JP2012509983A5 - - Google Patents
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- JP2012509983A5 JP2012509983A5 JP2011538669A JP2011538669A JP2012509983A5 JP 2012509983 A5 JP2012509983 A5 JP 2012509983A5 JP 2011538669 A JP2011538669 A JP 2011538669A JP 2011538669 A JP2011538669 A JP 2011538669A JP 2012509983 A5 JP2012509983 A5 JP 2012509983A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- block
- hydrophobic
- hydrophilic
- block copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001400 block copolymer Polymers 0.000 claims 25
- 230000002209 hydrophobic effect Effects 0.000 claims 23
- 239000000693 micelle Substances 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 229920002125 Sokalan® Polymers 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 229920002873 Polyethylenimine Polymers 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 5
- NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 5
- 229920000805 Polyaspartic acid Polymers 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 5
- 150000004676 glycans Chemical class 0.000 claims 5
- 229920002674 hyaluronan Polymers 0.000 claims 5
- 229960003160 hyaluronic acid Drugs 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 229920001603 poly (alkyl acrylates) Polymers 0.000 claims 5
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims 5
- 229920002401 polyacrylamide Polymers 0.000 claims 5
- 229920002643 polyglutamic acid Polymers 0.000 claims 5
- 229920001451 polypropylene glycol Polymers 0.000 claims 5
- 229920001282 polysaccharide Polymers 0.000 claims 5
- 239000005017 polysaccharide Substances 0.000 claims 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 5
- XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 claims 4
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical group C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 4
- 229920000359 diblock copolymer Polymers 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920006030 multiblock copolymer Polymers 0.000 claims 4
- 229920001713 poly(ethylene-co-vinyl alcohol) Polymers 0.000 claims 4
- 229920000917 poly(propylene sulfide) Polymers 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- OQXNUCOGMMHHNA-UHFFFAOYSA-N 4-methyl-1,3,2-dioxathiolane 2,2-dioxide Chemical compound CC1COS(=O)(=O)O1 OQXNUCOGMMHHNA-UHFFFAOYSA-N 0.000 claims 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- -1 acyl hydrazone Chemical class 0.000 claims 1
- 229940009456 adriamycin Drugs 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
- 229960003942 amphotericin b Drugs 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229920001038 ethylene copolymer Polymers 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920000962 poly(amidoamine) Polymers 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11789208P | 2008-11-25 | 2008-11-25 | |
| US61/117,892 | 2008-11-25 | ||
| PCT/US2009/065693 WO2010068432A1 (en) | 2008-11-25 | 2009-11-24 | Block copolymers and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217197A Division JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509983A JP2012509983A (ja) | 2012-04-26 |
| JP2012509983A5 true JP2012509983A5 (OSRAM) | 2013-01-17 |
| JP5814793B2 JP5814793B2 (ja) | 2015-11-17 |
Family
ID=42243027
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538669A Active JP5814793B2 (ja) | 2008-11-25 | 2009-11-24 | ブロックコポリマーおよびその使用 |
| JP2014217197A Active JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
| JP2016100375A Active JP6409020B2 (ja) | 2008-11-25 | 2016-05-19 | ブロックコポリマーおよびその使用 |
| JP2018119659A Active JP6641423B2 (ja) | 2008-11-25 | 2018-06-25 | ブロックコポリマーおよびその使用 |
| JP2019238237A Pending JP2020073678A (ja) | 2008-11-25 | 2019-12-27 | ブロックコポリマーおよびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217197A Active JP5995939B2 (ja) | 2008-11-25 | 2014-10-24 | ブロックコポリマーおよびその使用 |
| JP2016100375A Active JP6409020B2 (ja) | 2008-11-25 | 2016-05-19 | ブロックコポリマーおよびその使用 |
| JP2018119659A Active JP6641423B2 (ja) | 2008-11-25 | 2018-06-25 | ブロックコポリマーおよびその使用 |
| JP2019238237A Pending JP2020073678A (ja) | 2008-11-25 | 2019-12-27 | ブロックコポリマーおよびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (5) | US9271929B2 (OSRAM) |
| EP (1) | EP2356228B1 (OSRAM) |
| JP (5) | JP5814793B2 (OSRAM) |
| WO (1) | WO2010068432A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5329949B2 (ja) | 2005-05-31 | 2013-10-30 | エコーレ ポリテクニーク フェデラーレ デ ローザンヌ | 遺伝子に基づいた薬物の細胞質送達のためのトリブロックコポリマー |
| EP2356228B1 (en) * | 2008-11-25 | 2023-05-03 | École Polytechnique Fédérale de Lausanne (EPFL) | Block copolymers and uses thereof |
| EP2626130B1 (en) * | 2010-05-21 | 2016-07-06 | Japan Science And Technology Agency | Substance-encapsulating vesicle and process for producing the same |
