JP2012510821A - 二重可変ドメイン免疫グロブリンおよびその使用 - Google Patents

二重可変ドメイン免疫グロブリンおよびその使用 Download PDF

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JP2012510821A
JP2012510821A JP2011539744A JP2011539744A JP2012510821A JP 2012510821 A JP2012510821 A JP 2012510821A JP 2011539744 A JP2011539744 A JP 2011539744A JP 2011539744 A JP2011539744 A JP 2011539744A JP 2012510821 A JP2012510821 A JP 2012510821A
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disease
binding
binding protein
antibody
variable domain
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JP2012510821A5 (https=
Inventor
ジエイコブ，クラリツサ・ジー
ウー，チヨンビン
ウオルター，カール・エイ
ガユール，タリク
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Abbott Laboratories
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Abbott Laboratories
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
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  • Urology & Nephrology (AREA)
JP2011539744A 2008-12-04 2009-12-04 二重可変ドメイン免疫グロブリンおよびその使用 Withdrawn JP2012510821A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20087708P 2008-12-04 2008-12-04
US61/200,877 2008-12-04
US21207109P 2009-04-07 2009-04-07
US61/212,071 2009-04-07
PCT/US2009/066815 WO2010065882A1 (en) 2008-12-04 2009-12-04 Dual variable domain immunoglobulins and uses thereof

Publications (2)

Publication Number Publication Date
JP2012510821A true JP2012510821A (ja) 2012-05-17
JP2012510821A5 JP2012510821A5 (https=) 2013-01-24

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ID=42233634

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JP2011539744A Withdrawn JP2012510821A (ja) 2008-12-04 2009-12-04 二重可変ドメイン免疫グロブリンおよびその使用

Country Status (15)

Country Link
US (1) US20100233079A1 (https=)
EP (1) EP2373692A4 (https=)
JP (1) JP2012510821A (https=)
KR (1) KR20110097913A (https=)
CN (1) CN102300879A (https=)
AU (1) AU2009322236B2 (https=)
BR (1) BRPI0922807A2 (https=)
CA (1) CA2745271A1 (https=)
IL (1) IL213340A0 (https=)
MX (1) MX2011005953A (https=)
NZ (1) NZ593314A (https=)
RU (1) RU2011127198A (https=)
SG (1) SG171812A1 (https=)
WO (1) WO2010065882A1 (https=)
ZA (2) ZA201104854B (https=)

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