120187750A (zh) 2022-09-21 2025-06-20 瑞泽恩制药公司 治疗肥胖、糖尿病和肝功能障碍的方法

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JPH05506427A (ja) * 1990-01-24 1993-09-22 バツクレイ，ダグラス　アイ． 糖尿病治療に有用なｇｌｐ―１アナログ
JP2003505347A (ja) * 1999-07-12 2003-02-12 ジーランド ファーマ エー／エス 血糖値を降下させるペプチド
WO2007056681A2 (en) * 2005-11-04 2007-05-18 Smithkline Beecham Corporation Methods for administering hypoglycemic agents
WO2008033888A2 (en) * 2006-09-13 2008-03-20 Smithkline Beecham Corporation Methods for administering long-lasting hypoglycemic agents

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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH05506427A (ja) * 1990-01-24 1993-09-22 バツクレイ，ダグラス　アイ． 糖尿病治療に有用なｇｌｐ―１アナログ
JP2003505347A (ja) * 1999-07-12 2003-02-12 ジーランド ファーマ エー／エス 血糖値を降下させるペプチド
WO2007056681A2 (en) * 2005-11-04 2007-05-18 Smithkline Beecham Corporation Methods for administering hypoglycemic agents
WO2008033888A2 (en) * 2006-09-13 2008-03-20 Smithkline Beecham Corporation Methods for administering long-lasting hypoglycemic agents

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Also Published As

Publication number Publication date
US20140228284A1 (en) 2014-08-14
PL2373681T3 (pl) 2017-07-31
SI2373681T1 (sl) 2017-05-31
EP2373681A1 (en) 2011-10-12
LT2373681T (lt) 2017-04-10
DK2373681T3 (en) 2017-04-24
US20110301080A1 (en) 2011-12-08
ES2620610T3 (es) 2017-06-29
HRP20170478T1 (hr) 2017-05-19
US20140228288A1 (en) 2014-08-14
CY1118731T1 (el) 2017-07-12
SMT201700189T1 (it) 2017-05-08
US8748377B2 (en) 2014-06-10
HUE031900T2 (en) 2017-08-28
EP2373681B1 (en) 2017-01-18
PT2373681T (pt) 2017-04-11
WO2010068735A1 (en) 2010-06-17
EP2373681A4 (en) 2013-11-06

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