| EP2591792B1 (en) * | 2010-07-09 | 2016-12-21 | The University of Tokyo | Composition for nucleic acid delivery, carrier composition, pharmaceutical composition using the composition for nucleic acid delivery or the carrier composition, and method for delivering nucleic acid |
| WO2014134203A1 (en) * | 2013-02-26 | 2014-09-04 | The Regents Of The University Of California | Amphiphilic derivatives of thioether containing block copolypeptides |
| US10711106B2 (en) | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
| WO2015058141A1 (en) * | 2013-10-18 | 2015-04-23 | Virginia Tech Intellectual Properties, Inc. | Nucleobase-containing monomers and copolymers |
| US20160271268A1 (en) * | 2013-11-08 | 2016-09-22 | Dana-Farber Cancer Institute, Inc. | Nucleic acid nanostructures for in vivo agent delivery |
| US10351591B2 (en) | 2015-03-20 | 2019-07-16 | The Regents Of The University Of California | Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| EP3124495A1 (en) | 2015-07-31 | 2017-02-01 | Centre National de la Recherche Scientifique (C.N.R.S.) | Derivatives of elastin-like polypeptides and uses thereof |
| WO2017156264A1 (en) | 2016-03-11 | 2017-09-14 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| EP3448872A4 (en) | 2016-04-27 | 2019-12-11 | The Regents of the University of California | PREPARATION OF FUNCTIONAL HOMOCYSTEINRESTES IN POLYPEPTIDES AND PEPTIDES |
| ES2865481T3 (es) | 2016-04-29 | 2021-10-15 | Poseida Therapeutics Inc | Micelas basadas en poli(histidina) para la complejación y el aporte de proteínas y ácidos nucleicos |
| KR101913146B1 (ko) | 2016-06-16 | 2018-11-01 | 주식회사 엘지화학 | 양친성 트리블록 고분자 |
| WO2018022457A1 (en) * | 2016-07-29 | 2018-02-01 | The Regents Of The University Of California | Accelerated healing by injectable multi-arm branched amphiphilic scaffolds loaded with hydrophobic drugs |
| CN115948505B (zh) | 2016-08-02 | 2025-07-25 | 哈佛学院院长及董事 | 交叉协同自组装体 |
| JP6912876B2 (ja) * | 2016-10-06 | 2021-08-04 | 三洋化成工業株式会社 | アクリル系医薬固形製剤用添加剤 |
| CN107236106B (zh) * | 2017-06-13 | 2020-01-07 | 青岛科技大学 | 含酰腙键的芳香族端羟基扩链剂、自修复聚氨酯及其制备方法 |
| US10376468B2 (en) * | 2017-12-05 | 2019-08-13 | International Business Machines Corporation | Block copolymers and self-assembling nanoparticles formed therefrom |
| CN108904446B (zh) * | 2018-06-11 | 2021-05-11 | 中山大学 | 一种动脉斑块微环境响应的载药纳米胶束的制备方法及应用 |
| JP7154568B2 (ja) * | 2018-06-22 | 2022-10-18 | 国立大学法人福井大学 | 両親媒性高分子、およびその利用 |
| CA3117446A1 (en) * | 2018-10-22 | 2020-04-30 | Takeda Pharmaceutical Company Limited | Nanoparticle encapsulation to target g protein-coupled receptors in endosomes |
| WO2020210468A1 (en) | 2019-04-10 | 2020-10-15 | President And Fellows Of Harvard College | Nucleic acid nanostructures crosslinked with oligolysine |
| KR102329966B1 (ko) * | 2020-03-23 | 2021-11-23 | 전남대학교산학협력단 | 양친성 고분자 화합물, 이를 이용한 약물 전달체 및 종양 치료 시스템 |
| US20240024354A1 (en) * | 2020-09-04 | 2024-01-25 | The University Of Chicago | Materials and methods of treating viral infection with amphiphilic block copolymers |
| KR102418116B1 (ko) * | 2020-10-08 | 2022-07-06 | 강원대학교산학협력단 | 양친매성 공중합체로 안정화된 산화 응답성 에멀젼 |
| KR102696775B1 (ko) * | 2021-07-21 | 2024-08-20 | 주식회사 삼양홀딩스 | 조직 수복용 분말 제형 및 이의 제조 방법, 및 이를 포함하는 조직 수복용 주사제 조성물 |
| WO2025145010A1 (en) * | 2023-12-29 | 2025-07-03 | The University Of Chicago | Amphiphilic block copolymers, polymersomes, and methods of use |
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| US10711106B2 (en) | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
-
2009
- 2009-11-24 EP EP09832335.5A patent/EP2356228B1/en active Active
- 2009-11-24 JP JP2011538669A patent/JP5814793B2/ja active Active
- 2009-11-24 WO PCT/US2009/065693 patent/WO2010068432A1/en not_active Ceased
- 2009-11-24 US US13/130,892 patent/US9271929B2/en active Active
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2014
- 2014-10-24 JP JP2014217197A patent/JP5995939B2/ja active Active
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2016
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- 2016-05-19 JP JP2016100375A patent/JP6409020B2/ja active Active
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2018
- 2018-06-25 JP JP2018119659A patent/JP6641423B2/ja active Active
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2019
- 2019-07-01 US US16/459,039 patent/US20200000936A1/en not_active Abandoned
- 2019-12-27 JP JP2019238237A patent/JP2020073678A/ja active Pending
-
2021
- 2021-07-02 US US17/366,846 patent/US20220168448A1/en not_active Abandoned
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2024
- 2024-02-05 US US18/432,899 patent/US20250001005A1/en not_active Abandoned
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